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Articles In Press
1
Yang CW, Zhang YQ, Chang H, Gao R, Chen D, Yao H. Aligned nanofiber scaffolds combined with cyclic stretch facilitate mesenchymal stem cell differentiation for ligament engineering. World J Stem Cells 2025; In press
2025-07-04 | Browse: 30 | Download: 0
2
Cui CX, Shao XN, Li YY, Qiao L, Lin JT, Guan LH. Therapeutic potential of mesenchymal stem cells in neurodegenerative diseases. World J Stem Cells 2025; In press
2025-07-04 | Browse: 23 | Download: 0
3
Wu HL, Huang H, Chen BQ, Xia J, Jiang LB. Intraoperative blood perfusion factors in free anterolateral thigh flap repair for diabetic foot ulcers: A retrospective analysis. World J Diabetes 2025; In press
2025-07-04 | Browse: 23 | Download: 0
4
Wang YR, Gao Y, Liu YC, Xu ZP, Wang YY, Xu HB, Wang JZ, Zhang Y. Higher glycated hemoglobin amplifies the effect of apolipoprotein E epsilon 4-related cognition and olfaction impairments in type 2 diabetes. World J Diabetes 2025; In press
2025-07-04 | Browse: 23 | Download: 0
5
Liu MJ, Xiang SM, Hu XQ. Triglyceride glucose-body mass index is associated with cardiovascular outcomes and overall mortality in type-2 diabetes mellitus patients. World J Diabetes 2025; In press
2025-07-04 | Browse: 25 | Download: 0
6
Zhou RR, Chen LL, Lin LD. Mindfulness-based stress reduction and mental health in department of emergency nurses: A narrative review. World J Psychiatry 2025; In press
2025-07-04 | Browse: 29 | Download: 0
7
Chua MWE, Chan DKH. Challenges and proposed solutions to the adoption of cell free DNA in screening, detecting and prognosticating colorectal cancer. World J Gastrointest Oncol 2025; In press
2025-07-04 | Browse: 23 | Download: 0
8
Damarlapally N, Vempati R, Mourad D, Vasudevan SS, Mathur G, Khan A, Banda P, Polamarasetty H, Chauhan S, Manjappachar N, Bhatti T, Desai R. Association of neutrophil-lymphocyte ratio with all-cause and cardiovascular mortality in peritoneal dialysis patients: A systematic review and meta-analysis. World J Methodol 2025; In press
2025-07-04 | Browse: 32 | Download: 0
9
Shukla A, Nayyar N, Kumari P, Kumar A, Takkar P. Magnetic resonance imaging spectrum of acute hemorrhagic leukoencephalitis: Four case reports. World J Clin Cases 2025; In press
2025-07-04 | Browse: 25 | Download: 0
10
Wan JY, Zhang D, Wu XH, Yang H, Dong C. Progress of immune checkpoint inhibitors in gastric cancer. World J Gastrointest Oncol 2025; In press
2025-07-04 | Browse: 22 | Download: 0
11
Baddam S. Advancing predictive oncology: Integrating clinical and radiomic models to optimize transarterial chemoembolization outcomes in hepatocellular carcinoma. World J Clin Cases 2025; In press
2025-07-04 | Browse: 27 | Download: 0
12
Tornel Avelar AI, Gerrard CN, Priego Parra BA. Phospholipase D2: A biomarker implicated in various pancreatic diseases beyond acute pancreatitis. World J Gastroenterol 2025; In press
2025-07-04 | Browse: 26 | Download: 0
13
Ju UC, Kang WD, Kim SM. Adenomyosis-associated uterine rupture and pulmonary endometriosis mimicking advanced stage uterine malignancy in an adolescent female: A case report. World J Clin Cases 2025; In press
2025-07-04 | Browse: 20 | Download: 0
14
Lester JR, Abolhassani A, Patel H, Hreibe H. Novel approach to pulmonary vein isolation ablation via right internal jugular access: A case report. World J Cardiol 2025; In press
2025-07-04 | Browse: 23 | Download: 0
15
Sun JP, Zhou K, Pan J, Yang N, Sun XN, Zhao HT, Yang XB. Efficacy and safety of transcatheter arterial chemoembolization combined with microwave ablation for hepatic hemangiomas (> 5 cm). World J Gastroenterol 2025; In press
2025-07-04 | Browse: 31 | Download: 0
16
Amarasiri L, de Silva M, de Silva HJ, Devanarayana NM. Comparison of gastric emptying of solid and semi-solid meals using real-time ultrasonography in healthy Sri Lankan adults. World J Gastrointest Pathophysiol 2025; In press
2025-07-03 | Browse: 28 | Download: 0
17
Giri S, Harindranath S, Kulkarni A, Sahoo JK, Joshi H, Nath P, Sahu MK. Fatigue in inflammatory bowel disease: Prevalence, risk factors, assessment, outcomes, and management. World J Gastrointest Pathophysiol 2025; In press
2025-07-03 | Browse: 44 | Download: 0
18
Lin XN, Chan WS, Lu CW. Airway management strategies in a pediatric patient with MURCS association: A case report. World J Clin Cases 2025; In press
2025-07-03 | Browse: 28 | Download: 0
19
Raisa A Aringazina, Afshin Zare, Seyyed Mojtaba Mousavi, Nurgul Abenova, Nadiar Maratovich Mussin, Amin Tamadon. Autologous and allogeneic mesenchymal stem cell-based therapies for diabetes mellitus: A systematic review and meta-analysis. World J Stem Cells 2025; In press
2025-07-03 | Browse: 31 | Download: 0
20
Li WH, Yuan XY, Wang Z, Lin R. Nutrient sensing in intestinal stem cell: Linking dietary nutrients to cellular metabolic regulation. World J Stem Cells 2025; In press
2025-07-03 | Browse: 30 | Download: 0
683 items  Read more >>
Author Reviews
1
"We are very satisfied with the editorial and peer review process. The editors and reviewers have provided no additional comments or ..."  [Read more]
"We are very satisfied with the editorial and peer review process. The editors and reviewers have provided no additional comments or concerns regarding our manuscript. We appreciate the thorough and efficient review process, and we are pleased that our work meets the publication standards. We look forward to the next steps in the publication process. "  [Collapse]
Sun Q, Wu JC, Chen X, Li DH, Li BR, Xiao NJ, Wang XY, Tu XZ, Ning SB, Sun T. Efficacy and safety of sirolimus in the treatment of gastrointestinal angiodysplasias. World J Gastroenterol 2025; 31(25): 105677
2
"Our recent experience with submitting and publishing our manuscript, titled "Nursing care of a patient with negative symptoms of ..."  [Read more]
"Our recent experience with submitting and publishing our manuscript, titled "Nursing care of a patient with negative symptoms of schizophrenia who underwent tracheotomy: A case report," in the World Journal of Clinical Cases was exceedingly positive and surpassed our expectations. We extend our profound gratitude for the rigorous and constructive nature of the peer review process. The timely and highly perceptive feedback provided by the anonymous reviewers was greatly appreciated. Their comments, which were both critical and demonstrated a sophisticated understanding of our research domain, guided us in making significant improvements to the quality of our manuscript, enhancing the precision of our key information, and improving the clarity and overall impact of our findings. The editorial handling by the editorial team was also exemplary. Communication was consistently prompt, transparent, and highly professional at every stage, from initial submission decisions to post-acceptance production. Their efficiency ensured a smooth progression of our manuscript through all phases. Finally, the post-acceptance production team was swift and meticulous in preparing our article for publication. The entire process, from submission to online appearance, was surprisingly quick without compromising on quality checks. We are incredibly grateful for the opportunity to publish our work in the World Journal of Clinical Cases. We wholeheartedly recommend this journal to fellow researchers in Psychiatric nursing who are seeking a publishing venue that combines a streamlined submission process with an outstandingly supportive and rigorous peer-review and editorial experience. It truly contributes to advancing high-quality research within the field. "  [Collapse]
Li JY, Liu XE, Li W, Wang LN. Nursing care of a patient with negative symptoms of schizophrenia who underwent tracheotomy: A case report. World J Clin Cases 2025; 13(25): 108124
3
"I was very satisfied with the overall editorial and publication process. The peer review was fair, constructive, and timely. The ..."  [Read more]
"I was very satisfied with the overall editorial and publication process. The peer review was fair, constructive, and timely. The editorial office maintained clear communication throughout, and the revisions were handled efficiently. I did not encounter any particular difficulties, and I appreciate the professionalism and responsiveness of the editorial team. "  [Collapse]
Lee AY, Lim SG, Cho JY, Kim S, Lee KM, Shin SJ, Noh CK, Lee GH, Hur H, Han SU, Son SY, Song JH. Comparison of treatment strategies for submucosal tumors originating from the muscularis propria at esophagogastric junction or cardia. World J Gastroenterol 2025; 31(23): 106261
4
"The peer review process and publication process were compact and soon. In general, we were satisfied with the whole process of the ..."  [Read more]
"The peer review process and publication process were compact and soon. In general, we were satisfied with the whole process of the course of submission. In addition, we would like to suggest our colleagues to submit their works to the Journal according to the efficient managements from the editorial office. "  [Collapse]
Chang YC, Liu WN, Lin F, Lin GM. Mood alteration and heart rate variability in patients with cancer on treatment. World J Cardiol 2025; 17(6): 107114
5
"We feel extremely honored and delighted to have our article published in the World Journal of Gastroenterology. The entire submission ..."  [Read more]
"We feel extremely honored and delighted to have our article published in the World Journal of Gastroenterology. The entire submission process was smooth and efficient, and the editorial team was incredibly supportive and professional. Their constructive feedback significantly improved our manuscript. We truly appreciate the positive experience and the platform this journal provides for disseminating important research. "  [Collapse]
Huang SS, Chen W, Vaishnani DK, Huang LJ, Li JZ, Huang SR, Li YZ, Xie QP. Leucine-rich repeat-containing protein 19 suppresses colorectal cancer by targeting cyclin-dependent kinase 6/E2F1 and remodeling the immune microenvironment. World J Gastroenterol 2025; 31(25): 107893
6
"We sincerely thank the editorial board and reviewers of the World Journal of Gastroenterology for their constructive comments and ..."  [Read more]
"We sincerely thank the editorial board and reviewers of the World Journal of Gastroenterology for their constructive comments and professional handling of our manuscript. The review process was thorough, transparent, and timely, contributing to the refinement and clarity of our work. We are pleased that our study has been accepted for publication in this well-regarded journal. "  [Collapse]
Gajovic NM, Jovanovic IP, Jocic MV, Stojanovic B, Corovic IF, Todorovic N, Simovic Markovic BJ, Amedei A. Exploring the impact of galectins on liver cancer: From immunopathogenesis to potential targets. World J Gastroenterol 2025; 31(25): 107260
7
"Thank you for publishing our work. We are grateful for the opportunity to contribute to the scientific community through your esteemed ..."  [Read more]
"Thank you for publishing our work. We are grateful for the opportunity to contribute to the scientific community through your esteemed journal. The publication process was smooth and professional, and we appreciate the editorial team's guidance. We hope our findings will spark further research and dialogue, and we look forward to future collaborations with your journal. "  [Collapse]
Basit A, Noor S, Ahmad SA, Noor N, Maryam R, Basil AM. Otitis media with effusion and hearing outcomes - Myringotomy vs myringotomy and tympanostomy: A comparative study. World J Otorhinolaryngol 2025; 12(1): 109355
8
"The entire process took too long from submission to publishing. In particular, it took too long from the submission of the revised ..."  [Read more]
"The entire process took too long from submission to publishing. In particular, it took too long from the submission of the revised paper (according to peer review) and the final publishing. We are satisfied with overall quality of the journal and the edited paper, but it’s not the first time that after peer review you take several months to finally publish the accepted and revised paper. "  [Collapse]
Liguori A, Ainora ME, Di Gialleonardo L, Viceconti N, Petrucci L, Esposto G, Giustiniani MC, Mignini I, Borriello R, Galasso L, Paratore M, Garcovich M, Riccardi L, Pompili M, Grieco A, Gasbarrini A, Miele L, Zocco MA. Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(25): 105518
9
"We sincerely appreciate the professional and efficient editorial process of the World Journal of Gastroenterology. From initial ..."  [Read more]
"We sincerely appreciate the professional and efficient editorial process of the World Journal of Gastroenterology. From initial submission to final publication, the entire workflow was transparent, well-organized, and timely. The reviewers provided constructive and insightful comments that significantly improved the quality of our manuscript. The editorial team was responsive and meticulous in their guidance, and the language editing was of high standard. We are grateful for the opportunity to publish in this reputable journal and look forward to future collaborations. "  [Collapse]
Wang XP, Zhu JX, Liu C, Zhang HW, Sun GD, Zhai JM, Yang HJ, Liu DC. Deciphering lactate metabolism in colorectal cancer: Prognostic modeling, immune infiltration, and gene mutation insights. World J Gastroenterol 2025; 31(25): 107478
10
"Thank you so much for this opportunity to work with you. I am hopeful to continue this association with you in future. I would like ..."  [Read more]
"Thank you so much for this opportunity to work with you. I am hopeful to continue this association with you in future. I would like to express my gratitude to the entire staff for the wonderful work they are doing. Keep doing the good work. I would like to request to reduce the time after acceptance to online publication. "  [Collapse]
Parry AH, Rehaman B, Bhat SA, Wani AH, Jehangir M, Baba AA. Role of magnetic resonance defecography in the assessment of obstructed defecation syndrome. World J Radiol 2025; 17(6): 107205
11
"Thank you so much for this wonderful journey, from the kind invitation to publish an article to the article proofreading. The ..."  [Read more]
"Thank you so much for this wonderful journey, from the kind invitation to publish an article to the article proofreading. The reviewers' comments were greatly appreciated. There are many more requirements for this great journal, from which we have learned so much. Again thank you to all the Editorial Board and members. "  [Collapse]
Abdelrazek MA, Elghwab AI, Tabll AA, Elsayed EH, El Behery M. Evaluation of hyaluronic acid and type III procollagen peptide as predictors for treatment response to direct-acting antivirals. World J Virol 2025; 14(2): 106479
12
"Many thanks to the journal editors and reviewers. I have no further comments. The process is a bit lengthy, and many documents must ..."  [Read more]
"Many thanks to the journal editors and reviewers. I have no further comments. The process is a bit lengthy, and many documents must be submitted. I hope to make it easier by eliminating unnecessary documents. Thanks again for the usual support, and looking forward to submitting more articles Best regards Abdulqadir "  [Collapse]
D Souza LA, Nashwan AJ. Examining rhabdomyolysis-related acute kidney injury in COVID-19 patients and its comparison to other acute kidney injury types. World J Virol 2025; 14(2): 100986
13
"Many thanks to the journal editors and reviewers. I have no further comments. The process is a bit lengthy, and many documents must ..."  [Read more]
"Many thanks to the journal editors and reviewers. I have no further comments. The process is a bit lengthy, and many documents must be submitted. I hope to make it easier by eliminating unnecessary documents. Thanks again for the usual support, and looking forward to submitting more articles Best regards Abdulqadir "  [Collapse]
Ahmed S, Nashwan AJ. Rising adult hepatitis A in Pakistan: Shifting trends and public health solutions. World J Virol 2025; 14(2): 102519
14
"We sincerely thank the editorial team for the thorough and thoughtful peer review of our manuscript and for the high evaluation it ..."  [Read more]
"We sincerely thank the editorial team for the thorough and thoughtful peer review of our manuscript and for the high evaluation it received. We greatly appreciate the opportunity to have our work published in your esteemed journal. Your constructive feedback and support have been invaluable, and we are truly honored to contribute to your distinguished publication. "  [Collapse]
Semash K, Dzhanbekov T. Redefining the treatment paradigm for esophageal gastrointestinal stromal tumors: The emerging role of endoscopic resection. World J Gastroenterol 2025; 31(24): 106440
15
"It is a great honor to publish the results of our research in your journal. Throughout the submission and review process, we deeply ..."  [Read more]
"It is a great honor to publish the results of our research in your journal. Throughout the submission and review process, we deeply felt the rigorous and professional working attitude of the editorial board, and these meticulous editing work significantly improved the quality of the academic presentation of the paper. We look forward to continuing our academic cooperation with your journal in the future, and expect your journal to do better and better! "  [Collapse]
Bie LZ, Wu C, Wang JL. Dietary ω-3 polyunsaturated fatty acid intake improves skeletal muscle mass in patients with metabolic dysfunction-associated fatty liver disease: A nationwide cross-sectional study. World J Hepatol 2025; 17(6): 107931
16
"We sincerely thank the editorial team at World Journal of Gastroenterology for their rigorous and efficient review process and ..."  [Read more]
"We sincerely thank the editorial team at World Journal of Gastroenterology for their rigorous and efficient review process and professional support. Special appreciation is extended to the anonymous reviewers for providing invaluable insights and constructive suggestions on this study! Your profound perspectives and feedback significantly enhanced the quality of the manuscript, allowing this research to be presented in a more refined form. It has been a great privilege to collaborate with such a professional journal and review team. We hope this work will contribute modestly to advancing the field. "  [Collapse]
Wang JY, Yi B, Li CY, Xu HQ, Tang SH. Pay attention to the value of liver regeneration in the re-compensation of decompensated cirrhosis. World J Gastroenterol 2025; 31(24): 106564
17
"Overall, the process is good and author-friendly. I am highly satisfied with the review reports and the process followed by the ..."  [Read more]
"Overall, the process is good and author-friendly. I am highly satisfied with the review reports and the process followed by the journal. The editorial board keeps eyes on each minute aspect of the manuscript and suggests wherever it is required. Reviewers of the manuscript helped in a constructive way to enhance its quality. "  [Collapse]
Kumar S. Esophageal squamous cell carcinoma susceptibility of activin A receptor type 1C variants in Chinese population. World J Gastrointest Oncol 2025; 17(6): 102687
18
"The publishing procedure has been highly efficient and well-organized, ensuring that each stage of the process—from initial submission ..."  [Read more]
"The publishing procedure has been highly efficient and well-organized, ensuring that each stage of the process—from initial submission to final approval—was handled with care and precision. I particularly appreciated the prompt and regular updates, which kept me well-informed of the manuscript’s progress and any required actions. The communication from the editorial and production teams was consistently clear, courteous, and timely, reflecting a high level of professionalism. All inquiries were addressed quickly and effectively, which contributed to a seamless experience. Overall, I am thoroughly satisfied with the service provided, both in terms of quality and responsiveness. The smooth coordination and transparent workflow have made this publishing journey a positive and rewarding one, and I would not hesitate to recommend this process to fellow researchers and colleagues. "  [Collapse]
Liu TM. Mesenchymal stem cell-derived extracellular vesicles: Pioneering the next generation of biomedical applications. World J Stem Cells 2025; 17(6): 108197
19
"It was an excellent editorial process. The article was quickly reviewed for eligibility for publication and sent to the reviewers. ..."  [Read more]
"It was an excellent editorial process. The article was quickly reviewed for eligibility for publication and sent to the reviewers. Positive feedback from reviewers helped us in improving the quality of the manuscript. The editorial board rightly pointed out blurring of a part of the included figure , that was corrected in time. I am not in favour of English language certificate by a third party by paying a hefty fee. "  [Collapse]
Abbas Z, Abbas M. Hope on the horizon: Emerging therapies for hepatitis D. World J Hepatol 2025; 17(6): 107963
20
"The review process for the World Journal of Radiology was smooth, professional, and highly efficient. The submission system was ..."  [Read more]
"The review process for the World Journal of Radiology was smooth, professional, and highly efficient. The submission system was user-friendly, with clear instructions and timely updates. Reviewer feedback was constructive and helped enhance the quality of our work. Overall, the experience was positive, and we appreciate the journal’s commitment to a streamlined and supportive publication process. "  [Collapse]
Al Kiswani S, Nasser M, Alzibdeh A, Lahham EE. Enhancing back pain and sciatica diagnosis: Coronal short tau inversion recovery’s role in routine lumbar magnetic resonance imaging protocols. World J Radiol 2025; 17(6): 107164
18970 items  Read more >>
Article Quality Tracking-Peer-Review
1
"Non-alcoholic fatty liver disease (NAFLD), recently renamed NAFLD to metabolic dysfunction-associated fatty liver disease (MAFLD), ..."  [Read more]
"Non-alcoholic fatty liver disease (NAFLD), recently renamed NAFLD to metabolic dysfunction-associated fatty liver disease (MAFLD), is a widespread disease of high socio-economic importance and is not always amenable to therapy. Recent data show that gut microbiota plays an important role in the pathogenesis of NAFLD. The authors presented a well-structured overview based on current understanding on this actual problem. In particular, NAFLD is accompanied by a change in the gut microbiota composition the proportion of taxa deconjugating bile acids increases, while the proportion of taxa converting primary bile acids to secondary ones decreases. The number of bacteria forming lipopolysaccharide also increases. Lipopolysaccharide, entering the liver with the portal vein blood, promotes the development of its inflammation and insulin resistance. The disturbance of bile acids metabolism through the effect on the FXR and TGR5 receptors also leads to insulin resistance and liver steatosis. Indeed, targeted microbiota manipulation through dietary interventions, probiotics, prebiotics, synbiotics, and fecal microbiota transplantation represents a promising strategy for NAFLD treatment. "  [Collapse]
Pandey H, Goel P, Srinivasan VM, Tang DWT, Wong SH, Lal D. Gut microbiota in non-alcoholic fatty liver disease: Pathophysiology, diagnosis, and therapeutics. World J Hepatol 2025; 17(6): 106849
2
"As regard ethics: The IRB is only from porta said university while sherbin central hospital is one of the units of National committee ..."  [Read more]
"As regard ethics: The IRB is only from porta said university while sherbin central hospital is one of the units of National committee of control of viral hepatitis so all the data is belong to the national committee and need separate IRB what the time of this study it is stated that it is prospective while those patients receive treatment since the national program since 2017 and the center is closed since 4 years or more so it is actually retrospective study on stored samples????? Rational of the study:The SVR for DAAs even in cirrhotic HCV patients were 97% so research for predicting response as regard cost benefit at national program because the cost of generic drug cost about 10 dolars while these markers cost may exceed 1000 dollar's it is non practical for its use except from the research aspect. Methods: the inclusion criteria for the patients is not mentioned :if it is naïve cirrhotic or experienced cirrhotic what the duration of treatment for each group. - The method include major mistakes as the National protocol undergo PCR HCV at the start of treatment , at the end for treatment to define responder from non responders and after 6 month to define relapse from sustained virological response (SVR) so the definition of non responders in this study is not correct . the correct expression is SVR and relapsers so theses markers predict SVR not response to treatment"  [Collapse]
Abdelrazek MA, Elghwab AI, Tabll AA, Elsayed EH, El Behery M. Evaluation of hyaluronic acid and type III procollagen peptide as predictors for treatment response to direct-acting antivirals. World J Virol 2025; 14(2): 106479
3
"This review explores whether robotic-assisted lymphadenectomy provides measurable advantages over laparoscopic approaches in the ..."  [Read more]
"This review explores whether robotic-assisted lymphadenectomy provides measurable advantages over laparoscopic approaches in the treatment of gastric cancer. While robotic gastrectomy appears to offer comparable oncologic outcomes in terms of lymph node retrieval and survival rates, it may confer technical benefits such as reduced blood loss, lower pancreatic fistula rates, and more precise dissection—particularly in challenging cases following neoadjuvant therapy or involving suprapancreatic nodes. However, robust evidence remains limited, and further randomized controlled trials—especially in Western populations with varied surgical expertise—are warranted to validate these findings."  [Collapse]
Marrelli D, Carbone L, Poto GE, Fusario D, Gjoka M, Andreucci E, Piccioni SA, Calomino N, Sandini M, Roviello F. Minimally invasive lymphadenectomy for gastric cancer: Could the robotic approach provide any benefits than laparoscopy? World J Gastrointest Oncol 2025; 17(6): 104015
4
"Based on the article, this study highlights the prognostic significance of preoperative biomarkers—specifically fibrinogen and ..."  [Read more]
"Based on the article, this study highlights the prognostic significance of preoperative biomarkers—specifically fibrinogen and neutrophil-to-lymphocyte ratio (F-NLR), alpha-fetoprotein (AFP), and prealbumin (PA)—in patients with primary liver cancer undergoing transarterial chemoembolization (TACE). The integrated model incorporating all three indicators showed strong predictive accuracy for patient outcomes, suggesting its potential utility for personalized risk stratification and treatment planning. However, to enhance clinical applicability, external validation in diverse cohorts and prospective trials would be beneficial."  [Collapse]
Liu QQ, Li YD, Chen JX, Zhang LL, Guan RC, Zhao W, Meng LY. Prognostic value of preoperative fibrinogen, neutrophil-to-lymphocyte ratio, serum alpha-fetoprotein, and prealbumin for patients with primary liver cancer undergoing transarterial chemoembolization. World J Gastrointest Oncol 2025; 17(6): 103198
5
"This study sheds light on the genetic predisposition to esophageal squamous cell carcinoma (ESCC) in the Chinese population by ..."  [Read more]
"This study sheds light on the genetic predisposition to esophageal squamous cell carcinoma (ESCC) in the Chinese population by investigating activin A receptor type 1C (ACVR1C) polymorphisms. The findings suggest that certain SNPs may serve as potential biomarkers for early diagnosis and personalized treatment. However, integration of clinical features and treatment response data would further strengthen its translational relevance."  [Collapse]
Kumar S. Esophageal squamous cell carcinoma susceptibility of activin A receptor type 1C variants in Chinese population. World J Gastrointest Oncol 2025; 17(6): 102687
6
"This article discusses recent advances in the integrated application of genetic and imaging techniques in esophageal squamous cell ..."  [Read more]
"This article discusses recent advances in the integrated application of genetic and imaging techniques in esophageal squamous cell carcinoma and pancreatic cancer, highlighting the clinical potential of precision medicine. In particular, the identification of specific genetic polymorphisms and imaging biomarkers suggests meaningful implications for early diagnosis and individualized treatment strategies. Such a multidisciplinary approach could contribute to improved detection of high-risk patients and more personalized therapeutic interventions in the future."  [Collapse]
Zhang SK, Jiang L, Jiang CL, Cao Q, Chen YQ, Chi H. Unveiling genetic susceptibility in esophageal squamous cell carcinoma and revolutionizing pancreatic cancer diagnosis through imaging. World J Gastrointest Oncol 2025; 17(6): 102544
7
"Based on the document, the study emphasizes the prognostic significance of preoperative inflammatory and nutritional biomarkers—such ..."  [Read more]
"Based on the document, the study emphasizes the prognostic significance of preoperative inflammatory and nutritional biomarkers—such as neutrophil-to-lymphocyte ratio (NLR) and hemoglobin—in patients with colorectal cancer and peritoneal metastases. The development of a nomogram integrating these factors offers a practical tool for risk stratification and clinical decision-making, though external validation through larger, multicenter cohorts remains essential to confirm its broader utility."  [Collapse]
Cai Z, Dai WD, Cai XW. Prognostic impact of inflammatory and nutritional markers in colorectal cancer patients with peritoneal metastasis. World J Gastrointest Oncol 2025; 17(6): 100010
8
"The article was excellent and well-organized. MSC-derived extracellular vesicles (MSC-EVs) have emerged as a promising candidate across ..."  [Read more]
"The article was excellent and well-organized. MSC-derived extracellular vesicles (MSC-EVs) have emerged as a promising candidate across various medical fields, including tissue regeneration, biomarker development, and biomedical engineering. Therefore, a comprehensive review covering the applications of EVs in biomedicine, along with future perspectives, is essential for advancing our understanding and addressing current limitations in the field."  [Collapse]
Liu TM. Mesenchymal stem cell-derived extracellular vesicles: Pioneering the next generation of biomedical applications. World J Stem Cells 2025; 17(6): 108197
9
"Recent articles on the topic are fewer than expected. For example you could cite some of the following ..."  [Read more]
"Recent articles on the topic are fewer than expected. For example you could cite some of the following articles https://pmc.ncbi.nlm.nih.gov/articles/PMC9120231/ Wang Y, Wei J, Zhang W, Doherty M, Zhang Y, Xie H, Li W, Wang N, Lei G, Zeng C. Gut dysbiosis in rheumatic diseases: A systematic review and meta-analysis of 92 observational studies. EBioMedicine. 2022 Jun;80:104055. doi: 10.1016/j.ebiom.2022.104055. https://pubmed.ncbi.nlm.nih.gov/38352865/ Goudman L, Demuyser T, Pilitsis JG, Billot M, Roulaud M, Rigoard P, Moens M. Gut dysbiosis in patients with chronic pain: a systematic review and meta-analysis. Front Immunol. 2024 Jan 30;15:1342833. doi: 10.3389/fimmu.2024.1342833. https://pmc.ncbi.nlm.nih.gov/articles/PMC9895325/ https://pubmed.ncbi.nlm.nih.gov/29205415/"  [Collapse]
Tüsüz Önata E, Özdemir Ö. Microbiome, dysbiosis and use of probiotics in various diseases. World J Virol 2025; 14(2): 99574
10
"Gastroparesis is a severe diabetic complication caused by progressively worsening intestinal neuropathy. Early detection is achieved ..."  [Read more]
"Gastroparesis is a severe diabetic complication caused by progressively worsening intestinal neuropathy. Early detection is achieved through laboratory testing for delayed gastric emptying, mainly through annual real-time ultrasound. If the manometric study detects pyloric spasm, this should be treated endoscopically. If gastroparesis is detected by electrogastrographic body surface gastric mapping, it is treated with prokinetic drugs and careful management of diabetes mellitus. Early detection of the disease through blood or stool markers is not yet possible. Currently, the annual screening of patients who meet the criteria for potential disease appearance is the only way to achieve a successful and timely diagnosis. In cases of normal results, high-resolution intrapyloric-duodenal manometry or the EndoFLIP device should be used to check for pyloric spasm. Appropriate dietary interventions, prokinetic drugs, and blood sugar regulation follow this. However, both the diagnosis and treatment of the condition are not easy. The gastroenterologist should be well-informed about the diagnostic methodology and therapeutic interventions. Nevertheless, the future looks promising for emerging therapies aiming to treat the condition etiologically."  [Collapse]
Bortolotti M. Gastroparesis, a diabetic complication causing further, even serious, complications: How to prevent its worsening? World J Gastroenterol 2025; 31(23): 104932
11
"The paper is interesting and well written. The information s correct and useful. It is an updated review. Probably, if the Authors ..."  [Read more]
"The paper is interesting and well written. The information s correct and useful. It is an updated review. Probably, if the Authors have provided some images the comprehension of the issue would have been greater. A more detailed description of the haemodynamic problems for the presence of the sinus of Valsalva aneurysms would have increased the valute of the review."  [Collapse]
English K. Diagnosis and treatment options for sinus of Valsalva aneurysms: A narrative review. World J Cardiol 2025; 17(6): 102722
12
"This is very interesting paper. I ask some questions to author. 1.A liver biopsy is required to diagnose NASH, but there are risks ..."  [Read more]
"This is very interesting paper. I ask some questions to author. 1.A liver biopsy is required to diagnose NASH, but there are risks such as bleeding, so there are also noninvasive tests such as Fib-4 index, M2BPGi, and elastography. What combination would be best? 2.What are the reasons for the high incidence of NASH in developing countries?"  [Collapse]
Sato-Espinoza K, Valdivia-Herrera M, Chotiprasidhi P, Diaz-Ferrer J. Hepatocellular carcinoma in patients without cirrhosis. World J Gastroenterol 2025; 31(23): 107100
13
"The study investigates phenotypic attributes and survival in mismatch repair deficient/microsatellite instability-high ..."  [Read more]
"The study investigates phenotypic attributes and survival in mismatch repair deficient/microsatellite instability-high (MMR-deficient/MSI-H) colorectal carcinomas, a clinically relevant topic with clear translational implications. The retrospective design and focus on survival outcomes align with established research frameworks in oncology. This study provides valuable insights into MMR-deficient/MSI-H colorectal cancer, but enhancements in ethical documentation, statistical rigor, and methodological transparency are needed to strengthen its credibility. Addressing these gaps will not only improve the manuscript’s scientific quality but also position the findings to influence clinical practice. The authors are encouraged to prioritize multivariable analysis, standardized reporting, and contemporary literature integration to maximize the study’s impact."  [Collapse]
Mehta A, Bansal D, Tripathi R, Anoop V. Phenotypic attributes and survival in mismatch repair deficient/microsatellite instability-high colorectal carcinomas. World J Clin Oncol 2025; 16(6): 104243
14
"This is a very nice case that illustrates the Worldwide Problem that Medicine has with Bariatric Surgery when it is not properly ..."  [Read more]
"This is a very nice case that illustrates the Worldwide Problem that Medicine has with Bariatric Surgery when it is not properly indicated. The problem with obesity is that it has been tried to be solved with bariatric surgery alone. Obesity and overweight has caused a lot of health problems but most importantly are gastrointestinal symptomatology which is mostly attributed to a higher BMI. The solution to obesity is not surgery."  [Collapse]
Cass K, Leggett A, Gibson DG. Diagnostic dilemma of avoidant/restrictive food intake disorder after bariatric surgery: A case report and review of literature. World J Clin Cases 2025; 13(24): 106941
15
"This study comparatively analyzed cancer incidence data between China and the global context in 2022, aiming to reveal disparities ..."  [Read more]
"This study comparatively analyzed cancer incidence data between China and the global context in 2022, aiming to reveal disparities in cancer burden through multidimensional analysis of factors including gender, geographic distribution, and economic levels, while exploring risk factors associated with high-incidence cancer types. These findings provide a foundation for formulating targeted prevention and control strategies."  [Collapse]
Hu D, Yu J, Feng J, Liu P, Chen JM, Zhang HL. Comparison and trend analysis of cancer incidence in China and globally in 2022. World J Clin Oncol 2025; 16(6): 107016
16
"(1) The study adopted a retrospective cohort design with a sample size of 102 adult AML patients, which meets statistical requirements. ..."  [Read more]
"(1) The study adopted a retrospective cohort design with a sample size of 102 adult AML patients, which meets statistical requirements. However, the sample size may be insufficient for subgroup analyses (e.g., FAB-M2 subtype had only 44 cases) . (2) While the study clearly reported negative results (e.g., no significant association between SOX11 expression and CR, OS/DFS), it lacked biological justification for the SOX11 high/low expression grouping criteria . (3) Statistical analyses appropriately used Mann-Whitney tests and Kaplan-Meier survival methods for nonparametric data characteristics, but failed to implement multiple testing corrections (e.g., Bonferroni adjustment) . (4) This work validated SOX11's association with FLT3-ITD mutations and FAB-M2 subtype in AML, proposing its potential as a stratification marker for high-risk patients. However, functional experiments (e.g., CRISPR knockout/overexpression) are required to verify SOX11's oncogenicity and synergistic effects with FLT3-ITD in AML pathogenesis . Methodologically, the study demonstrated good standardization and result transparency, but was limited by sample size constraints and insufficient mechanistic exploration depth ."  [Collapse]
Abdel Aziz RS, Radwan EM, Fouad AM, Abdellateif MS, Elfishawi S. Clinical significance of the transcription factor (SOX11) expression in the bone marrow of acute myeloid leukemia patients. World J Clin Oncol 2025; 16(6): 107271
17
"(1) Objectivity and Credibility: The research design is rigorous and the data supports the conclusions, but confounding factor ..."  [Read more]
"(1) Objectivity and Credibility: The research design is rigorous and the data supports the conclusions, but confounding factor correction analysis needs to be added. (2) Scientific Value: For the first time, a systematic comparison of the lymph node characteristics and survival associations of MMR-D/MSI-H and MMR-P/MSS CRC was made, providing new basis for immunotherapy stratification. (3) Priority for Improvement: The results need to be verified through prospective cohort studies, and the clinical transformation pathways of LNY/LNR as prognostic markers need to be explored."  [Collapse]
Mehta A, Bansal D, Tripathi R, Anoop V. Phenotypic attributes and survival in mismatch repair deficient/microsatellite instability-high colorectal carcinomas. World J Clin Oncol 2025; 16(6): 104243
18
"Objectivity: Moderate. The topic discussed in this study is actually a legacy topic, so the publication bias is obvious. Credibility ..."  [Read more]
"Objectivity: Moderate. The topic discussed in this study is actually a legacy topic, so the publication bias is obvious. Credibility & Scientific quality: There are 2 papers included in this manuscript were reported on Pubpeer. Actually, there is one big problem for every meta-analysis article: There are too many fake papers published and indexed in various SciDatabases. "  [Collapse]
Zheng XD, Li HY, Gao SY, Wang Q, Liu JB. High hypoxia inducible factor-1α expression is associated with reduced survival in patients with breast cancer: A meta-analysis. World J Clin Oncol 2025; 16(6): 105691
19
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."  [Read more]
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."  [Collapse]
Younus A, Liu Y, Connor EE, Wu ZY, Lee H, Fu ZY. Segmental atrophy of the liver: Review of a rare pseudotumor. World J Clin Cases 2025; 13(24): 107825
20
"The ethical approval meets requirements. The study obtained approval (CE24431B) from Taichung Veterans General Hospital. The methods ..."  [Read more]
"The ethical approval meets requirements. The study obtained approval (CE24431B) from Taichung Veterans General Hospital. The methods are effective and can be repeated by fellow researchers. They conducted a robust retrospective cohort using the TriNetX database, which harmonizes EHR data across 80 U.S. healthcare organizations. Besides, the inclusion and exclusion criteria are clear. The results of this study are authentic, reliable and validate the initial hypothesis. The tables, graphs, and figures were constructed and annotated well. But one mistake was presented in Table 3. Gestational hypertension HR typo ("HR: 1.936(1.844,0.033)" – "0.033" likely should be "2.033"). The biostatistics data was generally right. However, more details of PSM and some sensitivity analyses (e.g., competing risks for mortality) are suggested to be added. Authors have cited key references to support the pathophysiological mechanisms and prior epidemiological relationship, as well as some recent references. I suggest adding recent reviews on PIH-related metabolic dysfunction. The language is generally clear, concise, and logically structed."  [Collapse]
Shih YH, Yang CY, Lung CC. Long-term risk of diabetes following hypertensive disorders of pregnancy: A retrospective cohort study. World J Diabetes 2025; 16(6): 105080
15319 items  Read more >>
Peer-Reviewers and Manuscript Statistics
Editorial board members
2266
Peer-reviewers
32103
Manuscripts received today
8
Manuscript reviews today
48
Unhandled manuscripts today
123
Active peer-reviewers today
1877
Reviewer acceptance today
100
Reviewer refusals today
81
Total accepted manuscripts
36724
Total rejected manuscripts
42251
Total peer-reviewers
4276766
Total submissions
34855
Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.
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All Journal Articles
1

Parchwani D, Singh R, Patel D. Biological and translational attributes of mitochondrial DNA copy number: Laboratory perspective to clinical relevance. World J Methodol 2025; 15(3): 102709

2025-09-20 | Browse: 4535 | Download: 677
2

Tawheed A, Ismail A, El-Tawansy A, Maurice K, Ali A, El-Fouly A, Madkour A. Third space endoscopy pulmonary complications and chylothorax post peroral endoscopic myotomy. World J Methodol 2025; 15(3): 102703

2025-09-20 | Browse: 4373 | Download: 676
3

Bajpai J, Saxena M, Pradhan A, Kant S. Sotatercept: A novel therapeutic approach for pulmonary arterial hypertension through transforming growth factor-β signaling modulation. World J Methodol 2025; 15(3): 102688

2025-09-20 | Browse: 5164 | Download: 630
4

Bale BI, Zeppieri M, Idogen OS, Okechukwu CI, Ojo OE, Femi DA, Lawal AA, Adedeji SJ, Manikavasagar P, Akingbola A, Aborode AT, Musa M. Seeing the unseen: The low treatment rate of eye emergency in Africa. World J Methodol 2025; 15(3): 102477

2025-09-20 | Browse: 4957 | Download: 712
5

Vo LT, Vu T, Pham TN, Trinh TH, Nguyen TT. Machine learning-based models for prediction of in-hospital mortality in patients with dengue shock syndrome. World J Methodol 2025; 15(3): 101837

2025-09-20 | Browse: 4570 | Download: 932
6

Chauhan R, Padiyar N, Kaurani P, Gupta A, Chauhan S. Comparative evaluation of retentive capacity of three different attachment systems for implant retained overdentures: An in vitro study. World J Methodol 2025; 15(3): 101057

2025-09-20 | Browse: 4780 | Download: 805
7

Shah P, Shah VM, Saravanan VR, Kumar K, Narendran S. Evaluation of macular and peripapillary structure and microvasculature with optical coherence tomography angiography in migraine in Indian population. World J Methodol 2025; 15(3): 100950

2025-09-20 | Browse: 4523 | Download: 919
8

Drăgoi AL, Nemeș RM. “Electronic Pediatrician”, a non-machine learning prototype artificial intelligence software for pediatric computer-assisted pathophysiologic diagnosis — general presentation. World J Methodol 2025; 15(3): 100903

2025-09-20 | Browse: 4494 | Download: 859
9

Drăgoi AL, Nemeș RM. The remarkable effects of the ionized medical water Asea® in 3 boys with Duchenne dystrophy: Three case reports. World J Methodol 2025; 15(3): 100840

2025-09-20 | Browse: 5501 | Download: 761
10

Fawaz P, El Sayegh P, Vande Vannet B. Artificial intelligence in revolutionizing orthodontic practice. World J Methodol 2025; 15(3): 100598

2025-09-20 | Browse: 7219 | Download: 797
11

Khokhar RK, Nashwan AJ. Gut virome and its emerging role in inflammatory bowel disease. World J Methodol 2025; 15(3): 100534

2025-09-20 | Browse: 3227 | Download: 631
12

English K. Echo contrast medium: How the use of contrast echocardiography (ultrasound contrast agents) can improve patient care. World J Methodol 2025; 15(3): 100490

2025-09-20 | Browse: 4006 | Download: 634
13

Tramontana A, Rulli M, Falegnami A, Bilotta F. Visual avatar to increase situational awareness in anaesthesia: Systematic review of recent evidence. World J Methodol 2025; 15(3): 100459

2025-09-20 | Browse: 4423 | Download: 671
14

Li XL, Megdadi M, Quadri HS. Interaction between gut virome and microbiota on inflammatory bowel disease. World J Methodol 2025; 15(3): 100332

2025-09-20 | Browse: 3243 | Download: 553
15

Raveendran AV. Clinical inertia in sexual medicine practice. World J Methodol 2025; 15(3): 99874

2025-09-20 | Browse: 4280 | Download: 601
16

Tarazi A, Aburrub A, Hijah M. Use of artificial intelligence in neurological disorders diagnosis: A scientometric study. World J Methodol 2025; 15(3): 99403

2025-09-20 | Browse: 5455 | Download: 771
17

Casu C, Inchingolo AM, Orrù G. Interleukin 10 supplement to reduce episodes of recurrent aphthous stomatitis. World J Methodol 2025; 15(3): 99176

2025-09-20 | Browse: 3992 | Download: 594
18

Singh K, Nashwan AJ. Innovative forecasting models for nurse demand in modern healthcare systems. World J Methodol 2025; 15(3): 99162

2025-09-20 | Browse: 3497 | Download: 572
19

Kodali R, Parasar K, Anand U, Singh BN, Kant K, Arora A, Karthikeyan V, Anwar S, Saha B, Wadaskar S. Evidence-based approach for intraabdominal drainage in pancreatic surgery: A systematic review and meta-analysis. World J Methodol 2025; 15(3): 99080

2025-09-20 | Browse: 4640 | Download: 793
20

Al-Beltagi M. Fishing reviewing: A threat to research integrity and credibility. World J Methodol 2025; 15(3): 98795

2025-09-20 | Browse: 3786 | Download: 643
59089 items  Read more >>
Featured Articles
1

Wang CH, Zhai YQ. Additional considerations on a combination of inflammatory markers and scoring systems for early severity stratification of acute pancreatitis. World J Gastroenterol 2025; 31(25): 108943

2025-07-04 | Browse: 27 | Download: 54
2

Huang SS, Chen W, Vaishnani DK, Huang LJ, Li JZ, Huang SR, Li YZ, Xie QP. Leucine-rich repeat-containing protein 19 suppresses colorectal cancer by targeting cyclin-dependent kinase 6/E2F1 and remodeling immune microenvironment. World J Gastroenterol 2025; 31(25): 107893

2025-07-04 | Browse: 24 | Download: 58
3

Sun Q, Wu JC, Chen X, Li DH, Li BR, Xiao NJ, Wang XY, Tu XZ, Ning SB, Sun T. Efficacy and safety of sirolimus in the treatment of gastrointestinal angiodysplasias. World J Gastroenterol 2025; 31(25): 105677

2025-07-04 | Browse: 25 | Download: 33
4

Liguori A, Ainora ME, Di Gialleonardo L, Viceconti N, Petrucci L, Esposto G, Giustiniani MC, Mignini I, Borriello R, Galasso L, Paratore M, Garcovich M, Riccardi L, Pompili M, Grieco A, Gasbarrini A, Miele L, Zocco MA. Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis and inflammation in metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(25): 105518

2025-07-04 | Browse: 29 | Download: 51
5

Wang Q, Sun LN, Shi H, Ma XY, Gao W, Xu B, Lin X, Liu YM, Huang CY, Jin RH. Multi-omics analysis reveals gut microbiota-metabolite interactions and their association with liver function in autoimmune overlap syndrome. World J Gastroenterol 2025; 31(25): 106371

2025-07-04 | Browse: 27 | Download: 60
6

Basit A, Noor S, Ahmad SA, Noor N, Maryam R, Basil AM. Otitis media with effusion and hearing outcomes - Myringotomy vs myringotomy and tympanostomy: A comparative study. World J Otorhinolaryngol 2025; 12(1): 109355

2025-07-02 | Browse: 30 | Download: 74
7

Mukundan A, Gupta D, Karmakar R, Wang HC. Transforming pediatric imaging: The role of four-dimensional flow magnetic resonance imaging in quantifying mesenteric blood flow. World J Radiol 2025; 17(6): 106582

2025-06-26 | Browse: 56 | Download: 96
8

Wang H, Wang X, Du YS, Wang Y, Bai ZJ, Wu D, Tang WL, Zeng HL, Tao J, He J. Non-contrast computed tomography radiomics model to predict benign and malignant thyroid nodules with lobe segmentation: A dual-center study. World J Radiol 2025; 17(6): 106682

2025-06-26 | Browse: 56 | Download: 160
9

Chika CE. Advances in dual energy computed tomography approach for proton stopping power ratio computation in radiotherapy. World J Radiol 2025; 17(6): 105728

2025-06-26 | Browse: 51 | Download: 108
10

Wang LL, Xiong YB, Feng XY, Liu YY, Su KX, Jiang SY, Wang SY, Zhou L, Li SK, Guo DD, Li R. Computed tomography-based assessment of pericoronary adipose tissue in cardiovascular diseases: Diagnostic and prognostic implications. World J Radiol 2025; 17(6): 107281

2025-06-26 | Browse: 53 | Download: 128
11

Fernandez CJ, Lakshmi V, Kamrul-Hasan ABM, Pappachan JM. Factors affecting disease control after pituitary tumor resection in acromegaly: What is the current evidence? World J Radiol 2025; 17(6): 106438

2025-06-26 | Browse: 46 | Download: 93
12

Xi XL, Yang YD, Liu HL, Jiang J, Wu B. Chromatin accessibility module identified by single-cell sequencing underlies the diagnosis and prognosis of hepatocellular carcinoma. World J Hepatol 2025; 17(6): 107329

2025-06-26 | Browse: 53 | Download: 168
13

Zhang MH, Meng N, Zhang KH, Yu JK, Huang CH, Yang S, Zhu DY. Correlation between gynecomastia and endocrine regulation in patients with metabolic dysfunction-associated fatty liver disease: A cross-sectional study. World J Hepatol 2025; 17(6): 108096

2025-06-26 | Browse: 49 | Download: 154
14

Bie LZ, Wu C, Wang JL. Dietary ω-3 polyunsaturated fatty acid intake improves skeletal muscle mass in patients with metabolic dysfunction-associated fatty liver disease: A nationwide cross-sectional study. World J Hepatol 2025; 17(6): 107931

2025-06-26 | Browse: 52 | Download: 113
15

Dobrowolska K, Zarębska-Michaluk D, Pawłowska M, Tudrujek-Zdunek M, Lorenc B, Berak H, Janczewska E, Mazur W, Janocha-Litwin J, Klapaczyński J, Sitko M, Dybowska D, Parfieniuk-Kowerda A, Piekarska A, Jaroszewicz J, Flisiak R. Sex-related differences in patients with chronic hepatitis C infection treated with direct-acting antiviral drugs. World J Hepatol 2025; 17(6): 105899

2025-06-26 | Browse: 48 | Download: 134
16

Li SF, Ouyang X, Feng S, Wan MZ, Zhou KN, Wen BY, Yin YZ, Yi H, Chen XY. Oncohepatology: Navigating liver injury in the era of modern cancer therapy. World J Hepatol 2025; 17(6): 106932

2025-06-26 | Browse: 48 | Download: 108
17

Schulze S, Keshvari S, Miller GC, Bridle KR, Hume DA, Irvine KM. Perisurgical colony stimulating factor one treatment ameliorates liver ischaemia/reperfusion injury in rats. World J Gastroenterol 2025; 31(24): 108234

2025-06-26 | Browse: 84 | Download: 141
18

Gao Z, Wang XY, Shen ZG, Liu JH, Wang XY, Wu SK, Jin X. Real-world comparison of chemotherapy plus bevacizumab with or without immunotherapy as first-line therapy in colorectal cancer. World J Gastroenterol 2025; 31(24): 108298

2025-06-26 | Browse: 68 | Download: 154
19

Wang JY, Yi B, Li CY, Xu HQ, Tang SH. Pay attention to the value of liver regeneration in the re-compensation of decompensated cirrhosis. World J Gastroenterol 2025; 31(24): 106564

2025-06-26 | Browse: 59 | Download: 90
20

Chen ZL, Wang C, Wang F. Revolutionizing gastroenterology and hepatology with artificial intelligence: From precision diagnosis to equitable healthcare through interdisciplinary practice. World J Gastroenterol 2025; 31(24): 108021

2025-06-26 | Browse: 72 | Download: 103
9657 items  Read more >>
Keyword Search Published Articles Processes
1
Case report
2853
2
Case report
1664
3
Hepatocellular carcinoma
1430
4
Gastric cancer
1005
5
Colorectal cancer
983
6
Inflammatory bowel disease
715
7
COVID-19
704
8
Prognosis
670
9
Liver transplantation
617
10
Ulcerative colitis
553
11
Treatment
552
12
Helicobacter pylori
517
13
Diagnosis
517
14
Crohn’s disease
513
15
Endoscopy
479
16
Cirrhosis
478
17
Meta-analysis
454
18
Pancreatic cancer
440
19
Magnetic resonance imaging
440
20
Surgery
423
69923 items  Read more >>
Reader Comments
1
"This paper provides an interesting exploration of the gut microbiota and its potential role in autoimmune overlap syndrome (OS), ..."  [Read more]
"This paper provides an interesting exploration of the gut microbiota and its potential role in autoimmune overlap syndrome (OS), combining features of autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC). The study integrates multi-omics data, focusing on microbial profiles and serum metabolites, to provide new insights into the pathophysiology of OS. The findings are clinically relevant, particularly in the context of identifying biomarkers for earlier and non-invasive diagnosis of OS, which could improve clinical management. However, the study is limited by its small sample size and lack of a healthy control group, which restricts the generalizability of the results. Despite these limitations, the paper opens up promising avenues for future research in microbiota-based diagnostics and therapeutic strategies for autoimmune liver diseases. "  [Collapse]
Wang Q, Sun LN, Shi H, Ma XY, Gao W, Xu B, Lin X, Liu YM, Huang CY, Jin RH. Multi-omics analysis reveals gut microbiota-metabolite interactions and their association with liver function in autoimmune overlap syndrome. World J Gastroenterol 2025; 31(25): 106371
2
"This study presents a comprehensive investigation into the use of multiparametric ultrasound (US) for the non-invasive assessment ..."  [Read more]
"This study presents a comprehensive investigation into the use of multiparametric ultrasound (US) for the non-invasive assessment of liver steatosis, fibrosis, and inflammation in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). The authors employed various advanced ultrasound techniques, including 2D shear-wave elastography (SWE), sound speed and attenuation imaging, and viscosity plane-wave ultrasound (Vi.PLUS), alongside traditional methods like FibroScan. The study's findings are promising, demonstrating that multiparametric ultrasound can effectively assess liver conditions such as fibrosis and steatosis, and even disease activity related to inflammation and ballooning. The diagnostic performance of the viscosity index (Vi.PLUS) and the VAS-MASH-US score was found to be good, especially for identifying patients with metabolic dysfunction-associated steatohepatitis (MASH). This approach could help reduce unnecessary liver biopsies, thereby minimizing costs and procedural risks, which is a significant clinical advantage. "  [Collapse]
Liguori A, Ainora ME, Di Gialleonardo L, Viceconti N, Petrucci L, Esposto G, Giustiniani MC, Mignini I, Borriello R, Galasso L, Paratore M, Garcovich M, Riccardi L, Pompili M, Grieco A, Gasbarrini A, Miele L, Zocco MA. Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(25): 105518
3
"Hepatocellular carcinoma (HCC) remains a major global health burden, ranking as the sixth most common cancer and the third leading ..."  [Read more]
"Hepatocellular carcinoma (HCC) remains a major global health burden, ranking as the sixth most common cancer and the third leading cause of cancer-related mortality worldwide. Despite advances in surveillance, early diagnosis, and the emergence of molecular-targeted and immunotherapeutic agents, the prognosis for many patients with HCC remains poor. This is particularly true in advanced-stage disease, where therapeutic resistance and immune escape mechanisms hinder durable responses. As our understanding of HCC pathogenesis deepens, the tumor microenvironment (TME) has emerged as a critical determinant of disease progression and therapeutic outcome. Among the key regulators in this microenvironment are galectins (Gals)—a family of glycan-binding proteins with various immunomodulatory and tumor-regulatory functions. Gal-1, Gal-3, Gal-4, and Gal-9 have attracted significant attention for their diverse roles in HCC. These proteins guide important cellular processes vital for tumor development, including inflammation, immune evasion, angiogenesis, epithelial–mesenchymal transition (EMT), proliferation, and metastasis. What sets galectins apart is their functional duality—their effects depend on their cellular location, expression levels, and the tumor microenvironment (TME). This complexity highlights their potential as both biomarkers and therapeutic targets in HCC. They coordinate processes like inflammation, angiogenesis, EMT, tumor growth, and spread. Importantly, galectins display dynamic, context-dependent behavior, capable of exerting both tumor-promoting and tumor-inhibiting effects depending on their expression, cellular localization, and the surrounding microenvironment. Recent studies, including the comprehensive review by Gajovic and colleagues (WJG 2025; 31:107260), highlight the diverse functions of Galectins in liver cancer. For instance, Gal-1 and Gal-3 are consistently associated with aggressive tumor features such as vascular invasion, immunosuppression, and poor prognosis. Conversely, Gal-4 and Gal-9 appear as favorable prognostic indicators in specific HCC subtypes, possibly due to their roles in immune activation and metastasis suppression. This duality not only reflects the complexity of Galectin biology but also encourages the development of improved biomarkers and personalized therapeutic strategies. The current therapeutic landscape of HCC—although expanded by immune checkpoint inhibitors and molecularly targeted agents—remains inadequate for many patients, especially those with advanced disease. In this context, Galectin-targeted therapies show considerable promise. Gal-3 inhibitors and Gal-3C fusion proteins, for example, are actively being studied for their ability to reverse immune suppression, disrupt tumor–stromal interactions, and improve the effectiveness of existing treatments. Meanwhile, profiling Galectin expression may help predict treatment responses and guide personalized therapy strategies. Elevated levels of Gal-1 and Gal-3 in serum or tumor tissue have consistently been associated with aggressive clinical features, such as vascular invasion, immune evasion, and poor overall survival. Conversely, Gal-4 and Gal-9 expression have been linked to favorable prognostic indicators in some patient groups, highlighting the biological diversity of HCC and the complex roles that galectins play in disease progression. The therapeutic implications are equally compelling. Galectin-targeted agents—such as Gal-3 inhibitors and Gal-3C fusion proteins—are being studied for their ability to modify the TME, boost anti-tumor immunity, and overcome resistance to current therapies. At the same time, integrating galectin profiling into clinical practice could improve risk assessment, enhance prognostic models, and support more personalized treatment approaches. However, these promising advancements must be accompanied by rigorous clinical validation. The dual and sometimes conflicting roles of galectins in cancer emphasize the importance of context—what may be beneficial in one cellular environment could be detrimental in another. Large-scale, well-controlled clinical trials and mechanistic research are critical for fully understanding the therapeutic potential of galectin modulation in HCC. Galectins are an area of study within the field of HCC biology and therapeutics that has not been extensively researched. In addressing treatment resistance and disease heterogeneity, galectins have potential for the development of biomarkers and targeted therapies. Including galectins in future HCC management strategies may contribute to more effective and personalized treatment methods. "  [Collapse]
Gajovic NM, Jovanovic IP, Jocic MV, Stojanovic B, Corovic IF, Todorovic N, Simovic Markovic BJ, Amedei A. Exploring the impact of galectins on liver cancer: From immunopathogenesis to potential targets. World J Gastroenterol 2025; 31(25): 107260
4
"This study demonstrates that reduced NRF2 activity contributes to ER stress and senescence in adipose-derived mesenchymal stem cells ..."  [Read more]
"This study demonstrates that reduced NRF2 activity contributes to ER stress and senescence in adipose-derived mesenchymal stem cells (ASCs) from hypertrophic obese mice, primarily through downregulation of MFN2. The use of multiple approaches, including NRF2/MFN2 knockdown and rescue, ChIP-qPCR, Co-IP, immunofluorescence, and IP-MS, adds robustness to the findings. Importantly, the functional relevance is strengthened by transplantation experiments, showing that disruption of NRF2 or MFN2 impairs the therapeutic potential of ASCs in insulin resistance, highlighting translational significance. However, while the authors suggest an interaction between MFN2 and BIP, the evidence remains indirect. Biochemical confirmation such as GST pull-down or FRET would be needed to verify a direct interaction. Additionally, NRF2 may affect ER stress and senescence through other targets beyond MFN2, which were not explored in this study. Future work should aim to clarify the structural basis of MFN2–BIP interaction and its functional consequences. Given the known role of MFN2 in mitochondrial dynamics and ER-mitochondrial tethering, investigating how this axis influences mitochondrial morphology, mitochondria-associated membranes integrity, and calcium signaling could provide further mechanistic insights. "  [Collapse]
Fang J. Reduced NRF2/Mfn2 activity promotes endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells in hypertrophic obese mice. World J Stem Cells 2025; 17(6): 104367
5
"Dear Editor, I read with great interest the editorial by Papadakos et al. on the evolving immunotherapeutic landscape in ..."  [Read more]
"Dear Editor, I read with great interest the editorial by Papadakos et al. on the evolving immunotherapeutic landscape in gastrointestinal stromal tumors (GISTs). The authors provide a comprehensive overview of the tumor microenvironment (TME), challenges in immunotherapy response, and emerging strategies. I would like to offer several complementary insights and suggest future directions for translational and clinical research. 1. Stratifying GISTs Through Immune Profiling: The authors rightly emphasize the immunosuppressive TME in GISTs. Building on this, emerging evidence from proteomic and transcriptomic studies supports the existence of distinct immune clusters ranging from inflamed “hot” tumors (TLS⁺/B-cell-rich) to immune-desert “cold” phenotypes. These immune subtypes have shown clear prognostic and predictive value for checkpoint inhibitor response, with objective response rates reaching 50% in TLS-rich subgroups. Integration of spatial profiling and CXCL13 expression as biomarkers may refine patient selection for PD-1/PD-L1 blockade. 2. 2. Rationale for Combination Strategies: While the editorial correctly notes the modest activity of ICIs in unselected patients, combinatorial approaches offer promise. For example, pegylated interferon-alpha-2b (PegIFNα2b) in conjunction with imatinib significantly enhances immune infiltration and suppresses PI3K/mTOR signaling, achieving remarkable response rates in early trials. Similarly, imatinib’s ability to reverse immunosuppression via IDO downregulation and Treg reduction provides a mechanistic rationale for synergy with ICIs, particularly in PDGFRA D842V-mutant GISTs. 3. Targeting Tumor Antigens and TME Components: Antibody-based therapies like SR1 (anti-KIT) have demonstrated macrophage-dependent cytotoxicity even in imatinib-resistant models. This offers a novel route to bypass TKI resistance. Additionally, novel modalities such as bispecific antibodies targeting KIT or PDGFRA in conjunction with CD3⁺ T cell engagement may overcome immune exclusion in “cold” tumors. 4. Addressing IDO Inhibitor Failures: The editorial notes the challenges with IDO1-targeted therapies. We propose that resistance may stem from spatial heterogeneity and compensatory activation of AhR and TDO2 pathways. Poly-pathway blockade, rather than IDO inhibition alone, may be essential to overcome this resistance. 5. Moving Forward: Future success in GIST immunotherapy will depend on Immune subtyping based on TLS, B cell density, and proteomic clusters (Im-I to Im-IV), Rational combination trials of TKIs + ICIs ± TME-modifying agents, Validation of biomarkers such as CXCL13, CD276, and KIT-derived neoantigens in prospective cohorts. In conclusion, the editorial provides an excellent foundation for discourse. We advocate for multi-center, biomarker-driven clinical trials to translate these emerging insights into tailored immunotherapy regimens for GIST patients. Sincerely, Fen Wang Oncology Department, Peking University Shenzhen Hospital. "  [Collapse]
Papadakos SP, Argyrou A, Karniadakis I, Vogli S, Theocharis S. Immunotherapy in gastrointestinal stromal tumors: Current landscape and future horizons. World J Clin Oncol 2025; 16(6): 104314
6
"Pulmonary fibrosis (PF), a chronic and fatal lung disease affecting millions of people worldwide, urgently needs more effective means. ..."  [Read more]
"Pulmonary fibrosis (PF), a chronic and fatal lung disease affecting millions of people worldwide, urgently needs more effective means. In this paper, the effect of cells vesicles in improving PF was verified through cell lines and rat models, and the possible pathways through which this effect was exerted were investigated. Anyway, there are still some aspects of the article that deserve further discussion. Most importantly, whether the therapeutic effect is exerted through the said signaling pathway needs to be further confirmed. In addition, the text has problems such as writing errors, suspected incompleteness of ethics, and relatively weak research significance. "  [Collapse]
Wang LL, Ouyang MY, Yang ZE, Xing SN, Zhao S, Yu HY. Mesenchymal stem cells-derived exosomes alleviate radiation induced pulmonary fibrosis by inhibiting the protein kinase B/nuclear factor kappa B pathway. World J Stem Cells 2025; 17(6): 106488
7
"We read with great interest the work of Abdelsamie and colleagues, who describe the characteristics of acute myocardial infarction ..."  [Read more]
"We read with great interest the work of Abdelsamie and colleagues, who describe the characteristics of acute myocardial infarction (AMI) in young patients, including presentation, risk factors, coronary angiography findings, and management strategies.1 While AMI is predominantly observed in individuals over 45, its occurrence in younger adults has garnered increasing attention due to its distinct risk factors and long-term consequences. When it occurs, early-onset AMI is often associated with substantial morbidity, psychosocial impact, and economic burden for patients and their families.2 We commend the authors for addressing this important topic, we would like to offer several suggestions that may help to further strengthen the clarity and clinical applicability of the study. First, the Methods section of the manuscript appears concise and would benefit from additional details to enhance reproducibility. Specifically, the Subjects subsection could provide a more comprehensive account of the exclusion criteria. While inclusion criteria are described, it remains unclear whether important conditions, such as severe cardiomyopathy, rheumatic heart disease, or malignancy, were excluded. Clarifying these aspects would strengthen the credibility and interpretability of the study findings. Additionally, more structured descriptions of Clinical data collection are warranted. It would be helpful to specify how many categories of clinical data were collected (e.g., demographic, biochemical, echocardiographic, electrocardiographic), which variables were included in each, and at what time points they were assessed (e.g., at admission, post-intervention, at discharge). Second, while the authors correctly note that single-vessel disease predominates among young AMI patients and present the distribution of culprit vessels, the severity and characteristics of the lesions remain insufficiently detailed. Specifically, the lack of ACC/AHA lesion classification and TIMI flow grading limits the angiographic assessment. These indices are clinically relevant for guiding intervention strategy and risk stratification and would add valuable context to the findings. Third, although the study aims to explore the presentation, risk factors, angiographic findings, and management of young AMI patients, it is noteworthy that clinical symptoms at presentation are not detailed. Given the clinical importance of symptom characterization for early recognition and diagnosis, including this information would help clinicians recognize such cases more effectively. Regarding the management domain, further elaboration on pharmacological therapy, particularly the use of beta-blockers, statins, and antiplatelet agents, would enhance the clinical relevance of the study. It also raises the question of whether young AMI patients tend to present with higher heart rates, and if so, whether adequate heart rate control was achieved during hospitalization or at discharge. As heart rate plays a crucial role in the progression and prognosis of coronary artery disease, such information would provide valuable insight into the effectiveness of secondary prevention strategies in this specific population. Finally, we appreciate the authors’ observation that obesity, hyperlipidemia, and smoking are prominent in young AMI patients. However, to strengthen this conclusion, we encourage the authors to consider a prospective cohort study design with multivariable adjustment, which could formally assess whether these are independent risk factors for early-onset AMI. Such analysis would increase the translational value of their findings and potentially guide targeted prevention strategies in this unique population. In conclusion, this study brings attention to a clinically important and under-explored population. We hope that the authors will consider these suggestions to further refine their methodological and clinical insights in future work. References 1. Ahmed Hegazi Abdelsamie HOA, Ahmed Taha Abdelwahed. Acute myocardial infarction in the young: A 3-year retrospective study. World Journal of Cardiology 2025;17(6) doi: 10.4330/wjc.v17.i6.106445 2. Aggarwal A, Srivastava S, Velmurugan M. Newer perspectives of coronary artery disease in young. World J Cardiol 2016;8(12):728-34. doi: 10.4330/wjc.v8.i12.728 "  [Collapse]
Hegazi Abdelsamie A, Abdelhadi HO, Abdelwahed AT. Acute myocardial infarction in the young: A 3-year retrospective study. World J Cardiol 2025; 17(6): 106445
8
"The manuscript by Camille Kass and co-authors focuses on the issue of eating disorders following bariatric surgery that may be ..."  [Read more]
"The manuscript by Camille Kass and co-authors focuses on the issue of eating disorders following bariatric surgery that may be associated with physical and physiological changes, as well as various psychological phenomena related to the effects of the surgery and dietary modifications. Diagnosis and treatment of these disorders require appropriate categorization within disease classification systems, particularly the DSM-5. However, creating such a classification with the inclusion of new categories in the existing list or expanding the diagnostic criteria requires a requires the accumulation of a sufficiently large database. The presented article describes a case of eating disorder after bariatric surgery with a detailed description of symptoms and their dynamics in the course of complex therapy. Based on the data obtained and the results of literature analysis, the authors conclude that the observed disorder is the closest to avoidant/restrictive food intake disorder according to DSM-5. At the same time, the results of the patient's follow-up confirm the opinions expressed by other authors about the need to include body dysmorphia, and the loss of personal identity associated with severe weight loss, in the diagnostic criteria for ARFID. The presented article has some relevance for the development of a diagnostic system for eating disorders. However, it should be noted that the authors did not practically consider the possible influence of the patient's premorbid background (generalized anxiety disorder) and its interaction with the effects of bariatric surgery on the observed eating disorders. In general, it seems reasonable and interesting to conduct such an analysis using author’s own results and data from the literature. "  [Collapse]
Cass K, Leggett A, Gibson DG. Diagnostic dilemma of avoidant/restrictive food intake disorder after bariatric surgery: A case report and review of literature. World J Clin Cases 2025; 13(24): 106941
9
"This article is a study on the development and validation of a visceral adipose tissue (VAT)-based delta radiomics model to predict ..."  [Read more]
"This article is a study on the development and validation of a visceral adipose tissue (VAT)-based delta radiomics model to predict secondary loss of response to infliximab therapy in patients with Crohn’s disease. Both VAT and mesenteric adipose tissue are types of fat tissue that influence the pathogenesis and treatment outcomes in Crohn’s disease, but each has distinct characteristics. VAT refers to a broad range of adipose tissue and affects systemic inflammation and treatment outcomes. In contrast, mesenteric adipose tissue is specifically located around the intestines and is deeply involved in local inflammation and the progression of intestinal pathology. Although mesenteric adipose tissue is considered a part of VAT, its specific role in Crohn’s disease has attracted particular attention. Abnormal proliferation of mesenteric adipose tissue has been suggested to contribute to complex conditions, including intestinal fibrosis, strictures, and perforation. In the future, further investigation into the relationship between VAT and mesenteric adipose tissue is warranted. "  [Collapse]
Li X, Song FL, He HF, Zeng SM, Feng ZC, Rong PF. Longitudinal computed tomography-based delta-radiomics of visceral adipose tissue predicts infliximab secondary loss of response in Crohn’s disease patients. World J Gastroenterol 2025; 31(21): 105895
10
"Commentary on articles published in World Journal of Gastroenterology Reader Perspective Prof. Zeinab Nabil Ahmed Said Reader’s code: ..."  [Read more]
"Commentary on articles published in World Journal of Gastroenterology Reader Perspective Prof. Zeinab Nabil Ahmed Said Reader’s code: 02441096) Prevalence and risk factors of Helicobacter pylori infection in Xinjiang Uygur Autonomous Region: A cross-sectional study of all age groups Jiang Q, Liu WD, Hui WJ, Kong WJ, Feng Y, Kuerbanjiang A, Huang XL, Gao F. Prevalence and risk factors of Helicobacter pylori infection in Xinjiang Uygur Autonomous Region: A cross-sectional study of all age groups. World J Gastroenterol 2025; 31(21): 106033 [PMID: 40538506 DOI: 10.3748/wjg.v31.i21.106033] The study is a cross sectional prevalence study to evaluate the H. pylori infection and risk factors in one of the large province in China that located in the northwest of the country with multiethnic aggregation. Such studies pave the way for policy makers for effective implementation of prevention and control strategies. The study involves 15 regions with 18951708 population. A total of 4665 people were surveyed, with questionnaire surveys and H. pylori antibody blood tests were conducted. 4361 were tested for H. pylori antibody. Social, economic factors, public health conditions, as well as dietary and living habits among different areas were evaluated to identify risk factors associated with H. pylori prevalence in different regions. Methodology: The reason for having blood samples in the morning on an empty stomach is not clarified. Also, the type of tested Ig must be mentioned. IgG is denoting previous exposure not current infection. Active infection is detected by urea breath tests and stool antigen tests. Results:  It is better to say overall H pylori prevalence rather than infection.  Tables: Significant p value is better to be marked, by *for example. Discussion: This section is well organized and theoretical analysis of data is well presented, however, to avoid the limitation of some missing data, sensitivity analysis is better to be done. "  [Collapse]
Zhang Y, Tang YW, Zhou J, Wei YR, Peng YT, Yan Z, Yue ZH. Electroacupuncture at ST36 ameliorates gastric dysmotility in rats with diabetic gastroparesis via the nucleus tractus solitarius-vagal axis. World J Gastroenterol 2025; 31(21): 107395
11
"Dear Editor, Thank you for inviting me to review the manuscript entitled "Efficacy Comparison of Intravenous Proton Pump Inhibitors ..."  [Read more]
"Dear Editor, Thank you for inviting me to review the manuscript entitled "Efficacy Comparison of Intravenous Proton Pump Inhibitors versus Oral Potassium-Competitive Acid Blockers Before Endoscopic Therapy for Bleeding Peptic Ulcers." Upon review, I am particularly impressed by the study's advancements and strengths in the following areas: Focused and Clinically Relevant Topic: This study directly addresses a critical question in gastroenterological practice: optimizing the management strategy for acute upper gastrointestinal bleeding before endoscopic intervention. Comparing the widely used intravenous PPIs with the emerging oral PCABs renders the topic highly timely and of significant clinical value, providing valuable evidence to inform optimal treatment decisions. Clinically Aligned Study Design: The authors employed a retrospective single-center design, effectively capturing the real-world scenario where physicians select medication (PPI or PCAB) based on individual patient circumstances. Such research based on real-world data yields results with greater direct relevance for guiding routine clinical practice. Sophisticated Statistical Methodology: Recognizing the potential for confounding inherent in retrospective observational studies, the authors proactively applied Propensity Score Matching (PSM), an advanced statistical technique, to mitigate potential confounders and balance inter-group differences. This demonstrates the authors' commitment to methodological rigor and enhancing the reliability of the findings. Focus on Core Clinical Outcomes: Selecting rebleeding rate as a primary endpoint is a key strength. This is a robust indicator directly reflecting treatment efficacy and patient safety. Focusing on this core outcome ensures the results possess clear clinical relevance and directly serve the fundamental goal of improving patient prognosis. Introduction of an Innovative Concept: The proposed "Green Endoscopy" hypothesis – suggesting oral PCABs might reduce waste associated with intravenous drug administration – represents a highly forward-thinking and innovative perspective. This reflects the authors' attention not only to efficacy but also to the sustainability and environmental impact of medical practice, thereby broadening the dimensions of treatment strategy evaluation and opening a valuable new direction for future research. Clear Data Presentation and Defined Core Findings: The core methodology and results sections are presented clearly, enabling readers to grasp the study's framework and principal findings. Particularly noteworthy is the preliminary indication of comparable efficacy between intravenous PPIs and oral PCABs on key observational metrics, which in itself provides valuable information for clinical practice. Overall Readability: The manuscript is generally well-written and fluent, effectively communicating the main content and intent of the research, ensuring the efficient transmission of scientific information. Summary: Scientific Quality: Grade B Language Quality: Grade B Recommendation: Meets publication standards "  [Collapse]
Lim NR, Chung WC. Intravenous proton pump inhibitors vs oral potassium competitive acid blockers before endoscopic treatment of bleeding peptic ulcers. World J Gastrointest Endosc 2025; 17(6): 104234
12
"The retrospective study on Comparison of treatment strategies for submucosal tumors originating from the muscularis propria at ..."  [Read more]
"The retrospective study on Comparison of treatment strategies for submucosal tumors originating from the muscularis propria at esophagogastric junction or cardia by Lee AY, Lim SG, Cho JY, Kim S, Lee KM, Shin SJ, Noh CK, Lee GH, Hur H, Han SU, Son SY, Song JH is well conducted and written.  It very nicely describes the three techniques ESD, STER and LSW for lesions of the esophagus with excellent illustrations of all the three techniques with figures. It paves the path for feasibility of further studies will large number of sample size. "  [Collapse]
Lee AY, Lim SG, Cho JY, Kim S, Lee KM, Shin SJ, Noh CK, Lee GH, Hur H, Han SU, Son SY, Song JH. Comparison of treatment strategies for submucosal tumors originating from the muscularis propria at esophagogastric junction or cardia. World J Gastroenterol 2025; 31(23): 106261
13
"This paper provides a systematic review of artificial intelligence (AI) models in the diagnosis of irritable bowel syndrome (IBS), ..."  [Read more]
"This paper provides a systematic review of artificial intelligence (AI) models in the diagnosis of irritable bowel syndrome (IBS), highlighting the potential of AI to improve diagnostic accuracy using complex biomarkers such as the fecal microbiome, gas chromatography, neuroimaging, and protease activity. The review comprehensively summarizes the performance of AI models across various studies, showing promising diagnostic accuracy, particularly in models using fecal microbiome analysis. The findings are clinically relevant, as AI has the potential to overcome the limitations of current symptom-based diagnostic frameworks like the Rome IV criteria, offering a more objective and precise approach to IBS diagnosis. "  [Collapse]
Bhagavathula AS, Al Qady AM, Aldhaleei WA. Diagnostic accuracy and quality of artificial intelligence models in irritable bowel syndrome: A systematic review. World J Gastroenterol 2025; 31(23): 106836
14
"This paper provides a timely and insightful review on the application of machine learning (ML) in diagnosing and treating esophageal ..."  [Read more]
"This paper provides a timely and insightful review on the application of machine learning (ML) in diagnosing and treating esophageal disorders, including conditions like GERD, esophageal cancer, and achalasia. The study highlights the potential of AI in enhancing diagnostic accuracy and personalizing treatment strategies, which could greatly improve patient outcomes in gastroenterology. The comprehensive synthesis of current literature and the focus on ML’s role in automating diagnosis and optimizing treatment are highly relevant for clinical practice. The manuscript offers significant value by showing how ML can transform the management of esophageal diseases and improve patient care. "  [Collapse]
Liu SW, Li P, Li XQ, Wang Q, Duan JY, Chen J, Li RH, Guo YF. Recent advances in machine learning for precision diagnosis and treatment of esophageal disorders. World J Gastroenterol 2025; 31(23): 105076
15
"The article focuses on the feasibility of using Wuling powder, which modulates the precursor of brain-derived neurotrophic factor/p75 ..."  [Read more]
"The article focuses on the feasibility of using Wuling powder, which modulates the precursor of brain-derived neurotrophic factor/p75 neurotrophin receptor/sortilin and brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling pathways, in the treatment of ulcerative colitis complicated by depression. This problem is highlighted in the article by Wang et al, where they demonstrate that application of the traditional Chinese medicine Wuling normalizes the signaling pathways in the nervous tissue, reduces manifestations of depression and intestinal inflammation in patients with ulcerative colitis. This study is notable for an extremely promising and strategically new objective and a very impressive methodological level of research "  [Collapse]
Smirnova OV, Sinyakov A, Kasparov EV. Application of Wuling powder in the treatment of ulcerative colitis complicated by depression as a new therapy principle. World J Gastroenterol 2025; 31(23): 106538
16
"Gastroparesis, a diabetic complication with a worsening delay in gastric emptying (GE), responsible of further serious complications, ..."  [Read more]
"Gastroparesis, a diabetic complication with a worsening delay in gastric emptying (GE), responsible of further serious complications, is due to the progressive multifactorial damage of the enteric neurons. It could be discovered early by performing the antral real-time ultrasonography annually, which measures the GE of a semi-solid meal. Furthermore if “the body surface gastric mapping”, evaluating the gastric bioelectric activity, is normal, the cause of GE may be pylorospasm, to be confirmed manometrically. Subsequently, a strict control of glycemia, even with “artificial pancreas” devices, together with prokinetics intake, which counteracts the symptoms and gastric dilatation, must be done, after the correction of a possible pylorospasm. "  [Collapse]
Bortolotti M. Gastroparesis, a diabetic complication causing further, even serious, complications: How to prevent its worsening? World J Gastroenterol 2025; 31(23): 104932
17
"This study highlights the transformative potential of artificial intelligence (AI) in irritable bowel syndrome diagnosis by leveraging ..."  [Read more]
"This study highlights the transformative potential of artificial intelligence (AI) in irritable bowel syndrome diagnosis by leveraging complex biomarkers such as fecal microbiome composition and neuroimaging features. By systematically evaluating the performance of various AI models, it reveals both their strengths and limitations, with some achieving near-perfect accuracy. However, significant variability in study methodologies and dataset heterogeneity pose challenges to clinical implementation. The findings emphasize the need for standardized validation protocols to enhance reproducibility and real-world applicability. As AI continues to evolve, its integration into irritable bowel syndrome diagnostics could refine precision medicine approaches, offering a data-driven alternative to current symptom-based diagnostic criteria. "  [Collapse]
Bhagavathula AS, Al Qady AM, Aldhaleei WA. Diagnostic accuracy and quality of artificial intelligence models in irritable bowel syndrome: A systematic review. World J Gastroenterol 2025; 31(23): 106836
18
"This study compares endoscopic submucosal dissection, submucosal tunneling endoscopic resection, and laparoscopic wedge resection ..."  [Read more]
"This study compares endoscopic submucosal dissection, submucosal tunneling endoscopic resection, and laparoscopic wedge resection for submucosal tumors originating from the muscularis propria at the esophagogastric junction and cardia. Despite technical challenges, all methods demonstrated safety, practicality, and high en bloc resection rates, with laparoscopic wedge resection showing superior microscopic complete resection. Recurrence rates were comparable across methods, even for high-risk gastrointestinal stromal tumors. These findings underscore the feasibility of minimally invasive approaches for treating submucosal tumors in challenging anatomical locations, advancing diagnostic precision and treatment efficacy while minimizing patient burden. "  [Collapse]
Lee AY, Lim SG, Cho JY, Kim S, Lee KM, Shin SJ, Noh CK, Lee GH, Hur H, Han SU, Son SY, Song JH. Comparison of treatment strategies for submucosal tumors originating from the muscularis propria at esophagogastric junction or cardia. World J Gastroenterol 2025; 31(23): 106261
19
"This review synthesizes machine learning (ML) applications in esophageal disorders, emphasizing three critical advances: (1) Automated ..."  [Read more]
"This review synthesizes machine learning (ML) applications in esophageal disorders, emphasizing three critical advances: (1) Automated analysis of multimodal diagnostic data achieving accuracy rates of 80%-95% across different conditions; (2) Integration of deep learning with endoscopic imaging enabling real-time assistance in diagnosis and risk stratification; and (3) Development of novel non-invasive screening approaches through ML-based biomarker identification. The convergence of artificial intelligence with clinical medicine demonstrates transformative potential in addressing current diagnostic challenges and enabling precision medicine in esophageal disease management. "  [Collapse]
Liu SW, Li P, Li XQ, Wang Q, Duan JY, Chen J, Li RH, Guo YF. Recent advances in machine learning for precision diagnosis and treatment of esophageal disorders. World J Gastroenterol 2025; 31(23): 105076
20
"This paper provides a comprehensive and timely comparison between intravenous proton pump inhibitors (PPIs) and oral potassium ..."  [Read more]
"This paper provides a comprehensive and timely comparison between intravenous proton pump inhibitors (PPIs) and oral potassium competitive acid blockers (PCABs) in the management of non-variceal upper gastrointestinal bleeding (NVUGIB) prior to endoscopic treatment. The study demonstrates that pre-endoscopic PCAB administration is more effective than PPI injection in reducing the need for therapeutic endoscopic interventions and minimizing re-bleeding events. Given the growing interest in optimizing acid suppression therapies, the findings are significant, suggesting that oral PCABs could offer a practical, effective alternative to intravenous PPIs, especially in emergency settings. Overall, the study contributes valuable insights into the management of bleeding peptic ulcers and has important clinical implications, especially for enhancing treatment protocols in emergency gastroenterology settings. "  [Collapse]
Lim NR, Chung WC. Intravenous proton pump inhibitors vs oral potassium competitive acid blockers before endoscopic treatment of bleeding peptic ulcers. World J Gastrointest Endosc 2025; 17(6): 104234
994 items  Read more >>
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