Baishideng Publishing Group

Wu YH, Zhang K, Chen HG, Wu WB, Li XJ, Zhang J. Primary small cell esophageal carcinoma, chemotherapy sequential immunotherapy: A case report. World J Clin Cases 2021; 9(22): 6478-6484 [DOI: 10.12998/wjcc.v9.i22.6478]

"No"

Zhou LQ, Li M, Li YQ, Wang YJ. Isolated fungus ball in a single cell of the left ethmoid roof: A case report. World J Clin Cases 2021; 9(21): 6005-6008 [DOI: 10.12998/wjcc.v9.i21.6005]

"Very good!"

Yao YF, Feng J, Liu J, Chen CF, Yu B, Hu XP. Disseminated infection by Fusarium solani in acute lymphocytic leukemia: A case report. World J Clin Cases 2021; 9(22): 6443-6449 [DOI: 10.12998/wjcc.v9.i22.6443]

"I'm satisfied with the whole process."

Rao YY, Zhang HJ, Wang XJ, Li MF. Primary hepatic neuroendocrine tumor — ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography findings: A case report. World J Clin Cases 2021; 9(22): 6450-6456 [DOI: 10.12998/wjcc.v9.i22.6450]

"The peer reviews are helpful for elevating the quality of manuscript.The only unsatisfied point is the long period for publication. ..." [Read more]

"The peer reviews are helpful for elevating the quality of manuscript.The only unsatisfied point is the long period for publication." [Collapse]

Huang X, Cai SL, Xie LP. Prostatic carcinosarcoma seven years after radical prostatectomy and hormonal therapy for prostatic adenocarcinoma: A case report. World J Clin Cases 2021; 9(22): 6388-6392 [DOI: 10.12998/wjcc.v9.i22.6388]

"Thanks very much for your kind work and consideration on publication of our paper."

Long HY, Huang TY, Xie XY, Long JT, Liu BX. Treatment strategies for hepatocellular carcinoma with extrahepatic metastasis. World J Clin Cases 2021; 9(21): 5754-5768 [DOI: 10.12998/wjcc.v9.i21.5754]

"Globally we were satisfied with the editorial review process."

Janicsák H, Ungvari GS, Gazdag G. Psychosocial aspects of hematopoietic stem cell transplantation. World J Transplant 2021; 11(7): 263-276 [PMID: 34316451 DOI: 10.5500/wjt.v11.i7.263]

"First of all, thank you for your hardworking. Next time, more investigations will be activated in my center. Though clinic study ..." [Read more]

"First of all, thank you for your hardworking. Next time, more investigations will be activated in my center. Though clinic study is difficult in a territorial hospital. It would be nice if the publishing fee could be cheaper." [Collapse]

Xiao R, Shao Q, Zhao N, Liu F, Qian KJ. Quantification analysis of pleural line movement for the diagnosis of pneumothorax. World J Clin Cases 2021; 9(21): 5889-5899 [DOI: 10.12998/wjcc.v9.i21.5889]

"I am satisfied with the entire submission process."

Yang CM, Li JM, Wang R, Lu LG. Malignant peripheral nerve sheath tumor in an elderly patient with superficial spreading melanoma: A case report. World J Clin Cases 2021; 9(22): 6457-6463 [DOI: 10.12998/wjcc.v9.i22.6457]

"Excellent!"

Huang XM, Shi ZS, Ma CL. Multifocal autoimmune pancreatitis: A retrospective study in a single tertiary center of 26 patients with a 20-year literature review. World J Gastroenterol 2021; 27(27): 4429-4440 [DOI: 10.3748/wjg.v27.i27.4429]

"We are satisfied with the work of the editorial team and the reviewers. Thank you"

Maranto M, Cigna V, Orlandi E, Cucinella G, Lo Verso C, Duca V, Picciotto F. Non-immune hydrops fetalis: Two case reports. World J Clin Cases 2021; 9(22): 6531-6537 [DOI: 10.12998/wjcc.v9.i22.6531]

"Thanks for the opportunity !!"

de Freitas Júnior JR, Ribeiro IB, de Moura DTH, Sagae VMT, de Souza GMV, de Oliveira GHP, Sánchez-Luna SA, de Souza TF, de Moura ETH, de Oliveira CPMS, Bernardo WM, de Moura EGH. Effects of intragastric balloon placement in metabolic dysfunction-associated fatty liver disease: A systematic review and meta-analysis. World J Hepatol 2021; 13(7): 815-829 [DOI: 10.4254/wjh.v13.i7.815]

"Very good magazine, hope to continue cooperation"

Yan JF, Zhou HY, Luo SF, Wang X, Yu JD. Rare case of brucellosis misdiagnosed as prostate carcinoma with lumbar vertebra metastasis: A case report. World J Clin Cases 2021; 9(21): 6009-6016 [DOI: 10.12998/wjcc.v9.i21.6009]

"Communication with authors should be improved, there are too many open channels (email, web site, etc.), this often generates confusion ..." [Read more]

"Communication with authors should be improved, there are too many open channels (email, web site, etc.), this often generates confusion in the authors. Everything else is of a high standard" [Collapse]

Cianci P, Restini E. Management of cholelithiasis with choledocholithiasis: Endoscopic and surgical approaches. World J Gastroenterol 2021; 27(28): 4536-4554 [DOI: 10.3748/wjg.v27.i28.4536]

"I do learn a lot .Thanks for help."

Hu XM, Lin CD, Huang DY, Li XM, Lu F, Wei WT, Yu ZH, Liao HS, Huang F, Huang XZ, Jia FJ. Analysis of sleep characteristics and clinical outcomes of 139 adult patients with infective endocarditis after surgery. World J Clin Cases 2021; 9(22): 6319-6328 [DOI: 10.12998/wjcc.v9.i22.6319]

"It was a very pleasant experience to communicate smoothly with editors during this submission."

Zhao Q, Yang Y, He SW, Wang XT, Liu C. Risk factors for intussusception in children with Henoch-Schönlein purpura: A case-control study. World J Clin Cases 2021; 9(22): 6244-6253 [DOI: 10.12998/wjcc.v9.i22.6244]

"Great job"

Zhou X, Duan ML. Malaria-associated secondary hemophagocytic lymphohistiocytosis: A case report. World J Clin Cases 2021; 9(22): 6403-6409 [DOI: 10.12998/wjcc.v9.i22.6403]

"非常满意，谢谢！"

Zhang JC, Li T. Awake extracorporeal membrane oxygenation support for a critically ill COVID-19 patient: A case report. World J Clin Cases 2021; 9(21): 5963-5971 [DOI: 10.12998/wjcc.v9.i21.5963]

"Thanks to the jointly efforts of all the involved editors and reviewers during the whole publication process of this manuscript. World ..." [Read more]

"Thanks to the jointly efforts of all the involved editors and reviewers during the whole publication process of this manuscript. World Journal of Gastroenterology is a high-quality academic journal, all the editors and reviewers worked industriously and responsibly, and kept communication with the author smoothly, which provided a solid foundation for the publication of this manuscript." [Collapse]

Li Z, Tao L, Zhang SS, Sun XH, Chen SN, Wu J. Modified Xiaochaihu Decoction for gastroesophageal reflux disease: A randomized double-simulation controlled trial. World J Gastroenterol 2021; 27(28): 4710-4721 [DOI: 10.3748/wjg.v27.i28.4710]

"we are truly grateful to have had the opportunity to publish in this magazine and there are no particular comments on it"

Ninfole E, Pinto C, Benedetti A, Marzioni M, Maroni L. Role of autophagy in cholangiocarcinoma: Pathophysiology and implications for therapy. World J Clin Cases 2021; 9(22): 6234-6243 [DOI: 10.12998/wjcc.v9.i22.6234]

6352 items Read more >>

Article Quality Tracking-Peer-Review

"This was awell written article, but the meesage that the authors wanted to convey was lost in their attempts to cover too many issues. ..." [Read more]

"This was awell written article, but the meesage that the authors wanted to convey was lost in their attempts to cover too many issues. For example, they discuss collaborative care (CC), difficulties in implementing this model, problems related to the pandemic, and the role of telepsychiatry. At the same time, the focus is restricted to one model of primay care. So the title is a bit misleading. The authors also restrict themselves to the problems of CC model in the US. This limits its usefulness for readers from other countries. " [Collapse]

Moise N, Wainberg M, Shah RN. Primary care and mental health: Where do we go from here? World J Psychiatr 2021; 11(7): 271-276 [DOI: 10.5498/wjp.v11.i7.271]

"This is an excellent article article by Professor Seeman about the dopamine about the history of the dopamine hypothesis of ..." [Read more]

"This is an excellent article article by Professor Seeman about the dopamine about the history of the dopamine hypothesis of antipsychotic action. The distinction between this hypothesis and the dopamine hypothesis of schizophrenia has been rightly pointed out, though I wish she could have written a few more lines on how the two differ. Apart from this minor deficiency, the review is comprehensive and up to date. It is also very well written and easy to read. " [Collapse]

Seeman MV. History of the dopamine hypothesis of antipsychotic action. World J Psychiatr 2021; 11(7): 355-364 [DOI: 10.5498/wjp.v11.i7.355]

"This study provides that the plasma levels of Ang-2 can be a potential tool to predict overall or recurrence-free survival in HCCs. ..." [Read more]

"This study provides that the plasma levels of Ang-2 can be a potential tool to predict overall or recurrence-free survival in HCCs." [Collapse]

Choi GH, Jang ES, Kim JW, Jeong SH. Prognostic role of plasma level of angiopoietin-1, angiopoietin-2, and vascular endothelial growth factor in hepatocellular carcinoma. World J Gastroenterol 2021; 27(27): 4453-4467 [DOI: 10.3748/wjg.v27.i27.4453]

"This study demonstrates that multifocal AIP is not as rare as previously thought, the combinations of CT and MRI imaging features ..." [Read more]

"This study demonstrates that multifocal AIP is not as rare as previously thought, the combinations of CT and MRI imaging features may be useful for differentiating multifocal AIP from PDA. " [Collapse]

"This review summarizes the available evidence for the application of AI in the interpretation of radiology, endoscopy, and histological ..." [Read more]

"This review summarizes the available evidence for the application of AI in the interpretation of radiology, endoscopy, and histological images of the GI tract. As pointed out by the authors, available data on the use of AI in the evaluation of GI radiology images are more abundant due to the asymmetric availability of data in both endoscopy and pathology, warranting further research." [Collapse]

Berbís MA, Aneiros-Fernández J, Mendoza Olivares FJ, Nava E, Luna A. Role of artificial intelligence in multidisciplinary imaging diagnosis of gastrointestinal diseases. World J Gastroenterol 2021; 27(27): 4395-4412 [DOI: 10.3748/wjg.v27.i27.4395]

"This study provides up-to-date information on the mechanisms of the direct and indirect effects of Sars-CoV-2 infection on the ..." [Read more]

"This study provides up-to-date information on the mechanisms of the direct and indirect effects of Sars-CoV-2 infection on the liver. It would have been more informative if the histopathological effects had been considered a little more comprehensively and presented with visual data (e.g., Zone 3 changes). " [Collapse]

Huang YK, Li YJ, Li B, Wang P, Wang QH. Dysregulated liver function in SARS-CoV-2 infection: Current understanding and perspectives. World J Gastroenterol 2021; 27(27): 4358-4370 [DOI: 10.3748/wjg.v27.i27.4358]

"This review highlights the necessity of adequate protocols and clinical trials for the application of stem cells in cosmetics, to ..." [Read more]

"This review highlights the necessity of adequate protocols and clinical trials for the application of stem cells in cosmetics, to warrant safety and efficacy. It would have been of relevance to include in more detail some of the current evidences supporting the use of stem cells in cosmetology at the molecular level. " [Collapse]

Al-Sowayan BS, Al-Shareeda AT. Stem cells and the pursuit of youth, a tale of limitless possibilities and commercial fraud. World J Biol Chem 2021; 12(4): 52-56 [DOI: 10.4331/wjbc.v12.i4.52]

"In this study, epidemiological and clinicopathological data on intrahepatic cholangiocarcinomas developing in the background of HBV ..." [Read more]

"In this study, epidemiological and clinicopathological data on intrahepatic cholangiocarcinomas developing in the background of HBV are presented comprehensively. In addition, the reader is informed about the fact that these rare tumors should be considered in the differential diagnosis by referring to the mechanisms that play a role in carcinogenesis. Moreover, it is emphasized in the article that a distinct phenotype of viral hepatitis-related iCCA exists, and this form is more frequently affects younger males and is characterized by mass-forming tumors with cholangiolar differentiation, higher AFP, lower carbohydrate antigen (CA) 19-9 levels, and higher N-cadherin expression. This finding prompts me to ask whether the source of these tumors is hepatocytes located in the periportal distance and having dual differentiation capacity." [Collapse]

Fragkou N, Sideras L, Panas P, Emmanouilides C, Sinakos E. Update on the association of hepatitis B with intrahepatic cholangiocarcinoma: Is there new evidence? World J Gastroenterol 2021; 27(27): 4252-4275 [DOI: 10.3748/wjg.v27.i27.4252]

"I thought this was an excellent editorial on the use of screening instruments for detection of cognitive impairments in elderly ..." [Read more]

"I thought this was an excellent editorial on the use of screening instruments for detection of cognitive impairments in elderly outpatients. It points out the deficiencies of a recently approved instrument, the Cognivue® when compared with the Montreal Cognitive Assessment. It makes the important observation that improper screening could lead to a diagnosis of a neurocognitive disorder being missed and this can have several adverse consequences for patients and families. There are a few more problems with the Cognivue® that could have been highlighted, but on the whole the editorial has a very important message to convey. " [Collapse]

Rose AF, Gilbertson AF, Cottrell C, Tampi RR. Cognitive screening for adult psychiatric outpatients: Comparison of the Cognivue^® to the Montreal Cognitive Assessment. World J Psychiatr 2021; 11(7): 265-270 [DOI: 10.5498/wjp.v11.i7.265]

"Dear author, thank you for submitting your review in the journal. As this is was a narrative review, you should add different tables ..." [Read more]

"Dear author, thank you for submitting your review in the journal. As this is was a narrative review, you should add different tables to depict the different findings of GIT in systemic sclerosis with possible management. Thanks" [Collapse]

Luquez-Mindiola A, Atuesta AJ, Gómez-Aldana AJ. Gastrointestinal manifestations of systemic sclerosis: An updated review. World J Clin Cases 2021; 9(22): 6201-6217 [DOI: 10.12998/wjcc.v9.i22.6201]

"An interesting review, but since it was evaluated by reviewers with B and C, there will be no chance to provide a prize for this paper. ..." [Read more]

"An interesting review, but since it was evaluated by reviewers with B and C, there will be no chance to provide a prize for this paper. As for the above criteria, the paper is a review, and hardly can be judged by the above criteria " [Collapse]

Sivandzadeh GR, Askari H, Safarpour AR, Ejtehadi F, Raeis-Abdollahi E, Vaez Lari A, Abazari MF, Tarkesh F, Bagheri Lankarani K. COVID-19 infection and liver injury: Clinical features, biomarkers, potential mechanisms, treatment, and management challenges. World J Clin Cases 2021; 9(22): 6178-6200 [DOI: 10.12998/wjcc.v9.i22.6178]

"The article addresses an interesting topic about the use of the statins in patients with severe liver disease known that this drugs ..." [Read more]

"The article addresses an interesting topic about the use of the statins in patients with severe liver disease known that this drugs decrease portal hypertension but are also associated with liver injuries in healthy persons. It is only a minireview that presents not all the studies with statins in liver diseases. There are not new conclusions and the authors suggest new studies for recommend the statins in patients with cirrhosis. " [Collapse]

Muñoz AE, Pollarsky FD, Marino M, Cartier M, Vázquez H, Salgado P, Romero G. Addition of statins to the standard treatment in patients with cirrhosis: Safety and efficacy. World J Gastroenterol 2021; 27(28): 4639-4652 [DOI: 10.3748/wjg.v27.i28.4639]

"It is a complex article about most frequent types of virus hepatitis with a very good documentation regarding the transmission route, ..." [Read more]

"It is a complex article about most frequent types of virus hepatitis with a very good documentation regarding the transmission route, clinical features, diagnosis and management, taking into account the efficiency and adverse event of the therapy. The article is well written and of interest for readers of the journal. It is a very well up to date in this area of hepatology, including the new approaches for the viral diseases. The authors provide well -constructed figures and graphics that facilitate the reading of the article and scientifically cite the latest references . " [Collapse]

Torre P, Aglitti A, Masarone M, Persico M. Viral hepatitis: Milestones, unresolved issues, and future goals. World J Gastroenterol 2021; 27(28): 4603-4638 [DOI: 10.3748/wjg.v27.i28.4603]

"this observational study from china showed that the intestinal bacteria flora of patients with UC differed significantly in terms ..." [Read more]

"this observational study from china showed that the intestinal bacteria flora of patients with UC differed significantly in terms of various sample types and disease activities. The intermicrobial correlations changed in patients with UC compared with controls.it is methodologically appropriate despite the fact it is governed by been related to a certain patient population , its references are up to date and discussion is appropriate. " [Collapse]

He XX, Li YH, Yan PG, Meng XC, Chen CY, Li KM, Li JN. Relationship between clinical features and intestinal microbiota in Chinese patients with ulcerative colitis. World J Gastroenterol 2021; 27(28): 4722-4737 [DOI: 10.3748/wjg.v27.i28.4722]

"This review concludes that new randomized controlled trials are necessary before endorsing statin use in patients with chronic liver ..." [Read more]

"This review concludes that new randomized controlled trials are necessary before endorsing statin use in patients with chronic liver disease. despite the fact that statins seem to be a hepatotoxic , there is a growing evidence to be a possible therapeutic agent in portal hypertension based on this review." [Collapse]

"this review that provide the reader with a general summary of gallbladder stone disease in association with the presence of common ..." [Read more]

"this review that provide the reader with a general summary of gallbladder stone disease in association with the presence of common bile duct stones by discussing their epidemiology, clinical and diagnostic aspects, and possible treatments and their advantages and limitations. with exhaustive over a 150 refences discussed a common gastroenterological and surgical disease that updated the literature , well illustrated with a clear images and operative demonstrations." [Collapse]

Cianci P, Restini E. Management of cholelithiasis with choledocholithiasis: Endoscopic and surgical approaches. World J Gastroenterol 2021; 27(28): 4536-4554 [DOI: 10.3748/wjg.v27.i28.4536]

"this manuscript that pointed to Approximately 10% of asymptomatic subjects with normal blood tests have small intestinal mucosal ..." [Read more]

"this manuscript that pointed to Approximately 10% of asymptomatic subjects with normal blood tests have small intestinal mucosal breaks. A reanalysis of our previous studies showed that small intestinal mucosal breaks were strongly correlated with body mass index, were significantly more prevalent in Helicobacter pylori-infected individuals and were more prevalent in men. These may be risk factors for small intestinal mucosal breaks. Overall, 1-2 small ulcerative lesions in asymptomatic patients are considered to be in the normal range and do not require close examination, and it is assumed that a follow-up medical examination is required. had tackled an important clinical issue with high prevalence in Asia , well presented and referenced ." [Collapse]

Fujimori S. Asymptomatic small intestinal ulcerative lesions: Obesity and Helicobacter pylori are likely to be risk factors. World J Gastroenterol 2021; 27(28): 4484-4492 [DOI: 10.3748/wjg.v27.i28.4484]

"This review describes the key functional bacterial proteins and antigens in the context of dysbiosis related-diseases in detail. The ..." [Read more]

"This review describes the key functional bacterial proteins and antigens in the context of dysbiosis related-diseases in detail. The authors have checked the spelling errors and abbreviations and added a summarizing table and future perspects according to the suggestions. The quality of manuscript has been improved." [Collapse]

Zeng XY, Li M. Looking into key bacterial proteins involved in gut dysbiosis. World J Methodol 2021; 11(4): 130-143 [PMID: 34322365 DOI: 10.5662/wjm.v11.i4.130]

"There is a complex and systematic review regarding the gastrointestinal and hepatic manifestations in patients with SARS COV 2 ..." [Read more]

"There is a complex and systematic review regarding the gastrointestinal and hepatic manifestations in patients with SARS COV 2 infection . The review is well conducted and well written. The graphic representation is very good. The conclusions are pertinent and with clinical utility: the presence of gastrointestinal symptoms are associated with severe complications and a poor prognosis. Also, the virus transmission is the fecal-oral route. The patients with chronic liver disease should be treated with medications that are able to prevent inflammatory responses and protect liver functions during the infection. " [Collapse]

Mohamed DZ, Ghoneim MES, Abu-Risha SES, Abdelsalam RA, Farag MA. Gastrointestinal and hepatic diseases during the COVID-19 pandemic: Manifestations, mechanism and management. World J Gastroenterol 2021; 27(28): 4504-4535 [DOI: 10.3748/wjg.v27.i28.4504]

"The aim of the study is to assess the incidence and pathogenesis of ulcerative lesions found in the small intestine in asymptomatic ..." [Read more]

"The aim of the study is to assess the incidence and pathogenesis of ulcerative lesions found in the small intestine in asymptomatic healthy persons , using capsule endoscopy. The are few studies regarding this subject and the results are interesting; risk factors are: male sex, obesity and H. pylori infection. The pathogenesis of all these factors are probably changes of intestinal microbiota. The study is well conducted but the limits are the small number of patients (21 patients with intestinal lesions) and the lack of clinical utility (an expensive investigation for asymptomatic and healthy patients) " [Collapse]

7188 items Read more >>

Peer-Reviewers and Manuscript Statistics

Editorial board members: 3776

Peer-reviewers: 42245

Manuscripts received today: 19

Manuscript reviews today: 39

Unhandled manuscripts today: 115

Active peer-reviewers today: 1183

Reviewer acceptance today: 74

Reviewer refusals today: 86

Total accepted manuscripts: 21664

Total rejected manuscripts: 27164

Total peer-reviewers: 720109

Total submissions: 18789

Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.

BPG Journals

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BPG Blog

All Journal Articles

Chen JW, Zheng LZ, Xu DH, Lin W. Extensive cutaneous metastasis of recurrent gastric cancer: A case report. World J Clin Cases 2021; 9(22): 6575-6581

2021-08-06 | Browse: 163 | Download: 27

Zhao YR, Hu RH, Wu R, Xu JK. Primary mucosa-associated lymphoid tissue lymphoma in the midbrain: A case report. World J Clin Cases 2021; 9(22): 6566-6574

2021-08-06 | Browse: 173 | Download: 25

Huang X, Hu YL, Zhao Y, Chen Q, Li YX. Neonatal necrotizing enterocolitis caused by umbilical arterial catheter-associated abdominal aortic embolism: A case report. World J Clin Cases 2021; 9(22): 6557-6565

2021-08-06 | Browse: 165 | Download: 29

Kim DS, Lee JW, Lee SH. Spontaneous rupture of adrenal myelolipoma as a cause of acute flank pain: A case report. World J Clin Cases 2021; 9(22): 6552-6556

2021-08-06 | Browse: 153 | Download: 25

Wei TT, Huang H, Chen G, He FF. Management of an intracranial hypotension patient with diplopia as the primary symptom: A case report. World J Clin Cases 2021; 9(22): 6544-6551

2021-08-06 | Browse: 172 | Download: 32

Zhang YS, Zhang YH, Li XJ, Hu TC, Chen WZ, Pan X, Chai HY, Ye YC. Bystander effect and abscopal effect in recurrent thymic carcinoma treated with carbon-ion radiation therapy: A case report. World J Clin Cases 2021; 9(22): 6538-6543

2021-08-06 | Browse: 132 | Download: 15

Maranto M, Cigna V, Orlandi E, Cucinella G, Lo Verso C, Duca V, Picciotto F. Non-immune hydrops fetalis: Two case reports. World J Clin Cases 2021; 9(22): 6531-6537

2021-08-06 | Browse: 149 | Download: 31

Huang XM, Luo M, Ran LY, You XH, Wu DW, Huang SS, Gong Q. Chylothorax following posterior low lumbar fusion surgery: A case report. World J Clin Cases 2021; 9(22): 6522-6530

2021-08-06 | Browse: 164 | Download: 27

Zhang SY, He BJ, Xu HH, Xiao MM, Zhang JJ, Tong PJ, Mao Q. Concealed mesenteric ischemia after total knee arthroplasty: A case report. World J Clin Cases 2021; 9(22): 6515-6521

2021-08-06 | Browse: 141 | Download: 27

Gan LW, Li QC, Yu ZL, Zhang LL, Liu Q, Li Y, Ou ST. Abdominal hemorrhage after peritoneal dialysis catheter insertion − a rare reason for luteal rupture: A case report. World J Clin Cases 2021; 9(22): 6510-6514

2021-08-06 | Browse: 161 | Download: 24

Liu H, Zhang T, Qu T, Yang CW, Li SK. Spinal epidural hematoma after spinal manipulation therapy: Three case reports and review of literature. World J Clin Cases 2021; 9(22): 6501-6509

2021-08-06 | Browse: 226 | Download: 35

Saito M, Morioka M, Izumiyama K, Mori A, Ogasawara R, Kondo T, Miyajima T, Yokoyama E, Tanikawa S. Phlegmonous gastritis developed during chemotherapy for acute lymphocytic leukemia: A case report. World J Clin Cases 2021; 9(22): 6493-6500

2021-08-06 | Browse: 170 | Download: 32

Huang HH, Cheng ZH, Ding BZ, Zhao J, Zhao CQ. Subdural fluid collection rather than meningitis contributes to hydrocephalus after cervical laminoplasty: A case report. World J Clin Cases 2021; 9(22): 6485-6492

2021-08-06 | Browse: 154 | Download: 22

Wu YH, Zhang K, Chen HG, Wu WB, Li XJ, Zhang J. Primary small cell esophageal carcinoma, chemotherapy sequential immunotherapy: A case report. World J Clin Cases 2021; 9(22): 6478-6484

2021-08-06 | Browse: 155 | Download: 32

Zhang JJ, Wang ZX, Niu JX, Zhang M, An N, Li PF, Zheng WH. Successful totally laparoscopic right trihepatectomy following conversion therapy for hepatocellular carcinoma: A case report. World J Clin Cases 2021; 9(22): 6469-6477

2021-08-06 | Browse: 189 | Download: 22

Yan J, He YS, Song Y, Chen XY, Liu HB, Rao CY. False positive of anti-immunoglobulin M hepatitis A virus in autoimmune hepatitis/primary biliary cholangitis overlap syndrome: A case report. World J Clin Cases 2021; 9(22): 6464-6468

2021-08-06 | Browse: 132 | Download: 16

Yang C, Li J, Wang R, Lu L. Malignant peripheral nerve sheath tumor in an elderly patient with superficial spreading melanoma: A case report. World J Clin Cases 2021; 9(22): 6457-6463

2021-08-06 | Browse: 147 | Download: 24

Rao YY, Zhang HJ, Wang XJ, Li MF. Primary hepatic neuroendocrine tumor — 18F-fluorodeoxyglucose positron emission tomography/computed tomography findings: A case report. World J Clin Cases 2021; 9(22): 6450-6456

2021-08-06 | Browse: 131 | Download: 25

Yao YF, Feng J, Liu J, Chen CF, Yu B, Hu XP. Disseminated infection by Fusarium solani in acute lymphocytic leukemia: A case report. World J Clin Cases 2021; 9(22): 6443-6449

2021-08-06 | Browse: 153 | Download: 28

Xu XL, Zhang RH, Wang YH, Zhou JY. Manifestation of severe pneumonia in anti-PL-7 antisynthetase syndrome and B cell lymphoma: A case report. World J Clin Cases 2021; 9(22): 6435-6442

2021-08-06 | Browse: 150 | Download: 32

44514 items Read more >>

Featured Articles

Jafari R, Jonaidi-Jafari N, Maghsoudi H, Dehghanpoor F, Schoepf UJ, Ulversoy KA, Saburi A. “Pulmonary target sign” as a diagnostic feature in chest computed tomography of COVID-19. World J Radiol 2021; 13(7): 233-242

2021-07-28 | Browse: 15 | Download: 7

Balaban DV, Baston OM, Jinga M. Abdominal imaging in COVID-19. World J Radiol 2021; 13(7): 227-232

2021-07-28 | Browse: 10 | Download: 6

Tagliafico AS. Imaging in multiple myeloma: Computed tomography or magnetic resonance imaging? World J Radiol 2021; 13(7): 223-226

2021-07-28 | Browse: 6 | Download: 7

Lu LY, Tang XY, Luo GJ, Tang MJ, Liu Y, Yu XJ. Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome in a Chinese family: A case report and review of literature. World J Clin Cases 2021; 9(22): 6393-6402

2021-07-27 | Browse: 24 | Download: 18

Pan PJ, Liu JX. Diagnostic and prognostic value of secreted protein acidic and rich in cysteine in the diffuse large B-cell lymphoma. World J Clin Cases 2021; 9(22): 6287-6299

2021-07-27 | Browse: 13 | Download: 26

Wu X, Li BL, Zheng CJ, He XD. Risk factors for preoperative carcinogenesis of bile duct cysts in adults. World J Clin Cases 2021; 9(22): 6278-6286

2021-07-27 | Browse: 13 | Download: 26

Xie L, Yi SX, Peng QF, Liu P, Jiang H. Retrospective study of effect of whole-body vibration training on balance and walking function in stroke patients. World J Clin Cases 2021; 9(22): 6268-6277

2021-07-27 | Browse: 13 | Download: 12

He YG, Li J, Peng XH, Wu J, Xie MX, Tang YC, Zheng L, Huang XB. Sequential therapy of combined trans-papillary endoscopic naso-pancreatic and endoscopic retrograde pancreatic drainage for pancreatic pseudocysts. World J Clin Cases 2021; 9(22): 6254-6267

2021-07-27 | Browse: 18 | Download: 10

Liu T, Xie XL, Zhou X, Chen SX, Wang YJ, Shi LP, Chen SJ, Wang YJ, Wang SL, Zhang JN, Dou SY, Jiang XY, Cui RL, Jiang HQ. Y-box binding protein 1 augments sorafenib resistance via the PI3K/Akt signaling pathway in hepatocellular carcinoma. World J Gastroenterol 2021; 27(28): 4667-4686

2021-07-26 | Browse: 23 | Download: 51

2021-07-26 | Browse: 21 | Download: 24

Mohamed DZ, Ghoneim MES, Abu-Risha SES, Abdelsalam RA, Farag MA. Gastrointestinal and hepatic diseases during COVID-19 pandemic: Manifestations, mechanism and management. World J Gastroenterol 2021; 27(28): 4504-4535

2021-07-26 | Browse: 21 | Download: 24

Bordry N, Astaras C, Ongaro M, Goossens N, Frossard JL, Koessler T. Recent advances in gastro-intestinal cancers. World J Gastroenterol 2021; 27(28): 4493-4503

2021-07-26 | Browse: 18 | Download: 25

Fujimori S. Asymptomatic small intestinal ulcerative lesions: Obesity and Helicobacter pylori are likely to be risk factors. World J Gastroenterol 2021; 27(28): 4484-4492

2021-07-26 | Browse: 20 | Download: 25

Soe KK, Seto AH. Sliding with the sines − fatal hyperkalemia: A case report. World J Cardiol 2021; 13(7): 230-236

2021-07-24 | Browse: 18 | Download: 30

Khalid N, Pandey Y, Khalid U, Kamran H, Wermers JP, Chhabra L, Alam M, Jneid H, Kayani WT. Modes of failure with fractional flow reserve guidewires: Insights from the manufacturer and user facility device experience database. World J Cardiol 2021; 13(7): 223-229

2021-07-24 | Browse: 17 | Download: 40

Yildirim G, Dursun M, Arslan R. Effect of trabeculated myocardial mass on left ventricle global and regional functions in noncompaction cardiomyopathy. World J Cardiol 2021; 13(7): 211-222

2021-07-24 | Browse: 17 | Download: 41

Onorato EM. Large eustachian valve fostering paradoxical thromboembolism: Passive bystander or serial partner in crime? World J Cardiol 2021; 13(7): 204-210

2021-07-24 | Browse: 17 | Download: 32

Sopek Merkaš I, Slišković AM, Lakušić N. Current concept in the diagnosis, treatment and rehabilitation of patients with congestive heart failure. World J Cardiol 2021; 13(7): 183-203

2021-07-24 | Browse: 21 | Download: 33

Alt E, Rothoerl R, Hoppert M, Frank HG, Wuerfel T, Alt C, Schmitz C. First immunohistochemical evidence of human tendon repair following stem cell injection: A case report and review of literature. World J Stem Cells 2021; 13(7): 944-970

2021-07-23 | Browse: 24 | Download: 39

Wong CY. Current advances of stem cell-based therapy for kidney diseases. World J Stem Cells 2021; 13(7): 914-933

2021-07-23 | Browse: 25 | Download: 51

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Published Articles Processes

Chen JW, Zheng LZ, Xu DH, Lin W. Extensive cutaneous metastasis of recurrent gastric cancer: A case report. World J Clin Cases 2021; 9(22): 6575-6581

2021-07-28 | Browse: 12 | Download: 15

Zhao YR, Hu RH, Wu R, Xu JK. Primary mucosa-associated lymphoid tissue lymphoma in the midbrain: A case report. World J Clin Cases 2021; 9(22): 6566-6574

2021-07-28 | Browse: 10 | Download: 15

2021-07-28 | Browse: 10 | Download: 9

Kim DS, Lee JW, Lee SH. Spontaneous rupture of adrenal myelolipoma as a cause of acute flank pain: A case report. World J Clin Cases 2021; 9(22): 6552-6556

2021-07-28 | Browse: 10 | Download: 9

Wei TT, Huang H, Chen G, He FF. Management of an intracranial hypotension patient with diplopia as the primary symptom: A case report. World J Clin Cases 2021; 9(22): 6544-6551

2021-07-28 | Browse: 5 | Download: 12

2021-07-28 | Browse: 9 | Download: 13

Maranto M, Cigna V, Orlandi E, Cucinella G, Lo Verso C, Duca V, Picciotto F. Non-immune hydrops fetalis: Two case reports. World J Clin Cases 2021; 9(22): 6531-6537

2021-07-28 | Browse: 9 | Download: 12

Huang XM, Luo M, Ran LY, You XH, Wu DW, Huang SS, Gong Q. Chylothorax following posterior low lumbar fusion surgery: A case report. World J Clin Cases 2021; 9(22): 6522-6530

2021-07-28 | Browse: 13 | Download: 14

Zhang SY, He BJ, Xu HH, Xiao MM, Zhang JJ, Tong PJ, Mao Q. Concealed mesenteric ischemia after total knee arthroplasty: A case report. World J Clin Cases 2021; 9(22): 6515-6521

2021-07-28 | Browse: 10 | Download: 12

2021-07-28 | Browse: 6 | Download: 9

Liu H, Zhang T, Qu T, Yang CW, Li SK. Spinal epidural hematoma after spinal manipulation therapy: Three case reports and review of literature. World J Clin Cases 2021; 9(22): 6501-6509

2021-07-28 | Browse: 14 | Download: 12

2021-07-28 | Browse: 8 | Download: 11

2021-07-28 | Browse: 9 | Download: 12

Wu YH, Zhang K, Chen HG, Wu WB, Li XJ, Zhang J. Primary small cell esophageal carcinoma, chemotherapy sequential immunotherapy: A case report. World J Clin Cases 2021; 9(22): 6478-6484

2021-07-28 | Browse: 7 | Download: 10

2021-07-28 | Browse: 10 | Download: 14

2021-07-28 | Browse: 10 | Download: 7

Yang C, Li J, Wang R, Lu L. Malignant peripheral nerve sheath tumor in an elderly patient with superficial spreading melanoma: A case report. World J Clin Cases 2021; 9(22): 6457-6463

2021-07-28 | Browse: 8 | Download: 12

2021-07-28 | Browse: 7 | Download: 10

Yao YF, Feng J, Liu J, Chen CF, Yu B, Hu XP. Disseminated infection by Fusarium solani in acute lymphocytic leukemia: A case report. World J Clin Cases 2021; 9(22): 6443-6449

2021-07-28 | Browse: 6 | Download: 10

Xu XL, Zhang RH, Wang YH, Zhou JY. Manifestation of severe pneumonia in anti-PL-7 antisynthetase syndrome and B cell lymphoma: A case report. World J Clin Cases 2021; 9(22): 6435-6442

2021-07-28 | Browse: 10 | Download: 12

20802 items Read more >>

Keyword Search Published Articles Processes

Hepatocellular carcinoma

992

Case report

979

Gastric cancer

697

Colorectal cancer

640

Inflammatory bowel disease

536

Case report

497

Prognosis

487

Liver transplantation

457

Ulcerative colitis

440

Crohn’s disease

412

Helicobacter pylori

401

Treatment

383

Cirrhosis

378

Endoscopy

361

Diagnosis

353

Meta-analysis

337

Hepatitis C virus

330

Inflammation

320

Magnetic resonance imaging

317

Pancreatic cancer

316

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Reader Comments

"It was an excellent paper. It would have been perfect if GI and liver abnormalities of first wave vs second wave COVID patients be ..." [Read more]

"It was an excellent paper. It would have been perfect if GI and liver abnormalities of first wave vs second wave COVID patients be analysed and discussed based on geographical location of review articles and their corresponding wave patterns. Another similar angle could have analysed and discussed w.r.t. similar variations in relation to real world geographical locations i.e. with altitudes, how these GI and liver abnormalities present. I am sure these two points would have shown major different findings considering our local experiences in second COVID wave where major liver abnormalities were transaminities even more common than respiratory involvements. The hypothesis reason could be delta plus variant of SARS-CoV-2 affecting extra-pulmonary organs more than wave one COVID variants. These viral phenotypes mark differences clinical phenotypes, need of the hour observations to be reviewed and published." [Collapse]

"Thanks to the authors for well-organized study. The overall of the study is good but there is small number of the control group. ..." [Read more]

"Thanks to the authors for well-organized study. The overall of the study is good but there is small number of the control group. If the control group was higher than or at least equal to the patient group, the impact of the study would be more. However, I think that it will contribute to the literature and future studies." [Collapse]

"This is a comprehensive review on a less common lesion of small intestines. This review is well-organized and updated. "

"This is a comprehensive review on the most important mechanism of mitochondria protein control, which is involved in several ..." [Read more]

"This is a comprehensive review on the most important mechanism of mitochondria protein control, which is involved in several physiological pathways to sustain cellular homeostasis. The Authors summarize current evidence of UPRmt involvement in several stem cell types. This review is well-organized and updated. The only criticism is related to the final part of the manuscript, which should have emphasized further research to manipulate this mechanism for pre-clinical and clinical application." [Collapse]

Gu LF, Chen JQ, Lin QY, Yang YZ. Roles of mitochondrial unfolded protein response in mammalian stem cells. World J Stem Cells 2021; 13(7): 737-752 [DOI: 10.4252/wjsc.v13.i7.737]

"A variety of molecular and biological roles of the hypoxic tumor microenvironment in contributing to pancreatic cancer progression ..." [Read more]

"A variety of molecular and biological roles of the hypoxic tumor microenvironment in contributing to pancreatic cancer progression have been well documented into different categories. However, the scope of the theory is very general, not specific to pancreatic cancer." [Collapse]

Estaras M, Gonzalez A. Modulation of cell physiology under hypoxia in pancreatic cancer. World J Gastroenterol 2021; 27(28): 4582-4602 [DOI: 10.3748/wjg.v27.i28.4582]

"The trends in the use of anticancer drugs and/or RTX in gastrointestinal cancer, presented at major clinical conferences including ..." [Read more]

"The trends in the use of anticancer drugs and/or RTX in gastrointestinal cancer, presented at major clinical conferences including ASCO, and the pros and cons of each treatment categorized by adjuvant, neo-adjuvant, and advance/metastasis are well summarized. In some contents, it must be better the information on the sort and regimen of chemotherapy and the dose and regimen used for RTx is provided." [Collapse]

Bordry N, Astaras C, Ongaro M, Goossens N, Frossard JL, Koessler T. Recent advances in gastrointestinal cancers. World J Gastroenterol 2021; 27(28): 4493-4503 [DOI: 10.3748/wjg.v27.i28.4493]

"I think that the manuscript is concisely and coherently well-organised but the cited latest articles are low as regards to the all ..." [Read more]

"I think that the manuscript is concisely and coherently well-organised but the cited latest articles are low as regards to the all references. The overall quality of the manuscript is very good, it will contributes to the literature. Best regards" [Collapse]

Cianci P, Restini E. Management of cholelithiasis with choledocholithiasis: Endoscopic and surgical approaches. World J Gastroenterol 2021; 27(28): 4536-4554 [DOI: 10.3748/wjg.v27.i28.4536]

"Comment on "Prognostic role of plasma level of angiopoietin-1, angiopoietin-2, and vascular endothelial growth factor in ..." [Read more]

"Comment on "Prognostic role of plasma level of angiopoietin-1, angiopoietin-2, and vascular endothelial growth factor in hepatocellular carcinoma" Yan-Dong Miao, Xiao-Long Tang, Jiang-Tao Wang, Li-Xia Yang, Deng-Hai Mi Yan-Dong Miao, Jiang-Tao Wang, Xiao-Long Tang, Deng-Hai Mi, The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China Li-Xia Yang, Deng-Hai Mi, Gansu Academy of Traditional Chinese Medicine, Lanzhou 730000, China We read with interest the article by Choi GH et al. They investigate the profiles of plasma levels of angiogenesis markers in patients with HCC and evaluate their roles in predicting overall survival (OS) and progression-free survival (PFS), which indicated the plasma levels of Ang-2 correlated with liver function, tumor stage, and tumor invasiveness, showing better performance in predicting OS and PFS than AFP, Ang-1, or VEGF. We appreciate the authors' unique perspective by exploring the prognostic role of plasma level of angiopoietin-1, angiopoietin-2, and vascular endothelial growth factor in HCC. However, it may make the results more meaningful if the authors build on this by presenting the differential expression of angiopoietin-1, angiopoietin-2, and vascular endothelial growth factor in normal and tumor tissues of HCC as a whole, such as analysis of HCC cases in The Cancer Genome Atlas (TCGA) database by bioinformatics or their data. We have completed this part of the work and will subsequently provide detailed data in the form of a letter to the editor." [Collapse]

"The article draws readers attention to the pandemic situation in Libya and provides useful information on a country with rising covid ..." [Read more]

"The article draws readers attention to the pandemic situation in Libya and provides useful information on a country with rising covid cases that has nevertheless received less attention in global media and publications. The article is well written and clearly structured overall. I provided a few editorial suggestions: Suggested Title: Exploiting epidemiological data to understand the COVID-19 pandemic in Libya. "This review is aimed to explain" => This review aims to explain "ontact testing within the time frame" => effective contact tracing "various transboundary viral diseases of public health and socio-economic importance" => "significant public health and socio-economic consequences" "positive test rate of COVID-19." => test positivity rate of COVID-19 "and several people not following the health instructions"=> change "several" to "some" "was considerably difficult to implement the Libyan national strategy for the prevention and control of COVID-19." => change "considerably" to "very" " [Collapse]

Mahmoud AS, Dayhum AS, Rayes AA, Annajar BB, Eldaghayes IM. Exploiting epidemiological data to understand the epidemiology and factors that influence COVID-19 pandemic in Libya. World J Virol 2021; 10(4): 156-167 [DOI: 10.5501/wjv.v10.i4.156]

"Thanks Saeed et al for publishing important research on Co-infections in COVID. However, it would be better if this co-infections ..." [Read more]

"Thanks Saeed et al for publishing important research on Co-infections in COVID. However, it would be better if this co-infections could be established as clinical disease/syndrome caused infections rather laboratory identified infections. This is because all these identified organism (both bacteria and fungi) are part of human microbiome/mycobiome or environmental contaminants, unless clinical disease/syndrome we share in the result section, only laboratory identifications will not solve the purpose of scientific evidences. These non-pathogen category of organism identification in laboratory is very vast as expected due to largeness of our microbiome/mycobiome. I suggest authors to share a table of each identified organism's clinical disease/syndrome then only, we can really say the true nature of organism whether pathogen with COVID or just non-pathogenic association. If this right etiologic diagnosis is not established as co-infections, then it is fruitless to say further the consequences in form of treatments, their outcomes, and overall prognosis. " [Collapse]

Saeed NK, Al-Khawaja S, Alsalman J, Almusawi S, Albalooshi NA, Al-Biltagi M. Bacterial co-infection in patients with SARS-CoV-2 in the Kingdom of Bahrain. World J Virol 2021; 10(4): 168-181 [DOI: 10.5501/wjv.v10.i4.168]

"A key early paper showing that HBx is actually expressed in clinical samples of cholangiocarcinoma from HBV infected patients is ..." [Read more]

"A key early paper showing that HBx is actually expressed in clinical samples of cholangiocarcinoma from HBV infected patients is missing. It should be included in the literature cited/references list. Wang WL, London WT, Feitelson MA. Hepatitis B x antigen in hepatitis B virus carrier patients with liver cancer. Cancer Res. 1991 Sep 15;51(18):4971-7. PMID: 1654208." [Collapse]

"The review focusing in all aspects of hepatocellular carcinoma in details and the authors reviewed very carefully with the available ..." [Read more]

"The review focusing in all aspects of hepatocellular carcinoma in details and the authors reviewed very carefully with the available literature." [Collapse]

Yeh H, Chiang CC, Yen TH. Hepatocellular carcinoma in patients with renal dysfunction: Pathophysiology, prognosis, and treatment challenges. World J Gastroenterol 2021; 27(26): 4104-4142 [DOI: 10.3748/wjg.v27.i26.4104]

"It is a pleasure to have been able to read this review article, which fully summarizes the most important aspects of inflammatory ..." [Read more]

"It is a pleasure to have been able to read this review article, which fully summarizes the most important aspects of inflammatory damage in the gastrointestinal tract (liver, pancreas, ileum and colon), caused by COVID-19 infection. This is a very important topic not only for gastroenterologists, but also for endocrinologists and internists. Perhaps my only suggestion could be to summarize the number of references, and consider the most necessary for future manuscripts." [Collapse]

Delgado-Gonzalez P, Gonzalez-Villarreal CA, Roacho-Perez JA, Quiroz-Reyes AG, Islas JF, Delgado-Gallegos JL, Arellanos-Soto D, Galan-Huerta KA, Garza-Treviño EN. Inflammatory effect on the gastrointestinal system associated with COVID-19. World J Gastroenterol 2021; 27(26): 4160-4171 [DOI: 10.3748/wjg.v27.i26.4160]

"This is a very interesting topic about the routine use of abdominal drainage in laparoscopic gastric surgery. It is still an important ..." [Read more]

"This is a very interesting topic about the routine use of abdominal drainage in laparoscopic gastric surgery. It is still an important matter of debate and discussion. The routine placement of drain in gastric surgery is still widely used in many countries. The methodology of the study is globally good, the results are clear as well as the discussion section. The prophylactic use of abdominal drain in gastrectomy has been questioned in the last 15 years, and a 2015 Cochrane meta-analysis on four RCTs demonstrated that there is no sufficient scientific evidence concerning the routine drain placement in gastrectomy. However, a multicenter prospective randomized non-inferiority trial (ADiGe trial) is ongoing, which aimed to verify whether avoiding routine use of abdominal drain is burdened with complications, particularly an increase in postoperative invasive procedures. To my opinion, the placement of abdominal drain should be tailored to each patient, by selecting high-risk patients." [Collapse]

Liu H, Jin P, Quan X, Xie YB, Ma FH, Ma S, Li Y, Kang WZ, Tian YT. Feasibility of totally laparoscopic gastrectomy without prophylactic drains in gastric cancer patients. World J Gastroenterol 2021; 27(26): 4236-4245 [DOI: 10.3748/wjg.v27.i26.4236]

"Comment on USP15 paper by Zhou M et al. To date, it has been identified that deregulated gene expression, affecting the genes ..." [Read more]

"Comment on USP15 paper by Zhou M et al. To date, it has been identified that deregulated gene expression, affecting the genes governing proliferation, programmed cell death plays a role in the occurrence of cancers. The expression of genes is regulated by such process of post-translational modification of histone or non-histone proteins including acetylation, methylation or deubiquitination on certain amino acid residues which are essential in maintaining the spatial configuration of these proteins. Deubiquitination targeting to the cancer related gene coding products may suppress or promote carcinogenesis. It has been shown that deubiquitination of a protein with dual activities, transforming growth factor (TGF)-beta catalyzed by ubiquitin specific protease 15 (USP-15) facilitates the progression of advanced malignant glioma by stabilizing the TGF b type I receptor (1). A protease with similar activity, but less structurally similar with USP-15, USP-19 regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination (2). It has been noted that inhibitors of apoptosis (IAPs) are over-expressed and highlighted in a number of human tumors, including mucosa-associated lymphoid tissue (MALT)(3), hepatocellular carcinoma (4), esophageal and nasopharynx cancers (5, 6). In the present study, it has been described that highly expressed USP-15 is correlated with clinical characteristics (tumor size, depth of invasion, lymph node involvement, tumor-node-metastasis stage in gastric cancer; and its role in gastric carcinogenesis is exerted by regulation of wnt /beta-catenin pathway. We had previously reported a compound derived from natural product, dalbinol inhibits wnt/beta catenin pathway through regulation of protein degradation mediated by ubiquitin-proteasome pathway (7). The available data suggested that tumor suppression and antitumor therapy are targeted by different machinery regulating gene expression. References: 1. Eichhorn PJ, Rodón L, Gonzàlez-Juncà A, et al. USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma. Nat Med. 2012;18:429-435 2. Mei Y., Hahn A.A., Hu S., Yang X. The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2. J. Biol. Chem. 2011; 286:35380-35387. 3. Isaacson P. G., Du M. Q. MALT lymphoma: from morphology to molecules. Nat. Rev. Cancer 2004; 4, 644–653. 4. Zender L, Spector MS, Xue W, et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell. 2006; 125 (7): 1253–1267. 5. Imoto I, Yang ZQ, Pimkhaokham A, et al. Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas. Cancer Res 2001; 61 (18): 6629–6634. 6. Friboulet L, Pioche-Durieu C, Rodriguez S, et al. Recurrent overexpression of c-IAP2 in EBV-associated nasopharyngeal carcinomas: critical role in resistance to Toll-like receptor 3-mediated apoptosis. Neoplasia 2008; 10(11): 1183–1194; 7. Zhu X, Wu X, Cheng J, Liao H, Di X, Li L, Li R, Zhou Y, Zhang X. Dalbinol, a rotenoid from Amorpha fruticosa L., exerts anti-proliferative activity by facilitating beta-catenin degradation in hepatocellular carcinoma cells. Oncotarget. 2017; 8(29):47755-47766." [Collapse]

Zhong M, Zhou L, Fang Z, Yao YY, Zou JP, Xiong JP, Xiang XJ, Deng J. Ubiquitin-specific protease 15 contributes to gastric cancer progression by regulating the Wnt/β-catenin signaling pathway. World J Gastroenterol 2021; 27(26): 4221-4235 [DOI: 10.3748/wjg.v27.i26.4221]

"Interesting topic for clinical medicine which will help to modify the artificial intelligence paradigm"

Bourcier S, Klug J, Nguyen LS. Non-occlusive mesenteric ischemia: Diagnostic challenges and perspectives in the era of artificial intelligence. World J Gastroenterol 2021; 27(26): 4088-4103 [DOI: 10.3748/wjg.v27.i26.4088]

"The manuscript "Liver dysfunction and SARS-CoV-2 infection" by Gracia-Ramos et al., presented an important frontier article, on the ..." [Read more]

"The manuscript "Liver dysfunction and SARS-CoV-2 infection" by Gracia-Ramos et al., presented an important frontier article, on the liver damage in SARS-CoV-2-infected patients, with or without pre-existing liver diseases, and the hepatotoxicity of some treatments commonly used during COVID-19." [Collapse]

Gracia-Ramos AE, Jaquez-Quintana JO, Contreras-Omaña R, Auron M. Liver dysfunction and SARS-CoV-2 infection. World J Gastroenterol 2021; 27(26): 3951-3970 [DOI: 10.3748/wjg.v27.i26.3951]

"The role of CCTA combined with AI in cardiovascular diseases is elaborated, which is a good guide for AI beginners to conduct related ..." [Read more]

"The role of CCTA combined with AI in cardiovascular diseases is elaborated, which is a good guide for AI beginners to conduct related studies." [Collapse]

Zhang ZZ, Guo Y, Hou Y. Artificial intelligence in coronary computed tomography angiography. Artif Intell Med Imaging 2021; 2(3): 73-85 [DOI: 10.35711/aimi.v2.i3.73]

"I really like the layered structure of the article. The article is well organized and scientifically sound. However, as a ..." [Read more]

"I really like the layered structure of the article. The article is well organized and scientifically sound. However, as a minireview(systematic review), the literature selection process of the article should be further refined, including different databases, different search strategies, the literature synthesis process, and the selection of literature inclusion criteria. In addition, the search graphs and charts are not aesthetically pleasing, and the authors need to pay attention to the reader's perception in future studies." [Collapse]

Stefanou IK, Gazouli M, Zografos GC, Toutouzas KG. Role of non-coding RNAs in pathogenesis of gastrointestinal stromal tumors. World J Meta-Anal 2020; 8(3): 233-244 [DOI: 10.13105/wjma.v8.i3.233]

"This is an excellent review o the topic, very well-structured and with a detailed and extensive covering of published literature. "

O'Neill RS, Stoita A. Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket? World J Gastroenterol 2021; 27(26): 4045-4087 [DOI: 10.3748/wjg.v27.i26.4045]

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