- Artificial Intelligence in Cancer
- Artificial Intelligence in Gastroenterology
- Artificial Intelligence in Gastrointestinal Endoscopy
- Artificial Intelligence in Medical Imaging
- World Journal of Anesthesiology
- World Journal of Biological Chemistry
- World Journal of Cardiology
- World Journal of Clinical Cases
- World Journal of Clinical Infectious Diseases
- World Journal of Clinical Oncology
- World Journal of Clinical Pediatrics
- World Journal of Clinical Urology
- World Journal of Critical Care Medicine
- World Journal of Dermatology
- World Journal of Diabetes
- World Journal of Experimental Medicine
- World Journal of Gastroenterology
- World Journal of Gastrointestinal Endoscopy
- World Journal of Gastrointestinal Oncology
- World Journal of Gastrointestinal Pathophysiology
- World Journal of Gastrointestinal Pharmacology and Therapeutics
- World Journal of Gastrointestinal Surgery
- World Journal of Hematology
- World Journal of Hepatology
- World Journal of Hypertension
- World Journal of Immunology
- World Journal of Medical Genetics
- World Journal of Meta-Analysis
- World Journal of Methodology
- World Journal of Nephrology
- World Journal of Neurology
- World Journal of Obstetrics and Gynecology
- World Journal of Ophthalmology
- World Journal of Orthopedics
- World Journal of Otorhinolaryngology
- World Journal of Pharmacology
- World Journal of Psychiatry
- World Journal of Radiology
- World Journal of Respirology
- World Journal of Rheumatology
- World Journal of Stem Cells
- World Journal of Stomatology
- World Journal of Surgical Procedures
- World Journal of Translational Medicine
- World Journal of Transplantation
- World Journal of Virology
- 世界华人消化杂志
Review
Brandon J Perumpail, Muhammad Ali Khan, Eric R Yoo, George Cholankeril, Donghee Kim, Aijaz Ahmed
World J Gastroenterol
23(47):8263-8276.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8263
Abstract (1658)
|
Core Tip (1613)
|
Full Article (HTML) (29192)
|
Figures (1-5) (398)
|
Full Article (PDF)-1695K (3131)
|
Audio-2230K (169)
|
Videos (1-1) (95)
|
Peer-Review Report-168K (319)
|
Answering Reviewers-62K (359)
|
Received: 10/22/2017
|
Revised: 11/14/2017
|
Accepted: 12/04/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (541)
|
Total Visits (44164)
|
Similar Articles (393)
|
Timeline of Article Publication (9)
|
Authors Evaluation (10)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(1)
|
Open
(1)
|
Open
Minireviews
Giusy Ranucci, Maria Immacolata Spagnuolo, Raffaele Iorio
World J Gastroenterol
23(47):8277-8282.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8277
Abstract (1722)
|
Core Tip (1184)
|
Full Article (HTML) (4309)
|
Tables (1-1) (335)
|
Full Article (PDF)-1389K (583)
|
Audio-1636K (20)
|
Videos (1-1) (10)
|
Peer-Review Report-203K (182)
|
Answering Reviewers-152K (200)
|
Received: 10/23/2017
|
Revised: 11/14/2017
|
Accepted: 12/04/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (10)
|
Total Visits (12677)
|
Similar Articles (247)
|
Timeline of Article Publication (6)
|
Authors Evaluation (5)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Giuseppe Lippi, Fabian Sanchis-Gomar
World J Gastroenterol
23(47):8283-8290.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8283
Abstract (1232)
|
Core Tip (1204)
|
Full Article (HTML) (6547)
|
Figures (1-3) (362)
|
Tables (1-1) (334)
|
Full Article (PDF)-1718K (709)
|
Audio-162K (17)
|
Videos (1-1) (18)
|
Peer-Review Report-139K (184)
|
Answering Reviewers-165K (231)
|
Received: 10/28/2017
|
Revised: 11/27/2017
|
Accepted: 12/04/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (34)
|
Total Visits (15886)
|
Similar Articles (11)
|
Timeline of Article Publication (5)
|
Authors Evaluation (6)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Basic Study
Gene mutations in stool from gastric and colorectal neoplasia patients by next-generation sequencing 
Omar Youssef, Virinder Sarhadi, Homa Ehsan, Tom Böhling, Monika Carpelan-Holmström, Selja Koskensalo, Pauli Puolakkainen, Arto Kokkola, Sakari Knuutila
World J Gastroenterol
23(47):8291-8299.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8291
Abstract (1361)
|
Core Tip (1337)
|
Article Highlights (1305)
|
Full Article (HTML) (5030)
|
Tables (1-2) (337)
|
Full Article (PDF)-1487K (600)
|
Audio-1142K (21)
|
Videos (1-1) (15)
|
Peer-Review Report-98K (222)
|
Answering Reviewers-103K (178)
|
Received: 10/03/2017
|
Revised: 11/01/2017
|
Accepted: 11/14/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (12)
|
Total Visits (15790)
|
Similar Articles (29)
|
Timeline of Article Publication (2)
|
Authors Evaluation (23)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Nezha Senhaji, Sellama Nadifi, Younes Zaid, Aurora Serrano, Daniel Arturo Leon Rodriguez, Nadia Serbati, Mehdi Karkouri, Wafaa Badre, Javier Martín
World J Gastroenterol
23(47):8300-8307.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8300
Abstract (1178)
|
Core Tip (1108)
|
Full Article (HTML) (3709)
|
Tables (1-6) (348)
|
Full Article (PDF)-1534K (413)
|
Audio-2717K (25)
|
Videos (1-1) (15)
|
Peer-Review Report-75K (187)
|
Answering Reviewers-235K (293)
|
Received: 03/23/2017
|
Revised: 05/14/2017
|
Accepted: 06/01/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (9)
|
Total Visits (13929)
|
Similar Articles (609)
|
Timeline of Article Publication (5)
|
Authors Evaluation (25)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Shi-Ying Wang, Ping Tao, Hong-Yi Hu, Jian-Ye Yuan, Lei Zhao, Bo-Yun Sun, Wang-Jun Zhang, Jiang Lin
World J Gastroenterol
23(47):8308-8320.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8308
Abstract (1360)
|
Core Tip (1291)
|
Article Highlights (1274)
|
Full Article (HTML) (4051)
|
Figures (1-6) (354)
|
Full Article (PDF)-3254K (560)
|
Audio-411K (15)
|
Videos (1-1) (15)
|
Peer-Review Report-77K (238)
|
Answering Reviewers-123K (242)
|
Received: 09/06/2017
|
Revised: 11/03/2017
|
Accepted: 11/14/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (15)
|
Total Visits (16291)
|
Similar Articles (1)
|
Timeline of Article Publication (3)
|
Authors Evaluation (6)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Bin-Rui Chen, Li-Jun Du, Hui-Qin He, John J Kim, Yan Zhao, Ya-Wen Zhang, Liang Luo, Ning Dai
World J Gastroenterol
23(47):8321-8333.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8321
Abstract (1161)
|
Core Tip (1093)
|
Article Highlights (1239)
|
Full Article (HTML) (6211)
|
Figures (1-6) (489)
|
Tables (1-1) (305)
|
Full Article (PDF)-1999K (720)
|
Audio-806K (25)
|
Videos (1-1) (16)
|
Peer-Review Report-122K (295)
|
Answering Reviewers-209K (312)
|
Received: 09/27/2017
|
Revised: 11/14/2017
|
Accepted: 11/21/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (41)
|
Total Visits (19002)
|
Similar Articles (248)
|
Timeline of Article Publication (4)
|
Authors Evaluation (7)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Liang Sang, Xue-Mei Wang, Dong-Yang Xu, Li-Xuan Sang, Yang Han, Long-Yang Jiang
World J Gastroenterol
23(47):8334-8344.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8334
Abstract (1265)
|
Core Tip (1205)
|
Article Highlights (1504)
|
Full Article (HTML) (5124)
|
Figures (1-7) (549)
|
Tables (1-3) (315)
|
Full Article (PDF)-1970K (692)
|
Audio-2384K (14)
|
Videos (1-1) (26)
|
Peer-Review Report-146K (239)
|
Answering Reviewers-153K (248)
|
Received: 09/21/2017
|
Revised: 10/20/2017
|
Accepted: 11/14/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (39)
|
Total Visits (18210)
|
Similar Articles (179)
|
Timeline of Article Publication (12)
|
Authors Evaluation (6)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Fan Yang, Dong-Yan Liu, Jin-Tao Guo, Nan Ge, Ping Zhu, Xiang Liu, Sheng Wang, Guo-Xin Wang, Si-Yu Sun
World J Gastroenterol
23(47):8345-8354.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8345
Abstract (1307)
|
Core Tip (1291)
|
Article Highlights (1432)
|
Full Article (HTML) (5582)
|
Figures (1-3) (606)
|
Tables (1-6) (476)
|
Full Article (PDF)-1659K (663)
|
Audio-1465K (17)
|
Videos (1-1) (8)
|
Peer-Review Report-107K (214)
|
Answering Reviewers-12K (226)
|
Received: 11/03/2017
|
Revised: 11/17/2017
|
Accepted: 11/27/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (151)
|
Total Visits (16855)
|
Similar Articles (460)
|
Timeline of Article Publication (5)
|
Authors Evaluation (6)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Case Control Study
Kosuke Kaji, Hiroaki Takaya, Soichiro Saikawa, Masanori Furukawa, Shinya Sato, Hideto Kawaratani, Mitsuteru Kitade, Kei Moriya, Tadashi Namisaki, Takemi Akahane, Akira Mitoro, Hitoshi Yoshiji
World J Gastroenterol
23(47):8355-8366.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8355
Abstract (1451)
|
Core Tip (1243)
|
Article Highlights (1374)
|
Full Article (HTML) (7039)
|
Figures (1-6) (340)
|
Tables (1-1) (302)
|
Full Article (PDF)-1677K (1058)
|
Audio-2315K (70)
|
Videos (1-1) (11)
|
Peer-Review Report-133K (242)
|
Answering Reviewers-84K (254)
|
Supplementary Material-36K (296)
|
Received: 10/04/2017
|
Revised: 10/30/2017
|
Accepted: 11/14/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (82)
|
Total Visits (20894)
|
Similar Articles (94)
|
Timeline of Article Publication (9)
|
Authors Evaluation (5)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Retrospective Study
Keisuke Kawasaki, Makoto Eizuka, Shotaro Nakamura, Masaki Endo, Shunichi Yanai, Risaburo Akasaka, Yosuke Toya, Yasuko Fujita, Noriyuki Uesugi, Kazuyuki Ishida, Tamotsu Sugai, Takayuki Matsumoto
World J Gastroenterol
23(47):8367-8375.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8367
Abstract (1196)
|
Core Tip (1471)
|
Article Highlights (1538)
|
Full Article (HTML) (3795)
|
Figures (1-6) (554)
|
Tables (1-2) (460)
|
Full Article (PDF)-2121K (443)
|
Audio-1263K (30)
|
Videos (1-1) (9)
|
Peer-Review Report-137K (160)
|
Answering Reviewers-92K (181)
|
Received: 10/25/2017
|
Revised: 11/30/2017
|
Accepted: 12/04/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (8)
|
Total Visits (15203)
|
Similar Articles (1)
|
Timeline of Article Publication (8)
|
Authors Evaluation (7)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Long-Long Cao, Jun Lu, Jian-Xian Lin, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Qi-Yue Chen, Mi Lin, Ru-Hong Tu, Chang-Ming Huang
World J Gastroenterol
23(47):8376-8386.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8376
Abstract (1117)
|
Core Tip (1049)
|
Full Article (HTML) (3738)
|
Figures (1-4) (405)
|
Tables (1-5) (441)
|
Full Article (PDF)-1938K (641)
|
Audio-903K (34)
|
Videos (1-1) (31)
|
Peer-Review Report-64K (197)
|
Answering Reviewers-46K (182)
|
Received: 03/09/2017
|
Revised: 06/03/2017
|
Accepted: 07/04/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (15)
|
Total Visits (13570)
|
Similar Articles (1)
|
Timeline of Article Publication (15)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Jun-Xi Xiang, Liang-Shuo Hu, Peng Liu, Bo-Yan Tian, Qing Su, Yi-Chun Ji, Xu-Feng Zhang, Xue-Min Liu, Zheng Wu, Yi Lv
World J Gastroenterol
23(47):8387-8394.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8387
Abstract (1121)
|
Core Tip (1085)
|
Article Highlights (1293)
|
Full Article (HTML) (3649)
|
Figures (1-2) (337)
|
Tables (1-3) (313)
|
Full Article (PDF)-1538K (507)
|
Audio-1527K (16)
|
Videos (1-1) (12)
|
Peer-Review Report-145K (178)
|
Answering Reviewers-136K (180)
|
Received: 10/18/2017
|
Revised: 11/11/2017
|
Accepted: 11/27/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (18)
|
Total Visits (14097)
|
Similar Articles (381)
|
Timeline of Article Publication (4)
|
Authors Evaluation (3)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Clinical Trials Study
Chih-Ming Liang, Ming-Te Kuo, Pin-I Hsu, Chao-Hung Kuo, Wei-Chen Tai, Shih-Cheng Yang, Keng-Liang Wu, Hsing-Ming Wang, Chih-Chien Yao, Cheng-En Tsai, Yao-Kuang Wang, Jiunn-Wei Wang, Chih-Fang Huang, Deng-Chyang Wu, Seng-Kee Chuah, Taiwan Acid-Related Disease Study Group
World J Gastroenterol
23(47):8395-8404.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8395
Abstract (1492)
|
Core Tip (1403)
|
Article Highlights (1508)
|
Full Article (HTML) (6332)
|
Figures (1-1) (528)
|
Tables (1-5) (452)
|
Full Article (PDF)-1577K (667)
|
Audio-5752K (48)
|
Videos (1-1) (25)
|
Peer-Review Report-80K (264)
|
Answering Reviewers-282K (285)
|
Received: 07/27/2017
|
Revised: 09/19/2017
|
Accepted: 09/26/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (6)
|
Total Visits (23087)
|
Similar Articles (111)
|
Timeline of Article Publication (3)
|
Authors Evaluation (8)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Observational Study
Henry Córdova, Lidia Argüello, Carme Loras, Antonio Naranjo Rodríguez, Faust Riu Pons, Joan B Gornals, David Nicolás-Pérez, Xavier Andújar Murcia, Luis Hernández, Santos Santolaria, Carles Leal, Carles Pons, Enrique Pérez-Cuadrado-Robles, Orlando García-Bosch, Michel Papo Berger, José Luis Ulla Rocha, Cristina Sánchez-Montes, Gloria Fernández-Esparrach
World J Gastroenterol
23(47):8405-8414.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8405
Abstract (1214)
|
Core Tip (1326)
|
Article Highlights (1316)
|
Full Article (HTML) (4602)
|
Figures (1-2) (320)
|
Tables (1-5) (328)
|
Full Article (PDF)-1552K (451)
|
Audio-1294K (17)
|
Videos (1-1) (16)
|
Peer-Review Report-145K (205)
|
Answering Reviewers-345K (258)
|
Received: 09/01/2017
|
Revised: 10/03/2017
|
Accepted: 10/26/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (3)
|
Total Visits (16224)
|
Similar Articles (33)
|
Timeline of Article Publication (3)
|
Authors Evaluation (25)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Meta-Analysis
Roland Hágendorn, Nelli Farkas, Áron Vincze, Zoltán Gyöngyi, Dezső Csupor, Judit Bajor, Bálint Erőss, Péter Csécsei, Andrea Vasas, Zsolt Szakács, László Szapáry, Péter Hegyi, Alexandra Mikó
World J Gastroenterol
23(47):8415-8425.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8415
Abstract (1158)
|
Core Tip (1023)
|
Article Highlights (1222)
|
Full Article (HTML) (7709)
|
Figures (1-7) (438)
|
Tables (1-3) (470)
|
Full Article (PDF)-1566K (613)
|
Audio-676K (39)
|
Videos (1-1) (14)
|
Peer-Review Report-133K (254)
|
Answering Reviewers-102K (242)
|
Supplementary Material-322K (200)
|
Received: 10/30/2017
|
Revised: 11/23/2017
|
Accepted: 12/04/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (20)
|
Total Visits (18933)
|
Similar Articles (150)
|
Timeline of Article Publication (6)
|
Authors Evaluation (20)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Case Report
Luca de Martinis, Gloria Groppelli, Riccardo Corti, Lorenzo Paolo Moramarco, Pietro Quaretti, Pasquale De Cata, Mario Rotondi, Luca Chiovato
World J Gastroenterol
23(47):8426-8431.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8426
Abstract (1030)
|
Core Tip (1065)
|
Article Highlights (1236)
|
Full Article (HTML) (3551)
|
Figures (1-4) (353)
|
Tables (1-1) (339)
|
Full Article (PDF)-2915K (576)
|
Audio-699K (18)
|
Videos (1-1) (21)
|
Peer-Review Report-120K (256)
|
Answering Reviewers-66K (246)
|
Received: 09/22/2017
|
Revised: 10/20/2017
|
Accepted: 11/01/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (3)
|
Total Visits (12668)
|
Similar Articles (4)
|
Timeline of Article Publication (1)
|
Authors Evaluation (10)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Bin Xie, Zhong-Zhou Si, Wei-Ting Tang, Hai-Zhi Qi, Ting Li
World J Gastroenterol
23(47):8432-8436.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8432
Abstract (1067)
|
Core Tip (1095)
|
Article Highlights (1086)
|
Full Article (HTML) (3576)
|
Figures (1-1) (401)
|
Full Article (PDF)-1509K (432)
|
Audio-396K (17)
|
Videos (1-1) (9)
|
Peer-Review Report-192K (154)
|
Answering Reviewers-46K (239)
|
Received: 10/20/2017
|
Revised: 11/22/2017
|
Accepted: 11/27/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (7)
|
Total Visits (13870)
|
Similar Articles (493)
|
Timeline of Article Publication (19)
|
Authors Evaluation (8)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open
Letters To The Editor
Carmela Colica, Luigi Boccuto, Ludovico Abenavoli
World J Gastroenterol
23(47):8437-8438.
Published online Dec 21, 2017.
doi: 10.3748/wjg.v23.i47.8437
Abstract (1297)
|
Core Tip (1234)
|
Full Article (HTML) (3934)
|
Full Article (PDF)-1239K (613)
|
Audio-319K (21)
|
Videos (1-1) (28)
|
Peer-Review Report-110K (194)
|
Answering Reviewers-83K (205)
|
Received: 11/08/2017
|
Revised: 11/27/2017
|
Accepted: 12/04/2017
|
RCA
|
PubMed Central
|
PubMed
|
CrossRef
|
Google Scholar
|
Times Cited (17)
|
Total Visits (11749)
|
Similar Articles (218)
|
Timeline of Article Publication (4)
|
Authors Evaluation (7)
|
Article Quality Tracking (0)
|
What about the content of this article? (0)
|
Cite
|
(0)
|
Open
(0)
|
Open