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2025-05-19 | Browse: 2 | Download: 0
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617 items Read more >>
1
"Dear Editor, Hello! I am a long-term author of your journal and have been closely following it. Overall, I am quite satisfied with ..."
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"Dear Editor, Hello! I am a long-term author of your journal and have been closely following it. Overall, I am quite satisfied with the journal's operations. However, I would like to propose some improvements regarding the invoice collection process. Specifically, I hope that the invoice can be provided promptly upon payment of the page fee. "
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Shao MH, Tan BB, Chen HL, Zhang H. Yttrium-90 radioembolization for advanced hepatocellular carcinoma with Budd-Chiari syndrome: A case report. World J Clin Oncol 2025; 16(5): 104762
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"Congratulations to the newspaper and the group. No complaints. Excellent!!! I recommend it to researchers because the process is ..."
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"Congratulations to the newspaper and the group. No complaints. Excellent!!! I recommend it to researchers because the process is transparent and the group's journals are of world-renowned quality. Submission is an easy process to carry out, the reviewers' comments are clear and objective. The editorial team's email responses are always quick and collaborative. The final PDF layout was very good, with high definition images. "
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Pagani BT, Rosso MPO, Moscatel MBM, Trazzi BFM, da Cunha MR, Issa JPM, Buchaim DV, Buchaim RL. Update on synthetic biomaterials combined with fibrin derivatives for regenerative medicine: Applications in bone defect treatment: Systematic review. World J Orthop 2025; 16(5): 106181
3
"We would like to express our sincere gratitude to editor and reviewers for the positive evaluation and acceptance of our manuscript. ..."
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"We would like to express our sincere gratitude to editor and reviewers for the positive evaluation and acceptance of our manuscript. Their professional work and constructive comments have been invaluable in improving the quality of our paper. We confirm that all the author information in the manuscript is accurate, and we agree to the publication of this paper according to the journal's regulations. Additionally, we would like to reiterate that there are no conflicts of interest related to this study, and all authors have approved the final version of the manuscript for publication. "
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Xiao PB, Yang XR. Anti-SSA/Ro antibody-positive autoimmune myocarditis combined with complete atrioventricular block requiring implantation with a permanent pacemaker: A case report. World J Clin Cases 2025; 13(22): 104283
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"I am truly honored to have my research published in your esteemed journal. The entire submission process has been exemplary, from ..."
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"I am truly honored to have my research published in your esteemed journal. The entire submission process has been exemplary, from the intuitive and user-friendly interface of the submission system to the highly professional and efficient communication from your editorial team. Every step of the process was impressive. The editorial team demonstrated remarkable attention to detail and commitment to service throughout, including timely notifications for each status update and clear guidance at every stage. This level of care truly reflects your journal's dedication to providing an outstanding author experience. I sincerely look forward to the opportunity to publish with your journal again in the future. "
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Wang PJ, Wang J, Yao XM, Cheng WL, Sun L, Yan J, Yu YL, Li SY, Li DP, Jia JH. Evaluation of efficacy and safety of targeted therapy and immune checkpoint inhibitors in metastatic colorectal cancer. World J Gastrointest Oncol 2025; 17(5): 105027
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"This journal collects cutting-edge research in the field, with many authoritative scholars as editorial board members. The publishing ..."
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"This journal collects cutting-edge research in the field, with many authoritative scholars as editorial board members. The publishing process is standardized and it is included in well-known databases. The quality of publications is guaranteed, and it has a high degree of recognition in the industry. It is a trustworthy academic exchange platform. The peer review process is rigorous and transparent, with professional and meticulous reviewers who provide both in-depth and constructive feedback, effectively improving the quality of the paper. The review cycle is reasonable, and the editorial department communicates efficiently, resulting in a good overall review experience. "
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Zu GX, Tang JQ, Huang HL, Han T. Validation and analysis of key factors of Banxia Xiexin decoction against gastric cancer. World J Gastrointest Oncol 2025; 17(5): 104737
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"Thank you so much for your efforts and valuable suggestions. I truly appreciate the opportunity to publish in this esteemed magazine. ..."
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"Thank you so much for your efforts and valuable suggestions. I truly appreciate the opportunity to publish in this esteemed magazine. The editor and peer reviewers are professional and rigours. The review process is very happy and sucessful. I will continue to strive for excellence in my future work. Maybe the editing process can be more quickly. "
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Wang YJ, Zhi ZZ, Liu T, Kang J, Xu GH. Long non-coding RNA GAS5 promotes neuronal apoptosis in spinal cord injury via the miR-21/PTEN axis. World J Orthop 2025; 16(5): 106183
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"The platform offered timely and clear responses at each step of the submission process, including detailed guidance on specific points. ..."
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"The platform offered timely and clear responses at each step of the submission process, including detailed guidance on specific points. This greatly facilitated both the manuscript submission and the peer review response. The user-friendly interface and efficient communication helped reduce stress and made the entire process more manageable. I am sincerely grateful for the support. "
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Mihara H, Nanjo S, Motoo I, Ando T, Fujinami H, Yasuda I. Artificial intelligence model on images of functional dyspepsia. Artif Intell Gastrointest Endosc 2025; 6(1): 105674
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"This was a pleasant submission experience. The reviewers provided very professional evaluations, and the editor was also very ..."
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"This was a pleasant submission experience. The reviewers provided very professional evaluations, and the editor was also very enthusiastic and professional.This was a pleasant experience of submitting an article. The reviewers provided very professional evaluations, and the editors were also very enthusiastic and professional. I will definitely submit related articles to this journal in the future and recommend it to people around me. "
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Tu HB, Feng SY, Chen LH, Huang YJ, Zhang JZ, Peng SY, Lin DL, Ye XJ. Integrating ultrasound and serum indicators for evaluating outcomes of targeted immunotherapy in advanced liver cancer. World J Gastrointest Oncol 2025; 17(5): 105872
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"Dear Editors, Thank you for your efficient manuscript handling process. The submission system is clear and user-friendly, allowing ..."
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"Dear Editors, Thank you for your efficient manuscript handling process. The submission system is clear and user-friendly, allowing me to track progress without confusion. I especially appreciate the reviewers’ thoughtful feedback—their expertise pinpointed key improvements while maintaining a fair turnaround time. Such a balance between thoroughness and timeliness is invaluable to authors. Your journal’s commitment to both quality research and practical author support makes it a trusted platform. Thank you once again for your dedication to excellence. I look forward to continuing my association with your journal and contributing more quality research in the future. Best regards, Bin Wang "
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Zhao YF, Lv JH, Chen DF, Wang ZH, Teng Y, Ntim M, Xia M, Li S, Wang B. Triglyceride-glucose index in predicting gastric cancer prognosis: A need for caution. World J Gastroenterol 2025; 31(18): 104525
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"We extend our deepest gratitude to the editorial team for their professional guidance throughout the publication process. On behalf ..."
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"We extend our deepest gratitude to the editorial team for their professional guidance throughout the publication process. On behalf of all contributing authors, we wish to acknowledge the invaluable contributions of the anonymous reviewers whose constructive feedback has enhanced the scholarly impact of this work. Allow me to reconfirm our appreciation for the meticulous guidance. "
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Zhu ZW, Wu J, Guo Y, Ren QY, Li DN, Li ZY, Han L. Prediction of Ki-67 expression in hepatocellular carcinoma with machine learning models based on intratumoral and peritumoral radiomic features. World J Gastrointest Oncol 2025; 17(5): 104172
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"Dear Editorial Office, I am very satisfied with the publication process of our manuscript in World Journal of Psychiatry. The peer ..."
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"Dear Editorial Office, I am very satisfied with the publication process of our manuscript in World Journal of Psychiatry. The peer review was thorough and constructive, the editorial team was professional and responsive, and the overall experience was efficient and well-organized. The journal maintains high ethical standards, and I appreciate its commitment to open-access publishing. Thank you for your excellent work in supporting researchers and advancing scientific communication in psychiatry. "
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Cao B, Liu YL, Wang N, Huang Y, Lu CX, Li QY, Zou HY. Alterations of serum metabolic profile in major depressive disorder: A case-control study in the Chinese population. World J Psychiatry 2025; 15(5): 102618
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"Thank you very much for your kind attention and dedicated efforts as the editor. I am truly impressed with the professionalism and ..."
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"Thank you very much for your kind attention and dedicated efforts as the editor. I am truly impressed with the professionalism and efficiency of the journal’s publishing system. The entire process has been smooth and pleasant. I look forward to submitting another case report in the near future and continuing our collaboration. "
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Shin SH, Koh YS, Song S. Hepatic epithelioid hemangioendothelioma managed with minimally invasive surgery: A case report. World J Clin Cases 2025; 13(22): 104924
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"The journal maintained highly professional standards throughout the publication process, with a peer-review phase that was both prompt ..."
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"The journal maintained highly professional standards throughout the publication process, with a peer-review phase that was both prompt and constructive, markedly enhancing the manuscript’s scientific rigor and clarity; subsequently, the accepted manuscript underwent an exceptionally meticulous and rigorous comprehensive editing phase, ensuring precision and consistency in every subtle minute detail. "
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Negoi I. Personalized surveillance in colorectal cancer: Integrating circulating tumor DNA and artificial intelligence into post-treatment follow-up. World J Gastroenterol 2025; 31(18): 106670
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"The editorial process at WJG is commendable. From the submission system to the thorough peer review process, every step is clear and ..."
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"The editorial process at WJG is commendable. From the submission system to the thorough peer review process, every step is clear and professional. Reviewer comments are insightful, and the editorial team is responsive and supportive. WJG provides an outstanding publishing experience, making it a highly recommended journal for researchers and academics. "
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Mittal G, A P, Dhali A, Prasad R, S Y, Nurani KM, Găman MA. Plant extracts with antioxidant and hepatoprotective benefits for liver health: A bibliometric analysis of drug delivery systems. World J Gastroenterol 2025; 31(18): 105836
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"The authors are extremely satisfied with the overall process of peer review, editing, and publication of our article. We greatly ..."
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"The authors are extremely satisfied with the overall process of peer review, editing, and publication of our article. We greatly appreciate the professionalism, efficiency, and constructive feedback provided throughout each stage. The timely communication and support from the editorial team significantly contributed to a smooth and enriching experience. We are pleased with the final outcome and thankful for the opportunity to share our work in this journal. "
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Fontalba-Navas A, Pozo Muñoz F, Garcia Cisneros R, Garcia Larrosa MJ, Callejon Gil MDM, Garcia Delgado I, Jimenez Martinez MB. Challenges and improvement strategies in the hospitalization of chronic multimorbid patients. World J Clin Cases 2025; 13(3): 98284
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"Dear editorial team, could the evaltion option include a third choice , not only yes, no. Otherwise i am satisfied with the review ..."
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"Dear editorial team, could the evaltion option include a third choice , not only yes, no. Otherwise i am satisfied with the review and publication process. The reviewrs comments were helpful and relevant. The editorial response was on time. This was the fisry experience with this journal and i am preparing the second manuscript to be submitted to the same journal. "
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Syed Y, Hassan MA, Kalayil RM, Othman OA, Mekkodathil A, El-Menyar A. Promising technique for managing nonspecific chronic low back pain using multi angular isometric lumbar exercise. World J Orthop 2025; 16(5): 104425
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"The process and system of uploading our document, as well as the reviewers' comments and guidance are satisfactory. Through the ..."
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"The process and system of uploading our document, as well as the reviewers' comments and guidance are satisfactory. Through the process, Autoanalyzer occasionally causes issues in terms of not providing all the issues at first, hence causing multiple corrections that might need to be done in the paper as well, meaning additional reviews. "
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Christodoulidis G, Tsagkidou K, Bartzi D, Prisacariu IA, Agko ES. Endoscopic management of upper non-variceal and lower gastrointestinal bleeding: Where do we stand? World J Gastrointest Endosc 2025; 17(5): 105580
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"I would like to commend your editorial team for maintaining an exceptionally timely and rigorous review process that significantly ..."
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"I would like to commend your editorial team for maintaining an exceptionally timely and rigorous review process that significantly elevates scholarly standards. The scientifically grounded feedback provided by your reviewers demonstrates both depth of expertise and remarkable attention to detail. Their suggestions have been invaluable in refining the academic rigor and communicative clarity of my work. Particularly noteworthy was the reviewers' ability to identify critical gaps while maintaining respect for the author's original contributions - a balance that truly fosters intellectual growth. This efficient yet thorough evaluation system not only accelerates scholarly progress but serves as an exemplary model of peer-review excellence in academic publishing. "
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Zheng HJ, Zhang JD, Wang ZC, Yao LY. Abdominal cocoon syndrome in a 10-year-old young adolescent after abdominal operation: A case report and review of literature. World J Clin Cases 2025; 13(22): 106122
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"good communication with guidance and perfecter review system , i thank all the journal staff with their guidance. I would like to ..."
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"good communication with guidance and perfecter review system , i thank all the journal staff with their guidance. I would like to thank all the journal staff for their effortless guidance an welcoming . good communication with guidance and perfecter review system , i thank all the journal staff with their guidance. I would like to thank all the journal staff for their effortless guidance an welcoming "
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Abdishakur AE, Ahmed MAA. Adult ileo cecal intussusception as a manifestation of colon carcinoma: A case report. World J Clin Cases 2025; 13(22): 104352
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"Low-grade appendiceal mucinous neoplasms (LAMNs) are a class of histologically well differentiated adenoma. For LAMNs with a mass ..."
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"Low-grade appendiceal mucinous neoplasms (LAMNs) are a class of histologically well differentiated adenoma. For LAMNs with a mass formation at the appendiceal orifice, if there is no metastatic lesion indicated by imaging, the appendix and the mass at the appendiceal orifice need to be completely resected. Our technique mainly targets a mass about 1 cm from the appendix opening. We made the first pouch 1cm from the root of the appendix, thus ensuring the anatomical integrity of the ileocecal valve. However, if a conventional cutting closure is used, the anatomy of the ileocecal flap may be destroyed. "
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Liu D, Xing YL, Chen D. Low-grade appendiceal mucinous neoplasm at appendiceal orifice treated via appendectomy with double purse-string suture method: A case report. World J Gastrointest Oncol 2025; 17(5): 104011
18665 items Read more >>
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"This systematic review highlighted the growing role of hydroxyapatite, β-tricalcium phosphate, and fibrin-based products in bone ..."
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"This systematic review highlighted the growing role of hydroxyapatite, β-tricalcium phosphate, and fibrin-based products in bone regeneration. However, this article contains few diagrams and the references are quite outdated. Although this literature provides a detailed account of the application of synthetic biomaterials combined with fibrin derivatives in bone regeneration medicine, there is still a significant lack of research at the molecular level."
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Pagani BT, Rosso MPO, Moscatel MBM, Trazzi BFM, da Cunha MR, Issa JPM, Buchaim DV, Buchaim RL. Update on synthetic biomaterials combined with fibrin derivatives for regenerative medicine: Applications in bone defect treatment: Systematic review. World J Orthop 2025; 16(5): 106181
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"This review is rich in illustrations and graphics, with appropriate methods and reliable results. Therefore, this article is highly ..."
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"This review is rich in illustrations and graphics, with appropriate methods and reliable results. Therefore, this article is highly scientific and innovative. The author elaborated in detail on the formation mechanism and progress of neutrophil extracellular traps in common osteoarticular diseases. However, the mechanism of interaction between neutrophil extracellular traps and other cells in osteoarticular diseases has not been fully elucidated, and this should be a direction for future research."
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Sun GJ, Xu F, Jiao XY, Yin Y. Advances in research of neutrophil extracellular trap formation in osteoarticular diseases. World J Orthop 2025; 16(5): 106377
3
"In this manuscript, the authors analyzed the prevalence and incidence of ulcerative colitis and Crohn's disease using large medical ..."
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"In this manuscript, the authors analyzed the prevalence and incidence of ulcerative colitis and Crohn's disease using large medical record databases from three regions: Hong Kong, Japan, and the United States. In the results, substantial differences were identified among regions in absolute prevalence/incidence, temporal trends, and disease characteristics. Although the authors discussed various potential factors contributing to these differences, it is difficult to accept several explanations, such as the difference in NO2 exposure leading to the different prevalence and incidence of Crohn's disease between Japan and the USA. NO2 exposure at the time point may not differ between Japan and the USA with the magnitude reflected in the different prevalence/incidence of Crohn's disease. It would be ideal for the authors to include a discussion that proposes possible solutions to reduce the prevalence and incidence of inflammatory bowel diseases in each society."
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Zhang Y, Chung H, Fang QW, Xu YR, Zhang YJ, Nakajo K, Wong ICK, Leung WK, Qiu H, Li X. Current and forecasted 10-year prevalence and incidence of inflammatory bowel disease in Hong Kong, Japan, and the United States. World J Gastroenterol 2025; 31(18): 105472
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"This manuscript employs a bibliometric analysis to map the field of spondylolisthesis research. Using the Web of Science database, ..."
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"This manuscript employs a bibliometric analysis to map the field of spondylolisthesis research. Using the Web of Science database, the authors identified 1831 relevant articles. The study reveals a dramatic increase in publications post-2010, with the United States leading in contributions. The University of California, San Francisco, emerges as the most prolific institution. Spine is identified as the top journal publishing in this area. Keyword analysis highlights themes in clinical presentation, diagnosis, and treatment. The authors conclude that this work provides a methodological framework to synthesize historical and current trends in spondylolisthesis studies, but the authors acknowledge limitations due to dependence on the web of science collection database."
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Xu JN, Li Y, Zhao TX, Wu WY, Yang XW, Zhang HW, Chen Q, Xia C, Zhang J. Mapping the field of spondylolisthesis: A bibliometric analysis. World J Clin Cases 2025; 13(22): 99221
5
"This editorial critically analyzes a study by Maranhão et al. investigating pleural adenosine deaminase (P-ADA) as a biomarker for ..."
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"This editorial critically analyzes a study by Maranhão et al. investigating pleural adenosine deaminase (P-ADA) as a biomarker for inflammatory pleural effusions. The editorial highlights the clinical relevance of the study, which established a cutoff value for P-ADA to differentiate between inflammatory and non-inflammatory pleural effusions. It emphasizes the study's novelty in providing a standardized P-ADA threshold in a Brazilian population, addressing inconsistencies found in previous studies. The editorial further explores the pathophysiological mechanisms underlying elevated P-ADA, linking it to purinergic signaling pathways and immune cell activation. The editorial acknowledges that using P-ADA leads to early diagnosis, improved treatment stratification and reduction in cost. The limitation is that the cutoff value requires validation across diverse population and the data is retrospective. Overall, the editorial positions P-ADA as a non-invasive, cost-effective biomarker with potential to streamline diagnostics, particularly in resource-limited settings, and calls for future research to prioritize global validation and explore integration with other biomarkers."
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Shi DD, Tian J, Ding J. Adenosine deaminase in pleural effusion: Bridging diagnosis and the pathophysiology of inflammation. World J Clin Cases 2025; 13(22): 106925
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Tasneem AA, Luck NH, Mubarak M. Mediastinal lymphadenopathy: Causes, symptoms and factors predicting good yield of endoscopic ultrasound-guided biopsy. World J Clin Cases 2025; 13(22): 105596
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Kucukakcali Z, Akbulut S. Role of immature granulocyte and blood biomarkers in predicting perforated acute appendicitis using machine learning model. World J Clin Cases 2025; 13(22): 104379
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Abdishakur AE, Ahmed MAA. Adult ileo cecal intussusception as a manifestation of colon carcinoma: A case report. World J Clin Cases 2025; 13(22): 104352
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Inoue Y, Yata Y, Yokota Y, Li ZL, Kawabata K. Acute pancreatitis after total aortic arch replacement leading to walled-off necrosis: A case report and review of literature. World J Clin Cases 2025; 13(22): 104165
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"This manuscript describes a rare case of walled-off necrosis (WON) after acute pancreatitis following total aortic arch replacement ..."
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"This manuscript describes a rare case of walled-off necrosis (WON) after acute pancreatitis following total aortic arch replacement in a 67-year-old man. The case was successfully managed with the endoscopic ultrasound (EUS)-guided drainage of the peripancreatic fluid collection (PFC). The manuscript underscores the feasibility and safety of this endoscopic intervention in this clinical scenario, even though large prospective studies are certainly needed to draw conclusions in this direction."
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Inoue Y, Yata Y, Yokota Y, Li ZL, Kawabata K. Acute pancreatitis after total aortic arch replacement leading to walled-off necrosis: A case report and review of literature. World J Clin Cases 2025; 13(22): 104165
11
"The authors conducted a single-centre retrospective study involving nearly 400 patients with ulcerative colitis and approximately ..."
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"The authors conducted a single-centre retrospective study involving nearly 400 patients with ulcerative colitis and approximately 300 patients with Crohn’s disease, compared with 100 controls. The sample was subsequently resampled using propensity score matching to homogenise the cohorts. The authors assessed 17 serum biomarkers, both as individual and composite markers, evaluating their association with endoscopic activity (measured using the Mayo score for ulcerative colitis and the SES-CD for Crohn’s disease), and constructed a predictive nomogram based on the biomarkers that demonstrated predictive value as independent variables. A subgroup of 100 patients was subsequently re-evaluated to verify the consistency of the analyses with the ensuing endoscopic response. The study has several strengths: a large sample size filtered through propensity score matching; the biomarkers evaluated by the authors are readily available in any laboratory; and the endoscopic outcome is highly relevant, as opposed to surrogate laboratory (e.g. faecal calprotectin) or clinical (e.g. partial Mayo score or HBI) outcomes. The analyses demonstrated a very high AUC for ulcerative colitis (0.93) and a fair AUC for Crohn’s disease (0.78). Nonetheless, several limitations emerged: the single-centre design undermines generalisability, the retrospective nature compromises data robustness, external validity is lacking, follow-up was limited to 14 weeks, and therapeutic heterogeneity was not thoroughly accounted for."
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Liu X, Pan LX, Pei JX, Pu T, Wen HT, Zhao Y. Role of serological biomarkers in evaluating and predicting endoscopic activity in inflammatory bowel disease. World J Gastroenterol 2025; 31(18): 104206
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"In abstract , it is 5 % of intussusceptions , whereas in in Introduction , it is 6%,which is correct.
After Physical examination ..."
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"In abstract , it is 5 % of intussusceptions , whereas in in Introduction , it is 6%,which is correct.
After Physical examination , t of the should be capital.
what is 8.5 g/DL.
What surgical resection was done ?
Various treatment options should have been described
References are outdated
There was room for improvement in this case , enhancing its credibility.Literature should have been searched.
Reviewers and editors should have reviewed literature to improve quality of case report for readers"
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Abdishakur AE, Ahmed MAA. Adult ileo cecal intussusception as a manifestation of colon carcinoma: A case report. World J Clin Cases 2025; 13(22): 104352
13
"This editorial provides a comprehensive interpretation of Maranhão et al. 's study, which establishes a pleural adenosine deaminase ..."
[Read more]
"This editorial provides a comprehensive interpretation of Maranhão et al. 's study, which establishes a pleural adenosine deaminase (P-ADA) cutoff for inflammatory pleural effusions. The authors successfully highlight the clinical utility of P-ADA in differentiating inflammatory from non-inflammatory effusions and connect this biomarker to broader pathophysiological processes involving purinergic signaling and ADA2 isoforms.
Strengths:
The article clearly emphasizes the practical implications of Maranhão et al. 's findings, especially in resource-limited settings where non-invasive, cost-effective biomarkers are highly needed.
The connection between P-ADA levels and immune modulation through ADA2 isoforms in macrophages and lymphocytes adds valuable biological context.
The editorial effectively highlights the need for global validation studies and standardization of P-ADA cutoffs, a crucial message for the field.
Suggestions for Improvement:
Add a paragraph critically discussing P-ADA's diagnostic overlap with malignant and parapneumonic effusions.
Include practical suggestions for standardizing P-ADA testing across different regions and populations.
Expand on the possible role of P-ADA within multi-marker panels and its integration into current diagnostic workflows.
"
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Shi DD, Tian J, Ding J. Adenosine deaminase in pleural effusion: Bridging diagnosis and the pathophysiology of inflammation. World J Clin Cases 2025; 13(22): 106925
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"It was with pleasure that I reviewed the article quality of the following manuscript.
1 Ethics: Not applicable given manuscript ..."
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"It was with pleasure that I reviewed the article quality of the following manuscript.
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The figures/tables add to the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: The references are appropriate/up-to-date
7 Language: This is a concise/well written manuscript
8 Caveats or drawbacks: None"
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Dong ZY, Zhu HB. Idiopathic retroperitoneal fibrosis arising from peritoneal space: A case report and review of literature. World J Gastroenterol 2025; 31(18): 105443
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"Full laparoscopic ALPPS for CRLM is safe and feasible, with the potential for reduced morbidity and mortality. However, due to the ..."
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"Full laparoscopic ALPPS for CRLM is safe and feasible, with the potential for reduced morbidity and mortality. However, due to the technical complexity of this procedure, it cannot be guaranteed that each center can perform successfully and safely. It requires surgeons to be highly experienced with laparoscopic hepatectomy.
What level of laparoscopic hepatectomy skills are required? For example, how many laparoscopic hepatectomy cases?
"
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Zheng ZY, Zhang L, Li WL, Dong SY, Song JL, Zhang DW, Huang XM, Pan WD. Laparoscopic associating liver partition and portal vein ligation for staged hepatectomy for colorectal liver metastases: A single-center experience. World J Gastroenterol 2025; 31(18): 105530
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"I think the manuscript is well written and compactly summarised. The topic is very intersting and nice. Furthermore, I believe this ..."
[Read more]
"I think the manuscript is well written and compactly summarised. The topic is very intersting and nice. Furthermore, I believe this paper is of high value because the research methods used to confirm the original hypotheses regarding the topic, as well as the results, analysis methods, and evaluation methods, all appear to be valid."
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Guo X, Guo L, Lu QZ, Xie H, Chen J, Su WL, Tian Y, Li XH, Miao HL, Zhang Y, Yang Y, Liao C, Deng JY, Yang YH, Tang CL, Liu HJ. Effect of electroacupuncture combined with Tuina therapy on gut microbiota in patients with knee osteoarthritis. World J Gastroenterol 2025; 31(18): 105495
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"I think the manuscript is well written and compactly summarised. The topic is very intersting and nice. Furthermore, I believe this ..."
[Read more]
"I think the manuscript is well written and compactly summarised. The topic is very intersting and nice. Furthermore, I believe this paper is of high value because the research methods used to confirm the original hypotheses regarding the topic, as well as the results, analysis methods, and evaluation methods, all appear to be valid."
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Kamimura K, Terai S. Importance of understanding a diagnostic-treatment algorithm for primary hyperparathyroidism-induced acute pancreatitis during pregnancy. World J Gastroenterol 2025; 31(18): 105866
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"I think the manuscript is well written and compactly summarised. The topic is very intersting and nice. Furthermore, I believe this ..."
[Read more]
"I think the manuscript is well written and compactly summarised. The topic is very intersting and nice. Furthermore, I believe this paper is of high value because the research methods used to confirm the original hypotheses regarding the topic, as well as the results, analysis methods, and evaluation methods, all appear to be valid."
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Zhang Y, Chung H, Fang QW, Xu YR, Zhang YJ, Nakajo K, Wong ICK, Leung WK, Qiu H, Li X. Current and forecasted 10-year prevalence and incidence of inflammatory bowel disease in Hong Kong, Japan, and the United States. World J Gastroenterol 2025; 31(18): 105472
19
"The authors conducted a systematic review and meta-analysis to compare the clinical outcomes and safety of TAVR and SAVR in patients ..."
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"The authors conducted a systematic review and meta-analysis to compare the clinical outcomes and safety of TAVR and SAVR in patients with severe AS. The methodology follows PRISMA guidelines, and both inclusion criteria and outcome assessment are clearly defined and presented. Multiple reviewers were involved in data extraction procedure eliminating the risk of selection bias. The authors used the Cochrane Collaboration Tool for assessing the risk of bias in the included studies. However, there are concerns regarding the blinding of participants in some studies which could have led to performance bias.
Statistical methods were appropriately applied making the study reproducible by other researchers. TAVR was associated with significantly lower risk of short-term mortality (1-year-mortality) and reduced complications like AKI, major bleeding and new-onset AF, while it was associated with higher rates of long-term mortality (5-year-mortality), permanent pacemaker implantation and major vascular complications compared to SAVR. The results are strongly supported by tables and forest plots. However, the interpretation of this difference in long-term and short-term mortality rates could be discussed further and explain possible factors. The statistical analysis was conducted using Review Manager which is a well-established software in the field.
References are current and relevant including major clinical trials and systematic reviews. The authors avoid excessive self-citation and provide a solid foundation of current literature. The language used in this manuscript is generally clear but some sentences are overly complex and could be simplified for better understanding. This study has several limitations which are appropriately presented and discussed in the relevant section of this manuscript. However, a major caveat regarding this study is that the analysis did not include several patient-specific factors which could have influenced both selection of treatment and outcomes.
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Moradi I, Mustafa MS, Sardar Sheikh J, Shojai Rahnama B, Fredericks M, Kumar Yennam A, Arain M, Saha U, Richard Ma A, Nagendran A, Bin Omer M, Armaghan M, Jaimes DCC, Avinash Bojanki NLSV, Shafique MA. Comparative effectiveness of transcatheter vs surgical aortic valve replacement: A systematic review and meta-analysis. World J Cardiol 2025; 17(4): 104168
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Chen LQ, Wu CY, Wu SJ, Ye K. Laparoscopic surgical approaches for various locations of gastrointestinal stromal tumours. World J Clin Cases 2025; 13(21): 105559
15265 items Read more >>
Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2266
- Peer-reviewers
- 31015
- Manuscripts received today
- 7
- Manuscript reviews today
- 23
- Unhandled manuscripts today
- 123
- Active peer-reviewers today
- 732
- Reviewer acceptance today
- 31
- Reviewer refusals today
- 26
- Total accepted manuscripts
- 36064
- Total rejected manuscripts
- 41710
- Total peer-reviewers
- 4222270
- Total submissions
- 34253
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1
"The article is devoted to the problem of introducing narrative medicine into primary health care systems. This process is part of ..."
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"The article is devoted to the problem of introducing narrative medicine into primary health care systems. This process is part of the enriching the humanistic dimensions of medical care and, in general, of a systemic approach to maintaining public health. The relevance of this problem has significantly increased recently due to the increasing role of instrumental component of the medical industry and some dehumanization associated primarily with the crisis of individualizing clinical approach and increasing standardization in the provision of medical services. It is expected that the development of narrative medicine can improve the comfort of doctor-patient interaction, provide a personalized approach with improved diagnostic efficiency and quality of treatment. The authors analyze the main problems of the widespread introduction of narrative medicine in primary health care, namely, the strengthening of the humanitarian component in the educational programs of medical professionals, increasing the burden on the staff, the need to allocate additional funds, the peculiarities of the national health care system of China. The article discusses possible solutions to some of these problems, such as the involvement of volunteers, application of artificial intelligence, optimization of equipment operation mode in order to save money. Feedback mechanisms, telemedicine methods, etc. are built into the implementation system proposed by the authors. However, it seems that the proposed schemes need experimental validation, which requires the creation of interdisciplinary research groups in which doctors and humanities can interact. Given the peculiarities of the humanitarian environment of Chinese society, it would be appropriate to include representatives of different schools of psychology and even philosophy in such groups. In general, given the novelty of the problem and its relevance, the quality of the article is quite high. "
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Lei NJ, Vaishnani DK, Shaheen M, Pisheh H, Zeng J, Ying FR, Yang QQ, Wang CY, Ma J, Pan JY, Hou NJ. Embedding narrative medicine in primary healthcare: Exploration and practice from a medical humanities perspective. World J Clin Cases 2025; 13(22): 105684
2
"The studied groups were not homogeneous by age and gender proportion. Research does not achieve the objectives of the experiment. ..."
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"The studied groups were not homogeneous by age and gender proportion. Research does not achieve the objectives of the experiment. The results are unreliable and cannot be considered to be a meaningful contribution to research progress in this field. Furthermore, the comorbidity was not reported: this represents a further limit that could affect the results. "
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Buterin A, Vuckovic M, Spanja Prpic S, Zaharija V, Nonkovic M, Prpic T. Comparison of functional recovery of the knee following total knee arthroplasty in patients with and without ankle symptoms. World J Orthop 2025; 16(5): 106004
3
"This prospective study rightly identifies a significant problem i.e.,preoperative ankle pain might effect the early functional outcome ..."
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"This prospective study rightly identifies a significant problem i.e.,preoperative ankle pain might effect the early functional outcome in patients undergoing total knee arthroplasty for primary Osteoarthritis knee.It is often overlooked but the deformity at the level of knee definitely impacts the biomechanics alignment of the entire lower limb and also at the ankle. The key finding was patients exhibited significantly lower KOOS scores and extension recovery at 3 months postoperatively, even after adjusting for demographic confounders. This reiterates the necessity for a complete lower limb assessment and managing preoperatively any hip/ankle symptoms preoperatively to optimize TKA outcomes. The methodology, protocol, grouping of patients was all good. The authors could have given a detailed radiographic alignment of the patient's lowerliimbs that were operated to substantiate the preoperative status and the results postoperatively. Even though AOFAS score, is an appropriate tool for assessing the ankle symptoms and pathologies, a detailed radiographic assessment of the ankle including ankle hind foot assessment, weight bearing alignment could have been added/ mentioned. Incorporating pre- and postoperative radiographs would have allowed the authors to better delineate whether the observed differences in KOOS and knee extension were attributable to underlying mechanical misalignment or simply symptomatic variation. A gait analysis of the patients can also be included to add objective assessment to the data. That would tell us whether the results are an outcome of any malalignment or just symptomatic variation. A longer followup would also suggest us whether the symptoms are resolving over time or still persisting. "
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Buterin A, Vuckovic M, Spanja Prpic S, Zaharija V, Nonkovic M, Prpic T. Comparison of functional recovery of the knee following total knee arthroplasty in patients with and without ankle symptoms. World J Orthop 2025; 16(5): 106004
4
"This study addresses the deficit of medical humanities in China’s resource-limited primary healthcare (PHC) system by systematically ..."
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"This study addresses the deficit of medical humanities in China’s resource-limited primary healthcare (PHC) system by systematically exploring pathways to integrate narrative medicine (NM) into grassroots care. Situated within the Healthy China 2030 policy framework, the research proposes actionable strategies for humanizing PHC through theoretical analysis and practical innovations, such as the One-Minute Patient Narrative and 11253 Family Doctor Service Model. Key contributions include: (1) revealing tensions between policy mandates and on-the-ground realities, emphasizing NM’s localization to regional disparities; (2) enhancing care efficiency via AI-mediated narrative analysis (e.g., a 25% increase in treatment adherence); and (3) offering scalable models to ensure PHC sustainability. However, three critical gaps require further exploration. First, cultural dynamics—such as patients’ traditional deference to medical authority and healthcare commercialization—demand culturally adaptive interventions (e.g., competency training for clinicians, redefining relational medicine values). Current analyses lack actionable steps to operationalize these strategies across diverse contexts. Second, sustainability challenges—including the feasibility of urban NM models in high-demand rural settings and volunteer system stability in under-resourced areas—are underexamined. Systemic inequities (e.g., funding gaps, workforce shortages) further constrain implementation. Third, while short-term metrics like patient satisfaction are prioritized, long-term systemic issues—health equity, clinician burnout, and bureaucratic barriers to PDCA (Plan-Do-Check-Act) cycles—remain unaddressed. Future studies must adopt mixed-method evaluations to bridge these gaps and enable NM’s transition from pilot projects to systemic reform. To further this agenda, this study presents a three-pillar framework. Firstly, by fostering interdisciplinary collaboration, we aim to integrate public health experts, community advocates, and policymakers. Together, they will devise NM interventions, such as narrative-driven public health campaigns. This approach will transform patient stories into effective social governance tools, thereby enhancing the inclusivity of medical decision-making. Secondly, we propose establishing an ethical AI governance system. This system will ensure that AI-driven narrative data processing aligns with China's data security regulations. We plan to adopt encryption technology and an informed consent mechanism to bolster privacy protections. Additionally, we will systematically mitigate technical biases through algorithm fairness audits and transparent training protocols, including the use of open dataset sources. Finally, we advocate for a global localization adaptation strategy, drawing inspiration from international practices like the Indian Asha worker model. While respecting the universal principle of patient autonomy, we intend to devise localized solutions, such as a health narrative literacy improvement project tailored for rural areas. This will facilitate the effective integration of medical humanistic values within diverse social and cultural contexts. Ultimately, this framework aims to shift healthcare paradigms from fragmented, biomarker-centric models to holistic, humanistic systems. By empowering patients and frontline workers as NM co-designers through participatory research, localized innovations can catalyze structural reforms, ensuring medical services prioritize humanistic care over purely biomedical metrics. "
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Lei NJ, Vaishnani DK, Shaheen M, Pisheh H, Zeng J, Ying FR, Yang QQ, Wang CY, Ma J, Pan JY, Hou NJ. Embedding narrative medicine in primary healthcare: Exploration and practice from a medical humanities perspective. World J Clin Cases 2025; 13(22): 105684
5
"Endoscopic gastroplasty treatments were significantly better in reducing total body weight, excessive weight, and average weight among ..."
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"Endoscopic gastroplasty treatments were significantly better in reducing total body weight, excessive weight, and average weight among obese population. No significant difference between endoscopic transoral outlet reduction and full-thickness suturing plus argon plasma mucosal coagulation. Lack of comparative, long-term follow-up and randomized studies, reporting and selection bias, high level of heterogeneity were the major limitations in the currently available meta-analyses. "
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Abdulla M, Mohammed N, AlQamish J, Arau RT. Efficacy and safety of endoscopic gastroplasty for treatment of obesity: An overview of comparative meta-analyses. World J Gastrointest Endosc 2025; 17(5): 105158
6
"This review comprehensively explores the latest advancements in gastrointestinal (GI) endoscopy, highlighting innovations in ..."
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"This review comprehensively explores the latest advancements in gastrointestinal (GI) endoscopy, highlighting innovations in diagnostic and therapeutic techniques for GI cancers. Cutting-edge technologies such as magnification endoscopy, narrow-band imaging, endoscopic ultrasound with fine-needle biopsy, and artificial intelligence-enhanced methods are transforming cancer detection, staging, and management. Endoscopic approaches like submucosal dissection and mucosal resection are improving outcomes for premalignant and malignant lesions. These developments underscore the pivotal role of endoscopy in reducing morbidity, mortality, and healthcare costs associated with GI cancers. "
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Abusuliman M, Jamali T, Zuchelli TE. Advances in gastrointestinal endoscopy: A comprehensive review of innovations in cancer diagnosis and management. World J Gastrointest Endosc 2025; 17(5): 105468
7
"Gastric polyps (GPs) are a common clinical disease. In recent years, with the change in dietary habits, the incidence of GPs is ..."
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"Gastric polyps (GPs) are a common clinical disease. In recent years, with the change in dietary habits, the incidence of GPs is increasing in China. GPs are usually found by gastroscopy. Some GPs may have malignant potential and are associated with hereditary diseases. Therefore, early detection and biopsy examination are important in clinical practice to better reduce the rate of cancer。It is an interesting manuscript. Authors can succeed to present their idea in a clear way adding information to the existing literature. "
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Zheng L, Shi YQ, Xue T, Duan SL. Evaluating the detection rate and pathological features of polyps in patients with upper gastrointestinal endoscopy. World J Gastrointest Endosc 2025; 17(5): 105471
8
"This Letter to Editor does a great job of highlighting an important issue that many of us face in real-world clinical practice—when ..."
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"This Letter to Editor does a great job of highlighting an important issue that many of us face in real-world clinical practice—when to perform cholecystectomy in patients with gallstone-related acute cholangitis. The authors point out the growing evidence in favor of same-admission surgery rather than waiting, and they support this with data from a large national database, which adds weight to their argument. What I appreciated most was how clearly the authors outlined the benefits of early surgery—not just in terms of clinical outcomes like reduced readmission and mortality, but also from a healthcare system perspective. These are the kinds of practical, patient-centered decisions we need to think more carefully about. That said, I would have liked to see a little more discussion on what makes early surgery difficult to implement in some hospitals. For example, resource limitations, operating room availability, or patient comorbidities could be relevant factors. A few thoughts on how to overcome those barriers would make the piece even more helpful. In summary, this is a well-written and very relevant commentary that reminds us of the gap that often exists between evidence and practice. I think it will be helpful not only for clinicians but also for institutions looking to improve care pathways for biliary emergencies. Reviewer Name: Bum-Soo Kim "
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Paramythiotis D, Tsavdaris D, Karlafti E. Reassessing cholecystectomy timing in gallstone-related acute cholangitis. World J Gastrointest Endosc 2025; 17(5): 106473
9
"This article is very innovative and has great reference value for clinical medical treatment, the language has no obvious errors, ..."
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"This article is very innovative and has great reference value for clinical medical treatment, the language has no obvious errors, the quality of charts and graphs is clear, it is worthy of publication, the level of publication meets the requirements of journals, and for the insufficiency of the research hopefully further in-depth discussion. "
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Singeap AM, Minea H, Stafie R, Stanciu C, Trifan A. Towards precision care: Fluctuations in albumin and fibrinogen as noninvasive predictors of endoscopic outcomes in Crohn’s disease. World J Gastrointest Endosc 2025; 17(5): 105365
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"I read an interesting article "Efficacy and safety of endoscopic gastroplasty for the treatment of obesity: An overview of comparative ..."
[Read more]
"I read an interesting article "Efficacy and safety of endoscopic gastroplasty for the treatment of obesity: An overview of comparative meta-analyses". The authors very accurately analyzed a large list of available publications on the topic of endoscopic gastroplasty in accordance with the PRISMA method. The authors also compared various strategies, including interventional ones for the treatment of obesity. They made interesting conclusions about the effectiveness of endoscopic gastroplasty for the treatment of obesity. "
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Abdulla M, Mohammed N, AlQamish J, Arau RT. Efficacy and safety of endoscopic gastroplasty for treatment of obesity: An overview of comparative meta-analyses. World J Gastrointest Endosc 2025; 17(5): 105158
11
"This article describes a prospective study evaluating the efficacy of colon capsule endoscopy (CCE) for surveillance of colonic ..."
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"This article describes a prospective study evaluating the efficacy of colon capsule endoscopy (CCE) for surveillance of colonic polyps. Although the study was conducted at a single institution and may lack diversity in its patient population, it is a prospective study that provides essential data demonstrating the utility of CCE. Currently, CCE is also used in routine clinical practice, such as for assessing the effectiveness of medications in ulcerative colitis. There are challenges to overcome, such as the volume of laxatives required for bowel preparation being greater than that for conventional colonoscopy (CS) and the higher examination cost. However, CCE can potentially reduce the number of unnecessary CS, suppress carbon dioxide emissions associated with endoscopic procedures, and significantly contribute to green endoscopy. For these reasons, determining how to promote the use of CCE further in daily clinical practice is considered an important issue for the future. "
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Semenov S, Ismail MS, Sihag S, Manoharan T, Reilly P, Boran G, Ryan B, Breslin N, O’Connor A, O’Donnell S, McNamara D. Colon capsule endoscopy is an effective filter test for colonic polyp surveillance. World J Gastrointest Endosc 2025; 17(5): 101322
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"This review article presents a comprehensive synthesis of recent developments in conversion therapy for intrahepatic ..."
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"This review article presents a comprehensive synthesis of recent developments in conversion therapy for intrahepatic cholangiocarcinoma (ICC), specifically focusing on strategies to render initially unresectable disease amenable to surgical resection. The authors have successfully compiled and analyzed a broad range of relevant studies, providing a balanced overview of multimodal treatment approaches, including systemic chemotherapy, targeted therapy, immunotherapy, and locoregional interventions such as TACE, TARE, and HAIC. The manuscript is commendable for its integration of recent clinical data and its emphasis on multidisciplinary management, which aligns with current oncologic practice. The inclusion of well-organized tables and illustrative figures contributes to the accessibility and clarity of the content. Furthermore, the discussion of strategies aimed at optimizing the future liver remnant—such as portal vein embolization (PVE) and ALPPS—offers valuable clinical insights for hepatobiliary surgeons and oncologists alike. To further strengthen the manuscript, the following suggestions are offered: 1. A more explicit and operational definition of “conversion therapy” would improve conceptual clarity, particularly if contrasted with related terms such as “bridging therapy” and “downstaging.” 2. While Figure 1 is informative, reformatting it into a structured algorithm or decision-making flowchart could enhance its clinical utility and instructional value. 3. The generalizability of findings from small-scale or non-standardized studies should be addressed, as this would add depth to the critical appraisal and enhance the scholarly rigor of the discussion. In conclusion, this review represents a timely and academically significant contribution to the evolving field of hepatobiliary oncology. With modest revisions, it has the potential to serve as both an educational reference and a practical guide for clinicians managing advanced ICC. "
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Liu JJ, Zhou M, Yuan T, Huang ZY, Zhang ZY. Conversion treatment for advanced intrahepatic cholangiocarcinoma: Opportunities and challenges. World J Gastroenterol 2025; 31(15): 104901
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"The title of this paper should condense the main idea of the article and clearly indicate that it is a retrospective study. The ..."
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"The title of this paper should condense the main idea of the article and clearly indicate that it is a retrospective study. The description of research methods is not specific and clear enough. The citation of literature should include more recent references, which will increase the novelty and scientific value of the paper. "
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Wu YP, Zhou JX, Wu HB, Wu DP, Qin LZ, Qin B, Xu XY, Yehya SAA, Cheng Y. Clinical characteristics and risk factors of esophageal reflux hypersensitivity: A multicenter study. World J Gastroenterol 2025; 31(17): 105281
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"The retrospective study by Zhao et al. offers critical insights into sex-based differences in achalasia symptomatology and outcomes ..."
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"The retrospective study by Zhao et al. offers critical insights into sex-based differences in achalasia symptomatology and outcomes following peroral endoscopic myotomy (POEM). By analyzing 526 cases over a decade, the authors address a significant gap in understanding how sex influences preoperative presentation, manometric parameters, and postoperative recovery. While the study reaffirms POEM’s efficacy and highlights sex-specific nuances, two methodological limitations warrant attention: the absence of normality testing for data distribution and incomplete reporting of statistical metrics in tables. These omissions slightly undermine the robustness of the statistical analysis but do not negate the study’s overall contributions. "
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Zhao CY, Xu N, Dong H, Chai NL, Linghu EQ. Effect of sex on the outcomes of peroral endoscopic myotomy for the treatment of achalasia. World J Gastroenterol 2025; 31(17): 104579
15
"This review by Liu and He provides a comprehensive exploration of intelligent hydrogel-based dressings for diabetic wound management. ..."
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"This review by Liu and He provides a comprehensive exploration of intelligent hydrogel-based dressings for diabetic wound management. Chronic diabetic wounds, characterized by impaired or delayed healing due to multiple physiological disruptions, demand innovative solutions. The authors systematically categorize hydrogels into natural, synthetic, and composite types, dissecting their structural and functional mechanisms while highlighting their clinical potential. Below is a critical analysis of the article’s strengths, limitations, and future implications. The article is well-organized, progressing logically from the pathophysiology of diabetic wounds to hydrogel design, responsiveness mechanisms, applications, and future challenges. This structure helps readers understand the progression from fundamental biological science to clinical findings in translational studies. The integration of materials science, nanotechnology, and biotechnology is a highlight. For instance, the discussion on composite hydrogels incorporating silver nanoparticles or conductive polymers demonstrates how hybrid materials enhance antibacterial efficacy and mimic bioelectrical environments. The inclusion of emerging technologies like 3D printing and real-time monitoring systems reflects a forward-thinking approach. The authors bolster their claims with recent preclinical and clinical studies (e.g., phase 4 trials of Fitostimoline and SANTYL hydrogels). References to advanced functionalities, such as glucose-responsive insulin release or photothermal antibacterial activity, are supported by robust experimental data, lending credibility to the proposed applications. The emphasis on personalized precision medicine aligns with current trends in healthcare. The concept of hydrogels adapting to wound microenvironment changes (pH, temperature, biomarkers) for tailored drug delivery represents a paradigm shift from traditional "one-size-fits-all" therapies. The article does have some limitations. In terms of clinical translation challenges, while the article acknowledges barriers like high costs and biocompatibility concerns, it lacks actionable strategies for overcoming these hurdles. For example, cost reduction could be addressed through scalable manufacturing techniques or public-private partnerships, yet these solutions are only briefly mentioned. Certain sections, particularly those detailing chemical cross-linking mechanisms or nanomaterial interactions, may alienate non-specialist readers. Simplifying jargon or incorporating analogies (e.g., comparing hydrogel networks to "smart sponges") could improve accessibility. In addition, long-term biocompatibility and potential side effects of nanomaterials (e.g., silver nanoparticle toxicity) are underexplored. A discussion on regulatory pathways or post-market surveillance would strengthen the clinical relevance of the review. For future direction of dressings development, combining hydrogel dressings with wearable sensors or AI-driven diagnostics could enable closed-loop systems for real-time wound management. For instance, hydrogels equipped with IoT-enabled sensors might autonomously adjust drug release based on cloud-analyzed biomarker data. Exploring eco-friendly materials (e.g., biodegradable polymers) and energy-efficient production methods would address environmental concerns. Additionally, cost-benefit analyses comparing hydrogel dressings to standard care could incentivize healthcare adoption. Future studies should prioritize patient feedback to improve usability, such as optimizing hydrogel adhesion for mobility or reducing dressing change frequency. Ethnographic studies on patient adherence could inform design modifications. In conclusion, Liu and He’s review underscores the transformative potential of intelligent hydrogels in diabetic wound care, bridging scientific innovation with clinical needs. By addressing microenvironmental challenges through responsive drug delivery, antibacterial action, and tissue regeneration, these materials represent a leap toward personalized medicine. However, translating laboratory success to bedside application requires tackling economic, technical, and regulatory barriers. Future efforts must prioritize interdisciplinary collaboration, patient-centric design, and sustainable scaling to unlock the full promise of intelligent hydrogels. This article serves as both a foundational reference and a call to action for researchers, clinicians, and policymakers to reimagine diabetic wound management. "
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Liu H, He L. Intelligent hydrogel-based dressings for treatment of chronic diabetic wounds. World J Diabetes 2025; 16(5): 104937
16
"This article provides important data and insights for the study of reflux hypersensitivity (RH). The study is well-designed as a ..."
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"This article provides important data and insights for the study of reflux hypersensitivity (RH). The study is well-designed as a multicenter, large-sample, retrospective investigation, comprehensively analyzing the clinical characteristics and risk factors of patients with reflux hypersensitivity (RH). The assessment is extensive, covering symptoms, esophageal motility, impedance-pH monitoring, and psychological factors, revealing the significance of weakly acidic reflux (WAR) and non-acid reflux (NAR) in RH. The use of multiple statistical methods ensures the scientific reliability of the results. However, there are some limitations. Despite involving three medical centers, the sample size is still relatively small, with only 109 cases. The follow-up period is short, from January 2022 to December 2023, which may limit the generalizability of the study results and the assessment of long-term effects. The study mainly focuses on the clinical characteristics and risk factors of RH, but there is relatively little analysis of treatment response and prognosis in patients. The article uses the Hamilton Anxiety Scale and the Hamilton Depression Scale to assess the psychological status of patients, but it does not evaluate the effectiveness of psychological interventions in RH patients. "
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Wu YP, Zhou JX, Wu HB, Wu DP, Qin LZ, Qin B, Xu XY, Yehya SAA, Cheng Y. Clinical characteristics and risk factors of esophageal reflux hypersensitivity: A multicenter study. World J Gastroenterol 2025; 31(17): 105281
17
"This article investigates the therapeutic potential of BIC in the context of MASLD, with a particular focus on its effects on lipid ..."
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"This article investigates the therapeutic potential of BIC in the context of MASLD, with a particular focus on its effects on lipid metabolism and inflammation. BIC, an alkaloid traditionally recognized as a GABA receptor antagonist, is presented as a novel therapeutic candidate for MASLD. This exploration is particularly intriguing, as the GABAergic pathways are well-documented for their roles within the nervous system; however, the investigation into BIC’s impact on hepatic lipid metabolism and inflammatory processes remains relatively novel and promising. The utilization of zebrafish, HepG2, and AML12 cellular models, alongside mouse models induced by a MCD diet, significantly enhances the validity of the findings. By employing multiple experimental models, the researchers provide robust evidence supporting the efficacy of BIC in alleviating MASLD, which is essential for the translation of these findings into clinical practice. Furthermore, the absence of significant toxicity observed in zebrafish embryos and cellular models, even at relatively high concentrations of BIC, suggests a favorable safety profile for this compound. This aspect is critical, as it bolsters the notion that BIC could potentially be developed into a therapeutic agent devoid of the toxic effects commonly associated with alternative treatments. However, while the study offers compelling evidence from preclinical models, it is imperative to investigate the long-term effects of BIC. Given that MASLD can progress to more severe forms, such as steatohepatitis and fibrosis, long-term studies are necessary to ascertain whether BIC can effectively prevent such progression. Moreover, although the results of the study confirm the absence of significant toxicity associated with the drug, the relationship between its pharmacological mechanisms and GABA warrants further discussion, or at the very least, should be acknowledged in the limitations section. "
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Wang XM, Dai Z, Lu DJ, Bao CQ, Yang NB, Zhou YP. Bicuculline ameliorates metabolic dysfunction-associated steatotic liver disease by inhibiting the nuclear factor-kappa B pathway and reducing lipid accumulation. World J Gastroenterol 2025; 31(17): 105438
18
"Title: Interventional effect of hesperetin on N-methyl-N’-nitro-N-nitrosoguanidine-induced exosomal circ008274 in affecting normal ..."
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"Title: Interventional effect of hesperetin on N-methyl-N’-nitro-N-nitrosoguanidine-induced exosomal circ008274 in affecting normal cells to promote gastric carcinogenesis. The study proved that hesperetin aleviated the gastric carcinogenesis by mediating exosome-derived circ0008274 targeting miR-526b-5p. The hesperidin-mediated exosomes circ0008274/miR-526b-5p axis and it can serve as a potential target for slowing the onset of gastric cancer. These findings play an important role in the management of gastric precancerous lesions. The overall study is good but this research used bioinformatics technique and future researches are need to used the integration of bioinformatics, genomics, and proteomics to give more explanation for the protective effect of hesperetin on the gastric cancer. "
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Liang ZF, Xu YM, Song JJ, Gao ZH, Qian H, Xu XZ. Interventional effect of hesperetin on N-methyl-N’-nitro-N-nitrosoguanidine-induced exosomal circ008274 in affecting normal cells to promote gastric carcinogenesis. World J Gastroenterol 2025; 31(16): 104920
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"The current study is very interesting as the authors addressed the role of gut micro biota in pathogenesis of chronic hepatitis B ..."
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"The current study is very interesting as the authors addressed the role of gut micro biota in pathogenesis of chronic hepatitis B infection. They reported that the abundance of Dorea varies significantly across various stages of liver fibrosis, making it a potential microbial marker for identifying the onset and progression of liver fibrosis. This useful conclusion will pave the way for modification of treatment strategy of chronic hepatitis B infection However, I have two comments: 1-The selection of patients with a wide range of age : 18-80 may have an impact on the results. Previous studies have sown as individuals age, the gut microbiota undergoes significant changes in composition, diversity, and functionality , which have been linked to various health conditions, including cognitive decline and inflammatory diseases. 2-It would have been better to select two equal groups of patients from the start: one group with hepatic fibrosis and the other without fibrosis .Having the equal or nearly equal groups would make statistical analysis more fair as the groups already studied had one with 35 patients and the other with 102 patients. "
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Zhu Y, Geng SY, Chen Y, Ru QJ, Zheng Y, Jiang N, Zhu FY, Zhang YS. Machine learning algorithms reveal gut microbiota signatures associated with chronic hepatitis B-related hepatic fibrosis. World J Gastroenterol 2025; 31(16): 105985
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"The authors have made a significant contribution by uncovering the role of the Interleukin-36 (IL-36) subfamily in liver cirrhosis, ..."
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"The authors have made a significant contribution by uncovering the role of the Interleukin-36 (IL-36) subfamily in liver cirrhosis, particularly highlighting the relationship between these cytokines and gut microbiota. This work provides a fresh perspective on the gut-liver axis, demonstrating how an imbalance in the gut microbiome might contribute to liver disease progression through inflammatory cytokine signaling. The innovation of the study lies in its identification of IL-36 cytokines, such as IL-36α, IL-36γ, IL-36Ra, and IL-38, as crucial players in the inflammatory processes associated with liver cirrhosis. By correlating these cytokines with gut microbiota alterations, the authors open new avenues for potential biomarkers and therapeutic targets in liver disease management. Their findings suggest that the IL-36 subfamily could help us better understand the pathophysiological mechanisms underlying liver cirrhosis and its association with dysbiosis in the gut microbiome. However, a notable limitation of the study is the lack of mechanistic exploration of how IL-36 cytokines mediate these effects in the liver. While the paper discusses correlations between IL-36 subfamily levels and gut microbiota, the underlying mechanisms linking these factors to liver cirrhosis progression are not fully explored. Further research into how IL-36 cytokines influence microbiota composition and how they interact with liver disease would enhance the understanding of the gut-liver axis. "
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Pan YZ, Chen WT, Jin HR, Liu Z, Gu YY, Wang XR, Wang J, Lin JJ, Zhou Y, Xu LM. Correlation between the interleukin-36 subfamily and gut microbiota in patients with liver cirrhosis: Implications for gut-liver axis imbalance. World J Hepatol 2025; 17(4): 105660
947 items Read more >>
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