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512 items Read more >>
1
"I am extremely satisfied with the entire publication process. The peer review report was very detailed and constructive, which was ..."
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"I am extremely satisfied with the entire publication process. The peer review report was very detailed and constructive, which was of great help in improving my manuscript. The editing quality is excellent, and the presentation of figures and tables is also outstanding. The online full - text article provides a good reading experience, and the publication period is within a reasonable range. I look forward to future cooperation. "
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Liao H, Liao S, Gao YJ, Wang X, Guo LH, Zheng S, Yang W, Dai YN. Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders. World J Psychiatry 2025; 15(1): 97945
2
"I am truly grateful to the reviewers and editors for their insightful comments and suggestions, which have greatly improved the quality ..."
[Read more]
"I am truly grateful to the reviewers and editors for their insightful comments and suggestions, which have greatly improved the quality of my paper. The peer - review process was efficient and fair, providing me with valuable guidance for revising my manuscript. I am satisfied with the publication process of the journal and am glad to have chosen it for publishing my work. This experience has motivated me to continue conducting in - depth research in this field and I look forward to contributing more high - quality papers in the future. "
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Shen YZ, Yang GP, Ma QM, Wang YS, Wang X. Regulation of lncRNA-ENST on Myc-mediated mitochondrial apoptosis in mesenchymal stem cells: In vitro evidence implicated for acute lung injury therapeutic potential. World J Stem Cells 2025; 17(3): 100079
3
"This process was very easy and we felt professionalism in every commentary and methods to let our article feet the audience and ..."
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"This process was very easy and we felt professionalism in every commentary and methods to let our article feet the audience and journal. This is a very high level journal and we felt that the process of editors is accordant to its importance. We are very pleased to work in this paper and to publish in this journal "
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Rodríguez Lima DR, Rodríguez Aparicio EE, Otálora González L, Hernández DC, González-Muñoz A. Performance of the EuroSCORE in coronary artery bypass graft in Colombia, a middle-income country: A retrospective cohort. World J Cardiol 2025; 17(3): 100506
4
"I gave the same comments earlier also but with the each submission, I am finding the submission process more tedious, time-consuming ..."
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"I gave the same comments earlier also but with the each submission, I am finding the submission process more tedious, time-consuming and unnecessary. Even top-most journals like JAMA and Lancet are making submission process easier but it is vice versa in this journal. No journal asks for so many files as you are asking. "
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Jain S, Agrawal A, Sharma S, Chinnadurai R. Impact of nutritional status on the outcome of critically ill pediatric patients. World J Clin Pediatr 2025; 14(2): 103377
5
"Overall, our experience publishing the systematic review entitled "Clinical course and management of hypertriglyceridemia thalassemia ..."
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"Overall, our experience publishing the systematic review entitled "Clinical course and management of hypertriglyceridemia thalassemia syndrome" in the World Journal of Clinical Pediatrics has been excellent. Although the waiting time for reviewers to accept manuscripts for peer review was relatively long, this delay is entirely understandable given the rarity of hypertriglyceridemia thalassemia syndrome. "
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Choed-Amphai C, Kusontammarat P, Chanthong S, Arkarattanakul N, Rodchaprom P, Sathitsamitphong L, Natesirinilkul R, Charoenkwan P. Clinical course and management of hypertriglyceridemia thalassemia syndrome: A case-based systematic review. World J Clin Pediatr 2025; 14(2): 101543
6
"Publication with WJSC has always been a learning experience for me. Every time i submit a paper for publication in WJSC, I learn ..."
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"Publication with WJSC has always been a learning experience for me. Every time i submit a paper for publication in WJSC, I learn something new. However, I suggest that the reviewer's grading should not be published as part of the paper because this adds to readers bias because reading the grades (A, B C, D which is an arbitrary thing depending upon the liking or disliking of each reviewer) it blocks the independent evaluation of the paper by the reader. "
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Safwan M, Bourgleh MS, Haider KH. Clinical experience with cryopreserved mesenchymal stem cells for cardiovascular applications: A systematic review. World J Stem Cells 2025; 17(3): 102067
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Yang W, Lu J, Si SC, Wang WH, Li J, Ma YX, Zhao H, Liu J. Digital health technologies/interventions in smart ward development for elderly patients with diabetes: A perspective from China and beyond. World J Diabetes 2025; 16(4): 103002
8
"We sincerely appreciate the dedication and efforts of the entire editorial team, including the assistant editor, science editor, peer ..."
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"We sincerely appreciate the dedication and efforts of the entire editorial team, including the assistant editor, science editor, peer reviewers, editorial director, journal editor-in-chief, company editor-in-chief, language editor, and production editor. Your hard work, professionalism, and meticulous attention to detail have been instrumental in successfully publishing our manuscript, ensuring high-quality standards and a smooth process. "
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Kamal AF, Abdelaziz EA, Fahim VF, Saad MH, Badr M. Drug prescribing pattern in upper respiratory tract infections among the pediatric population attending outpatient clinics in pediatric hospitals. World J Clin Pediatr 2025; 14(2): 100614
9
"I think the publishing and review processes were fair and accurate. The only problem I had was that I was unable to correspond with ..."
[Read more]
"I think the publishing and review processes were fair and accurate. The only problem I had was that I was unable to correspond with the journal by email due to the Chinese New Year holidays. I hope this point will be improved. As for other points, I am grateful for the quick response and the online publishing system, which is easy to handle. "
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Hara M, Yashiro T, Yashiro Y. Delayed diagnosis of pulmonary tuberculosis with pleuritis due to ampicillin/sulbactam: A case report. World J Clin Cases 2025; 13(19): 104083
10
"Your meticulous editing and insightful suggestions have transformed my manuscript into a refined and captivating piece. Your attention ..."
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"Your meticulous editing and insightful suggestions have transformed my manuscript into a refined and captivating piece. Your attention to detail and commitment to excellence have not only enhanced the quality of my writing but also broadened my perspective on effective communication. Through your efforts, my ideas have been presented in a more coherent and impactful way. I truly appreciate the time and energy you dedicated to this project. I look forward to future collaborations. "
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Yuan XX, Tan QQ, Chen C, He QQ, Li YN. Lumbar methicillin-resistant Staphylococcus aureus infection caused by a peripherally inserted central catheter: A case report. World J Clin Cases 2025; 13(19): 104294
11
"My experience with submitting and publishing an article with your journal was generally positive. The submission process was ..."
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"My experience with submitting and publishing an article with your journal was generally positive. The submission process was straightforward and the instructions provided were clear and easy to follow. I appreciated the efficient communication throughout the review process, and the feedback I received from the reviewers was constructive and helpful in improving my work. "
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Son Y, Quiring M, Serpico S, Wu E, Wood E, Deynzer S, Olive W, Henderson B, Choudhry H, Ahmed A, Aljameey U, Terrenzio D, Dean GE. Factors and outcomes leading to postoperative emergency department visits after ureteroneocystostomy. World J Clin Pediatr 2025; 14(2): 99455
12
"Dear Editors and the Editorial Team! The submission process was easy and the instructions are clear. The reviewing process was rigorous ..."
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"Dear Editors and the Editorial Team! The submission process was easy and the instructions are clear. The reviewing process was rigorous and very constructive. I and my c-Authors were satisfied the submission process and the results. The manuscript processing was fast and very clear Thank you for the kind support of the Authors in all steps of submission process. "
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Yakovlev AA, Gaidar EV, Sorokina LS, Nikitina TN, Kalashnikova OV, Kostik MM. Uveitis associated with juvenile idiopathic arthritis and chronic idiopathic uveitis in children: A retrospective cohort study. World J Clin Pediatr 2025; 14(2): 100336
13
"Dear Editors and Editorial Team! Thank you for the kind support of the Authors in all steps of submission process. The submission ..."
[Read more]
"Dear Editors and Editorial Team! Thank you for the kind support of the Authors in all steps of submission process. The submission process was easy and the instructions are clear. The reviewing process was rigorous, but very constructive. I almost satisfied the submission process and the results. The manuscript processing was fast and clear "
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Boeskorova S, Afonskaya M, Argunova V, Sleptsova P, Leonteva L, Burtseva T, Kostik MM. Ethnic heterogeneity of juvenile arthritis in the Republic of Sakha (Yakutia) related to a high human leukocyte antigen B27 frequency. World J Clin Pediatr 2025; 14(2): 101873
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"We deeply appreciate the editor's and reviewer's comprehensive evaluation, which has been a valuable guide in our revision. We are ..."
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"We deeply appreciate the editor's and reviewer's comprehensive evaluation, which has been a valuable guide in our revision. We are also heartened by the editor's and reviewer's positive remarks on our manuscript, which have reinforced our belief in the value of our research. The comprehensive and constructive feedback has been instrumental in elevating the quality of our manuspript, for which we are immensely grateful. "
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Huang HQ, Gong FM, Sun CT, Xuan Y, Li L. Brain and scalp metastasis of cervical cancer in a patient with human immunodeficiency virus infection: A case report. World J Clin Cases 2025; 13(19): 103946
15
"We are happy with the submission. I hope that y the editor can provide us with additional invited papers. We look forward to working ..."
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"We are happy with the submission. I hope that y the editor can provide us with additional invited papers. We look forward to working with BPG. The reviewing process needs work. It takes numerous months before reviewers are found. The system could be improved by slimlining the entire submission process. Other journals take 1-2 for complete publication. "
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Miotti G, Quaglia D, De Marco L, Parodi PC, D’Esposito F, Musa M, Tognetto D, Gagliano C, Zeppieri M. Surgical management of patients with corneal lesions due to lid pathologies. World J Clin Cases 2025; 13(19): 101889
16
"I sincerely appreciate the support and constructive feedback from the editors and reviewers, which have been invaluable in improving ..."
[Read more]
"I sincerely appreciate the support and constructive feedback from the editors and reviewers, which have been invaluable in improving the quality of my manuscript. The professionalism and dedication of the editorial team have made this a highly rewarding experience. I am truly pleased with the collaboration and look forward to future opportunities to contribute and work with the journal again. "
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Nguyen Tran T, Luong TV, Nguyen NVD, Dang HNN. Complex relationship between childhood obesity and the gut microbiota. World J Clin Pediatr 2025; 14(2): 100975
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"I sincerely appreciate the support and constructive feedback from the editors and reviewers, which have been invaluable in improving ..."
[Read more]
"I sincerely appreciate the support and constructive feedback from the editors and reviewers, which have been invaluable in improving the quality of my manuscript. The professionalism and dedication of the editorial team have made this a highly rewarding experience. I am truly pleased with the collaboration and look forward to future opportunities to contribute and work with the journal again. "
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Luong TV, Cao MTT, Nguyen NVD, Dang HNN, Nguyen TT. Roles of autophagy and long non-coding RNAs in gastric cancer. World J Gastroenterol 2025; 31(11): 101124
18
"I sincerely appreciate the opportunity to publish my article, Breaking the Cycle: Psychological and Social Dimensions of Pediatric ..."
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"I sincerely appreciate the opportunity to publish my article, Breaking the Cycle: Psychological and Social Dimensions of Pediatric Functional Gastrointestinal Disorders, in [Journal Name]. Thank you for your support, insightful feedback, and dedication to advancing pediatric research. I truly value your efforts in bringing this work to publication. Best regards, Prof. Mohammed Elbeltagi "
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Al-Beltagi M, Saeed NK, Bediwy AS, Elbeltagi R. Breaking the cycle: Psychological and social dimensions of pediatric functional gastrointestinal disorders. World J Clin Pediatr 2025; 14(2): 103323
19
"I sincerely appreciate the opportunity to publish my article on the role of human milk oligosaccharides (HMOs) during breastfeeding ..."
[Read more]
"I sincerely appreciate the opportunity to publish my article on the role of human milk oligosaccharides (HMOs) during breastfeeding in [Journal Name]. Thank you for your support, insightful feedback, and commitment to advancing scientific knowledge. I am grateful for your efforts in bringing this work to publication. Best regards, Prof. Mohammed Elbeltagi "
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Al-Beltagi M. Human milk oligosaccharide secretion dynamics during breastfeeding and its antimicrobial role: A systematic review. World J Clin Pediatr 2025; 14(2): 104797
20
"F6 system interface is very easy to use, peer review gave adequate input, the final paper looked really good, the editors were very ..."
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"F6 system interface is very easy to use, peer review gave adequate input, the final paper looked really good, the editors were very understanding. We are happy to publish Dr. Haifa's MSc thesis, and she was very proud to see her work being recognized. Everything was in its right place. Thanks! "
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Eldew H, Soldera J. Evaluation of biological therapies in autoimmune hepatitis: A case-based systematic review. World J Gastrointest Pathophysiol 2025; 16(1): 101481
18319 items Read more >>
1
"The study provides valuable insights into the mechanism by which DNMT1 promotes gastric cancer (GC) progression through miR-125a-5p ..."
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"The study provides valuable insights into the mechanism by which DNMT1 promotes gastric cancer (GC) progression through miR-125a-5p methylation, leading to increased SERPINE1 expression. The study extensively relies on in vitro models, with limited data from clinical samples. Expanding the analysis to include larger patient cohorts or diverse GC subtypes would enhance the reliability and translational relevance of the conclusions. Graphs and data presentation, particularly in figures depicting proliferation, migration, and invasion assays, could benefit from clear scale bars and consistent sample size labeling. The study identifies potential therapeutic targets (e.g., DNMT1 inhibitors), but a discussion on the challenges or feasibility of translating these findings into clinical practice is limited. Adding this perspective could strengthen the impact of the study. "
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Xie H, Wang H, Li RH, Zhang YW, Fan XR, He XX, Guan AR. DNMT1 promotes the proliferation and migration of gastric cancer cells by inducing microRNA-125a-5p methylation to promote SERPINE1 protein. World J Gastrointest Oncol 2025; 17(3): 98703
2
"The study successfully evaluates the three nodal staging systems and provides valuable insights for clinical practice. The study relies ..."
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"The study successfully evaluates the three nodal staging systems and provides valuable insights for clinical practice. The study relies heavily on pooled data; validating these findings with GC-specific clinical data from diverse populations would strengthen its applicability. The analysis merges groups with varying cutoff values, which could introduce bias. Standardizing criteria for cutoff values in future studies would improve reliability. While LODDS emerges as a strong prognostic predictor, the practical implementation of LODDS staging in routine clinical settings requires further exploration to bridge research and application gaps. The study holds promise, but addressing these areas would enhance its scientific impact and clinical relevance."
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Cheng M, Yu Y, Watanabe T, Yoshimoto Y, Kaji S, Yube Y, Kaneda M, Orita H, Mine S, Wu YY, Fukunaga T. Evaluation of three lymph node staging systems for prognostic prediction in gastric cancer: A systematic review and meta-analysis. World J Gastrointest Oncol 2025; 17(3): 98103
3
"The study effectively highlights the relationship between TMEM176B, the NLRP3 inflammasome, and EMT in CRC. Maybe, incorporating human ..."
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"The study effectively highlights the relationship between TMEM176B, the NLRP3 inflammasome, and EMT in CRC. Maybe, incorporating human clinical data or validating the findings in human CRC tissues would provide stronger evidence of TMEM176B's therapeutic potential in a real-world setting. Further, while the study demonstrates correlations, it would benefit from a deeper exploration of the molecular mechanisms linking TMEM176B, inflammasome inhibition, and EMT regulation. Overall, the findings are promising but require additional validation and mechanistic insights to solidify TMEM176B's role as a therapeutic target in CRC."
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Qian W, Xu CY, Hong W, Li ZM, Xu DG. Transmembrane protein 176B promotes epithelial-mesenchymal transition in colorectal cancer through inflammasome inhibition. World J Gastrointest Oncol 2025; 17(3): 97673
4
"Concise and well-structured editorial describing novel therapeutic strategies for the treatment of IgA nephropathy, including those ..."
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"Concise and well-structured editorial describing novel therapeutic strategies for the treatment of IgA nephropathy, including those based on B-cell-depleting immune therapies or complement system inhibitors. This is highly relevant, since IgA nephropathy represents the most prevalent form of primary glomerulonephritis worldwide. The disease often progresses to end-stage renal disease. Novel therapeutic options for IgA nephropathy are warranted because current treatments have limited effectiveness and can cause significant side effects.
"
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Şener YZ, Şener S. Treatment of immunoglobulin A nephropathy: Current perspective and future prospects. World J Clin Cases 2025; 13(19): 101196
5
"The article demonstrates strong scientific quality and credibility through its systematic approach to standardizing pathological ..."
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"The article demonstrates strong scientific quality and credibility through its systematic approach to standardizing pathological diagnostic processes for ESD specimens in China. Resolved issues include ethical approval and clear methodological descriptions of the "Drum Tower tissue strip processing method," supported by statistical rigor (McNemar’s test, P < 0.01). Results are compelling, showing significant post-training improvements in specimen photography (58% to 79%), embedding accuracy (62% to 92%), and lymphovascular invasion assessment (23% to 0%). Figures and tables are well-annotated, and references appropriately cite international guidelines and recent studies. However, unresolved issues include reliance on oral consent (vs. written), self-reported survey data risking bias, lack of control groups, and incomplete supplementary materials. Confounding variables (e.g., hospital resources) were unaddressed. For future research, the authors could enhance validity by adopting written consent, publishing supplementary materials, incorporating control groups, and performing multivariate analyses. These steps would strengthen generalizability and address current limitations, advancing both clinical practice and interdisciplinary collaboration in pathology."
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Xu C, Chen L, Feng AN, Nie L, Fu Y, Li L, Li W, Sun Q. Establishing and popularizing a standard pathological diagnostic model of endoscopic submucosal dissection specimens in China. World J Gastrointest Endosc 2025; 17(3): 101525
6
"This is a nicely written article. Apart from the information presented, the authors may have added the details about Combined ..."
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"This is a nicely written article. Apart from the information presented, the authors may have added the details about Combined Multichannel Intraluminal Impedance (MMI) and pH measurement. This has been found to be better than 24 hours pH monitoring alone.
Role of nuclear scan in the diagnosis of GERD may also be included whenever possible. "
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Raza D, Mohiuddin F, Khan MH, Fawad M, Raza SM. Childhood gastroesophageal reflux disease: A comprehensive review of disease, diagnosis, and therapeutic management. World J Clin Pediatr 2025; 14(2): 101175
7
"Risk factors for intrahepatic bile duct cancer include not only hepatitis B, but also hepatitis C, liver cirrhosis, drinking, diabetes, ..."
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"Risk factors for intrahepatic bile duct cancer include not only hepatitis B, but also hepatitis C, liver cirrhosis, drinking, diabetes, obesity, smoking, nonalcoholic fatty liver disease, liver fluke infection, primary sclerosing cholangitis, intrahepatic stones, congenital biliary dilatation (choledochal cyst), Caroline's disease, and inflammatory bowel disease. In Japan, we often experience cases of intrahepatic stones, especially cholangiocarcinoma in the atrophic lobe. The authors include Child-Pugh score, ECOG, hepatitis B, and tumor size in TO, but what about the item for intrahepatic stones?
"
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Huang TF, Luo C, Guo LB, Liu HZ, Li JT, Lin QZ, Fan RL, Zhou WP, Li JD, Lin KC, Tang SC, Zeng YY. Preoperative prediction of textbook outcome in intrahepatic cholangiocarcinoma by interpretable machine learning: A multicenter cohort study. World J Gastroenterol 2025; 31(11): 100911
8
"It was with pleasure that I tracked the quality of the following article:
1 Ethics: Not applicable given manuscript type
2 Methods: ..."
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"It was with pleasure that I tracked the quality of the following article:
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The figures/tables add to the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: The references are appropriate and up to date
7 Language: This is a detailed/well written review
8 Caveats or drawbacks: None"
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Kotsifa E, Saffioti F, Mavroeidis VK. Cholangiocarcinoma: The era of liquid biopsy. World J Gastroenterol 2025; 31(11): 104170
9
"Assessment of the Article
1. Ethics
The article does not provide an explicit ethical approval form, which is understandable as it ..."
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"Assessment of the Article
1. Ethics
The article does not provide an explicit ethical approval form, which is understandable as it is a mini-review rather than an empirical study involving human or animal subjects.
2. Methods
As a review article, the methods section focuses on the methodology of data collection rather than experimental procedures. The authors conducted a comprehensive search of peer-reviewed articles and preclinical studies using PubMed, Scopus, and Web of Science databases, with clear inclusion criteria. The methods used to collect and analyze the data are well-described and can be repeated by fellow researchers. The references provided offer adequate textual/citation content to support the findings.
3. Results
The results presented in the article are based on the findings of previously published studies. While the authors do not present new empirical data, they synthesize and interpret existing research to draw conclusions about the therapeutic potential of elafibranor in alcohol-associated liver disease. The theories and hypotheses discussed are partially validated by the cited preclinical and clinical studies. The results are true and authentic to the extent that they accurately reflect the current state of knowledge in the field.
4. Figures and Tables
The article contains one figure and one table that effectively illustrate the key mechanisms of elafibranor's action in alcohol-associated liver disease. The figure is well-constructed, annotated, and easy to understand. The table provides a concise summary of elafibranor's mechanisms and their benefits in ALD, which enhances the readability and comprehensibility of the review.
5. Biostatistics
As a review article, the focus is on the synthesis and interpretation of existing research rather than the presentation of new biostatistical data. The authors do not provide tables or line charts with biostatistical data. Instead, they discuss the results of previous studies and their implications for elafibranor's therapeutic potential.
6. References
The authors scientifically and reasonably cite the latest references in the field of alcohol-associated liver disease and related scientific problems. The references cover a wide range of topics, including the pathogenesis of ALD, the role of macrophages, and the preclinical and clinical studies of elafibranor. The authors do not appear to self-cite, omit, mis-cite, or over-cite references.
7. Language
The language in the article is clear, concise, and accurate. The information is presented in a logical and well-organized manner. The article does not contain multiple grammatical or spelling mistakes, which enhances its readability and credibility.
8. Caveats or Drawbacks
While the article provides a comprehensive review of elafibranor's therapeutic potential in ALD, it is important to note that the majority of the evidence is based on preclinical studies. Clinical trials are ongoing, and the long-term safety and efficacy of elafibranor in humans remain to be established. Additionally, the heterogeneity of ALD patients and the complexity of the disease pathogenesis may limit the generalizability of the findings. These caveats should be considered when interpreting the results of the review.
"
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Farhadi S, Mohammadi S, AlKindi AY, Al-Amri IS. Therapeutic potential of elafibranor in alcohol-associated liver disease: Insights into macrophage modulation and fibrosis reduction. World J Biol Chem 2025; 16(1): 104535
10
"This article explores the development of both 2D and 3D osteogenic coculture models to investigate the dynamic interactions between ..."
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"This article explores the development of both 2D and 3D osteogenic coculture models to investigate the dynamic interactions between macrophages and ADSCs. It highlights possible mechanisms governing osteogenesis and immune modulation, offering valuable insights into bone tissue engineering and regenerative medicine. However, integrating novel and advanced methodologies, along with the potential for futuristic in vivo translation and a critical evaluation of existing limitations, could further clarify the significance of the findings."
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Zhang HA, Zhang BY, Tang HB. Effects of macrophages on the osteogenic differentiation of adipose tissue-derived stem cells in two-dimensional and three-dimensional cocultures. World J Stem Cells 2025; 17(2): 99326
11
"It is a well-designed study that presents evidence for WDR36’s inhibitory role in the osteogenic differentiation and migration of ..."
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"It is a well-designed study that presents evidence for WDR36’s inhibitory role in the osteogenic differentiation and migration of PDLSCs. The microscopic images are of good quality and effectively illustrate the findings. However, improving the quality of western blots and providing stronger quantification would further enhance the impact and readability of the manuscript "
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Wang Y, Zhang FQ, Fan ZP, Zhu XL, Yan WH, Zhang XL. WDR36 inhibits the osteogenic differentiation and migration of periodontal ligament stem cells. World J Stem Cells 2025; 17(2): 99132
12
"It is a good review with high-quality illustrations. This article describes various stem cell-based and exosome-based therapeutic ..."
[Read more]
"It is a good review with high-quality illustrations. This article describes various stem cell-based and exosome-based therapeutic possibilities for skeletal muscle atrophy, highlighting their potential in regeneration and functional recovery. The comprehensive insights into emerging strategies make it a valuable resource for advancing regenerative medicine approaches in muscle disorders. However, the concluding remarks on the superiority of stem cell therapy over other treatment options remain open for further exploration."
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Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693
13
"It is a good article, highlighting the use of NAD⁺ to boost the viability of BM-MSCs, offering a promising therapeutic strategy for ..."
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"It is a good article, highlighting the use of NAD⁺ to boost the viability of BM-MSCs, offering a promising therapeutic strategy for regenerative medicine and immune modulation. As this study primarily relies on in vitro models, the cost and affordability of MSC treatments, along with other cost-effective alternatives, raise important considerations for widespread clinical application."
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Xia X, Zhou K, An LY, Zhao M, Tian BL, Zhao JY, Zhou ZG, Tong Y. Nicotinamide adenine dinucleotide rejuvenates septic bone marrow mesenchymal stem cells. World J Stem Cells 2025; 17(2): 96893
14
"This article reviewed the advances in the diagnosis and management of
coronary microvascular dysfunction focusing on the patients ..."
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"This article reviewed the advances in the diagnosis and management of
coronary microvascular dysfunction focusing on the patients who underwent PCI.
I think the following two explanation could be added for this excellent review article.
The authors admirably discussed the pathophysiology and metabolic risk interactions.
However, the authors did not refer the (epicardial) coronary artery spasm as one of the causes of post PCI myocardial ischemia. I think epicardial coronary spasm is often associated with epicardial coronary stenosis which is physiologically significant. In these patients, chest pain occurs often even after PCI even if there is no coronary microvascular dysfunction.
Coronary microvascular dysfunction might be classified into two groups. One group is recognized also before PCI, and the other occurred only after PCI in cases such as acute coronary syndrome (no reflow phenomenon).
"
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Tang N, Li KM, Li HR, Zhang QD, Hao J, Qi CM. Advances in the diagnosis and management of post-percutaneous coronary intervention coronary microvascular dysfunction: Insights into pathophysiology and metabolic risk interactions. World J Cardiol 2025; 17(2): 103950
15
"Indeed, TIPS is an interventional radiological procedure that significantly reduces portal pressure, prevents decompensation and ..."
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"Indeed, TIPS is an interventional radiological procedure that significantly reduces portal pressure, prevents decompensation and improves survival of cirrhotic patients. The authors provided interesting but very limited information about the TIPS as a method for the treatment of portal hypertension complications. For example, the main TIPS-related problems, namely shunt dysfunction and post-TIPS hepatic encephalopathy, have not been considered at all."
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de Mattos AA, de Mattos AZ, Manica M, Tovo CV. Which patients benefit the most? An update on transjugular intrahepatic portosystemic shunt. World J Hepatol 2025; 17(2): 99809
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"1. Ethics:
The ethical approval for this study is mentioned as granted by the Ethics Committee of Xuzhou Central Hospital.
2. ..."
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"1. Ethics:
The ethical approval for this study is mentioned as granted by the Ethics Committee of Xuzhou Central Hospital.
2. Methods:
The study is a retrospective comparative study analyzing 123 patients treated with either microwave ablation (MWA) or laparoscopic hepatectomy (LH). The inclusion and exclusion criteria are clearly outlined. The treatment protocols for both procedures are well described, making it possible for other researchers to replicate the methods.
3. Results:
The results indicate that MWA has advantages over LH, with shorter operative time, lower intraoperative bleeding, and faster recovery. The study shows statistically significant differences in postoperative complications (4.84% in the MWA group vs. 19.67% in the LH group, P = 0.012). The effective rate of treatment was also significantly higher in the MWA group (P = 0.027).
However, long-term survival outcomes such as recurrence-free survival (RFS) or overall survival (OS) are expected.
4. Figures and Tables:
The manuscript contains clear tables and well-labeled figures comparing perioperative indicators and postoperative outcomes. Data is systematically structured, and statistical significance is appropriately indicated (P values provided).
5. Biostatistics:
The study employs basic statistical methods (t-test, χ² test) to compare continuous and categorical variables. The analysis appears appropriate, but there are no multivariate analyses to control for confounders, which is a limitation.
6. References:
The references include recent and relevant studies, particularly those from Nature Reviews Gastroenterology & Hepatology, Hepatology, and World Journal of Gastrointestinal Surgery.
7. Language and Clarity:
The manuscript is written in clear and professional English, with minimal grammatical errors. However, some sentences are redundant or could be more concise, particularly in the discussion.
The study provides valuable short-term comparative data on MWA vs. LH for primary small liver cancer. However, the lack of long-term follow-up and absence of multivariate analysis limits the strength of its conclusions. The authors should be encouraged to include propensity score matching, long-term survival data, and quality-of-life outcomes in future studies."
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Li HS, Zhang XF, Fu J, Yuan B. Efficacy of microwave ablation vs laparoscopic hepatectomy for primary small liver cancer: A comparative study. World J Gastrointest Surg 2025; 17(3): 101786
17
"1. Ethics
The ethical approval process is clearly documented.
2. Methods
The case report aligns with typical diagnostic and ..."
[Read more]
"1. Ethics
The ethical approval process is clearly documented.
2. Methods
The case report aligns with typical diagnostic and therapeutic workflows for CHD and PE. However, methodological details could be improved further (e.g., specific criteria for selecting CABG over other interventions, anticoagulant dosing protocols).
3. Results
Results are consistent with clinical findings (elevated D-dimer, CTPA-confirmed PE, CAG-confirmed CHD).
Limitation: No long-term follow-up data beyond 2 months.
4. Figures and Tables
Figures clearly demonstrate the patient’s progression and treatment response.
5. Biostatistics
Not applicable to this case report, as no statistical analysis was performed.
6. References
Citations include key guidelines and recent studies. References support the discussion of overlapping CHD/PE symptoms and treatment strategies.
7. Language
The language is generally clear and professional.
8. Caveats or Drawbacks
Relative sShort follow-up period."
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Xu JQ, Jiang MX, Wang F, Yang KQ, Xu YJ, Wang YJ, Dong SJ. Coronary heart disease with pulmonary embolism: A case report. World J Cardiol 2025; 17(2): 101588
18
"The topic is of great interest. Assessment of VOCs is novel, non-ivasive approach to diagnose cardiovascular disease such as ischemic ..."
[Read more]
"The topic is of great interest. Assessment of VOCs is novel, non-ivasive approach to diagnose cardiovascular disease such as ischemic heart disease and heart failure. It is also important to help secandary prevention of such diseases. However we need some more data and advanced technologies for assessement of VOCs. In this perspective, thie review is worth reading. "
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Marzoog BA, Chomakhidze P, Gognieva D, Parunova AY, Demchuk SN, Silantyev A, Kuznetsova N, Kostikova A, Podgalo D, Nagornov E, Gadzhiakhmedova A, Kopylov P. Updates in breathomics behavior in ischemic heart disease and heart failure, mass-spectrometry. World J Cardiol 2025; 17(2): 102851
19
"The authors reported substantial findings regarding novel predictibe biomarler for ACS based on the calculation of RBC width to albumin ..."
[Read more]
"The authors reported substantial findings regarding novel predictibe biomarler for ACS based on the calculation of RBC width to albumin ratio. The aim of the study is clear and the paper is well written. The manuscript has high relevance and adequacy of the literature presented, including recognition of gaps in knowledge, interpretation of findings and significance of other recent research on the topic, and readable conclusion. The findings are based on the relevant statistics, while the weaknes of the study was a retrospective design. However, the authors obtained promising results which are likely to be implemented in clinical practice without sufficient economic expenditure. Overall, the article scientifically sounds and contributes to the reader attractivity. I congratulate the authors on the study."
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Wang JN, Hu ZS, Yu YW, Peng XH. Red blood cell distribution width to albumin ratio is correlated with prognosis of patients in coronary care unit. World J Cardiol 2025; 17(2): 103273
20
"• Echinococcosis is a parasitic disease caused by tapeworms of the genus Echinococcus. It can be transmitted to humans from animals, ..."
[Read more]
"• Echinococcosis is a parasitic disease caused by tapeworms of the genus Echinococcus. It can be transmitted to humans from animals, making it a zoonotic disease. Treatment options include surgery, albendazole, and PAIR (puncture, aspiration, injection, re-aspiration).Please comment about PAIR. The diagnosis of echinococcosis relies mainly on findings by ultrasonography and/or other imaging techniques supported by positive serologic test. I ask you .
What kinds of examination do you performed for seronegative patients with hepatic image findings compatible with echinococcosis。
"
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Pavlidis ET, Galanis IN, Pavlidis TE. Current considerations for the management of liver echinococcosis. World J Gastroenterol 2025; 31(10): 103973
15136 items Read more >>
Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2267
- Peer-reviewers
- 29499
- Manuscripts received today
- 9
- Manuscript reviews today
- 9
- Unhandled manuscripts today
- 143
- Active peer-reviewers today
- 0
- Reviewer acceptance today
- 6
- Reviewer refusals today
- 14
- Total accepted manuscripts
- 35348
- Total rejected manuscripts
- 40886
- Total peer-reviewers
- 4111146
- Total submissions
- 33611
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1
"The author has constructed a predictive model with strong forecasting capabilities, designed to estimate the probability of a textbook ..."
[Read more]
"The author has constructed a predictive model with strong forecasting capabilities, designed to estimate the probability of a textbook outcome following surgery. Additionally, the study elucidates the machine learning computational process using the SHAP algorithm. This research is highly innovative, as it visualizes the otherwise opaque computational processes of machine learning, thereby enhancing its credibility. Clinicians can easily input specific clinical parameters of patients to obtain immediate, personalized risk assessments, enabling timely preventive measures and ensuring the best possible medical care for patients.This study substantiates the feasibility of explainable machine learning in future applications, marking a new direction in the research of predictive models and supervised learning. "
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Huang TF, Luo C, Guo LB, Liu HZ, Li JT, Lin QZ, Fan RL, Zhou WP, Li JD, Lin KC, Tang SC, Zeng YY. Preoperative prediction of textbook outcome in intrahepatic cholangiocarcinoma by interpretable machine learning: A multicenter cohort study. World J Gastroenterol 2025; 31(11): 100911
2
"This study provides valuable insights into the effectiveness of combining three-dimensional computed tomography (3D CT) reconstruction ..."
[Read more]
"This study provides valuable insights into the effectiveness of combining three-dimensional computed tomography (3D CT) reconstruction and laparoscopic techniques for accurately measuring the myopectineal orifice (MPO) in inguinal hernia repair. The research clearly demonstrates that preoperative 3D CT measurements closely match intraoperative laparoscopic findings, suggesting that CT could reliably guide surgical planning. The authors effectively highlight the clinical implications, emphasizing how precise measurement and patch placement can minimize complications such as nerve injury, recurrence, and chronic postoperative pain. Additionally, they provide a thoughtful analysis regarding demographic factors, noting significant differences in MPO measurements between sexes, while age and body mass index showed less impact. One of the strengths of this article is its detailed methodological description, which facilitates replication and further research. However, future studies might benefit from larger sample sizes and expanded demographic variability to enhance generalizability. Overall, the paper makes a significant contribution to personalized surgical approaches for inguinal hernia treatment. "
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Zhang L, Chen J, Zhang YY, Liu L, Wang HD, Zhang YF, Sheng J, Hu QS, Liu ML, Yuan YL. Three-dimensional reconstruction under computed tomography and myopectineal orifice measurement under laparoscopy for quality control of inguinal hernia treatment. World J Gastrointest Endosc 2025; 17(3): 104966
3
"As this is a editorial article, it has got no sections of methods, results, tables, biostatistics, units and ethical statement to ..."
[Read more]
"As this is a editorial article, it has got no sections of methods, results, tables, biostatistics, units and ethical statement to provide commentary on these sections. The editorial by Behrens and Elgafy provides an insightful analysis of factors influencing outcomes in indirect decompression through oblique and lateral lumbar interbody fusions (OLIF and LLIF). The discussion on patient selection criteria, particularly regarding preoperative spinal canal dimensions and lateral recess depth, is a valuable contribution to clinical decision-making. The emphasis on the unpredictability of outcomes in patients with severe lateral recess stenosis and the potential need for staged procedures highlights a crucial consideration for spine surgeons. However, one area that could benefit from further exploration is the long-term stability of indirect decompression compared to direct decompression, especially concerning adjacent segment disease and fusion longevity. Additionally, a deeper comparison of OLIF and LLIF in terms of specific complications and recovery trajectories would provide even greater clinical relevance. Overall, this editorial offers a comprehensive and well-referenced synthesis of the current literature on indirect decompression. It serves as a useful guide for surgeons considering minimally invasive approaches while remaining cautious about their limitations. "
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M Behrens KM, Elgafy H. Factors affecting outcomes of indirect decompression after oblique and lateral lumbar interbody fusions. World J Orthop 2025; 16(3): 100772
4
"The clinical significance of this study lies in its innovative approach to predicting colorectal polyp recurrence using machine ..."
[Read more]
"The clinical significance of this study lies in its innovative approach to predicting colorectal polyp recurrence using machine learning (ML), specifically the eXtreme Gradient Boosting (XGBoost) model. Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, largely preventable through early detection and effective management of precancerous polyps. Endoscopic mucosal resection (EMR) is widely utilized for the removal of colorectal polyps, yet it carries a considerable risk of recurrence, highlighting the need for accurate predictive tools to guide postoperative surveillance. This study identifies critical independent risk factors for polyp recurrence one year post-EMR, such as age, family history, smoking habits, diarrhea, Helicobacter pylori infection, polyp size, number of polyps, and hazard classification. By leveraging ML algorithms, particularly XGBoost, the researchers have developed a model with superior predictive performance, evidenced by high Area Under the Curve (AUC) values exceeding 0.90 across multiple validation cohorts, including a prospective validation set, indicating robust predictive accuracy and clinical utility. Clinically, the XGBoost model offers substantial advantages. Its high sensitivity, specificity, accuracy, precision, and F1 scores suggest that it effectively stratifies patients based on recurrence risk. Such a model significantly enhances personalized patient management by informing more accurate follow-up intervals, potentially improving patient outcomes through timely interventions and reducing unnecessary colonoscopies in low-risk individuals. Additionally, the authors' development of an accessible online web calculator based on this predictive model further underscores its practical utility in routine clinical practice. Clinicians can conveniently input patient-specific clinical parameters to obtain immediate, individualized risk predictions, facilitating shared decision-making between physicians and patients. Decision Curve Analysis further underscores the practical value of this tool, demonstrating that using the XGBoost model provides superior clinical net benefit compared to standard follow-up strategies. This methodical approach not only advances clinical decision-making but also optimizes healthcare resources by prioritizing surveillance for those most at risk. Finally, the interpretability of the model via SHapley Additive exPlanations (SHAP) analysis significantly mitigates concerns about the "black box" nature commonly associated with ML models, thus increasing clinician trust and acceptability. In conclusion, this ML-based predictive model represents a critical advancement in clinical gastroenterology, providing robust, data-driven support for clinicians in making individualized recommendations for colorectal polyp surveillance and potentially reducing colorectal cancer incidence through targeted early intervention. "
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Huang TF, Luo C, Guo LB, Liu HZ, Li JT, Lin QZ, Fan RL, Zhou WP, Li JD, Lin KC, Tang SC, Zeng YY. Preoperative prediction of textbook outcome in intrahepatic cholangiocarcinoma by interpretable machine learning: A multicenter cohort study. World J Gastroenterol 2025; 31(11): 100911
5
"The author has shown that knocking out SERPINB5 not only inhibits the proliferation and metastasis of cancer cells but also suppresses ..."
[Read more]
"The author has shown that knocking out SERPINB5 not only inhibits the proliferation and metastasis of cancer cells but also suppresses tumor growth in xenograft mice, effectively reducing tumor progression. This suggests that SERPINB5 could potentially serve as an important target for tumor treatment. We sincerely appreciate the author's dedication and hard work. The quality of this article is truly outstanding, and we eagerly look forward to your next research contribution. "
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Meng ZS, Hu JT, Wu H, Li BK. Inhibition of the SERPINB5/HSP90AA1 axis restrains the proliferation and invasion of rectal cancer. World J Gastroenterol 2025; 31(11): 103412
6
"This study provides valuable data specifically focused on endoscopic resection (ER) of esophageal GISTs. Thorough evaluation of the ..."
[Read more]
"This study provides valuable data specifically focused on endoscopic resection (ER) of esophageal GISTs. Thorough evaluation of the ER technique, complications, and resection margin status enhances our understanding of ER safety and effectiveness. Furthermore, the study presented a relatively large case series of 32 patients, which increases the statistical reliability of the findings for esophageal GIST research. By presenting long-term follow-up results, it assessed the long-term prognosis after ER and suggested potential benefits for future treatment strategy development. "
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Xu EP, Qi ZP, Zhang JW, Li B, Ren Z, Cai MY, Cai SL, Lv ZT, Chen ZH, Liu JY, Zhong YS, Zhou PH, Shi Q. Endoscopic treatment outcome of oesophageal gastrointestinal stromal tumours. World J Gastroenterol 2025; 31(10): 102393
7
"We greatly appreciate the authors and their team for their in-depth study on treatment strategies for rectal neuroendocrine neoplasms ..."
[Read more]
"We greatly appreciate the authors and their team for their in-depth study on treatment strategies for rectal neuroendocrine neoplasms (R-NENs). This retrospective analysis compares the efficacy of endoscopic full-thickness resection (EFTR) and endoscopic submucosal dissection (ESD) in the treatment of R-NENs, demonstrating the superior R0 resection rate of EFTR while maintaining comparable short-term safety with ESD. This study provides critical clinical evidence supporting the use of EFTR in R-NENs and contributes to the refinement of function-preserving surgical approaches. However, we would like to offer some constructive suggestions to enhance the clinical applicability and long-term evaluation of this study. First, some terminology and definitions in the study are somewhat ambiguous, which may affect the interpretability of the results. For instance, the study mentions that some patients had "severe comorbidities" but does not specify the types of comorbidities or the inclusion/exclusion criteria applied. Certain comorbidities, such as diabetes or chronic kidney disease, may impact postoperative healing, and failing to differentiate them could introduce confounding among patients with varying risk profiles. Additionally, the description of lesion morphology is inherently subjective, and the study does not clarify whether standardized imaging assessments, such as endoscopic ultrasound (EUS), were used to measure lesion size and invasion depth. Inconsistencies in preoperative evaluation criteria could lead to bias in treatment selection. For example, was EFTR preferentially chosen for lesions with specific morphological characteristics? Future studies should adopt more detailed imaging assessment criteria and pathological grading methods to improve reproducibility and the interpretability of results. Second, the study does not assess the impact of the learning curve for EFTR and ESD on surgical outcomes. As a relatively novel technique, EFTR may require a longer period of experience accumulation to achieve stable performance. The study does not clarify whether operator experience was comparable between the EFTR and ESD groups or whether surgical success rates varied with increasing experience. If EFTR procedures were performed by highly experienced endoscopists while ESD procedures involved a broader range of operators, the results could be biased in favor of EFTR. Additionally, since EFTR has a steeper learning curve, factors such as procedure time and complication rates may decrease with increased experience, but the study does not conduct a dynamic analysis of these trends. Future studies should incorporate learning curve analyses to evaluate the influence of experience on surgical outcomes, ensuring a fair comparison between the two techniques. Furthermore, EFTR may cause greater bowel wall injury than ESD, potentially affecting postoperative bowel function, yet this study focuses primarily on R0 resection rates and short-term complications without assessing long-term functional outcomes. As a full-thickness resection technique, EFTR may alter rectal compliance, bowel movement frequency, and gut motility. However, the study does not provide data on postoperative bowel function changes, alterations in defecation patterns, bloating, or incontinence. If EFTR improves R0 resection rates but increases the risk of postoperative functional impairment, its clinical utility must be considered more cautiously. Future research should incorporate patient-reported outcomes (PROs) and quality of life (QoL) assessments and include long-term functional evaluations such as anorectal manometry and bowel dysfunction scoring to comprehensively assess the impact of EFTR on patient prognosis. "
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Zhang XL, Jiang YY, Chang YY, Sun YL, Zhou Y, Wang YH, Dou XT, Guo HM, Ling TS. Endoscopic full-thickness resection: A definitive solution for local complete resection of small rectal neuroendocrine neoplasms. World J Gastroenterol 2025; 31(10): 100444
8
"This is a well-constructed and well-written review, which gives readers with a general bioscience background updated information about ..."
[Read more]
"This is a well-constructed and well-written review, which gives readers with a general bioscience background updated information about the stem cell application in liver diseases (fatty liver diseases and steatohepatitis). The language is fluent, and the references are up to date. It will be easier for readers to understand the concepts if the authors provide a table to compare the 2D model with the 3D model. It will be helpful to include the abbreviation for each key word. "
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Silva B, Bragança J. Induced pluripotent stem cell-derived mesenchymal stem cells for modeling and treating metabolic associated fatty liver disease and metabolic associated steatohepatitis: Challenges and opportunities. World J Stem Cells 2025; 17(2): 99331
9
"The authors should provide adequate legends for each figure. Some parts of the paper are just a listing of facts and are poorly ..."
[Read more]
"The authors should provide adequate legends for each figure. Some parts of the paper are just a listing of facts and are poorly organized or discussed. The table in the paper is well organized and suited. A table to compare the pros and cons of different kinds of stem cells for muscle atrophy therapy will be helpful. "
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Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693
10
"Stem Cell Therapy: A New Hope for Patients with Skeletal Muscle Atrophy? Skeletal muscle atrophy refers to the reduction or loss of ..."
[Read more]
"Stem Cell Therapy: A New Hope for Patients with Skeletal Muscle Atrophy? Skeletal muscle atrophy refers to the reduction or loss of muscle fibers due to nutritional deficiencies or diseases, leading to a decline in muscle mass. Current studies indicate that skeletal muscle atrophy is closely associated with an imbalance between protein synthesis and degradation, driven by multiple factors such as inflammation, oxidative stress, autophagy, and apoptosis [1-3]. Due to the complexity of its molecular mechanisms, effective therapeutic strategies are lacking, and traditional approaches like rehabilitation training and pharmacological interventions show limited efficacy. Therefore, exploring more effective treatments is imperative. Stem cell therapy, with its unique regenerative potential and immunomodulatory properties, offers a promising avenue for treating this condition. In the current issue of the World Journal of Stem Cells, Ying-Jie Wang and colleagues published a review titled "Stem Cell Therapy: A Promising Therapeutic Approach for Skeletal Muscle Atrophy." The article summarizes the molecular mechanisms of muscle atrophy and highlights the applications of mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and their derivatives (e.g., exosomes) in treating skeletal muscle atrophy. These stem cells exert therapeutic effects by modulating inflammation, promoting angiogenesis, suppressing oxidative stress, and facilitating muscle regeneration. The authors also address challenges in clinical translation, including immune rejection, tumorigenic risks, inefficient stem cell homing, and the absence of standardized protocols. Despite these hurdles, the review expresses optimism about the future of stem cell therapy, particularly emphasizing the superior potential of stem cell-derived acellular therapies (e.g., exosomes) over traditional cell transplantation. We maintain a cautiously optimistic view regarding the prospects of stem cell therapy for skeletal muscle atrophy. While stem cell-based approaches, especially MSC- and exosome-based strategies, demonstrate promising safety and efficacy [4, 5], several issues must be resolved. These include addressing heterogeneity in stem cell sources, ensuring long-term safety, and establishing standardized protocols for clinical translation. Although iPSCs circumvent ethical concerns, their differentiation and purification techniques require optimization, and potential genetic mutations remain a concern. Exosomes, as acellular therapeutics, may reduce immune reactions; however, challenges in large-scale production and quality control persist. Therapeutic Potential of Stem Cells Stem cell therapy exhibits multidimensional potential in treating muscle atrophy. First, its mechanisms are highly synergistic: MSCs and iPSCs improve the muscle microenvironment by regulating inflammatory cytokines (e.g., suppressing IL-6 and TNF-α), promoting angiogenesis, inhibiting oxidative stress, and enhancing autophagy. Exosomes further amplify therapeutic effects by delivering functional miRNAs (e.g., miR-132-3p/FoxO3 axis) to delay protein degradation and stimulate regeneration [4, 6]. Second, exosomes as acellular carriers broaden clinical applicability: MSC-derived exosomes (e.g., hUC-MSC-Exos, ADSC-Exos) avoid immune rejection and tumorigenic risks associated with live cell transplantation. Their high biocompatibility and cargo of bioactive molecules (e.g., circHIPK3, AMPK/ULK1 regulators) enable targeted intervention in diabetes- or neuropathy-related atrophy, positioning them as pivotal tools for clinical translation [6, 7]. Third, iPSCs hold exceptional promise for personalized medicine. Their ability to differentiate into myogenic progenitor cells (MPCs) or motor neurons facilitates the reconstruction of neuromuscular junctions, offering precise repair for genetic atrophy (e.g., facioscapulohumeral muscular dystrophy, FSHD). While autologous iPSCs mitigate immune rejection, clinical application demands improved differentiation efficiency and safety [8, 9]. Current Challenges and Solutions Clinical translation of stem cell therapy faces multiple challenges requiring innovative solutions. First, heterogeneity and standardization: MSC efficacy varies with donor age, tissue source (e.g., bone marrow, adipose, umbilical cord), and culture conditions [10]. Establishing unified quality control standards—via surface marker screening, secretome profiling, and single-cell sequencing—is critical to identify functional subpopulations and enable precision manufacturing [11]. Second, genetic instability and differentiation inefficiency hinder iPSC applications: reprogramming-induced mutations and inconsistent differentiation protocols (transgene-dependent or -independent) limit reliability [12]. Integrating non-integrative methods (e.g., mRNA reprogramming) and 3D organoid culture systems may optimize differentiation pathways [8]. Third, exosome scalability and targeting: natural exosomes suffer from low bioactive content and short half-lives. Engineering strategies (e.g., ligand modification or drug loading) can enhance tissue-specific delivery [13, 14], while microfluidic-nanocarrier systems may resolve production bottlenecks. Finally, accelerating clinical translation: preclinical studies predominantly rely on animal models; multicenter trials are needed to validate long-term safety (e.g., tumorigenicity, immune tolerance) [15, 16]. Combining stem cell therapy with anti-inflammatory agents (e.g., IL-1β inhibitors), rehabilitation, or gene editing (e.g., CRISPR-Cas9) may synergistically enhance efficacy [17, 18]. Future Directions Future research should prioritize interdisciplinary integration and precision strategies. First, mechanistic insights: single-cell and spatial transcriptomics can unravel dynamic interactions between stem cells and the muscle microenvironment (e.g., satellite cells, macrophages), identifying key regulatory nodes (e.g., Wnt/β-catenin, PI3K/Akt pathways) [3, 19]. Second, biomaterial innovations: smart hydrogels or electroconductive scaffolds combined with localized stem cell/exosome delivery systems could enhance homing efficiency and functional persistence [20, 21]. Third, personalized approaches: tailored therapies based on disease-specific etiologies (e.g., ALS, diabetic atrophy) and molecular subtypes (e.g., inflammatory signatures) are essential. For instance, AMPK-activated umbilical cord MSCs may rectify metabolic dysregulation in diabetic atrophy [22, 23]. Lastly, ethical and regulatory frameworks: international guidelines must standardize stem cell therapies and clarify regulatory classifications (e.g., exosomes as "drugs") to accelerate clinical translation. Stem cell therapy for skeletal muscle atrophy is transitioning from bench to bedside, yet critical hurdles—standardization, safety, and efficacy validation—remain. Integrating multidisciplinary technologies (e.g., synthetic biology, bioinformatics) and advancing translational research will bridge the gap between "laboratory breakthroughs" and "patient benefits." References: 1. Zhang, H., et al., Oxidative stress: Roles in skeletal muscle atrophy. Biochem Pharmacol, 2023. 214: p. 115664. 2. Ji, Y., et al., Inflammation: Roles in Skeletal Muscle Atrophy. Antioxidants (Basel), 2022. 11(9). 3. Liang, W., et al., Epigenetic control of skeletal muscle atrophy. Cell Mol Biol Lett, 2024. 29(1): p. 99. 4. Huang, Z., et al., Skeletal Muscle Atrophy Was Alleviated by Salidroside Through Suppressing Oxidative Stress and Inflammation During Denervation. Front Pharmacol, 2019. 10: p. 997. 5. Song, J., et al., Mesenchymal stromal cells ameliorate diabetes-induced muscle atrophy through exosomes by enhancing AMPK/ULK1-mediated autophagy. J Cachexia Sarcopenia Muscle, 2023. 14(2): p. 915-929. 6. Archacka, K., et al., Hypoxia preconditioned bone marrow-derived mesenchymal stromal/stem cells enhance myoblast fusion and skeletal muscle regeneration. Stem Cell Res Ther, 2021. 12(1): p. 448. 7. Leong, J., et al., Surface Tethering of Inflammation-Modulatory Nanostimulators to Stem Cells for Ischemic Muscle Repair. ACS Nano, 2020. 14(5): p. 5298-5313. 8. Kim, H., et al., Genomic Safe Harbor Expression of PAX7 for the Generation of Engraftable Myogenic Progenitors. Stem Cell Reports, 2021. 16(1): p. 10-19. 9. Azzag, K., et al., Transplantation of PSC-derived myogenic progenitors counteracts disease phenotypes in FSHD mice. NPJ Regen Med, 2022. 7(1): p. 43. 10. Li, J., et al., The heterogeneity of mesenchymal stem cells: an important issue to be addressed in cell therapy. Stem Cell Res Ther, 2023. 14(1): p. 381. 11. Oguma, Y., et al., Single-cell RNA sequencing reveals different signatures of mesenchymal stromal cell pluripotent-like and multipotent populations. iScience, 2022. 25(11): p. 105395. 12. Shamsian, A., et al., Cancer cells as a new source of induced pluripotent stem cells. Stem Cell Res Ther, 2022. 13(1): p. 459. 13. Rezaie, J., et al., Mesenchymal stem cells derived extracellular vesicles: A promising nanomedicine for drug delivery system. Biochem Pharmacol, 2022. 203: p. 115167. 14. Yang, Q., et al., Exosomes-loaded electroconductive nerve dressing for nerve regeneration and pain relief against diabetic peripheral nerve injury. Bioact Mater, 2023. 26: p. 194-215. 15. Drela, K., et al., Experimental Strategies of Mesenchymal Stem Cell Propagation: Adverse Events and Potential Risk of Functional Changes. Stem Cells Int, 2019. 2019: p. 7012692. 16. Deuse, T., et al., Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients. Nat Biotechnol, 2019. 37(3): p. 252-258. 17. Iyer, S.R., et al., Exosomes Isolated From Platelet-Rich Plasma and Mesenchymal Stem Cells Promote Recovery of Function After Muscle Injury. Am J Sports Med, 2020. 48(9): p. 2277-2286. 18. Chang, M., et al., Duchenne muscular dystrophy: pathogenesis and promising therapies. J Neurol, 2023. 270(8): p. 3733-3749. 19. Sartori, R., V. Romanello, and M. Sandri, Mechanisms of muscle atrophy and hypertrophy: implications in health and disease. Nat Commun, 2021. 12(1): p. 330. 20. Luo, W., et al., Biomaterials-Based Technologies in Skeletal Muscle Tissue Engineering. Adv Healthc Mater, 2024. 13(18): p. e2304196. 21. Shan, Y., et al., Pharmacokinetic characteristics of mesenchymal stem cells in translational challenges. Signal Transduct Target Ther, 2024. 9(1): p. 242. 22. Shen, Y., et al., Diabetic Muscular Atrophy: Molecular Mechanisms and Promising Therapies. Front Endocrinol (Lausanne), 2022. 13: p. 917113. 23. Yeo, C.J.J., E.F. Tizzano, and B.T. Darras, Challenges and opportunities in spinal muscular atrophy therapeutics. Lancet Neurol, 2024. 23(2): p. 205-218. "
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Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693
11
"Top-down therapy for Crohn's disease (CD) involves starting with the most potent medications, such as biologics and immunomodulators, ..."
[Read more]
"Top-down therapy for Crohn's disease (CD) involves starting with the most potent medications, such as biologics and immunomodulators, immediately after early diagnosis. This strategy may lead to rapid induction of remission, promotion of mucosal healing, prevention of complications, and reduced need for surgery. However, the background factors influencing this top-down therapy have not been sufficiently examined. A recent report on a Japanese cohort found that factors significantly associated with the recent top-down treatment approach were male gender, perianal lesions, no immunomodulators, and anti-tumor necrosis factor therapy. (Miyoshi J, Yoon A, Matsuura M, Hisamatsu T. Real-world use of biologics during the first year of treatment for newly diagnosed Crohn's disease in Japan: a claims analysis from 2010 to 2021. Intest Res. 2025 [PMID: 39848334 DOI: 10.5217/ir.2024.00082]) Top-down therapy for CD should be considered case-by-case, weighing potential benefits against risks and costs. As the authors suggest, identifying patients with a high genetic predisposition for CD may help predict their response to medications, the risk of side effects, and the cost-effectiveness. Further investigation in this area is desirable. "
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Fan YH, Wang MW, Gao YN, Li WM, Jiao Y. Genetic and environmental factors influencing Crohn’s disease. World J Gastrointest Surg 2025; 17(3): 98526
12
"Suggested Title:From Weakness to Wellness: The Role of Stem Cells in Muscle Atrophy Recovery A. Clarity and Conciseness • Some ..."
[Read more]
"Suggested Title:From Weakness to Wellness: The Role of Stem Cells in Muscle Atrophy Recovery A. Clarity and Conciseness • Some sections, particularly those on molecular mechanisms, are dense and could benefit from simplification or restructuring. B. Novelty and Critical Analysis • The review summarizes existing knowledge well but lacks critical analysis of conflicting findings. • Consider discussing limitations of existing studies, such as sample size issues in preclinical models, potential biases, and reproducibility concerns. • More emphasis could be placed on recent breakthroughs or innovative approaches in stem cell therapy, particularly in clinical trials. C. Clinical Relevance and Future Directions • The discussion of clinical applications is somewhat broad. It would be beneficial to include: o Specific ongoing clinical trials (if available). o A comparison of animal models vs. human studies to highlight translational challenges. • The challenges section should offer potential solutions or strategies to overcome issues like immune rejection, tumorigenicity, and ethical concerns. D. Specific Suggestions for Improvement • Introduction: Emphasize the gap in current treatments that stem cell therapy aims to address. • Current Treatment Strategies: Compare rehabilitation and pharmacological treatments with stem cell therapy in terms of: Efficacy, Limitations, Side effects. • Exosome Therapy: This part is well-detailed, but it could benefit from a discussion on manufacturing challenges and standardization issues for clinical application. • Conclusion: Strengthen the future perspectives by suggesting research directions or potential improvements in stem cell delivery methods. "
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Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693
13
"This review presents a comprehensive analysis of the role of Traditional Chinese Medicine (TCM) in the treatment of chronic atrophic ..."
[Read more]
"This review presents a comprehensive analysis of the role of Traditional Chinese Medicine (TCM) in the treatment of chronic atrophic gastritis (CAG), highlighting its multi-targeted therapeutic effects, including gastric mucosal protection, modulation of inflammatory responses, and improvement of microcirculation. The discussion is well-supported by clinical studies and meta-analyses, underscoring the potential benefits of specific herbal compounds such as berberine, morroniside, and notoginsenoside R1. However, the review also acknowledges a key challenge—the lack of standardized research methodologies and evaluation criteria, which limits the broader clinical application of TCM. While the evidence presented suggests promising therapeutic effects, future research should focus on large-scale randomized controlled trials to further validate these findings and establish consistent guidelines for integrating TCM into mainstream gastroenterology practice. Additionally, a more detailed discussion on potential interactions between TCM and conventional Western therapies would strengthen the clinical relevance of this review. Overall, this article makes a valuable contribution to the understanding of CAG management and provides a strong foundation for future research in this field. "
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Wang L, Lian YJ, Dong JS, Liu MK, Liu HL, Cao ZM, Wang QN, Lyu WL, Bai YN. Traditional Chinese medicine for chronic atrophic gastritis: Efficacy, mechanisms and targets. World J Gastroenterol 2025; 31(9): 102053
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"The study by Real Martinez et al. provides valuable insights into the role of circulating myokines such as irisin and FGF21 in MASLD, ..."
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"The study by Real Martinez et al. provides valuable insights into the role of circulating myokines such as irisin and FGF21 in MASLD, particularly their association with severe steatosis and advanced liver fibrosis. However, the absence of a relationship between skeletal muscle alterations (SMAs) and liver fibrosis stages raises intriguing questions. Could the lack of association be attributed to the heterogeneity of the cohort, or might it suggest that SMAs play a more indirect role in MASLD progression? Additionally, how might other metabolic or inflammatory pathways, not directly evaluated in this study, influence the interplay between muscle health and liver disease? Further studies exploring these aspects, especially in longitudinal designs or larger cohorts, would be invaluable in clarifying these relationships and their implications for clinical practice. "
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Real Martinez Y, Fernandez-Garcia CE, Fuertes-Yebra E, Calvo Soto M, Berlana A, Barrios V, Caldas M, Gonzalez Moreno L, Garcia-Buey L, Molina Baena B, Sampedro-Nuñez M, Beceiro MJ, García-Monzón C, González-Rodríguez Á. Assessment of skeletal muscle alterations and circulating myokines in metabolic dysfunction-associated steatotic liver disease: A cross-sectional study. World J Gastroenterol 2025; 31(7): 100039
15
"I congratulate the authors for the publication of their write up. It is well written with practical points. The information on greater ..."
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"I congratulate the authors for the publication of their write up. It is well written with practical points. The information on greater likelihood of antibody generation with premixed insulins was new to me, although I believe it would have been partly due to the highly prevalent use of this form of insulin. I would like the authors to understand this point as well while promoting the advantages of the newer insulins. In the international guidelines, at diagnosis of diabetes if the blood glucose levels are above 300 mg/dl and/or glycosylated hemoglobin level is more than 10 %, it is suggested to start the patient on insulin to reduce the glucotoxicity. Once the blood glucose levels reduce, say after 2-3 weeks, the patient may be switched to oral anti-diabetic agents. Such a guideline recommended practice is regularly followed in developing countries such as ours. In such a situation I have observed that the acceptance rate of premixed insulin which involves two pricks, is a lot better than that of multiple short acting insulin doses along with basal insulin. Since the duration of premixed insulin therapy in this context is short, the possible side effects of anti-insulin antibody generation as well as lipodystrophy are less likely. "
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Xia Y, Hu Y, Ma JH. Premixed insulin: Advantages, disadvantages, and future. World J Diabetes 2025; 16(3): 102526
16
"This study presents an evaluation of a novel contrast-enhanced catheter with a chamfered tip. Achieving selective biliary cannulation ..."
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"This study presents an evaluation of a novel contrast-enhanced catheter with a chamfered tip. Achieving selective biliary cannulation is one of the most challenging endoscopic maneuver. We congratulate the authors on demonstrating in this paper that a novel device granted higher rates of biliary cannulation when retrospectively compared to a standard sphincterotome. However, a few points warrant further discussion: 1. Generalizability: As a single-center retrospective study, the external validity of these findings could be enhanced with multicenter randomized trials. Variations in patient populations, procedural techniques, and institutional expertise might influence outcomes. 2. Non-expert outcomes: The results indicate a lack of significant improvement in outcomes among non-experts or trainees using the novel catheter. This suggests the device's utility may be contingent on the operator's skill. We also noticed that the expert performed procedure percentage was slightly higher (57% vs 50%) in the novel cathether group, and, although not statistically significant, this could explain the lower use of advanced or rescue cannulation techniques. 3. Adverse Events (AEs): While the overall AE rates were low and comparable between groups, the trend toward fewer cases of PEP with the novel catheter merits closer scrutiny in larger cohorts as this could be an advantage in patients at risk for PEP. On the other hand, the non-statistically significant difference between the two groups in PEP incidence suggests us that the device used to achieve initial selective cannulation maybe isn’t that relevant in increasing PEP risk or incidence, but this should be confirmed in larger studies. 4. Cost-effectiveness: Although not discussed, evaluating the cost implications of adopting this catheter, including potential savings from reduced reliance on rescue techniques and decreased procedural times, would be beneficial for broader clinical adoption. We should also think of the negative aspects: for example, like stone clearance, achieving cannulation with a catheter would require a subsequent switch to a sphincterotome, increasing procedure length and costs, as you would be using two devices instead of one to achieve cannulation. 5. Papilla characteristics: we noticed that in the baseline characteristics intradiverticular papillas and oral oriented papillas were less represented in the catheter group. These types of papilla could benefit of the angling capabilities of a sphincterotome, so this could be a bias that needs to be furthermore cleared. In our experience the angling capabilities of a sphincterotome are crucial in achieving bile duct cannulation in difficult situations. 6. Malignant disease: we do know that malignant diseases (e.g. pancreatic cancer) affecting the ampullar area negatively affect rates of cannulation and increase the need for rescue or advanced techniques of cannulation. This point could have been furthermore discussed by making a distinction between cannulation failures in the setting of benign vs. malignant disease in both groups. In conclusion, this study gives us valuable insights into advancing ERCP outcomes through innovative device design. We must experiment with more designs to compare results and finally choose the best device for cannulation in unexpected and difficult anatomies. "
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Kaneko T, Kida M, Kurosu T, Kitahara G, Koyama S, Nomura N, Tahara K, Kusano C. Outcomes of bile duct cannulation using a novel contrast-enhanced catheter: A single-center, retrospective cohort study. World J Gastrointest Endosc 2025; 17(1): 97840
17
"As a colorectal surgeon interested in colorectal cancer and the microbiome, I found this study highly relevant. The authors ..."
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"As a colorectal surgeon interested in colorectal cancer and the microbiome, I found this study highly relevant. The authors effectively highlight differences in mucosa-associated colonic microbiota between colorectal cancer (CRC) and non-CRC patients in Indonesia. A key strength is the focus on mucosal rather than fecal microbiota, providing a clearer picture of the tumor microenvironment. The use of 16S rRNA sequencing with Oxford Nanopore Technologies enables detailed bacterial diversity analysis at the genus and species levels. The study confirms the increased presence of Fusobacterium nucleatum and Bacteroides fragilis in CRC patients, supporting the link between microbial dysbiosis and carcinogenesis. The diagnostic potential of these bacterial markers is particularly noteworthy. Further research with larger sample sizes and functional analyses, such as metagenomics or metabolomics, would enhance understanding of microbiota’s role in CRC. Additionally, while this study offers important insights for Asia, global research is needed to assess regional differences and their impact on CRC diagnostics and treatment. "
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Darnindro N, Abdullah M, Sukartini N, Rumende CM, Pitarini A, Nursyirwan SA, Fauzi A, Makmun D, Nelwan EJ, Shatri H, Rinaldi I, Tanadi C. Differences in diversity and composition of mucosa-associated colonic microbiota in colorectal cancer and non-colorectal cancer in Indonesia. World J Gastroenterol 2025; 31(7): 100051
18
"The manuscript is very clinically relevant. Here's a suggestion. Authors should provide the data on patients undergoing colonoscopy ..."
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"The manuscript is very clinically relevant. Here's a suggestion. Authors should provide the data on patients undergoing colonoscopy prior to capsule endoscopy examination. The retention rate of capsule endoscopy at 72 hours was 42.2%, which is still relatively high.It helps to reduce capsule retention in the colon after colonoscopy examination. "
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O'Hara FJ, Costigan C, McNamara D. Extended 72-hour patency capsule protocol improves functional patency rates in high-risk patients undergoing capsule endoscopy. World J Gastrointest Endosc 2024; 16(12): 661-667
19
"This case report highlights the importance of en-bloc resection without fragmentation during endoscopic procedures and the challenges ..."
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"This case report highlights the importance of en-bloc resection without fragmentation during endoscopic procedures and the challenges of endoscopic treatment for anal canal cancer. Traditionally, anal lesions have been primarily managed by surgeons, but ESD-related technique is performed mainly by the gastrointestinal endoscopists of internal medicine. Future collaboration between internal medicine and surgery departments will be crucial. Surgery for anal cancer can significantly decrease patients' quality of life, which is why the authors' dedication to endoscopic treatment and follow-up is commendable. Anal canal cancer is rare, and it will be essential to determine which cases are suitable for endoscopic therapy in the future. With the increasing prevalence of inflammatory bowel diseases in Asian regions, a rise in anal cancer cases associated with conditions like Crohn's disease is anticipated. Further case reports in this field are desirable. "
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Kinoshita M, Maruyama T, Hike S, Hirosuna T, Kainuma S, Kinoshita K, Nakano A, Ohira G, Uesato M, Matsubara H. Complete resection of recurrent anal canal cancer using endoscopic submucosal dissection and transanal resection: A case report. World J Gastrointest Endosc 2025; 17(1): 101119
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"This is an excellent and insightful article. The authors have provided a comprehensive overview of the most impactful studies in the ..."
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"This is an excellent and insightful article. The authors have provided a comprehensive overview of the most impactful studies in the field of gastrointestinal endoscopy. It has greatly enhanced my understanding of the current research landscape and has inspired me to define more focused and meaningful directions for my own research in this area. "
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Sui J, Luo JS, Xiong C, Tang CY, Peng YH, Zhou R. Bibliometric analysis on the top one hundred cited studies on gastrointestinal endoscopy. World J Gastrointest Endosc 2025; 17(1): 100219
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