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494 items Read more >>
1
"I would like to express my gratitude to the entire World Journal of Transplantation team. Their constructive, professional, and ..."
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"I would like to express my gratitude to the entire World Journal of Transplantation team. Their constructive, professional, and friendly cooperation and attitude were greatly appreciated. The journal's requirements were meticulously detailed, making it straightforward to address the reviewers' queries and concerns. I would like to acknowledge the peer reviewers in particular. Their questions and comments were formulated in a highly professional and empathetic manner, without offending the authors. All this motivates for further collaboration. "
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Junk E, Tzivian L, Folkmane I, Folkmanis K, Jushinskis J, Strazda G, Folkmanis V, Kuzema V, Petersons A. Major adverse cardiovascular events and hyperuricemia as an effect-modifying factor in kidney transplant recipients. World J Transplant 2025; 15(3): 102287
2
"Publishing the accepted article is taking a long time. The journal has unique requirements that deviate from international norms, ..."
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"Publishing the accepted article is taking a long time. The journal has unique requirements that deviate from international norms, such as requiring English certification and statistical analysis certificates for every article. This adds complexity to the review process. Publishing the accepted article is taking a long time. The journal has unique requirements that deviate from international norms, such as requiring English certification and statistical analysis certificates for every article. This adds complexity to the review process. "
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Rengaraj S, Thilagar SS, Yadalam PK, Pampani P, Mani E, Ardila CM. Evaluation of the clinical efficacy of green tea extract gel as local drug delivery for periodontitis. World J Exp Med 2025; 15(2): 105636
3
"Overall, my experience with World Journal of Transplantation and BPG was extremely positive. The final quality of the product is ..."
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"Overall, my experience with World Journal of Transplantation and BPG was extremely positive. The final quality of the product is excellent. I will certainly recommend the journal and company to fellow colleagues. At the same time, World Journal of Transplantation will have top priority for future publications. Thank you very much for your valuable support. "
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Favi E, Morabito M. Living donor transplant: Right vs left kidney. World J Transplant 2025; 15(3): 104873
4
"I would like to sincerely thank you to the editors and peer review process for valuable comments. The final version of manuscript ..."
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"I would like to sincerely thank you to the editors and peer review process for valuable comments. The final version of manuscript is significant better and informative. Although this is a case report, it should contribute to the transplant society of our region. I also appreciate the journal that always publish the valuable transplant article to our society too. "
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Dumronggittigule W, Kositamongkol P, Sirivatanauksorn Y, Limsrichamrern S, Mahawithitwong P, Tovikkai C, Sangserestid P, Assawasirisin C. Multivisceral transplantation as a rescue treatment for intestinal failure following pancreaticoduodenectomy: A case report. World J Transplant 2025; 15(3): 101427
5
"We sincerely appreciate the editors and peer reviewers for their invaluable contributions to our manuscript. The editors demonstrated ..."
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"We sincerely appreciate the editors and peer reviewers for their invaluable contributions to our manuscript. The editors demonstrated exceptional diligence and professionalism by engaging diverse experts, whose constructive feedback provided multifaceted perspectives. Their insightful suggestions not only enhanced the quality of our manuscript but also strengthened our team’s scientific writing skills. Ultimately, their efforts were instrumental in ensuring the acceptance of our research. We extend our deepest gratitude to the editors for their unwavering support. "
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Guo LL, Liu HK, Cao JF, Zhang HX, Li B, Li T, Li L. Senility, defecation disorders, sleep disorders, and non-operative spinal infections: A single-center retrospective analysis. World J Orthop 2025; 16(4): 103388
6
"The Comments are objective. The peer review well organised. The anonymus strategies of revision is important to avoid conflict of ..."
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"The Comments are objective. The peer review well organised. The anonymus strategies of revision is important to avoid conflict of interests. The journal is fast in the review process and online publication. The different rounds of revision and frequent editor in chief involvement represent an optimal strategie of work. The overall satification is very positive. "
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Annicchiarico A, Barile B, Buccoliero C, Nicchia GP, Brunetti G. Alternative therapeutic strategies in diabetes management. World J Diabetes 2024; 15(6): 1142-1161
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"We would like to express our sincere gratitude to the journal editorial team, the reviewers, and all contributing authors for their ..."
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"We would like to express our sincere gratitude to the journal editorial team, the reviewers, and all contributing authors for their collaborative efforts in meticulously refining this article. Through this rigorous process, we have developed a more profound understanding of the research and significantly enhanced the clarity of its presentation. "
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Han L, Peng QY, Yu J, Liu YW, Li W, Ping F, Zhang HB, Li YX, Xu LL. Early detection of gastroparesis with diabetic ketoacidosis as initial manifestation: A case-control study. World J Gastroenterol 2025; 31(15): 101695
8
"I think that it was an excellent review process by world Journal of transplantation where the editors did an amazing job and the whole ..."
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"I think that it was an excellent review process by world Journal of transplantation where the editors did an amazing job and the whole process was very rapid. I believe the reviewers had excellent constructive criticism and indeed helped to improve our editorial. Overall, it was a fantastic experience and very easy to handle platform. "
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Pahari H, Tripathi S, Nundy S. What about the caregivers? Rethinking chronic illness support in the age of transplantation. World J Transplant 2025; 15(3): 104230
9
"I think that it was an excellent review process by world Journal of transplantation where the editors did an amazing job and the whole ..."
[Read more]
"I think that it was an excellent review process by world Journal of transplantation where the editors did an amazing job and the whole process was very rapid. I believe the reviewers had excellent constructive criticism and indeed helped to improve our editorial. Overall, it was a fantastic experience and very easy to handle platform. "
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Pahari H, Tripathi S, Nundy S. Frailty as a determinant of liver transplant outcomes: A call for integrative strategies. World J Transplant 2025; 15(3): 104500
10
"The time between the submission and the first decision was too long, please try to extend the panel of reviewers to reduce this time ..."
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"The time between the submission and the first decision was too long, please try to extend the panel of reviewers to reduce this time span. Also, you allow yourself enough time for each step, but when it concerns the time for the authors it is very reduced, 24h, 48h, etc. Thank you! "
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Năstasie OC, Radu DA, Onciul S, Drăgoescu MB, Popa-Fotea NM. Nexilin mutations, a cause of chronic heart failure: A state-of-the-art review starting from a clinical case. World J Cardiol 2025; 17(3): 100290
11
"I am very satisfied with the review and publication work of your journal. I think the entire process of handling manuscripts in ..."
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"I am very satisfied with the review and publication work of your journal. I think the entire process of handling manuscripts in journals is very professional and timely. I hope the journal will continue to thrive in the future. I will continue to support the work of the journal and submit articles to it. Thank you again for the hard work of the journal. "
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Ye XX, Qu HH, Yang C, Teng WJ, Chen YP, Lin JM, Wang XB. Precision medicine in the prediction of metachronous liver metastasis in rectal cancer: Applications and challenges. World J Gastrointest Oncol 2025; 17(4): 102469
12
"I extend my heartfelt thanks to the editorial team for the invaluable opportunity to publish our research work. It is an honor to ..."
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"I extend my heartfelt thanks to the editorial team for the invaluable opportunity to publish our research work. It is an honor to have our paper included in such a respected and impactful publication. I am especially grateful for the insightful comments and and constructive suggestions provided by the reviewers,which played a key role in improving the clarity and strength of the manuscript. The professionalism, prompt communication , and guidance throughout the editorial process was truly commendable. Being published is not only a personal milestone but also a significant encouragement for our future research endeavors. I am sincerely thankful for your support and trust in our work. I look forward to continued collaboration in the future. Thank you once again for this honor. With deep appreciation, Dr. Chanda R. Vyawahare "
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Ratnaparkhi MM, Vyawahare CR, Gandham NR. Hepatitis B virus genotype distribution and mutation patterns: Insights and clinical implications for hepatitis B virus positive patients. World J Exp Med 2025; 15(2): 102395
13
"The complete process starting from the submission, inviting reviewers, acceptance of invitation by the reviewers to final online ..."
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"The complete process starting from the submission, inviting reviewers, acceptance of invitation by the reviewers to final online publication, each step can be visualised my the author. Which is very transparent and help us to track it easily. Every step, we can able to feel the quality that added to the article. Thanks to Editorial Team "
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Rout S, Mishra PR, Balamurugan AN, Ravi PK. Islet dimension and its impact on transplant outcome: A systematic review. World J Transplant 2025; 15(3): 102383
14
"The manuscript submission process has been simplified and pleasurable. The amendments implemented following feedback and criticism ..."
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"The manuscript submission process has been simplified and pleasurable. The amendments implemented following feedback and criticism from the editors and reviewers significantly improved the scientific quality of the manuscript. We would like to take this opportunity to extend our appreciation to everyone who has played a part in ensuring that this entire process has been carried out in a competent manner and, whenever possible, been completed in a timely manner. "
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Celik AS, Yosunkaya H, Yayilkan Ozyilmaz A, Memis KB, Aydin S. Echinococcus granulosus in atypical localizations: Five case reports. World J Nephrol 2025; 14(2): 103027
15
"I had a very good experience while writing the review article I co-authored with Hayrunnisa Bekis Bozkurt under the title 'Changes ..."
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"I had a very good experience while writing the review article I co-authored with Hayrunnisa Bekis Bozkurt under the title 'Changes regarding solid organ transplantation during the COVID-19 pandemic' in Volume 15 (3) of the journal. I would like to thank the editors, the editorial secretariat and all those who took part in an official/authorized role. "
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Bozkurt HB, Özdemir Ö. Changes regarding solid organ transplantation during the COVID-19 pandemic. World J Transplant 2025; 15(3): 100591
16
"The authors express their most sincere gratitude to the assistant editor, science editor, peer reviewers, editorial director, journal ..."
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"The authors express their most sincere gratitude to the assistant editor, science editor, peer reviewers, editorial director, journal editor-in-chief, company editor-in-chief, language editor and production editor, as well as with the full cooperation of all authors for accepting and publication of the results of our study in the prestigious World Journal of Experimental Medicine. We thank the reviewers for their fair critical comments, which allowed us to improve the submitted manuscript "Cytoplasmic and nuclear programmed death-ligand 1 expression in peritumoral stromal cells in breast cancer: Prognostic and predictive value". We are very grateful to Science Editor Huo Liu, Executive Editor-in-Chief Jia-Ping Yan and Assistant Editor; Responsible Production Editor Wen-Bo Wang for editing and preparation for printing our manuscript and apologize for the typos and errors we made while preparing the manuscript. We express our most sincere gratitude to Founder and Chief Executive Officer, Professor Lian-Sheng Ma for the opportunity to publish in the most prestigious journals of Baishideng Publishing Group Inc. With respect and gratitude, Prof. Marina A. Senchukova, Dr. Evgeniya Yu Zubareva, Dr. Natalia V Saidler "
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Zubareva EY, Senchukova MA, Saidler NV. Cytoplasmic and nuclear programmed death ligand 1 expression in peritumoral stromal cells in breast cancer: Prognostic and predictive value. World J Exp Med 2025; 15(2): 102761
17
"We sincerely appreciate the professionalism demonstrated by the editorial and production team throughout the entire publication ..."
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"We sincerely appreciate the professionalism demonstrated by the editorial and production team throughout the entire publication process. The online submission system was user-friendly and efficient, and the peer review process was fair, timely, and highly constructive. The editing quality of the article, as well as the preparation of the article PDFs, figures, and tables, was of a consistently high standard. The online full-text version was accurate and well-presented, ensuring the research was easily accessible to readers. We also recognize and value the journal’s commitment to academic norms and its thorough approach to detecting academic misconduct, which helps maintain a credible and ethical publishing environment. The publication timeline was well-structured, and the editing and publishing guidelines were clear and easy to follow. These factors collectively contributed to a smooth and positive experience throughout the process. We would like to extend our gratitude to the entire editorial team, including the assistant editor, science editor, peer reviewers, editorial director, editor-in-chief, language editor, and production editor, for their collective efforts in ensuring the successful completion of our manuscript. We look forward to future opportunities to engage with and contribute to the journal. "
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Wang B, Li Y, Ouyang Q, Xu MT, Wang YY, Fu SJ, Liu WQ, Liu XT, Ling H, Zhang X, Xiu RJ, Liu MM. Strain- and sex-dependent variability in hepatic microcirculation and liver function in mice. World J Gastroenterol 2025; 31(15): 101058
18
"Overall, the process was very good and streamlined! My only critique is that some of the documents were here difficult to find online ..."
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"Overall, the process was very good and streamlined! My only critique is that some of the documents were here difficult to find online to complete properly. Otherwise, the process was efficient and easy to navigate! Again, if the documents required to fill out for the process could be easier to find and maybe connected to the submission website. "
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Reynolds M, Walsh MG, Cui EY, Satija D, Gouchoe DA, Henn MC, Choi K, Mokadam NA, Ganapathi AM, Whitson BA. Extended travel for donor organs: Is cold static storage still relevant. World J Transplant 2025; 15(3): 102150
19
"I genuinely appreciated the peer review process, as it provided valuable insights that significantly enhanced the quality of my ..."
[Read more]
"I genuinely appreciated the peer review process, as it provided valuable insights that significantly enhanced the quality of my manuscript. The reviewers' thoughtful and constructive comments not only helped clarify key points but also strengthened the overall structure and scientific rigor of the work. Their feedback was instrumental in refining the manuscript and ensuring it met a high standard of academic excellence. "
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Georgakopoulou VE. Optimizing patient outcomes in interstitial lung disease through pre- and post-transplant management strategies. World J Transplant 2025; 15(3): 101866
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"we were satisfied with theF6punlising system.Thank you very much to the editorial team for their hard work. We will respond to ..."
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"we were satisfied with theF6punlising system.Thank you very much to the editorial team for their hard work. We will respond to questions for our readers. And consider prioritizing our manuscripts next time to publishe in this journal. Thank you very much to the editorial team for their hard work. We will respond to questions for our readers. And consider prioritizing our manuscripts next time to your journal. "
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Wang XY, Liu F, Wang QT, Li SZ, Ye YZ, Chen T, Cai BC. Rhapontin activates nuclear factor erythroid 2-related factor 2 to ameliorate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced gastrointestinal dysfunction in Parkinson's disease mice. World J Gastroenterol 2025; 31(15): 104875
18527 items Read more >>
1
"Although the manuscript is well written, number of references is only 150. Need more than 200 references for the review article of ..."
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"Although the manuscript is well written, number of references is only 150. Need more than 200 references for the review article of this journal.
Transjugular intrahepatic portosystemic shunts (TIPSs) are generally used for the management of complications of portal hypertension in patients with decompensated cirrhosis. However, hepatic encephalopathy (HE), which impairs neuropsychiatric function and motor control, remains the primary adverse effect of TIPS, limiting its utility. Prompt prevention and treatment of post-TIPS HE are critical, as they are strongly associated with readmission rates and poor quality of life. This review focuses on the main pathophysiological mechanisms underlying post-TIPS HE, explores advanced biomarkers and predictive tools, and discusses current management strategies and future directions to prevent or reverse HE following TIPS. These strategies include preoperative patient assessment, individualized shunt diameter optimization, spontaneous portosystemic shunt embolization during the TIPS procedure, postoperative preventive and therapeutic measures such as nutrition management, medical therapy, fecal microbiota transplantation, and stent reduction.
Li Y, Wu YT, Wu H. Management of hepatic encephalopathy following transjugular intrahepatic portosystemic shunts: Current strategies and future directions. World J Gastroenterol 2025; 31(15): 103512 [DOI: 10.3748/wjg.v31.i15.103512]"
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Li Y, Wu YT, Wu H. Management of hepatic encephalopathy following transjugular intrahepatic portosystemic shunts: Current strategies and future directions. World J Gastroenterol 2025; 31(15): 103512
2
"It was a pleasure tracking the article of the following article. Please see my comments below:
1 Ethics: N/A given manuscript type ..."
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"It was a pleasure tracking the article of the following article. Please see my comments below:
1 Ethics: N/A given manuscript type
2 Methods: N/A given manuscript type
3 Results: N/A given manuscript type
4 Figures and tables: The included figures/tables add to the readability of the manuscript
5 Biostatistics: N/A given manuscript type
6 References: The references are timely/appropriate
7 Language: This is a thorough and well-thought out review of the topic of interest
8 Caveats or drawbacks: None"
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Liu JJ, Zhou M, Yuan T, Huang ZY, Zhang ZY. Conversion treatment for advanced intrahepatic cholangiocarcinoma: Opportunities and challenges. World J Gastroenterol 2025; 31(15): 104901
3
"This study has provided ethical approval and features a clear and reproducible methodology. The sample size is adequate, and the ..."
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"This study has provided ethical approval and features a clear and reproducible methodology. The sample size is adequate, and the results are credible and reliable. Figures and tables are well-organized and clearly annotated. Statistical analyses are appropriate and well presented. The authors have cited relevant and up-to-date references in the field appropriately. The language is clear and concise throughout the manuscript. Although the study is retrospective and may have inherent biases, these were addressed through propensity score matching, lending the findings considerable reference value. A prospective multicenter study is recommended to further validate the generalizability of the results."
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Li X, Zhang XB, Shao JK, Zhang B, Li LS, Zhu RQ, Zou JL, Wang JF, Zhao X, Wu QZ, Chai NL, Linghu EQ. Peroral endoscopic myotomy for achalasia and patients with normal lower-esophageal-sphincter integrated relaxation pressure: A propensity-score-matched retrospective study. World J Gastroenterol 2025; 31(12): 99846
4
"This is an excellent and timely article that captures the expanding role of point-of-care ultrasonography (POCUS) in nephrology with ..."
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"This is an excellent and timely article that captures the expanding role of point-of-care ultrasonography (POCUS) in nephrology with clarity and depth. The authors have done a commendable job highlighting both the practical utility and the common misconceptions surrounding POCUS, particularly in the context of renal diagnostics and volume status assessment. The discussion on its integration into nephrology training and practice is especially valuable, as it underscores the growing recognition of POCUS as a vital clinical skill. Additionally, the forward-looking perspective on future innovations and research directions adds meaningful insight into where the field is headed. A well-structured and informative read for both clinicians and trainees alike. I particularly appreciated the VEXUS score paragraph, a recent and revolutionary technique that can consistently help the clinicians to assess and monitor the fluid excess in our patients. "
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Diniz H, Ferreira F, Koratala A. Point-of-care ultrasonography in nephrology: Growing applications, misconceptions and future outlook. World J Nephrol 2025; 14(2): 105374
5
"Please tell me the reason from the point of gut flora why genera Bacteroides, Campylobacter, peptostreptococcus, and pavimouas are ..."
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"Please tell me the reason from the point of gut flora why genera Bacteroides, Campylobacter, peptostreptococcus, and pavimouas are abundant in CRC, while Faecalibacterium, haemophilus, and phocaicola are abundant in non-CRC. According to author's data, cancer occurs, the intestinal flora changes, and if the intestinal flora in CRC group is restored to normal through fecal transplantation, will the cancer regress?"
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Liu YL, Liu J. Gut microbiota plays a key role in the development of colorectal cancer. World J Gastroenterol 2025; 31(14): 105420
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"Good article reflecting detailed discussion on 15 calcium ion channels that could be potential targets for T2DM treatment via AMPK. ..."
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"Good article reflecting detailed discussion on 15 calcium ion channels that could be potential targets for T2DM treatment via AMPK. Thus, developing therapeutic targets. Authors stated "targeting calcium-permeable channels is a very promising direction in the exploration of new drugs for T2DM." However, challenges such as: The structures and functions of these channels, non availability of highly specific agonists and inhibitors for many of these channels
remains potential to achieve. Wishing them good luck for future endeavors."
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Zhu JX, Pan ZN, Li D. Intracellular calcium channels: Potential targets for type 2 diabetes mellitus? World J Diabetes 2025; 16(4): 98995
7
"Nabil Eid and Fabian Davamani wrote the Editorial review article, entitled 'Human β-defensin-1 activates autophagy in human colon ..."
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"Nabil Eid and Fabian Davamani wrote the Editorial review article, entitled 'Human β-defensin-1 activates autophagy in human colon cancer cells via regulation of long non-coding RNA TCONS_00014506'. This document is indicative for journal readers in this field. Also, their algorithm is informative for journal readers. Further research is needed to explore the modulating effects of lncRNAs on autophagy pathways. LncRNAs in cancer cells could serve as prognostic and diagnostic biomarkers, assisting in tumor therapy.
"
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Eid N, Davamani F. Human β-defensin-1 activates autophagy in human colon cancer cells via regulation of long non-coding RNA TCONS_00014506. World J Gastrointest Oncol 2024; 16(7): 2894-2901
8
"Yusuf Ilhan and Yakup Ergun wrote the Editorial review article, entitled 'Maximizing therapeutic outcomes in hepatocellular carcinoma: ..."
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"Yusuf Ilhan and Yakup Ergun wrote the Editorial review article, entitled 'Maximizing therapeutic outcomes in hepatocellular carcinoma: Insights into combinatorial strategies'. This document is indicative for journal readers in this field. Combining TACE with tyrosine kinase inhibitors and immune checkpoint inhibitors shows promise in enhancing therapeutic outcomes for HCC patients. Further exploration and validation of these combination therapies with TACE, as well as investigating other local treatment options for potential synergistic effects, are warranted to optimize HCC treatment strategies."
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Ilhan Y, Ergun Y. Maximizing therapeutic outcomes in hepatocellular carcinoma: Insights into combinatorial strategies. World J Gastrointest Oncol 2024; 16(7): 2888-2893
9
"Meer M Chisthi wrote the Editorial article, entitled 'Effectiveness of transarterial chemoembolization in combination with lenvatinib ..."
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"Meer M Chisthi wrote the Editorial article, entitled 'Effectiveness of transarterial chemoembolization in combination with lenvatinib and programmed cell death protein-1 inhibition for unresectable hepatocellular carcinoma'. This document is indicative for clinical physicians in the field of HCC. This Editorial article underscores the effectiveness and safety of integrating TACE with lenvatinib and PD-1 inhibition for unresectable HCC. "
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Chisthi MM. Effectiveness of transarterial chemoembolization in combination with lenvatinib and programmed cell death protein-1 inhibition for unresectable hepatocellular carcinoma. World J Gastrointest Oncol 2024; 16(7): 2884-2887
10
"Chun-Yao Cheng, Wen-Rui Hao and Tzu-Hurng Cheng wrote the Editorial article entitled 'Esophageal cancer: A global challenge requiring ..."
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"Chun-Yao Cheng, Wen-Rui Hao and Tzu-Hurng Cheng wrote the Editorial article entitled 'Esophageal cancer: A global challenge requiring tailored strategies'. This document is indicative for journal readers in the field of esophageal cancer. In this editorial we comment on the article published in a recent issue of the World Journal of Gastrointestinal Oncology. Characterized by high mortality rates and geographical variations in its incidence, esophageal cancer poses a major global health challenge."
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Cheng CY, Hao WR, Cheng TH. Esophageal cancer: A global challenge requiring tailored strategies. World J Gastrointest Oncol 2024; 16(7): 2881-2883
11
"Yu-Wei Feng, Hai-Ying Wang and Qiang Lin wrote excellent marticle, entitled 'Can the preoperative prognostic nutritional index be ..."
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"Yu-Wei Feng, Hai-Ying Wang and Qiang Lin wrote excellent marticle, entitled 'Can the preoperative prognostic nutritional index be used as a postoperative predictor of gastric or gastroesophageal junction adenocarcinoma?'. This document is indicative for journal readers in this field. Despite continuous improvement in treatment techniques, patient prognosis with gastric cancer and adenocarcinoma of the esophageal junction is still affected by multiple factors. The prognostic nutritional index was associated with significantly better survival in patients with gastric cancer. "
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Feng YW, Wang HY, Lin Q. Can the preoperative prognostic nutritional index be used as a postoperative predictor of gastric or gastroesophageal junction adenocarcinoma? World J Gastrointest Oncol 2024; 16(7): 2877-2880
12
"Rong Xiao, Hao Jin, Fang Huang, Biao Huang, Hui Wang and Yi-Gang Wang wrote article entitled 'Oncolytic virotherapy for hepatocellular ..."
[Read more]
"Rong Xiao, Hao Jin, Fang Huang, Biao Huang, Hui Wang and Yi-Gang Wang wrote article entitled 'Oncolytic virotherapy for hepatocellular carcinoma: A potent immunotherapeutic landscape'. Their schema is excellent. This article is informative for journal readers in this field. Based on clinical background, oncolytic viruses for the treatment of HCC, including immunotherapy strategies, is crucial for HCC patiuents. Physicians looks forward to more good clinical results. "
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Xiao R, Jin H, Huang F, Huang B, Wang H, Wang YG. Oncolytic virotherapy for hepatocellular carcinoma: A potent immunotherapeutic landscape. World J Gastrointest Oncol 2024; 16(7): 2867-2876
13
"Importance of Snail family transcriptional repressor 1 (SNAI1) for esophageal cancer is documented. This study highlights SNAI1's ..."
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"Importance of Snail family transcriptional repressor 1 (SNAI1) for esophageal cancer is documented. This study highlights SNAI1's role in esophageal cancer radiosensitivity, offering prognostic insights and therapeutic strategies to enhance radiotherapy by targeting SNAI1 and modulating processes of epithelial-mesenchymal transition. This basic study is well designed, and their results are informative for journal readers in this field. "
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Lv XL, Peng QL, Wang XP, Fu ZC, Cao JP, Wang J, Wang LL, Jiao Y. Snail family transcriptional repressor 1 radiosensitizes esophageal cancer via epithelial-mesenchymal transition signaling: From bioinformatics to integrated study. World J Gastrointest Oncol 2025; 17(4): 97644
14
"1. Abstract can be brief when reporting a case, sticking to the essential points of why it needs reporting, essence of report and ..."
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"1. Abstract can be brief when reporting a case, sticking to the essential points of why it needs reporting, essence of report and a take home message
2. The reason for bile duct injury following lap cholecystectomy in the index case is not mentioned.
3. How long after the bile duct injury the hepatico jeunostomy was performed? Was there any difficulty in performing the same?
4.The complexity of the case calls for stressing the importance of performing safe cholecystectomy and appropriate recognition of bile duct injury in the conclusion."
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Elsayed G, Mohamed L, Almasaabi M, Barakat K, Gadour E. Hepaticojejunostomy and long-term interventional treatment for recurrent biliary stricture after proximal bile duct injury: A case report. World J Clin Cases 2025; 13(20): 104609
15
"1. What were the differentials?
2. What were the clinical findings of the respiratory system on inspection, palpation, percussion ..."
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"1. What were the differentials?
2. What were the clinical findings of the respiratory system on inspection, palpation, percussion and auscultation?
3. Was a chest xray taken?
4. Why was CT chest taken? Was it taken after a plain xray of the chest?
5. Imaging findings to be pointed with arrows
6. Conclusion to be short with inclusion of the essential findings and management as 'take home' instead of summarising the case report and review of literature."
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Gao CY, Yang XJ, Guo E, Zheng YL. Invasive pulmonary cryptococcosis mimicking metastatic lung cancer: A case report and review of literature. World J Clin Cases 2025; 13(20): 105133
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"1. How was it known that pt consumed antifreeze?
2. The dosage of the medications (Vitamin B1, Vitamin B6 Dexamethasone, Ceftazidime, ..."
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"1. How was it known that pt consumed antifreeze?
2. The dosage of the medications (Vitamin B1, Vitamin B6 Dexamethasone, Ceftazidime, Moxafloxacin, etc) administered including the route, frequency are not available and need to be included
3. Did the patient receive Psychiatric counselling on follow up?
4. Ethylene Glycol measurement in the blood may not be required for mangement"
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Deng SK, Wang Q, Duan SJ, Yu SH. Ethylene glycol poisoning: A case report and review of the literature. World J Clin Cases 2025; 13(20): 103842
17
"1. The title can include urinary bladder for clarity
2. The Uro Dynamic Study requires costly equipment, training of user and ..."
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"1. The title can include urinary bladder for clarity
2. The Uro Dynamic Study requires costly equipment, training of user and interpretation
3. The parameters included are simple, but not new as bladder diary, clinical examination are core in the evaluation of patients with neurogenic bladder
4. Maintenance of bladder diary (times voided, volume, wetting episodes, intake volume, etc on a weekly chart) is a requisite for neurogenic bladder patients"
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Swarnakar R, Yadav SL. Clinical bladder evaluation: A new, cost-effective, clinical method for neurogenic bladder evaluation and rehabilitation. World J Clin Cases 2025; 13(20): 103729
18
"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist ..."
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"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016).
3 Results: case sharing of case presentation, findings and images.
4 Figures and tables: The author provides perfect images which is good quality and easily understandable.
5 Biostatistics: Yes, the author provide perfect biostatistics data that complied with standard quality.
6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Lee J, Suh JW. Adenocarcinoma originating from a colonic duplication cyst: A case report. World J Gastrointest Surg 2025; 17(4): 103136
19
"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist ..."
[Read more]
"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016).
3 Results: case sharing of case presentation, findings and images.
4 Figures and tables: The author provides perfect images which is good quality and easily understandable.
5 Biostatistics: Yes, the author provide perfect biostatistics data that complied with standard quality.
6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Wang ZM, Su S, Ling-Hu EQ, Chai NL. Type III choledochal cyst confirmed by aspiration and treated with endoscopic fenestration plus internal drainage: A case report. World J Gastrointest Surg 2025; 17(4): 104102
20
"1 Ethics: This retrospective study was approved by The Ethics Committee of the SBU Bursa Yuksek Ihtisas Research and Training Hospital ..."
[Read more]
"1 Ethics: This retrospective study was approved by The Ethics Committee of the SBU Bursa Yuksek Ihtisas Research and Training Hospital provided its approval for our clinical research on 10.08.2022 with the decision number is 2011-KAEK–25 2022/08–02. This study adhered to the principles of the Declaration of Helsinki.
2 Methods: This retrospective method effective and proper method following guidelines and methods.
3 Results: The results true and authentic and significance validated that followed the objectives.
4 Figures and tables: The author provides perfect tables, images and graphic which is good quality and easily understandable.
5 Biostatistics: Yes, the author provide perfect biostatistics data that complied with standard quality.
6 References: Record the latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Ay OF, Firat D, Özçetin B, Ocakoglu G, Ozcan SGG, Bakır Ş, Ocak B, Taşkin AK. Role of pelvimetry in predicting surgical outcomes and morbidity in rectal cancer surgery: A retrospective analysis. World J Gastrointest Surg 2025; 17(4): 104726
15187 items Read more >>
Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2266
- Peer-reviewers
- 30333
- Manuscripts received today
- 4
- Manuscript reviews today
- 37
- Unhandled manuscripts today
- 143
- Active peer-reviewers today
- 2247
- Reviewer acceptance today
- 48
- Reviewer refusals today
- 30
- Total accepted manuscripts
- 35674
- Total rejected manuscripts
- 41389
- Total peer-reviewers
- 4188175
- Total submissions
- 33980
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1
"Dear Baishideng Office, I read a very interesting article «Management of hepatic encephalopathy following transjugular intrahepatic ..."
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"Dear Baishideng Office, I read a very interesting article «Management of hepatic encephalopathy following transjugular intrahepatic portosystemic shunts: Current strategies and future directions». The article format corresponds to the review format. The authors of the review presented the current problem of post-TIPS hepatic encephalopathy. The list of references consists of 155 sources. The article is well illustrated with figures and tables. Easy to read despite the large amount of information material. All problematic sections are analyzed in depth and detail, and modern fields of view for each section are also taken into account. An article worthy of publication in the World Journal of Gastroenterology. "
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Li Y, Wu YT, Wu H. Management of hepatic encephalopathy following transjugular intrahepatic portosystemic shunts: Current strategies and future directions. World J Gastroenterol 2025; 31(15): 103512
2
"This study addresses a critical gap in acute pancreatitis management by systematically comparing established scoring systems with ..."
[Read more]
"This study addresses a critical gap in acute pancreatitis management by systematically comparing established scoring systems with novel hematological markers. The focus on early-phase severity stratification aligns with clinical urgency, as delayed interventions in severe AP significantly worsen outcomes. The inclusion of 463 patients across severity categories provides sufficient statistical power. The use of multivariate logistic regression to identify independent predictors and AUC comparisons for ROC analyses strengthens validity. Notably, the combined PNI48 + Ranson model achieved an AUC of 0.936, outperforming individual parameters. However, the study has several issues that need to be addressed. 1) While CTSI showed the highest individual AUC, its reliance on CT imaging (performed 2–5 days post-admission) limits utility in hyperacute settings. The BISAP score’s superiority over APACHE II/SOFA within 24 h is consistent with prior literature , but the lack of comparison with newer tools is a missed opportunity. 2) The study’s retrospective nature introduces risks of selection bias, particularly in excluding patients with brief hospital stays ( "
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Shi PN, Song ZZ, He XN, Hong JM. Evaluation of scoring systems and hematological parameters in the severity stratification of early-phase acute pancreatitis. World J Gastroenterol 2025; 31(15): 105236
3
"This article presents a series of clinically practical and easily obtainable diagnostic indices, enabling medical professionals to ..."
[Read more]
"This article presents a series of clinically practical and easily obtainable diagnostic indices, enabling medical professionals to more accurately evaluate patient conditions in real-world clinical settings. These indicators are particularly valuable for the early diagnosis and severity assessment of pancreatitis, offering crucial guidance for subsequent treatment decisions. By incorporating these measurable parameters into routine clinical practice, healthcare providers can enhance diagnostic efficiency, improve risk stratification, and facilitate timely therapeutic interventions. The systematic application of these indices not only supports evidence-based medical decision-making but also contributes to standardized patient management protocols, ultimately leading to better clinical outcomes in pancreatitis care. "
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Shi PN, Song ZZ, He XN, Hong JM. Evaluation of scoring systems and hematological parameters in the severity stratification of early-phase acute pancreatitis. World J Gastroenterol 2025; 31(15): 105236
4
"The reader possesses professional expertise in digestive endoscopy, EUS-guided biopsy, and tumor diagnosis. The authors have declared ..."
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"The reader possesses professional expertise in digestive endoscopy, EUS-guided biopsy, and tumor diagnosis. The authors have declared no conflicts of interest. According to the standards for commenting on published articles, which include evaluation of study design, statistical methods, and reliability of conclusions, this study is a well-designed prospective randomized controlled trial with clear data analysis and high scientific quality. The language is generally fluent, though some sentences could be further polished. The reader believes that this study, which compares the diagnostic sensitivity of two types of needles under conditions without rapid onsite evaluation (ROSE), has significant clinical relevance and suggests that future studies with larger sample sizes are warranted to validate the broader applicability of the findings. "
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Paduani GF, Felipe LM, De Paulo GA, Lenz L, Martins BC, Matuguma SE, Safatle-Ribeiro AV, De Mello ES, Maluf-Filho F. Prospective randomized study comparing Franseen 22-gauge vs standard 22-gauge needle for endoscopic ultrasound guided sampling of pancreatic solid lesions. World J Gastrointest Endosc 2025; 17(4): 101998
5
"Leucine-rich α2 glycoprotein (LRG) is a biomarker easily and conveniently evaluated through blood sampling. Because LRG reflects ..."
[Read more]
"Leucine-rich α2 glycoprotein (LRG) is a biomarker easily and conveniently evaluated through blood sampling. Because LRG reflects cytokines other than IL-6, it is expected to be useful for assessing the activity of small intestinal lesions in Crohn’s disease, which are often difficult to detect with CRP. Although there is still room for discussion regarding the cutoff value of LRG, it is considered more important to monitor the trend of LRG values over time in each patient rather than focusing solely on the absolute value itself. "
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Krishnan A. Leucine-rich alpha-2 glycoprotein for detecting small bowel lesions in Crohn’s disease: A critical review and the path forward. World J Gastrointest Endosc 2025; 17(4): 106671
6
"1. Figure 1: If both the pre-radiofrequency ablation enhanced MR images and the post- radiofrequency ablation enhanced MR images at ..."
[Read more]
"1. Figure 1: If both the pre-radiofrequency ablation enhanced MR images and the post- radiofrequency ablation enhanced MR images at regular follow-up are provided, the changes in tumor characteristics before and after treatment can be more accurately assessed. 2. The pathological image of HE staining lacks a scale bar for measurement reference. 3. The MRI report omits the examination time, which is critical for temporal correlation. 4. Figure 4: The examination date is not specified, and no arrows have been used to clearly indicate lesions. 5. Figure 5: Contrast-enhanced MR imaging is necessary to detect potential small metastases due to the limited sensitivity of CT scans. 6. Page 3: Chief Complaints: "The patient was admitted to the hospital on March 03, 2018." History of Past Illness: "On March 18, 2018, the patient underwent CT examination at a foreign hospital." Based on the timeline, the chief complaint (admission date) precedes the CT examination date, which appears inconsistent. Please clarify. 7. Page 3: History of Present Illness and History of Past Illness: The content structure does not adhere to standard medical documentation conventions. It is recommended to reorganize these sections for clarity and consistency. 8. Page 3: Physical Examination: Radiofrequency ablation (RFA) for liver metastases was performed; however, RFA is a therapeutic intervention rather than a physical examination. This procedure should not be listed under the physical examination section. 9. Page 4: Treatment: Two rounds of radiofrequency ablation were completed, but the exact dates of these procedures are missing. To facilitate accurate comparison of pre- and post-ablation images, the specific timing of each session must be documented. Additionally, when comparing images (e.g., "compared with those in the July 07, 2020 slices"), it is essential to provide corresponding images from the same anatomical region at two distinct time points to more effectively illustrate tumor size changes. "
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Yong JP, Mu XY, Zhou CF, Zhang KK, Gao JQ, Guo ZZ, Zhou SF, Ma Z. Radiofrequency ablation of liver metastases in a patient with pancreatic cancer and long-term survival: A case report. World J Clin Cases 2025; 13(20): 100169
7
"This retrospective cohort study presented an interesting results to combine the Raman spectroscopy and machine learning for evaluation ..."
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"This retrospective cohort study presented an interesting results to combine the Raman spectroscopy and machine learning for evaluation of the pathogenic degree in esophageal squamous cell carcinoma. There is a result in the figure 4 to show the decreased effect on peak of high-low group. Maybe author perform the potential interaction from these high and low grade tissues in Raman spectroscopy analysis. "
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Yu XY, Chen J, Li LY, Chen FE, He Q. Rapid pathologic grading-based diagnosis of esophageal squamous cell carcinoma via Raman spectroscopy and a deep learning algorithm. World J Gastroenterol 2025; 31(14): 104280
8
"The study’s prospective design and the use of validated instruments, including a simplified Profile of Mood States and the Pittsburgh ..."
[Read more]
"The study’s prospective design and the use of validated instruments, including a simplified Profile of Mood States and the Pittsburgh Sleep Quality Index, are notable strengths. The findings demonstrate that the observation group, which received both CBT and MBSR, achieved significantly better outcomes in terms of reduced negative mood dimensions and improved sleep quality compared to the control group (CBT only). These results suggest that the dual intervention not only alleviates depressive symptoms but also enhances sleep quality, thereby addressing two interrelated facets of patient well-being. Zhang et al.’s study makes a valuable contribution by demonstrating that an integrated CBT and MBSR intervention can significantly improve both mood state and sleep quality in patients with diabetes and endometrial cancer. We encourage the authors to address the aforementioned aspects in future research to further refine and validate this promising therapeutic approach. Integrating detailed intervention protocols and extending follow-up durations will enhance the generalizability and clinical utility of their findings. "
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Zhang QS, Zhang W, Mao Y, Wang XS, Zhang JW, Cao YJ. Effects of cognitive combined with mindfulness-based stress reduction and sleep in patients with diabetes and endometrial cancer. World J Psychiatry 2025; 15(4): 100849
9
"This article is a high-quality academic editorial that systematically explores the potential value of PLD2 in acute pancreatitis (AP) ..."
[Read more]
"This article is a high-quality academic editorial that systematically explores the potential value of PLD2 in acute pancreatitis (AP) and proposes actionable future research directions. Its core contributions lie in: 1. Integrating molecular mechanisms with clinical applications, shifting AP biomarker research from "phenomenological association" to "mechanism-driven" investigation; 2. Emphasizing multi-omics integration and precision medicine, offering a novel paradigm for AP management. "
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Wang ZH, Lv JH, Teng Y, Michael N, Zhao YF, Xia M, Wang B. Phospholipase D2: A biomarker for stratifying disease severity in acute pancreatitis? World J Gastroenterol 2025; 31(11): 104033
10
"This study provides novel insights into the risk factors for metachronous gastric cancer (MGC) in elderly patients, particularly ..."
[Read more]
"This study provides novel insights into the risk factors for metachronous gastric cancer (MGC) in elderly patients, particularly highlighting the clinical significance of the association with metabolic dysfunction-associated steatotic liver disease (MASLD) and the proposed risk stratification system. However, the retrospective design and small sample size limit the robustness of the evidence, necessitating further validation through multicenter prospective studies. The paper is well-structured but requires refinement in statistical details. "
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Xiang Y, Yuan Y, Wang ZY, Zhu YM, Li WY, Ye QG, Wang YN, Sun Q, Ding XW, Longi F, Tang DH, Xu GF. Comorbidities related to metachronous recurrence for early gastric cancer in elderly patients. World J Gastrointest Endosc 2025; 17(3): 99540
11
"The author has constructed a predictive model with strong forecasting capabilities, designed to estimate the probability of a textbook ..."
[Read more]
"The author has constructed a predictive model with strong forecasting capabilities, designed to estimate the probability of a textbook outcome following surgery. Additionally, the study elucidates the machine learning computational process using the SHAP algorithm. This research is highly innovative, as it visualizes the otherwise opaque computational processes of machine learning, thereby enhancing its credibility. Clinicians can easily input specific clinical parameters of patients to obtain immediate, personalized risk assessments, enabling timely preventive measures and ensuring the best possible medical care for patients.This study substantiates the feasibility of explainable machine learning in future applications, marking a new direction in the research of predictive models and supervised learning. "
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Huang TF, Luo C, Guo LB, Liu HZ, Li JT, Lin QZ, Fan RL, Zhou WP, Li JD, Lin KC, Tang SC, Zeng YY. Preoperative prediction of textbook outcome in intrahepatic cholangiocarcinoma by interpretable machine learning: A multicenter cohort study. World J Gastroenterol 2025; 31(11): 100911
12
"This study provides valuable insights into the effectiveness of combining three-dimensional computed tomography (3D CT) reconstruction ..."
[Read more]
"This study provides valuable insights into the effectiveness of combining three-dimensional computed tomography (3D CT) reconstruction and laparoscopic techniques for accurately measuring the myopectineal orifice (MPO) in inguinal hernia repair. The research clearly demonstrates that preoperative 3D CT measurements closely match intraoperative laparoscopic findings, suggesting that CT could reliably guide surgical planning. The authors effectively highlight the clinical implications, emphasizing how precise measurement and patch placement can minimize complications such as nerve injury, recurrence, and chronic postoperative pain. Additionally, they provide a thoughtful analysis regarding demographic factors, noting significant differences in MPO measurements between sexes, while age and body mass index showed less impact. One of the strengths of this article is its detailed methodological description, which facilitates replication and further research. However, future studies might benefit from larger sample sizes and expanded demographic variability to enhance generalizability. Overall, the paper makes a significant contribution to personalized surgical approaches for inguinal hernia treatment. "
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Zhang L, Chen J, Zhang YY, Liu L, Wang HD, Zhang YF, Sheng J, Hu QS, Liu ML, Yuan YL. Three-dimensional reconstruction under computed tomography and myopectineal orifice measurement under laparoscopy for quality control of inguinal hernia treatment. World J Gastrointest Endosc 2025; 17(3): 104966
13
"As this is a editorial article, it has got no sections of methods, results, tables, biostatistics, units and ethical statement to ..."
[Read more]
"As this is a editorial article, it has got no sections of methods, results, tables, biostatistics, units and ethical statement to provide commentary on these sections. The editorial by Behrens and Elgafy provides an insightful analysis of factors influencing outcomes in indirect decompression through oblique and lateral lumbar interbody fusions (OLIF and LLIF). The discussion on patient selection criteria, particularly regarding preoperative spinal canal dimensions and lateral recess depth, is a valuable contribution to clinical decision-making. The emphasis on the unpredictability of outcomes in patients with severe lateral recess stenosis and the potential need for staged procedures highlights a crucial consideration for spine surgeons. However, one area that could benefit from further exploration is the long-term stability of indirect decompression compared to direct decompression, especially concerning adjacent segment disease and fusion longevity. Additionally, a deeper comparison of OLIF and LLIF in terms of specific complications and recovery trajectories would provide even greater clinical relevance. Overall, this editorial offers a comprehensive and well-referenced synthesis of the current literature on indirect decompression. It serves as a useful guide for surgeons considering minimally invasive approaches while remaining cautious about their limitations. "
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M Behrens KM, Elgafy H. Factors affecting outcomes of indirect decompression after oblique and lateral lumbar interbody fusions. World J Orthop 2025; 16(3): 100772
14
"The clinical significance of this study lies in its innovative approach to predicting colorectal polyp recurrence using machine ..."
[Read more]
"The clinical significance of this study lies in its innovative approach to predicting colorectal polyp recurrence using machine learning (ML), specifically the eXtreme Gradient Boosting (XGBoost) model. Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, largely preventable through early detection and effective management of precancerous polyps. Endoscopic mucosal resection (EMR) is widely utilized for the removal of colorectal polyps, yet it carries a considerable risk of recurrence, highlighting the need for accurate predictive tools to guide postoperative surveillance. This study identifies critical independent risk factors for polyp recurrence one year post-EMR, such as age, family history, smoking habits, diarrhea, Helicobacter pylori infection, polyp size, number of polyps, and hazard classification. By leveraging ML algorithms, particularly XGBoost, the researchers have developed a model with superior predictive performance, evidenced by high Area Under the Curve (AUC) values exceeding 0.90 across multiple validation cohorts, including a prospective validation set, indicating robust predictive accuracy and clinical utility. Clinically, the XGBoost model offers substantial advantages. Its high sensitivity, specificity, accuracy, precision, and F1 scores suggest that it effectively stratifies patients based on recurrence risk. Such a model significantly enhances personalized patient management by informing more accurate follow-up intervals, potentially improving patient outcomes through timely interventions and reducing unnecessary colonoscopies in low-risk individuals. Additionally, the authors' development of an accessible online web calculator based on this predictive model further underscores its practical utility in routine clinical practice. Clinicians can conveniently input patient-specific clinical parameters to obtain immediate, individualized risk predictions, facilitating shared decision-making between physicians and patients. Decision Curve Analysis further underscores the practical value of this tool, demonstrating that using the XGBoost model provides superior clinical net benefit compared to standard follow-up strategies. This methodical approach not only advances clinical decision-making but also optimizes healthcare resources by prioritizing surveillance for those most at risk. Finally, the interpretability of the model via SHapley Additive exPlanations (SHAP) analysis significantly mitigates concerns about the "black box" nature commonly associated with ML models, thus increasing clinician trust and acceptability. In conclusion, this ML-based predictive model represents a critical advancement in clinical gastroenterology, providing robust, data-driven support for clinicians in making individualized recommendations for colorectal polyp surveillance and potentially reducing colorectal cancer incidence through targeted early intervention. "
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Huang TF, Luo C, Guo LB, Liu HZ, Li JT, Lin QZ, Fan RL, Zhou WP, Li JD, Lin KC, Tang SC, Zeng YY. Preoperative prediction of textbook outcome in intrahepatic cholangiocarcinoma by interpretable machine learning: A multicenter cohort study. World J Gastroenterol 2025; 31(11): 100911
15
"The author has shown that knocking out SERPINB5 not only inhibits the proliferation and metastasis of cancer cells but also suppresses ..."
[Read more]
"The author has shown that knocking out SERPINB5 not only inhibits the proliferation and metastasis of cancer cells but also suppresses tumor growth in xenograft mice, effectively reducing tumor progression. This suggests that SERPINB5 could potentially serve as an important target for tumor treatment. We sincerely appreciate the author's dedication and hard work. The quality of this article is truly outstanding, and we eagerly look forward to your next research contribution. "
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Meng ZS, Hu JT, Wu H, Li BK. Inhibition of the SERPINB5/HSP90AA1 axis restrains the proliferation and invasion of rectal cancer. World J Gastroenterol 2025; 31(11): 103412
16
"This study provides valuable data specifically focused on endoscopic resection (ER) of esophageal GISTs. Thorough evaluation of the ..."
[Read more]
"This study provides valuable data specifically focused on endoscopic resection (ER) of esophageal GISTs. Thorough evaluation of the ER technique, complications, and resection margin status enhances our understanding of ER safety and effectiveness. Furthermore, the study presented a relatively large case series of 32 patients, which increases the statistical reliability of the findings for esophageal GIST research. By presenting long-term follow-up results, it assessed the long-term prognosis after ER and suggested potential benefits for future treatment strategy development. "
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Xu EP, Qi ZP, Zhang JW, Li B, Ren Z, Cai MY, Cai SL, Lv ZT, Chen ZH, Liu JY, Zhong YS, Zhou PH, Shi Q. Endoscopic treatment outcome of oesophageal gastrointestinal stromal tumours. World J Gastroenterol 2025; 31(10): 102393
17
"We greatly appreciate the authors and their team for their in-depth study on treatment strategies for rectal neuroendocrine neoplasms ..."
[Read more]
"We greatly appreciate the authors and their team for their in-depth study on treatment strategies for rectal neuroendocrine neoplasms (R-NENs). This retrospective analysis compares the efficacy of endoscopic full-thickness resection (EFTR) and endoscopic submucosal dissection (ESD) in the treatment of R-NENs, demonstrating the superior R0 resection rate of EFTR while maintaining comparable short-term safety with ESD. This study provides critical clinical evidence supporting the use of EFTR in R-NENs and contributes to the refinement of function-preserving surgical approaches. However, we would like to offer some constructive suggestions to enhance the clinical applicability and long-term evaluation of this study. First, some terminology and definitions in the study are somewhat ambiguous, which may affect the interpretability of the results. For instance, the study mentions that some patients had "severe comorbidities" but does not specify the types of comorbidities or the inclusion/exclusion criteria applied. Certain comorbidities, such as diabetes or chronic kidney disease, may impact postoperative healing, and failing to differentiate them could introduce confounding among patients with varying risk profiles. Additionally, the description of lesion morphology is inherently subjective, and the study does not clarify whether standardized imaging assessments, such as endoscopic ultrasound (EUS), were used to measure lesion size and invasion depth. Inconsistencies in preoperative evaluation criteria could lead to bias in treatment selection. For example, was EFTR preferentially chosen for lesions with specific morphological characteristics? Future studies should adopt more detailed imaging assessment criteria and pathological grading methods to improve reproducibility and the interpretability of results. Second, the study does not assess the impact of the learning curve for EFTR and ESD on surgical outcomes. As a relatively novel technique, EFTR may require a longer period of experience accumulation to achieve stable performance. The study does not clarify whether operator experience was comparable between the EFTR and ESD groups or whether surgical success rates varied with increasing experience. If EFTR procedures were performed by highly experienced endoscopists while ESD procedures involved a broader range of operators, the results could be biased in favor of EFTR. Additionally, since EFTR has a steeper learning curve, factors such as procedure time and complication rates may decrease with increased experience, but the study does not conduct a dynamic analysis of these trends. Future studies should incorporate learning curve analyses to evaluate the influence of experience on surgical outcomes, ensuring a fair comparison between the two techniques. Furthermore, EFTR may cause greater bowel wall injury than ESD, potentially affecting postoperative bowel function, yet this study focuses primarily on R0 resection rates and short-term complications without assessing long-term functional outcomes. As a full-thickness resection technique, EFTR may alter rectal compliance, bowel movement frequency, and gut motility. However, the study does not provide data on postoperative bowel function changes, alterations in defecation patterns, bloating, or incontinence. If EFTR improves R0 resection rates but increases the risk of postoperative functional impairment, its clinical utility must be considered more cautiously. Future research should incorporate patient-reported outcomes (PROs) and quality of life (QoL) assessments and include long-term functional evaluations such as anorectal manometry and bowel dysfunction scoring to comprehensively assess the impact of EFTR on patient prognosis. "
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Zhang XL, Jiang YY, Chang YY, Sun YL, Zhou Y, Wang YH, Dou XT, Guo HM, Ling TS. Endoscopic full-thickness resection: A definitive solution for local complete resection of small rectal neuroendocrine neoplasms. World J Gastroenterol 2025; 31(10): 100444
18
"This is a well-constructed and well-written review, which gives readers with a general bioscience background updated information about ..."
[Read more]
"This is a well-constructed and well-written review, which gives readers with a general bioscience background updated information about the stem cell application in liver diseases (fatty liver diseases and steatohepatitis). The language is fluent, and the references are up to date. It will be easier for readers to understand the concepts if the authors provide a table to compare the 2D model with the 3D model. It will be helpful to include the abbreviation for each key word. "
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Silva B, Bragança J. Induced pluripotent stem cell-derived mesenchymal stem cells for modeling and treating metabolic associated fatty liver disease and metabolic associated steatohepatitis: Challenges and opportunities. World J Stem Cells 2025; 17(2): 99331
19
"The authors should provide adequate legends for each figure. Some parts of the paper are just a listing of facts and are poorly ..."
[Read more]
"The authors should provide adequate legends for each figure. Some parts of the paper are just a listing of facts and are poorly organized or discussed. The table in the paper is well organized and suited. A table to compare the pros and cons of different kinds of stem cells for muscle atrophy therapy will be helpful. "
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Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693
20
"Stem Cell Therapy: A New Hope for Patients with Skeletal Muscle Atrophy? Skeletal muscle atrophy refers to the reduction or loss of ..."
[Read more]
"Stem Cell Therapy: A New Hope for Patients with Skeletal Muscle Atrophy? Skeletal muscle atrophy refers to the reduction or loss of muscle fibers due to nutritional deficiencies or diseases, leading to a decline in muscle mass. Current studies indicate that skeletal muscle atrophy is closely associated with an imbalance between protein synthesis and degradation, driven by multiple factors such as inflammation, oxidative stress, autophagy, and apoptosis [1-3]. Due to the complexity of its molecular mechanisms, effective therapeutic strategies are lacking, and traditional approaches like rehabilitation training and pharmacological interventions show limited efficacy. Therefore, exploring more effective treatments is imperative. Stem cell therapy, with its unique regenerative potential and immunomodulatory properties, offers a promising avenue for treating this condition. In the current issue of the World Journal of Stem Cells, Ying-Jie Wang and colleagues published a review titled "Stem Cell Therapy: A Promising Therapeutic Approach for Skeletal Muscle Atrophy." The article summarizes the molecular mechanisms of muscle atrophy and highlights the applications of mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and their derivatives (e.g., exosomes) in treating skeletal muscle atrophy. These stem cells exert therapeutic effects by modulating inflammation, promoting angiogenesis, suppressing oxidative stress, and facilitating muscle regeneration. The authors also address challenges in clinical translation, including immune rejection, tumorigenic risks, inefficient stem cell homing, and the absence of standardized protocols. Despite these hurdles, the review expresses optimism about the future of stem cell therapy, particularly emphasizing the superior potential of stem cell-derived acellular therapies (e.g., exosomes) over traditional cell transplantation. We maintain a cautiously optimistic view regarding the prospects of stem cell therapy for skeletal muscle atrophy. While stem cell-based approaches, especially MSC- and exosome-based strategies, demonstrate promising safety and efficacy [4, 5], several issues must be resolved. These include addressing heterogeneity in stem cell sources, ensuring long-term safety, and establishing standardized protocols for clinical translation. Although iPSCs circumvent ethical concerns, their differentiation and purification techniques require optimization, and potential genetic mutations remain a concern. Exosomes, as acellular therapeutics, may reduce immune reactions; however, challenges in large-scale production and quality control persist. Therapeutic Potential of Stem Cells Stem cell therapy exhibits multidimensional potential in treating muscle atrophy. First, its mechanisms are highly synergistic: MSCs and iPSCs improve the muscle microenvironment by regulating inflammatory cytokines (e.g., suppressing IL-6 and TNF-α), promoting angiogenesis, inhibiting oxidative stress, and enhancing autophagy. Exosomes further amplify therapeutic effects by delivering functional miRNAs (e.g., miR-132-3p/FoxO3 axis) to delay protein degradation and stimulate regeneration [4, 6]. Second, exosomes as acellular carriers broaden clinical applicability: MSC-derived exosomes (e.g., hUC-MSC-Exos, ADSC-Exos) avoid immune rejection and tumorigenic risks associated with live cell transplantation. Their high biocompatibility and cargo of bioactive molecules (e.g., circHIPK3, AMPK/ULK1 regulators) enable targeted intervention in diabetes- or neuropathy-related atrophy, positioning them as pivotal tools for clinical translation [6, 7]. Third, iPSCs hold exceptional promise for personalized medicine. Their ability to differentiate into myogenic progenitor cells (MPCs) or motor neurons facilitates the reconstruction of neuromuscular junctions, offering precise repair for genetic atrophy (e.g., facioscapulohumeral muscular dystrophy, FSHD). While autologous iPSCs mitigate immune rejection, clinical application demands improved differentiation efficiency and safety [8, 9]. Current Challenges and Solutions Clinical translation of stem cell therapy faces multiple challenges requiring innovative solutions. First, heterogeneity and standardization: MSC efficacy varies with donor age, tissue source (e.g., bone marrow, adipose, umbilical cord), and culture conditions [10]. Establishing unified quality control standards—via surface marker screening, secretome profiling, and single-cell sequencing—is critical to identify functional subpopulations and enable precision manufacturing [11]. Second, genetic instability and differentiation inefficiency hinder iPSC applications: reprogramming-induced mutations and inconsistent differentiation protocols (transgene-dependent or -independent) limit reliability [12]. Integrating non-integrative methods (e.g., mRNA reprogramming) and 3D organoid culture systems may optimize differentiation pathways [8]. Third, exosome scalability and targeting: natural exosomes suffer from low bioactive content and short half-lives. Engineering strategies (e.g., ligand modification or drug loading) can enhance tissue-specific delivery [13, 14], while microfluidic-nanocarrier systems may resolve production bottlenecks. Finally, accelerating clinical translation: preclinical studies predominantly rely on animal models; multicenter trials are needed to validate long-term safety (e.g., tumorigenicity, immune tolerance) [15, 16]. Combining stem cell therapy with anti-inflammatory agents (e.g., IL-1β inhibitors), rehabilitation, or gene editing (e.g., CRISPR-Cas9) may synergistically enhance efficacy [17, 18]. Future Directions Future research should prioritize interdisciplinary integration and precision strategies. First, mechanistic insights: single-cell and spatial transcriptomics can unravel dynamic interactions between stem cells and the muscle microenvironment (e.g., satellite cells, macrophages), identifying key regulatory nodes (e.g., Wnt/β-catenin, PI3K/Akt pathways) [3, 19]. Second, biomaterial innovations: smart hydrogels or electroconductive scaffolds combined with localized stem cell/exosome delivery systems could enhance homing efficiency and functional persistence [20, 21]. Third, personalized approaches: tailored therapies based on disease-specific etiologies (e.g., ALS, diabetic atrophy) and molecular subtypes (e.g., inflammatory signatures) are essential. For instance, AMPK-activated umbilical cord MSCs may rectify metabolic dysregulation in diabetic atrophy [22, 23]. Lastly, ethical and regulatory frameworks: international guidelines must standardize stem cell therapies and clarify regulatory classifications (e.g., exosomes as "drugs") to accelerate clinical translation. Stem cell therapy for skeletal muscle atrophy is transitioning from bench to bedside, yet critical hurdles—standardization, safety, and efficacy validation—remain. Integrating multidisciplinary technologies (e.g., synthetic biology, bioinformatics) and advancing translational research will bridge the gap between "laboratory breakthroughs" and "patient benefits." References: 1. Zhang, H., et al., Oxidative stress: Roles in skeletal muscle atrophy. Biochem Pharmacol, 2023. 214: p. 115664. 2. Ji, Y., et al., Inflammation: Roles in Skeletal Muscle Atrophy. Antioxidants (Basel), 2022. 11(9). 3. Liang, W., et al., Epigenetic control of skeletal muscle atrophy. Cell Mol Biol Lett, 2024. 29(1): p. 99. 4. Huang, Z., et al., Skeletal Muscle Atrophy Was Alleviated by Salidroside Through Suppressing Oxidative Stress and Inflammation During Denervation. Front Pharmacol, 2019. 10: p. 997. 5. Song, J., et al., Mesenchymal stromal cells ameliorate diabetes-induced muscle atrophy through exosomes by enhancing AMPK/ULK1-mediated autophagy. J Cachexia Sarcopenia Muscle, 2023. 14(2): p. 915-929. 6. Archacka, K., et al., Hypoxia preconditioned bone marrow-derived mesenchymal stromal/stem cells enhance myoblast fusion and skeletal muscle regeneration. Stem Cell Res Ther, 2021. 12(1): p. 448. 7. Leong, J., et al., Surface Tethering of Inflammation-Modulatory Nanostimulators to Stem Cells for Ischemic Muscle Repair. ACS Nano, 2020. 14(5): p. 5298-5313. 8. Kim, H., et al., Genomic Safe Harbor Expression of PAX7 for the Generation of Engraftable Myogenic Progenitors. Stem Cell Reports, 2021. 16(1): p. 10-19. 9. Azzag, K., et al., Transplantation of PSC-derived myogenic progenitors counteracts disease phenotypes in FSHD mice. NPJ Regen Med, 2022. 7(1): p. 43. 10. Li, J., et al., The heterogeneity of mesenchymal stem cells: an important issue to be addressed in cell therapy. Stem Cell Res Ther, 2023. 14(1): p. 381. 11. Oguma, Y., et al., Single-cell RNA sequencing reveals different signatures of mesenchymal stromal cell pluripotent-like and multipotent populations. iScience, 2022. 25(11): p. 105395. 12. Shamsian, A., et al., Cancer cells as a new source of induced pluripotent stem cells. Stem Cell Res Ther, 2022. 13(1): p. 459. 13. Rezaie, J., et al., Mesenchymal stem cells derived extracellular vesicles: A promising nanomedicine for drug delivery system. Biochem Pharmacol, 2022. 203: p. 115167. 14. Yang, Q., et al., Exosomes-loaded electroconductive nerve dressing for nerve regeneration and pain relief against diabetic peripheral nerve injury. Bioact Mater, 2023. 26: p. 194-215. 15. Drela, K., et al., Experimental Strategies of Mesenchymal Stem Cell Propagation: Adverse Events and Potential Risk of Functional Changes. Stem Cells Int, 2019. 2019: p. 7012692. 16. Deuse, T., et al., Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients. Nat Biotechnol, 2019. 37(3): p. 252-258. 17. Iyer, S.R., et al., Exosomes Isolated From Platelet-Rich Plasma and Mesenchymal Stem Cells Promote Recovery of Function After Muscle Injury. Am J Sports Med, 2020. 48(9): p. 2277-2286. 18. Chang, M., et al., Duchenne muscular dystrophy: pathogenesis and promising therapies. J Neurol, 2023. 270(8): p. 3733-3749. 19. Sartori, R., V. Romanello, and M. Sandri, Mechanisms of muscle atrophy and hypertrophy: implications in health and disease. Nat Commun, 2021. 12(1): p. 330. 20. Luo, W., et al., Biomaterials-Based Technologies in Skeletal Muscle Tissue Engineering. Adv Healthc Mater, 2024. 13(18): p. e2304196. 21. Shan, Y., et al., Pharmacokinetic characteristics of mesenchymal stem cells in translational challenges. Signal Transduct Target Ther, 2024. 9(1): p. 242. 22. Shen, Y., et al., Diabetic Muscular Atrophy: Molecular Mechanisms and Promising Therapies. Front Endocrinol (Lausanne), 2022. 13: p. 917113. 23. Yeo, C.J.J., E.F. Tizzano, and B.T. Darras, Challenges and opportunities in spinal muscular atrophy therapeutics. Lancet Neurol, 2024. 23(2): p. 205-218. "
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Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693
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