Retrospective Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2017; 23(47): 8367-8375
Published online Dec 21, 2017. doi: 10.3748/wjg.v23.i47.8367
Association between white opaque substance under magnifying colonoscopy and lipid droplets in colorectal epithelial neoplasms
Keisuke Kawasaki, Makoto Eizuka, Shotaro Nakamura, Masaki Endo, Shunichi Yanai, Risaburo Akasaka, Yosuke Toya, Yasuko Fujita, Noriyuki Uesugi, Kazuyuki Ishida, Tamotsu Sugai, Takayuki Matsumoto
Keisuke Kawasaki, Shotaro Nakamura, Shunichi Yanai, Risaburo Akasaka, Yosuke Toya, Takayuki Matsumoto, Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University, Morioka 020-8505, Japan
Makoto Eizuka, Yasuko Fujita, Noriyuki Uesugi, Kazuyuki Ishida, Tamotsu Sugai, Department of Diagnostic Pathology, Iwate Medical University, Morioka 020-8505, Japan
Masaki Endo, Kaiunbashi Endoscopy Clinic, Morioka 020-0022, Japan
Author contributions: Kawasaki K designed the study, and was involved in patients’ management, performed endoscopic examinations and drafted the manuscript; Eizuka M reviewed the histological specimens and was responsible for the pathological diagnosis; Nakamura S, Endo M, Yanai S, Akasaka R, Toya Y, Fujita Y, Uesugi N and Ishida K participated in helped to draft the manuscript; Sugai T reviewed the histological specimens and was responsible for the pathological diagnosis; Matsumoto T critically reviewed and revised the manuscript; all authors have read and approved the final version of the manuscripts.
Institutional review board statement: The protocol of this retrospective study was approved by the Institutional Review Board at Iwate Medical University.
Informed consent statement: Patients were not required to give informed consent as this is a retrospective study.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Keisuke Kawasaki, MD, PhD, Doctor, Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University, 19-1, Uchimaru, Morioka 020-8505, Japan. kkeisuke@iwate-med.ac.jp
Telephone: +81-19-6515111 Fax: +81-19-6526664
Received: October 25, 2017
Peer-review started: October 26, 2017
First decision: November 21, 2017
Revised: November 30, 2017
Accepted: December 4, 2017
Article in press: December 4, 2017
Published online: December 21, 2017
Processing time: 55 Days and 17.9 Hours
Core Tip

Core tip: We investigated the association between the distribution of the lipid droplets and endoscopically-verified white opaque substance (WOS) in colorectal neoplasms. The incidence of deep adipophilin expression was higher in WOS-positive lesions than in WOS-negative lesions. The incidence of deep expression was predominant among cancers with massive submucosal invasion compared to adenoma and high-grade dysplasia or cancers with slight submucosal invasion. We thus concluded that the distribution of lipid droplets may be closely associated with the visibility of WOS, and also with histologic grade and depth of tumor invasion.