Copyright
©The Author(s) 2017.
World J Gastroenterol. Dec 21, 2017; 23(47): 8395-8404
Published online Dec 21, 2017. doi: 10.3748/wjg.v23.i47.8395
Published online Dec 21, 2017. doi: 10.3748/wjg.v23.i47.8395
Table 1 Baseline characteristics of the patients [n = 81, n (%)]
Variables | Dexlansoprazole | Esomeprazole | P value |
Age (mean ± SD, yr) | 50.6 ± 13.3 | 49.9 ± 12.8 | 0.985 |
Male sex | 34 (42.0) | 43 (53.1) | 0.137 |
Smoking | 12 (14.8) | 9 (11.1) | 0.483 |
Alcohol use | 22 (27.2) | 22 (27.2) | 1.000 |
Ingestion of coffee | 44 (54.3) | 36 (44.4) | 0.209 |
Ingestion of tea | 58 (71.6) | 49 (60.5) | 0.230 |
Betel nut | 4 (4.9) | 1 (1.2) | 0.173 |
Spicy food | 52 (64.2) | 51 (63.0) | 0.870 |
Sweet food | 72 (88.9) | 75 (92.6) | 0.416 |
Body mass index | 25.4 ± 4.8 | 24.9 ± 4.4 | 0.420 |
Waist girth | 88.8 ± 12.2 | 88.7 ± 11.4 | 0.361 |
Metabolic syndrome | 36 (44.4) | 38 (46.9) | 0.950 |
Atypical symptoms | |||
Chest pain | 38 (46.9) | 39 (48.1) | 0.588 |
Dysphagia | 20 (24.7) | 22 (27.2) | 0.557 |
Regurgitation of food | 29 (35.8) | 31 (38.3) | 0.561 |
Nausea | 26 (32.1) | 23 (28.4) | 0.544 |
Hiccup | 37 (45.7) | 44 (54.3) | 0.300 |
Foreign body sensation (throat) | 48 (59.3) | 40 (49.4) | 0.301 |
Foreign body sensation (chest) | 16 (19.8) | 16 (19.8) | 0.604 |
Hoarseness | 28 (34.6) | 28 (34.6) | 0.604 |
Throat cleaning | 44 (54.3) | 44 (54.3) | 0.602 |
Cough | 38 (46.9) | 34 (42.0) | 0.516 |
Sore throat | 20 (24.7) | 20 (24.7) | 0.604 |
Dry mouth | 54 (66.7) | 52 (64.2) | 0.590 |
Bad breath | 29 (35.8) | 30 (37.0) | 0.590 |
Epigastric pain | 36 (44.4) | 45 (55.6) | 0.197 |
Epigastric fullness | 65 (80.2) | 54 (66.7) | 0.111 |
Insomnia | 36 (44.4) | 28 (34.6) | 0.199 |
Sinusitis | 7 (8.6) | 14 (17.3) | 0.102 |
Otitis media | 5 (6.2) | 5 (6.2) | 1.000 |
Sugar | 97.4 ± 12.5 | 97.0 ± 12.8 | 0.604 |
Cholesterol | 205.3 ± 36.7 | 207.7 ± 35.4 | 0.971 |
Triglyceride | 121.9 ± 57.2 | 113.7 ± 64.7 | 0.284 |
HDL | 54.7 ± 18.2 | 55.3 ± 14.4 | 0.866 |
LDL | 127.0 ± 32.7 | 127.5 ± 32.8 | 0.942 |
H. pylori infection | |||
Previous history - no | 10 (12.3) | 15 (18.5) | 0.553 |
Current infection - no | 10 (12.3) | 12 (14.8) | 0.703 |
Endoscopic findings | |||
Hiatal hernia | 10 (12.3) | 15 (18.5) | 0.347 |
GEFV (grade 3 or 4) | 7 (8.6) | 8 (9.9) | 0.521 |
Esophagitis grade B | 15 (18.5) | 13 (16.0) | 0.678 |
Table 2 Comparison of the complete symptom resolution rates and night-time breakthrough heartburn between dexlansoprazole and esomeprazole over one week [n = 81, n (%)]
Variables | Dexlansoprazole | Esomeprazole | P value |
CSR Day 1 | 21 (25.9) | 23 (28.4) | 0.724 |
CSR Day 3 | 27 (33.3) | 26 (32.1) | 0.867 |
CSR Day 7 | 42 (51.9) | 39 (48.1) | 0.637 |
Night reflux | 45 (76.3) | 40 (74.1) | 0.787 |
Night heart burn | 20 (33.9) | 18 (33.3) | 0.949 |
Night acid reflux | 20 (33.9) | 19 (35.2) | 0.886 |
Frequency of night symptoms | 2.7 ± 2.0 | 2.7 ± 2.4 | 0.343 |
Table 3 Comparison of the complete symptom resolution rates between dexlansoprazole and esomeprazole over one week (Subgroup analysis by gender) n (%)
Time | Gender | Dexlansoprazole | Esomeprazole | P value |
CSR Day 1 | Female | 13 (27.7) | 6 (15.8) | 0.192 |
Male | 8 (23.5) | 17 (39.5) | 0.136 | |
CSR Day 3 | Female | 18 (38.3) | 7 (18.4) | 0.046 |
Male | 9 (26.5) | 19 (44.2) | 0.109 | |
CSR Day 7 | Female | 26 (55.3) | 14 (36.8) | 0.090 |
Male | 16 (47.1) | 25 (58.1) | 0.333 |
Table 4 Multivariate analysis of the clinical factors predictive of complete symptom resolution within one week based on dexlansoprazole and esomeprazole administration
Time | PPI | Clinical factors | CSR | Coefficient of variation | Odds ratio (95%CI) | P value |
Day 1 | Dexlansoprazole | Null | ||||
Esomeprazole | Female | 15.80% | -1.249 ± 0.543 | 0.285 (0.103-0.789) | 0.022 | |
Day 3 | Dexlansoprazole | Null | ||||
Esomeprazole | Female | 18.40% | -1.254 ± 0.519 | 0.287 (0.099-0.832) | 0.016 | |
Day 7 | Dexlansoprazole | Null | ||||
Esomeprazole | Null |
Table 5 Multivariate analysis of the clinical factors predictive of complete symptom resolution within one week
Time | Clinical factor | CSR | Coefficient of variation | Odds ratio (95%CI) | P value |
Day 1 | Spicy food | No: 37.3% | -0.969 ± 0.438 | 0.380 (0.161-0.896) | 0.027 |
Yes: 21.4% | |||||
Day 3 | Null | ||||
Day 7 | Null |
- Citation: Liang CM, Kuo MT, Hsu PI, Kuo CH, Tai WC, Yang SC, Wu KL, Wang HM, Yao CC, Tsai CE, Wang YK, Wang JW, Huang CF, Wu DC, Chuah SK, Taiwan Acid-Related Disease Study Group. First-week clinical responses to dexlansoprazole 60 mg and esomeprazole 40 mg for the treatment of grades A and B gastroesophageal reflux disease. World J Gastroenterol 2017; 23(47): 8395-8404
- URL: https://www.wjgnet.com/1007-9327/full/v23/i47/8395.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i47.8395