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2025-02-08 | Browse: 14 | Download: 4
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505 items Read more >>
1
"I think that the native language certificate is not useful and should not be required, since English is a world language nowadays ..."
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"I think that the native language certificate is not useful and should not be required, since English is a world language nowadays in the scientific field. Changes made by native speakers not directly involved in the original research could, in some cases, negatively interfere with the original message. I also think that in general there should be no cost to authors for publishing articles. I also think that a strict count of words, as in this case, should be avoided. "
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Solazzo A, Lassandro G, Lassandro F. Gastric blunt traumatic injuries: A computed tomography grading classification. World J Radiol 2017; 9(2): 85-90
2
"The system publishing too difficult find location to revise and see comments of article. Overall this journal was good and fast ..."
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"The system publishing too difficult find location to revise and see comments of article. Overall this journal was good and fast publication. I hope next our article can be published in your journal. The publication fee was very nice and that help author with limited resources. I hope your journal still free for publication fee. Thank you "
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Irawan H, Bharata MBS. Sternocleidomastoid flap for reconstruction of tongue small cell carcinoma: A case report. World J Surg Proced 2024; 14(2): 8-14
3
"Author‘s Comments: they are highly regarded for their rigorous peer review, high impact factors, and global reach. They ensure ..."
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"Author‘s Comments: they are highly regarded for their rigorous peer review, high impact factors, and global reach. They ensure credible, ethical research dissemination and support open access. However, high costs and slow processes remain concerns. In conclusion, they play a vital role in advancing medical science and fostering academic collaboration. aa a a a "
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Diao YH, Shu XP, Tan C, Wang LJ, Cheng Y. Preoperative albumin-bilirubin score predicts short-term outcomes and long-term prognosis in colorectal cancer patients undergoing radical surgery. World J Gastrointest Surg 2024; 16(7): 2096-2105
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"We are satisfied with the editing and publishing process. Thanks for the help from those peer-reviewers, as their comments are valuable ..."
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"We are satisfied with the editing and publishing process. Thanks for the help from those peer-reviewers, as their comments are valuable and helpful for improving our manuscript. For the publication part, the fee is too high and we hope it could be reduced a little bit in the future. Thanks a lot. "
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Chen YY, Xu XZ, Xu XJ. Low interleukin-10 level indicates a good prognosis in Salmonella enterica serovar typhimurium-induced pediatric hemophagocytic lymphohistiocytosis: A case report. World J Clin Cases 2024; 12(9): 1660-1668
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"The editors are very serious and responsible, and the reviewers are very professional. The online submission system is convenient ..."
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"The editors are very serious and responsible, and the reviewers are very professional. The online submission system is convenient and fast. The anonymous peer review process is fast and efficient. The peer review report and editor's suggestions have greatly helped our manuscript, making it more scientific, rigorous, and complete. We are very satisfied with the submission process. "
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Nie LJ, Cheng Z, He YX, Yan QH, Sun YH, Yang XY, Tian J, Zhu PF, Yu JY, Zhou HP, Zhou XQ. Role of duodenal mucosal resurfacing in controlling diabetes in rats. World J Diabetes 2025; 16(3): 102277
6
"The time to publication has had one or two unnecessary delays. Apart from that everything was fine. We found that the process is easy ..."
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"The time to publication has had one or two unnecessary delays. Apart from that everything was fine. We found that the process is easy to understand and to follow and I found the reviewers comments constructive and objective. The other authors and I will definitely consider this journal for my future publications "
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Ruiz MA, Kaiser Junior RL, Piron-Ruiz L, Pinho TS, Castiglioni L, de Quadros LG. COVID-19 impact in Crohn’s disease patients submitted to autologous hematopoietic stem cell transplantation. World J Hematol 2024; 11(1): 89084
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"Thank you for reaching out. I sincerely appreciate the opportunity to provide feedback on the manuscript submission and publication ..."
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"Thank you for reaching out. I sincerely appreciate the opportunity to provide feedback on the manuscript submission and publication process.Throughout the process, I have been highly satisfied with the efficiency and professionalism demonstrated by the editorial team. The timely and constructive feedback provided during peer review was invaluable in improving the quality of our manuscript. Additionally, the editors' close follow-up and clear communication ensured a smooth experience, from submission to final revisions. The structured workflow, reasonable timelines, and academic rigor of the journal reflect a commitment to maintaining high publishing standards. Best regards, "
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Arslan M, Kozan R. Pelvic floor dysfunction in patients with gestational diabetes mellitus. World J Diabetes 2025; 16(2): 99823
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"The Journal team was very serious during the publication process; the publishers were very kind and cooperative in reporting the ..."
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"The Journal team was very serious during the publication process; the publishers were very kind and cooperative in reporting the missing documents requested. The reviewers were fair and objective, demanding but helpful and they really improved the quality of the final work. I think it's a Journal destined to grow. Very good experience "
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Casu C, Orrù G. Potential of photodynamic therapy in the management of infectious oral diseases. World J Exp Med 2024; 14(1): 84284
9
"I think that the journal made an accurate rewiew that made the article better than the submission, advice were preciuous to work ..."
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"I think that the journal made an accurate rewiew that made the article better than the submission, advice were preciuous to work better, and made a more accurate work, on one heand with the languages on the other hand with the contents. I hope we could collaborate togheter more and more. Tkank you "
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Sciarrone SS, Fini L, De Luca L. Trans-jugular intrahepatic portosystemic stent shunting benefits and limits. World J Gastrointest Surg 2025; 17(1): 100554
10
"I would like to express my heartfelt gratitude for the opportunity to have my article published. The entire publication process was ..."
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"I would like to express my heartfelt gratitude for the opportunity to have my article published. The entire publication process was thorough and professional, and I appreciate the efforts of the editorial team in enhancing the quality of my work. Reflecting on the survey, I have no additional comments or suggestions to offer, as I am fully satisfied with the final outcome and the valuable insights it provides to the field. "
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Hetta HF, Ahmed R, Ramadan YN, Fathy H, Khorshid M, Mabrouk MM, Hashem M. Gut virome: New key players in the pathogenesis of inflammatory bowel disease. World J Methodol 2025; 15(2): 92592
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"Everything was great. the whole proces was unremarkable. I hope to cooperate with you in future. Regards from Croatia. This was great ..."
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"Everything was great. the whole proces was unremarkable. I hope to cooperate with you in future. Regards from Croatia. This was great experience. Fast and hight quality review. The process was professional and all steps were clear and consise I thank to all people invilved in BPG publishing process. I am truly grateful for the professional and swift review process of my scientific article. The reviewers' insightful feedback and timely responses significantly enhanced the quality of my work. Their dedication and efficiency ensured a smooth publication journey, allowing me to share my research with the wider community effectively. Thank you! "
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Romic I, Separovic I, Grgic D, Petrovic I, Mavrek J, Silovski H. Reducing invasiveness in liver surgery-where is the limit? World J Gastrointest Surg 2025; 17(2): 101852
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"The submission process was overall a very positive experience. The peer review played a crucial role in significantly enhancing the ..."
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"The submission process was overall a very positive experience. The peer review played a crucial role in significantly enhancing the quality of the manuscript. The feedback provided by the reviewers was both thorough and constructive, offering valuable insights that helped refine the work and elevate it to a higher standard. Additionally, the editors were incredibly helpful throughout the process. They were not only prompt in their responses but also provided clear guidance on any necessary revisions, making the entire process feel smooth and efficient. Their support ensured that any questions or concerns I had were addressed in a timely manner, which was reassuring. Furthermore, the submission portal itself was well-designed and user-friendly. Navigating the platform was straightforward, and it made submitting the manuscript, tracking its progress, and communicating with the editorial team a seamless experience. Overall, the combination of a well-organized submission system, helpful editorial staff, and valuable peer feedback made the entire process much easier and more efficient than I initially anticipated. "
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Venkatesan S, Lucke-Wold B. Mind the gut: Navigating the complex landscape of gastroprotection in neurosurgical patients. World J Gastroenterol 2025; 31(8): 102959
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"It was an overall very positive experience to publish our work under Baishideng. The editorial team is highly professional, ensuring ..."
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"It was an overall very positive experience to publish our work under Baishideng. The editorial team is highly professional, ensuring that all submitted manuscripts are evaluated with the utmost care and expertise. The feedback from peer reviewers is both constructive and thorough, contributing significantly to the improvement of our work. This journal continues to maintain its reputation for publishing high-quality, impactful research in the field of general surgery, making it a valuable platform for academic exchange and advancement in the field "
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Ntampakis G, Pramateftakis MG, Anestiadou E, Bitsianis S, Ioannidis O, Bekiari C, Koliakos G, Karakota M, Tsakona A, Cheva A, Angelopoulos S. Experimental models of high-risk bowel anastomosis in rats: A systematic review. World J Exp Med 2024; 14(2): 94135
14
"I am completely satisfied with the submission, peer-reviewing, and publication process. The revision process was smooth and easily ..."
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"I am completely satisfied with the submission, peer-reviewing, and publication process. The revision process was smooth and easily accessible. The publication format aligns with the authors' intentions, including tables (Our paper did not include any figures). I have not experienced any issues regarding these processes. I have no further comments to add. Thank you. "
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Colapietro F, Pugliese N, Voza A, Aghemo A, De Nicola S. Risk of hepatitis B virus reactivation in oncological patients treated with tyrosine kinase inhibitors: A case report and literature analysis. World J Gastroenterol 2024; 30(9): 1253-1256
15
"The article is novel, reliable, and readable, the author of the article has a certain academic level, and the research has a certain ..."
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"The article is novel, reliable, and readable, the author of the article has a certain academic level, and the research has a certain degree of innovation. At the same time, this study has certain clinical value and reference significance. It can be used as an important reference for follow-up research. "
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Zhang X, Liu Y, Tang HF, Jiang F, Chen CL, Wang TT, Gu HZ, Zhao Q, Ma R. Retraction note to: Shugan Jieyu capsule effects on peripheral blood micro-124, micro-132, and brain-derived neurotrophic factor in patients with mild to moderate depression. World J Psychiatry 2025; 15(2): 103118
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"I am satisfied with the online submission system、the peer review report 、 the editing quality of the article、the online full-text ..."
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"I am satisfied with the online submission system、the peer review report 、 the editing quality of the article、the online full-text article、the published articles processes、 the requirement for providing academic rules and norms、the time spent for peer review and the anonymous peer review process, I think the peer review report of great help to my manuscript. "
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Wang YY, Shen MM, Gao J. Metadherin promotes stem cell phenotypes and correlated with immune infiltration in hepatocellular carcinoma. World J Gastroenterol 2024; 30(8): 901-918
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"Overall, the review system and journal process were reasonable. But our manuscript was applied to 2nd review even after we got an ..."
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"Overall, the review system and journal process were reasonable. But our manuscript was applied to 2nd review even after we got an acceptance from the journal, which was ridiculous. Also review and process time took so long time. They asked us to respond within a week, but their process was so slow and took forever. "
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Kim OH, Kang H, Chang ES, Lim Y, Seo YJ, Lee HJ. Extended protective effects of three dimensional cultured human mesenchymal stromal cells in a neuroinflammation model. World J Stem Cells 2025; 17(1): 101485
18
"I feel incredibly honored to have the opportunity to submit my research to your journal. Thank you for this chance, as it means a ..."
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"I feel incredibly honored to have the opportunity to submit my research to your journal. Thank you for this chance, as it means a lot to me. I sincerely hope that you will consider my research favorably for future opportunities as well. Your support is deeply appreciated, and I look forward to meeting again under even better circumstances where we can collaborate further and continue to advance our shared interests in this field. Thank you once again, and I hope for more fruitful opportunities in the future. "
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Kim KH, Myung E, Oh HH, Im CM, Seo YE, Kim JS, Lim CJ, You GR, Cho SB, Lee WS, Noh MG, Lee KH, Joo YE. Clinical and endoscopic characteristics of colorectal traditional serrated adenomas with dysplasia/adenocarcinoma in a Korean population. World J Gastrointest Oncol 2025; 17(2): 101780
19
"Overall process was satisfying. However, the article processing fee could be more affordable for the authors in developing ..."
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"Overall process was satisfying. However, the article processing fee could be more affordable for the authors in developing countries.ALthough, it is good to have email notification, as it come right away to authors. However, sometime it was confusing when it also required to response through email instead of the publication web portal. "
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Pakvisal N, Goldberg RM, Sathitruangsak C, Silaphong W, Faengmon S, Teeyapun N, Teerapakpinyo C, Tanasanvimon S. Overall survival with frontline vs subsequent anti-epidermal growth factor receptor therapies in unresectable, RAS/BRAF wild-type, left-sided metastatic colorectal cancer. World J Clin Oncol 2025; 16(3): 102076
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"I appreciate the collaborative effort involved in the publication process. A heartfelt thank you goes to the assistant editor for ..."
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"I appreciate the collaborative effort involved in the publication process. A heartfelt thank you goes to the assistant editor for their meticulous attention to detail, ensuring that every aspect of the manuscript was thoroughly reviewed. The science editor's insights have been invaluable in enhancing the clarity and impact of the research presented. Moreover, I extend my gratitude to the peer reviewers whose constructive feedback has significantly contributed to the quality of the publication. Their expertise and critical analysis played a crucial role in refining the manuscript. The editorial director and journal editor-in-chief have provided essential guidance throughout this journey, facilitating a smooth and efficient review process. Additionally, I acknowledge the contributions of the company editor-in-chief, whose support has been instrumental in aligning our work with the journal’s standards and objectives. Finally, I would like to recognize the language editor and production editor for their efforts in ensuring that the final manuscript is polished and professionally presented. Their dedication to preserving the integrity of the research while enhancing its readability is commendable. Overall, this publication is a testament to the collective hard work and commitment of everyone involved, and I am truly satisfied with the outcome. Thank you all once again for your invaluable contributions. "
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He YC, Wang NX, Zhong T. Reference diagnosis and treatment process of juvenile hemochromatosis patients. World J Clin Cases 2025; 13(15): 99198
18052 items Read more >>
1
"1. The title does not include the type of study. For better understanding the type of the study (prospective / observational) can ..."
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"1. The title does not include the type of study. For better understanding the type of the study (prospective / observational) can be included in the title.
2. How was the sample size fixed at 103?
3. What was the previous renal function, before the study?
4. Would the dose variation have an effect on the measurement of levels? Can this may be study limitation?
5. In retrospect, if the study was planned how better can it be done (prospective, randomised, blinded)?"
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Guo T, Du LY, Liu MF, Zhou XJ, Chen XR. Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit. World J Clin Cases 2025; 13(16): 102866
2
"1. The title requires appropriate modification. Adjectives such as 'extremely severe' without objective criteria may be avoided. To ..."
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"1. The title requires appropriate modification. Adjectives such as 'extremely severe' without objective criteria may be avoided. To clarify the term 'head and lumbar disc herniation'.
"Diagnosis and surgical challenges of extremely severe head and lumbar disc herniation in young patients: A case report."
2. Introduction can have a short paragraph with the rest of the material including grading / diagrams included in discussion."
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Zhou JG. Diagnosis and surgical challenges of extremely severe head and lumbar disc herniation in young patients: A case report. World J Clin Cases 2025; 13(16): 103373
3
"1. The title refers to all genetic disorders in general "Genetic disorders leading to severe hyperlipidemia in children: A case ..."
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"1. The title refers to all genetic disorders in general "Genetic disorders leading to severe hyperlipidemia in children: A case report." But the manuscript discusses only a single case of Alagille syndrome.
2. In a child with cholestasis accompanied by syndromic features such as stenosis of pulmonary artery, abnormal butterfly-shaped vertebrae, posterior embryotoxon, and triangular facial features, Alagille syndrome to be considered.
"
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Jiang CX, Meng YL, Chen D, Shi LP, Yang G, Guo Y, Zhang B, Zhai ZC, Wu ZJ, Liu TN, Wang ZJ, Tian X, Su PY. Genetic disorders leading to severe hyperlipidemia in children: A case report. World J Clin Cases 2025; 13(16): 101732
4
"Generative AI, especially ChatGPT, is revolutionizing chronic disease management, including diabetes. It allows for targeted and ..."
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"Generative AI, especially ChatGPT, is revolutionizing chronic disease management, including diabetes. It allows for targeted and generalized approaches to care, improving treatment plans and patient support. This further underlines the growing role of AI and ML in healthcare, optimizing workflows and making it more accessible. As AI continues to advance, its potential in personalized disease management increases, making healthcare more efficient and proactive. ChatGPT is an example of how intelligent systems can revolutionize medical support, offering scalable, data-driven solutions for better patient outcomes.
"
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Sridhar GR, Gumpeny L. Prospects and perils of ChatGPT in diabetes. World J Diabetes 2025; 16(3): 98408
5
"Good work. However, there are few observations.
1. ABSTRACT:
a) “Invasive coronary procedures” more readily mean interventional ..."
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"Good work. However, there are few observations.
1. ABSTRACT:
a) “Invasive coronary procedures” more readily mean interventional procedures, e.g., percutaneous coronary intervention. “Invasive coronary procedures, including coronary intervention and CABG” might give the clear idea that both coronary intervention and surgery have been included.
b) Outcomes measured could be included in METHODS of “Abstract”.
2. MATERIALS AND METHODS:
a. “Two researchers (Shafiq A and Ahmed M) carried out the literature search, study selection, and data extraction independently. In the event of any disagreements, a third reviewer (Shafiq A) was consulted.” Who is the third reviewer (Shafiq A)? this might be clarified here.
3. CONCLUSION
a) “Patients having cardiac surgery who already struggle with one or more psychological issues need special consideration.” Only cardiac surgery, or coronary intervention as well?
"
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Siddiqi AK, Shafiq A, Ahmed M, Anwer A, Maniya MT, Ahmed A, Chachar MA, Hasibuzzaman MA. Therapeutic use of music listening in patients undergoing invasive coronary procedures: A meta-analysis. World J Cardiol 2025; 17(1): 97406
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"This is a very nice case. And the approach is rather accurate. Presentation is adequate and correctly studied. There is only one ..."
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"This is a very nice case. And the approach is rather accurate. Presentation is adequate and correctly studied. There is only one concern. Although there is "a specific" cause of bleeding. I think this case report deserves a broader discussion. That is, discussing different causes of upper gastrointestinal bleeding. Apparently there was a cause-effect bleeding. However, as academicians we have to take advantage of the case to analyze different causes of upper GI bleeding. But a very nice case. Congratulations..."
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Jiang HH, Tang Q, Huang L, Yun X, Shan QW, Chen XQ. Severe upper gastrointestinal hemorrhage due to milk protein allergy: A case report. World J Clin Cases 2025; 13(14): 104039
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"This study provides key insights into DR pathogenesis, focusing on the lnc-MGC/miR-495-3p/GRP78 axis in regulating ER stress and ..."
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"This study provides key insights into DR pathogenesis, focusing on the lnc-MGC/miR-495-3p/GRP78 axis in regulating ER stress and ferroptosis. Although the results are compelling, reliance on animal and in vitro models limits clinical relevance, and validation in human studies is required. The study effectively integrates past research but could strengthen mechanistic claims with broader pathway analysis and deeper functional validation. Despite these limitations, it identifies promising therapeutic targets for DR treatment. Further downstream effects and interactions may even add to the translational value of this molecule, making this contribution valuable for DR research. Best Wishes"
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Luo YY, Ba XY, Wang L, Zhang YP, Xu H, Chen PQ, Zhang LB, Han J, Luo H. LEF1 influences diabetic retinopathy and retinal pigment epithelial cell ferroptosis via the miR-495-3p/GRP78 axis through lnc-MGC. World J Diabetes 2025; 16(3): 92003
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"This editorial explained the importance of systemic inflammation index (SII) to predict the recurrence of atrial fibrillation after ..."
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"This editorial explained the importance of systemic inflammation index (SII) to predict the recurrence of atrial fibrillation after successful RFCA by referring the retrospective study published in the World Journal of cardiology. This editorial recall the usefulness of SII in various fields in medicine, because SII is easily calculated. All clinicians should calculate this index frequently and will be able to find a clue of the novel study initiation. "
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Berezin AE. Predictive value of the systemic immune inflammation index in recurrence of atrial fibrillation after radiofrequency catheter ablation. World J Cardiol 2025; 17(1): 102981
9
"Recent epidemiological data show that despite implementing preventive control programs for the early detection of malignant neoplasms ..."
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"Recent epidemiological data show that despite implementing preventive control programs for the early detection of malignant neoplasms of the digestive tract, their frequency is increasing and is expected to increase further in the coming years. At the same time, the increase in life expectancy, along with more effective therapeutic methods, has resulted in an increase in patient survival. The diagnosis of patients with simultaneous (within three months) detection of a second (or even third) malignant neoplasm is no longer a surprise. Therefore, detecting a malignant neoplasm should not prevent the physician from performing a complete clinical and laboratory examination to investigate the possibility of distant metastases and the possibility of a second simultaneous malignant neoplasm of the same or different system. Failure to detect the second neoplasm promptly will significantly reduce patients' chances of survival. The reviewed article refers to three cases of patients who developed simultaneous cancers. The authors emphasize the fact that all patients with malignant neoplasms of the digestive tract, especially elderly patients, patients with a positive family history of cancer, smokers, people who systematically use alcohol, as well as patients who have undergone radiotherapy in the past, should be carefully and diligently monitored for the possibility of a synchronous or metachronous malignant neoplasm."
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Bi XR, Zhao SY, Ma YQ, Duan XY, Hu TT, Bi LZ, Cai HY. Multiple primary cancers with gastrointestinal malignant tumors as the first manifestation: Three case reports and review of literature. World J Gastroenterol 2025; 31(8): 100146
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"1 Ethics: This experimental study was approved by the Experimental Ethics Committee of Xi’an Jiaotong University. The ethical approval ..."
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"1 Ethics: This experimental study was approved by the Experimental Ethics Committee of Xi’an Jiaotong University. The ethical approval form provided by the author meet the requirements.
2 Methods: This animal experimental method effective and proper method following guidelines and histopathology methods.
3 Results: The results true and authentic and significance validated that followed the objectives.
4 Figures and tables: The author provide perfect tables and graphic which is good quality and easily understandable.
5 Biostatistics: Yes, the author provide perfect biostatistics data that complied with standard quality.
6 References: Record the latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Zhang MM, Shi AH, Muensterer OJ, Uygun I, Lyu Y, Yan XP. Comparative study of cylindrical vs circular ring magnets for colonic anastomosis in rats. World J Gastrointest Surg 2025; 17(2): 94270
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" This study explores the incorporation of human β-defensin-1 (hBD-1) into immunoliposomes as a targeted nanotherapeutic strategy ..."
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" This study explores the incorporation of human β-defensin-1 (hBD-1) into immunoliposomes as a targeted nanotherapeutic strategy for colon cancer, leveraging its ability to induce autophagy and inhibit tumor proliferation. By integrating anti-EGFR antibodies onto the liposomal surface, the study aims to enhance targeted delivery, stability, and bioavailability of hBD-1, addressing its druggability challenges. This approach is promising, as it aligns with nanotechnology-driven advancements in oncology and represents a potential alternative for improving therapeutic efficacy in colorectal cancer.
The article is well-structured and scientifically sound, presenting a rational framework for utilizing immunoliposomes in cancer therapy. It highlights the limitations of hBD-1 as a therapeutic agent, particularly its poor stability, non-specific distribution, and susceptibility to degradation, and proposes a liposomal delivery system to overcome these challenges. However, while the study introduces an innovative concept, several critical aspects remain underexplored.
One major limitation is the lack of in-depth preclinical validation. Although the study proposes a theoretical model, no experimental data are provided to demonstrate the efficacy of hBD-1 immunoliposomes in vitro or in vivo. The absence of key findings, such as tumor growth inhibition, biodistribution, pharmacokinetics, or toxicity profiles, limits the practical applicability of the proposed system. Future studies should include functional assays, such as cell viability, apoptosis induction, autophagy markers (LC3-II, Beclin-1), and EGFR signaling analysis, to validate the effectiveness of this approach.
Furthermore, the immunoliposome formulation details are not thoroughly discussed. While the concept of conjugating anti-EGFR antibodies to liposomes is well-supported, specific parameters such as antibody-liposome conjugation efficiency, encapsulation stability, and release kinetics are not provided. These factors are crucial for ensuring effective tumor targeting and sustained drug delivery. Addressing these concerns with detailed characterization studies would significantly strengthen the credibility of the proposed system.
From a translational perspective, clinical feasibility and potential toxicity of hBD-1 immunoliposomes remain uncertain. While nanocarriers enhance drug delivery, nanotoxicology and immune system interactions must be carefully assessed. The study acknowledges the need for further research before clinical application, but a clear roadmap for preclinical testing and regulatory considerations is lacking. Future investigations should include in vivo biodistribution studies, immune response evaluation, and large-scale manufacturing feasibility to assess the potential for clinical translation.
In conclusion, this article presents a novel and conceptually strong therapeutic approach by integrating hBD-1 into EGFR-targeted immunoliposomes to enhance colon cancer therapy. However, to strengthen its impact and translational potential, future studies should focus on comprehensive preclinical validation, formulation optimization, and safety assessments. If validated through rigorous experimental studies, this strategy could represent a valuable addition to nanotechnology-based cancer therapeutics."
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Huang Y, Wang XY, Huang JY, Huang ZW. Incorporation of human β-defensin-1 into immunoliposomes to facilitate targeted autophagy therapy of colon carcinoma. World J Clin Oncol 2025; 16(3): 101098
12
" This review provides a comprehensive overview of the molecular landscape of lung cancer diagnosis, targeted therapy, and ..."
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" This review provides a comprehensive overview of the molecular landscape of lung cancer diagnosis, targeted therapy, and immunotherapy, highlighting key oncogenic drivers such as EGFR, ALK, ROS1, KRAS, and MET, along with the current state and challenges of PD-1/PD-L1 immune checkpoint blockade. Additionally, the article discusses emerging technologies, including liquid biopsy, ctDNA analysis, multi-omics integration, and artificial intelligence (AI), emphasizing their potential role in precision oncology. The breadth of topics covered makes this review highly relevant to both researchers and clinicians seeking insights into the evolving landscape of lung cancer treatment.
As a review article, the structure is clear, and the content is well-organized, effectively summarizing recent advancements. However, several limitations remain that could be addressed to enhance the scientific rigor and impact of the study. First, while the discussion on targeted therapies across different molecular subtypes is extensive, the article lacks quantitative data from large-scale clinical trials, such as progression-free survival (PFS), overall survival (OS), and objective response rates (ORR) across various treatment strategies. Incorporating such comparative data would significantly strengthen the review’s credibility and practical relevance. Furthermore, although the review touches on immune resistance mechanisms, it does not provide an in-depth exploration of T-cell exhaustion, tumor microenvironment influences, or key immune escape pathways, which are crucial to understanding the limitations of immunotherapy.
In terms of data presentation, the existing tables and figures are informative but primarily descriptive. The review would benefit from more comparative analyses or statistical insights, such as Kaplan-Meier survival curves to illustrate the prognostic differences between molecular subtypes. Additionally, while the discussion on AI and multi-omics is timely and important, it lacks a concrete implementation framework. A more detailed explanation of how AI is being integrated into lung cancer diagnostics and treatment decision-making, along with real-world case studies, would enhance the clarity and applicability of this section.
Overall, this review effectively synthesizes current knowledge on lung cancer molecular diagnostics and therapeutic strategies, making it a valuable resource for both clinicians and researchers. However, to further improve its impact, integrating more quantitative data, refining mechanistic discussions, enhancing data visualization, and providing a clearer outlook on future research directions would elevate its scientific contribution and clinical relevance."
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Xiong Y, Cheng L, Zhou YJ, Ge WH, Qian M, Yang H. Diagnosis and treatment of lung cancer: A molecular perspective. World J Clin Oncol 2025; 16(3): 100361
13
" The article presents a compelling case of a HER2-positive, NRAS-mutant metastatic colorectal cancer (mCRC) patient responding ..."
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" The article presents a compelling case of a HER2-positive, NRAS-mutant metastatic colorectal cancer (mCRC) patient responding favorably to disitamab vedotin-based therapy, highlighting a potential therapeutic option in an otherwise challenging clinical setting. The well-documented treatment course, including biomarker trends and imaging assessments, provides valuable clinical insights. However, as a single-patient case report, the study's applicability remains limited, and the underlying mechanisms of response warrant further exploration.
Despite the known resistance of RAS-mutant tumors to HER2-targeted therapy, the patient exhibited a significant clinical response, raising important questions about the interplay between HER2 and NRAS signaling. The absence of a mechanistic investigation leaves this aspect unexplored, and future studies should aim to elucidate whether this response is mediated through alternative signaling pathways or compensatory mechanisms. Additionally, while CEA reduction and radiological improvement are promising indicators, the study lacks long-term survival data, such as progression-free survival (PFS) and overall survival (OS), which are crucial for assessing the durability of therapeutic efficacy.
To strengthen the study’s impact, a comparative analysis with similar HER2-positive mCRC cases—especially those with and without NRAS mutations—would provide a broader context for evaluating treatment efficacy. Moreover, integrating functional studies to investigate HER2 signaling dynamics in NRAS-mutant tumors could offer mechanistic insights and support the rationale for targeted therapy combinations. A retrospective or multi-patient case series analysis could also enhance statistical robustness and clinical relevance.
Overall, the article adds value by documenting an exceptional clinical response in a patient subgroup typically considered resistant to HER2 inhibition. However, to maximize its scientific contribution, future research should focus on validating these findings in larger cohorts, exploring resistance and response mechanisms at the molecular level, and providing longer follow-up data to assess treatment durability."
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Yan HC, Liu Y, Feng Y, Li JM, Sheng LM, Chen X, Xie YP, Li N. Efficacy of disitamab vedotin-containing therapy in metastatic colorectal cancer: A case report. World J Clin Oncol 2025; 16(3): 99527
14
"The manuscript is well written, concise, easy to read, without spelling or grammatical errors. The references are updated and the ..."
[Read more]
"The manuscript is well written, concise, easy to read, without spelling or grammatical errors. The references are updated and the main idea of this article is of a great interest regarding this pathology with a rising incidence and also a higher risk of reccurence, so the sclerobanding is indeed a future therapeutic approach. Thank you. "
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Gravante G. Sclerotherapy for hemorrhoidal disease: Recent evolutions of an oldies goldy. World J Gastroenterol 2025; 31(8): 98704
15
"1. The most frequent complication is pain (in 22–32 % of cases), followed by bleeding (18 %), urinary retention (3 perianal fistula ..."
[Read more]
"1. The most frequent complication is pain (in 22–32 % of cases), followed by bleeding (18 %), urinary retention (3 perianal fistula (0.5 %), and abscess (0.04 %). Please comment about complication after sclerotheraphy
2. Various sclerosants have been injected, including aluminum potassium sulfate tannic acid (ALTA),5 % phenol in almond oil,and 1–3 % liquid or foam Lauromacrogol, with 3 % foam proving more effective than 3 % liquid. Please comment about the superiority of polidocanol foam compared to other various sclerosants.
"
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Gravante G. Sclerotherapy for hemorrhoidal disease: Recent evolutions of an oldies goldy. World J Gastroenterol 2025; 31(8): 98704
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"The study provides valuable insights into the immunosuppressive mechanisms in GC, highlighting the potential role of the CSF3/CSF3R ..."
[Read more]
"The study provides valuable insights into the immunosuppressive mechanisms in GC, highlighting the potential role of the CSF3/CSF3R pathway in promoting immune evasion. The use of multiple methodologies, including transcriptome sequencing, immunohistochemistry, and quantitative reverse transcriptase-polymerase chain reaction, strengthens the validity of the findings. The identification of hnRNPH1 as a regulatory factor adds depth to the understanding of CSF3-mediated effects. However, further research is needed to explore the functional implications of these findings and to validate them in larger cohorts."
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Wang L, Wu Q, Zhang ZW, Zhang H, Jin H, Zhou XL, Liu JY, Li D, Liu Y, Fan ZS. Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor B2 expression and ligands in gastric cancer. World J Gastrointest Oncol 2025; 17(2): 97858
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"The study provides valuable insights into the clinical characteristics and prognosis of pancreatic PNETs. The use of a comprehensive ..."
[Read more]
"The study provides valuable insights into the clinical characteristics and prognosis of pancreatic PNETs. The use of a comprehensive dataset and multiple analytical methods strengthens the validity of the findings. The identification of lymph node metastasis as a key prognostic factor is particularly noteworthy, offering potential targets for improving patient outcomes. However, the study's retrospective nature and limited sample size may affect the generalizability of the results. Further research with larger cohorts and prospective designs is needed to confirm these findings and develop effective treatment strategies."
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He YF, Wang HZ, Hu XD, Liu JQ, Li HM, Wang J, Lu SF. Pancreatic primitive neuroectodermal tumors: Clinical features, treatment, and influencing factors. World J Gastrointest Oncol 2025; 17(2): 97298
18
"The study provides a comprehensive analysis of cell dynamics across different stages of GC, offering valuable insights into the tumor ..."
[Read more]
"The study provides a comprehensive analysis of cell dynamics across different stages of GC, offering valuable insights into the tumor microenvironment. The use of scRNA-seq, along with qRT-PCR and flow cytometry, strengthens the validity of the findings. The identification of key interactions within the tumor microenvironment and the elevated presence of specific cell types provide potential targets for developing novel therapeutic strategies. However, further research is needed to explore the functional implications of these findings and to validate them in larger cohorts."
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Tang XS, Xu CL, Li N, Zhang JQ, Tang Y. Landscape of four different stages of human gastric cancer revealed by single-cell sequencing. World J Gastrointest Oncol 2025; 17(2): 97125
19
"The study is comprehensive and provides valuable insights into the role of lncRNA PCAT6 in colonic NEC. The use of multiple ..."
[Read more]
"The study is comprehensive and provides valuable insights into the role of lncRNA PCAT6 in colonic NEC. The use of multiple methodologies, including immunohistochemistry, RT-qPCR, and western blotting, strengthens the validity of the findings. The identification of PCAT6 as a potential therapeutic target is particularly noteworthy, offering new directions for cancer treatment. However, further experimental validation and exploration of PCAT6's role in other cancer types are necessary to fully understand its therapeutic potential."
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Wang F, Mu HF, Wang C, Tang Y, Si MY, Peng J. LncRNA PCAT6 promotes progression and metastasis of colonic neuroendocrine carcinoma via MAPK pathway. World J Gastrointest Oncol 2025; 17(2): 96230
20
"The study is comprehensive and provides valuable insights into the prognostic factors affecting gastric carcinoma patients. The use ..."
[Read more]
"The study is comprehensive and provides valuable insights into the prognostic factors affecting gastric carcinoma patients. The use of multiple methodologies, including LASSO regression and Cox regression analyses, strengthens the validity of the findings. The development of a web-based nomogram tool enhances the model's clinical utility, allowing for personalized treatment strategies. However, further validation with larger, multicenter studies is necessary to confirm these findings and improve the generalizability of the results."
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Liang GZ, Li XS, Hu ZH, Xu QJ, Wu F, Wu XL, Lei HK. Development and validation of a nomogram model for predicting overall survival in patients with gastric carcinoma. World J Gastrointest Oncol 2025; 17(2): 95423
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Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2282
- Peer-reviewers
- 28405
- Manuscripts received today
- 15
- Manuscript reviews today
- 41
- Unhandled manuscripts today
- 131
- Active peer-reviewers today
- 4100
- Reviewer acceptance today
- 89
- Reviewer refusals today
- 173
- Total accepted manuscripts
- 34853
- Total rejected manuscripts
- 40392
- Total peer-reviewers
- 3971626
- Total submissions
- 33076
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1
"The study by Real Martinez et al. provides valuable insights into the role of circulating myokines such as irisin and FGF21 in MASLD, ..."
[Read more]
"The study by Real Martinez et al. provides valuable insights into the role of circulating myokines such as irisin and FGF21 in MASLD, particularly their association with severe steatosis and advanced liver fibrosis. However, the absence of a relationship between skeletal muscle alterations (SMAs) and liver fibrosis stages raises intriguing questions. Could the lack of association be attributed to the heterogeneity of the cohort, or might it suggest that SMAs play a more indirect role in MASLD progression? Additionally, how might other metabolic or inflammatory pathways, not directly evaluated in this study, influence the interplay between muscle health and liver disease? Further studies exploring these aspects, especially in longitudinal designs or larger cohorts, would be invaluable in clarifying these relationships and their implications for clinical practice. "
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Real Martinez Y, Fernandez-Garcia CE, Fuertes-Yebra E, Calvo Soto M, Berlana A, Barrios V, Caldas M, Gonzalez Moreno L, Garcia-Buey L, Molina Baena B, Sampedro-Nuñez M, Beceiro MJ, García-Monzón C, González-Rodríguez Á. Assessment of skeletal muscle alterations and circulating myokines in metabolic dysfunction-associated steatotic liver disease: A cross-sectional study. World J Gastroenterol 2025; 31(7): 100039
2
"I congratulate the authors for the publication of their write up. It is well written with practical points. The information on greater ..."
[Read more]
"I congratulate the authors for the publication of their write up. It is well written with practical points. The information on greater likelihood of antibody generation with premixed insulins was new to me, although I believe it would have been partly due to the highly prevalent use of this form of insulin. I would like the authors to understand this point as well while promoting the advantages of the newer insulins. In the international guidelines, at diagnosis of diabetes if the blood glucose levels are above 300 mg/dl and/or glycosylated hemoglobin level is more than 10 %, it is suggested to start the patient on insulin to reduce the glucotoxicity. Once the blood glucose levels reduce, say after 2-3 weeks, the patient may be switched to oral anti-diabetic agents. Such a guideline recommended practice is regularly followed in developing countries such as ours. In such a situation I have observed that the acceptance rate of premixed insulin which involves two pricks, is a lot better than that of multiple short acting insulin doses along with basal insulin. Since the duration of premixed insulin therapy in this context is short, the possible side effects of anti-insulin antibody generation as well as lipodystrophy are less likely. "
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Xia Y, Hu Y, Ma JH. Premixed insulin: Advantages, disadvantages, and future. World J Diabetes 2025; 16(3): 102526
3
"This study presents an evaluation of a novel contrast-enhanced catheter with a chamfered tip. Achieving selective biliary cannulation ..."
[Read more]
"This study presents an evaluation of a novel contrast-enhanced catheter with a chamfered tip. Achieving selective biliary cannulation is one of the most challenging endoscopic maneuver. We congratulate the authors on demonstrating in this paper that a novel device granted higher rates of biliary cannulation when retrospectively compared to a standard sphincterotome. However, a few points warrant further discussion: 1. Generalizability: As a single-center retrospective study, the external validity of these findings could be enhanced with multicenter randomized trials. Variations in patient populations, procedural techniques, and institutional expertise might influence outcomes. 2. Non-expert outcomes: The results indicate a lack of significant improvement in outcomes among non-experts or trainees using the novel catheter. This suggests the device's utility may be contingent on the operator's skill. We also noticed that the expert performed procedure percentage was slightly higher (57% vs 50%) in the novel cathether group, and, although not statistically significant, this could explain the lower use of advanced or rescue cannulation techniques. 3. Adverse Events (AEs): While the overall AE rates were low and comparable between groups, the trend toward fewer cases of PEP with the novel catheter merits closer scrutiny in larger cohorts as this could be an advantage in patients at risk for PEP. On the other hand, the non-statistically significant difference between the two groups in PEP incidence suggests us that the device used to achieve initial selective cannulation maybe isn’t that relevant in increasing PEP risk or incidence, but this should be confirmed in larger studies. 4. Cost-effectiveness: Although not discussed, evaluating the cost implications of adopting this catheter, including potential savings from reduced reliance on rescue techniques and decreased procedural times, would be beneficial for broader clinical adoption. We should also think of the negative aspects: for example, like stone clearance, achieving cannulation with a catheter would require a subsequent switch to a sphincterotome, increasing procedure length and costs, as you would be using two devices instead of one to achieve cannulation. 5. Papilla characteristics: we noticed that in the baseline characteristics intradiverticular papillas and oral oriented papillas were less represented in the catheter group. These types of papilla could benefit of the angling capabilities of a sphincterotome, so this could be a bias that needs to be furthermore cleared. In our experience the angling capabilities of a sphincterotome are crucial in achieving bile duct cannulation in difficult situations. 6. Malignant disease: we do know that malignant diseases (e.g. pancreatic cancer) affecting the ampullar area negatively affect rates of cannulation and increase the need for rescue or advanced techniques of cannulation. This point could have been furthermore discussed by making a distinction between cannulation failures in the setting of benign vs. malignant disease in both groups. In conclusion, this study gives us valuable insights into advancing ERCP outcomes through innovative device design. We must experiment with more designs to compare results and finally choose the best device for cannulation in unexpected and difficult anatomies. "
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Kaneko T, Kida M, Kurosu T, Kitahara G, Koyama S, Nomura N, Tahara K, Kusano C. Outcomes of bile duct cannulation using a novel contrast-enhanced catheter: A single-center, retrospective cohort study. World J Gastrointest Endosc 2025; 17(1): 97840
4
"As a colorectal surgeon interested in colorectal cancer and the microbiome, I found this study highly relevant. The authors ..."
[Read more]
"As a colorectal surgeon interested in colorectal cancer and the microbiome, I found this study highly relevant. The authors effectively highlight differences in mucosa-associated colonic microbiota between colorectal cancer (CRC) and non-CRC patients in Indonesia. A key strength is the focus on mucosal rather than fecal microbiota, providing a clearer picture of the tumor microenvironment. The use of 16S rRNA sequencing with Oxford Nanopore Technologies enables detailed bacterial diversity analysis at the genus and species levels. The study confirms the increased presence of Fusobacterium nucleatum and Bacteroides fragilis in CRC patients, supporting the link between microbial dysbiosis and carcinogenesis. The diagnostic potential of these bacterial markers is particularly noteworthy. Further research with larger sample sizes and functional analyses, such as metagenomics or metabolomics, would enhance understanding of microbiota’s role in CRC. Additionally, while this study offers important insights for Asia, global research is needed to assess regional differences and their impact on CRC diagnostics and treatment. "
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Darnindro N, Abdullah M, Sukartini N, Rumende CM, Pitarini A, Nursyirwan SA, Fauzi A, Makmun D, Nelwan EJ, Shatri H, Rinaldi I, Tanadi C. Differences in diversity and composition of mucosa-associated colonic microbiota in colorectal cancer and non-colorectal cancer in Indonesia. World J Gastroenterol 2025; 31(7): 100051
5
"The manuscript is very clinically relevant. Here's a suggestion. Authors should provide the data on patients undergoing colonoscopy ..."
[Read more]
"The manuscript is very clinically relevant. Here's a suggestion. Authors should provide the data on patients undergoing colonoscopy prior to capsule endoscopy examination. The retention rate of capsule endoscopy at 72 hours was 42.2%, which is still relatively high.It helps to reduce capsule retention in the colon after colonoscopy examination. "
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O'Hara FJ, Costigan C, McNamara D. Extended 72-hour patency capsule protocol improves functional patency rates in high-risk patients undergoing capsule endoscopy. World J Gastrointest Endosc 2024; 16(12): 661-667
6
"This case report highlights the importance of en-bloc resection without fragmentation during endoscopic procedures and the challenges ..."
[Read more]
"This case report highlights the importance of en-bloc resection without fragmentation during endoscopic procedures and the challenges of endoscopic treatment for anal canal cancer. Traditionally, anal lesions have been primarily managed by surgeons, but ESD-related technique is performed mainly by the gastrointestinal endoscopists of internal medicine. Future collaboration between internal medicine and surgery departments will be crucial. Surgery for anal cancer can significantly decrease patients' quality of life, which is why the authors' dedication to endoscopic treatment and follow-up is commendable. Anal canal cancer is rare, and it will be essential to determine which cases are suitable for endoscopic therapy in the future. With the increasing prevalence of inflammatory bowel diseases in Asian regions, a rise in anal cancer cases associated with conditions like Crohn's disease is anticipated. Further case reports in this field are desirable. "
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Kinoshita M, Maruyama T, Hike S, Hirosuna T, Kainuma S, Kinoshita K, Nakano A, Ohira G, Uesato M, Matsubara H. Complete resection of recurrent anal canal cancer using endoscopic submucosal dissection and transanal resection: A case report. World J Gastrointest Endosc 2025; 17(1): 101119
7
"This is an excellent and insightful article. The authors have provided a comprehensive overview of the most impactful studies in the ..."
[Read more]
"This is an excellent and insightful article. The authors have provided a comprehensive overview of the most impactful studies in the field of gastrointestinal endoscopy. It has greatly enhanced my understanding of the current research landscape and has inspired me to define more focused and meaningful directions for my own research in this area. "
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Sui J, Luo JS, Xiong C, Tang CY, Peng YH, Zhou R. Bibliometric analysis on the top one hundred cited studies on gastrointestinal endoscopy. World J Gastrointest Endosc 2025; 17(1): 100219
8
"This paper examines the differences in proficiency of AI tools for IBD patients and is considered a critical study for the inevitable ..."
[Read more]
"This paper examines the differences in proficiency of AI tools for IBD patients and is considered a critical study for the inevitable future utilization of large language models in healthcare. However, it is merely a comparative study of large language models, and it remains unclear whether it contributes to improving IBD patients' literacy. Regarding patient education, Crohn's disease and ulcerative colitis belong to different categories, making it challenging to evaluate IBD as a whole comprehensively. Separate evaluations for ulcerative colitis and Crohn's disease patients would be preferable. Furthermore, large language models alone are insufficient for shared decision-making that considers patients' social backgrounds for treatment selection, including biological agents (especially for Crohn's disease). Simply improving knowledge on several items through large language models may not be enough for clinical application. Future evaluations using large language models should address these points. "
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Zhang Y, Wan XH, Kong QZ, Liu H, Liu J, Guo J, Yang XY, Zuo XL, Li YQ. Evaluating large language models as patient education tools for inflammatory bowel disease: A comparative study. World J Gastroenterol 2025; 31(6): 102090
9
"Dear editor, this is a review that summarizes the most recent evidence focused on the safety of the peroral endoscopic myotomy (POEM). ..."
[Read more]
"Dear editor, this is a review that summarizes the most recent evidence focused on the safety of the peroral endoscopic myotomy (POEM). The manuscript is well written. However, I found some inaccuracies in the background. The style, language and grammar are appropriate. Since there are no figures or tables in the paper I answered no to the dedicated questions. Although the safety of POEM is well explained, superficial informations were provided on the precision and the post-procedural management. Therefore, I would focus the article mainly on the safety, explaining better the post-procedural management. "
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Christodoulidis G, Tsagkidou K, Koumarelas KE, Kouliou MN. Advances and challenges in peroral endoscopic myotomy: Safety, precision, and post-procedure management. World J Gastroenterol 2025; 31(5): 97574
10
"This case is an extensively worked-up and well-written report. Best regards to the team. Stroke is not a clear-cut biophysics in ..."
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"This case is an extensively worked-up and well-written report. Best regards to the team. Stroke is not a clear-cut biophysics in neurology, with challenges in the clinical-radiological correlation encountered so often in clinical practice. As in this case, the work-up in SPECT could not convincingly determine theexact biomechanism of the clinical phenomena. However, it opened up information for future scopes of research into lacunar strokes. DSA, functional MRI, and Perfusion mismatch studies can also help in this type of situations. In contrast, the treatment is fairly less complicated in lacunar stroke. "
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Tsai YH, Chen YH, Chao TC, Lin LF, Chang ST. New type of lacunar stroke presenting in brain perfusion images: A case report. World J Neurol 2024; 10(1): 98672
11
"Fu et al.'s recent study published in the World Journal of Psychiatry examines a complex connection between parenting stress, various ..."
[Read more]
"Fu et al.'s recent study published in the World Journal of Psychiatry examines a complex connection between parenting stress, various family parenting styles, and the behavioral and emotional challenges that children experience. This study highlights the need for appropriate emotional management during the preschool years, demonstrating how differences in parental stress may have a significant impact on children's early emotional health. The analytical strength of this study is really impressive. The authors use structural equation modeling (SEM) to give a detailed examination of how different parenting styles mediate the relationships between these factors. Moreover, comprehensive questionnaire data collection contributes to a better understanding of family dynamics in a variety of environments. According to the findings, parents report high levels of stress, which suggests that they face constant challenges. The study discovers a link between "hostile/coercive" parenting and problem behaviors in children, revealing the deleterious effects of negative strategies for parenting. This conclusion is consistent with previous research, which emphasizes the importance of understanding how inadequate parenting may lead to behavioral problems in children. Conversely, the negative connection with "supportive/engaged" parenting implies that positive approaches might provide large protective benefits, emphasizing the importance of specific treatments. Besides, this study emphasizes how parenting styles serve as mediators in the relationship between parental stress and children's emotional health. The data show a 28.99% mediation impact, indicating that how parents handle stress influences the behaviors of their kids through their strategies for parenting. This finding not only strengthens the foundation for designing personalized therapies, but it also emphasizes the important need to improve parental practices. Also, the study points out the importance of providing parents with evidence-based strategies for managing their emotional health, with a focus on both parental and child well-being. The study aims to establish a caring environment for preschoolers by giving practical ways to reduce stress and promoting positive parenting behaviors. It focuses on the broader impacts of various parenting styles, implying that investing in parental support systems is important for enhancing children's mental health and promoting total family happiness. This perspective is consistent with current trends in mental health initiatives and requires a comprehensive effort to address families' emotional needs, supplying the framework for future research in this important area. Although Fu et al.'s work contributes significantly to our understanding of the link between parental stress and children's behavior, future research might profit from using a longitudinal strategy. Such an approach might allow researchers to investigate the changing dynamics of parental stress and child behavior over time, leading to a more comprehensive explanation of their causal relationships. Longitudinal studies may track how changes in parental stress affect the growth path of children's behavior by following the same set of participants at different points in time. This method not only gives a more in-depth understanding of these dynamics, but it also identifies potential mediators and moderators, offering light on the underlying reasons of the connections. Finally, this strategy may help us understand how the family environment affects children's developmental achievement. "
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Fu ZW, Li YJ, Yu R, Guo RQ, Gao LX, Zhao SX. Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis. World J Psychiatry 2025; 15(1): 100068
12
"There is a need for non-invasive methods of evaluating mucosal healing in the small bowel. This study applies the principles of ..."
[Read more]
"There is a need for non-invasive methods of evaluating mucosal healing in the small bowel. This study applies the principles of radiomics using small bowel CTE to develop a predictive normogram capable of predicting mucosal healing. Despite the study's stated limitations, it adds to the current literature, and extends the emerging field of radiomics in Crohn's disease. "
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Ding H, Fang YY, Fan WJ, Zhang CY, Wang SF, Hu J, Han W, Mei Q. Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease. World J Gastroenterol 2025; 31(3): 102283
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"The article presents a strong case for the use of endoscopic ultrasound-guided gastroenterostomy (EUS-GE) in managing gastric outlet ..."
[Read more]
"The article presents a strong case for the use of endoscopic ultrasound-guided gastroenterostomy (EUS-GE) in managing gastric outlet obstruction (GOO). However, a few points could be clarified to strengthen its conclusions. Specifically, it would be helpful to elaborate on the inclusion or exclusion criteria for patient selection, as well as provide data on long-term outcomes like stent patency and recurrence rates. Additionally, discussing the learning curve associated with EUS-GE and the level of expertise required for its successful implementation would offer valuable insight for broader clinical adoption. "
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Jagielski M. Endoscopic ultrasound guided-gastroenterostomy is the best choice in the treatment of gastric outlet obstruction. World J Gastrointest Endosc 2024; 16(12): 691-693
14
"The manuscript is very interesting. Global burden of human disorders caused by parasites is high. The topic is hot in selected areas. ..."
[Read more]
"The manuscript is very interesting. Global burden of human disorders caused by parasites is high. The topic is hot in selected areas. Those areas include not only Asia or Africa, but some parts of Eastern and Central Europe. I recommend to read the article for specialists in Hepatology, Liver surgery, including liver transplantation, Epademiology and Infectious Diuseases. "
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Shahid Y, Emman B, Abid S. Liver parasites: A global endemic and journey from infestation to intervention. World J Gastroenterol 2025; 31(1): 101360
15
"This editorial pointed out the connection between adipose tissue and intestinal bacteria in Crohn's disease (CD). It is an interesting ..."
[Read more]
"This editorial pointed out the connection between adipose tissue and intestinal bacteria in Crohn's disease (CD). It is an interesting paper. The authors found that Clostridium innocuum migrates to adjacent adipose tissue and remains "trapped" in the fat. As a result, immune cell migration and macrophage differentiation increase, leading to fibrosis, narrowing, and, eventually, the formation of creeping fat. Although the main cytokine release is mainly TNFα and IL-6 in adipocytes, the cytokine profile changes over time, especially in fibrosis, may be related to IL-17, and the dominant cytokines will change from IL-12 to IL-23, as previously pointed out. It is interesting to evaluate the aging adipose tissue in CD. However, it is difficult to determine the actual time of onset in patients with CD, and it is challenging to evaluate this issue. "
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Quaglio AE, Magro DO, Imbrizi M, De Oliveira EC, Di Stasi LC, Sassaki LY. Creeping fat and gut microbiota in Crohn’s disease. World J Gastroenterol 2025; 31(1): 102042
16
"The authors provide evidence supporting the efficacy of serum-free cultured human umbilical cord mesenchymal stem cells (N-hUCMSCs) ..."
[Read more]
"The authors provide evidence supporting the efficacy of serum-free cultured human umbilical cord mesenchymal stem cells (N-hUCMSCs) in treating knee osteoarthritis (OA). However, as the results indicate that the therapeutic effects of N-hUCMSCs, serum-cultured hUCMSCs (S-hUCMSCs), and hyaluronic acid (HA) are comparable, the rationale for prioritizing N-hUCMSCs warrants further exploration, particularly in comparison to the well-established use of HA. There are also issues with data quality and clarity 1.The study administered three injections (at 2, 4, and 6 weeks after model establishment). However, the rationale for this dosing schedule is not provided. HA dosing is not described in the manuscript. 2.The source of the N-hUCMSCs and S-hUCMSCs should be disclosed. Were these cells derived from the same donor? If not, what were the baseline characteristics of each donor (e.g., age, health status)? Such details are critical, as MSC functionality can vary significantly based on donor conditions. 3.Some results, such as those described in Figure 1 and the observation that “Uneven chondrocyte thickness, disorganized cartilage structure, and increased clefts were more pronounced in the model control group than in the blank control group,” are inappropriately placed in the methods section. These descriptions should be moved to the results section. 4. Figure 3c and 3d: Both graphs have the same y-axis label, but according to the results section, one should represent IL-6 and the other IL-1β. Figure 4a and 4b: These panels illustrate hematoxylin-eosin (HE) staining for the model and control groups. However, the HE results for the treatment groups (N-hUCMSCs, S-hUCMSCs, and HA) are missing. Including these results would provide a clearer comparison of treatment effects. 5.Figure 4d: The manuscript mentions that “The Mankin scores were significantly lower in the experimental group than in the model control group (P < 0.05),” but this result is not adequately represented in the figure. "
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Xiao KZ, Liao G, Huang GY, Huang YL, Gu RH. Efficacy of serum-free cultured human umbilical cord mesenchymal stem cells in the treatment of knee osteoarthritis in mice. World J Stem Cells 2024; 16(11): 944-955
17
"he significant impact of surgical approaches on male sexual dysfunction after rectal cancer surgery is highlighted by both this letter ..."
[Read more]
"he significant impact of surgical approaches on male sexual dysfunction after rectal cancer surgery is highlighted by both this letter to the editor and the latest study by Numata et al. published in Annals of Surgery1). Damage to the autonomic nervous system during rectal cancer surgery is a major cause of sexual dysfunction, with problems such as ejaculatory dysfunction, erectile dysfunction, and sexual dysfunction commonly reported. These complications are particularly common with open surgery, and previous research has also shown that the incidence of sexual dysfunction following surgery is high. However, advances in surgical techniques such as robotic surgery are expected to reduce these complications. The LANDMARC Study provided convincing evidence that robotic surgery significantly reduces the incidence of postoperative sexual dysfunction compared to laparoscopic surgery. The incidence of ejaculatory dysfunction at 12 months postoperatively was 25% in robotic surgery patients compared to 40.9% in laparoscopic surgery patients. The incidence of sexual dysfunction was 17.8% and 29%, respectively. This letter to editor alos emphasized the importance of accurate surgical technique and knowledge of pelvic nerve anatomy. It also discussed the benefits of new techniques such as robotic surgery and transanal total mesorectal excision (Ta-TME), as well as the use of intraoperative pelvic nerve monitoring. These advances enhance nerve preservation, reduce complications, and improve patients' postoperative quality of life. These findings highlight the need to adapt innovative surgical techniques in rectal cancer treatment to minimize adverse effects on sexual health while maintaining oncologic effectiveness. 1) Numata, Masakatsu, et al. "Prospective Multicenter Comprehensive Survey on Male Sexual Dysfunction following Laparoscopic, Robotic, and Transanal Approaches for Rectal Cancer (the LANDMARC Study)." Annals of Surgery: 10-1097 "
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Kolokotronis T, Pantelis D. Urinary and sexual dysfunction after rectal cancer surgery: A surgical challenge. World J Gastroenterol 2024; 30(47): 5081-5085
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"since the patient also had general anesthesia, it should be clairifed to whihc degree analgesics given for the procedure prevented ..."
[Read more]
"since the patient also had general anesthesia, it should be clairifed to whihc degree analgesics given for the procedure prevented the patient from experienceing severe pain xxxx xx x x x x x x x x x x x x x x x x x x x x x x xx x x x x x xx "
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Chen KH, Kang MY, Chang YT, Huang SY, Wu YS. Enhancing postoperative pain control by surgically-initiated rectus sheath block in abdominal aortic aneurysm open repair: A case report. World J Clin Cases 2025; 13(6): 100673
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"The novelty of the topic is very important, suitable for fine rather than too broad content. The interpretation of statistical results ..."
[Read more]
"The novelty of the topic is very important, suitable for fine rather than too broad content. The interpretation of statistical results needs to be rigorous, correlation does not mean causation, and the HR presented may be inaccurate. The discussion needs to be tightly focused on the results and not extend to other unwarranted conclusions. "
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Chen DQ, Wu YX, Zhang YX, Yang HL, Huang HH, Lv JY, Xiao Q. Sarcopenia-associated factors and their bone mineral density levels in middle-aged and elderly male type 2 diabetes patients. World J Diabetes 2024; 15(12): 2285-2292
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"I would like to commend the authors for their comprehensive analysis of the complex interplay between gut microbiota, mesenteric ..."
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"I would like to commend the authors for their comprehensive analysis of the complex interplay between gut microbiota, mesenteric adipose tissue (MAT), and creeping fat (CF) in the context of Crohn’s disease (CD). The manuscript provides a valuable contribution to the field. The article meticulously elucidates the profound clinical significance of the interplay between the gut microbiota and MAT/CF. The authors have not only reviewed the current body of knowledge but have also contributed novel insights into the role of MAT and CF in shaping CD phenotypes and treatment strategies.The structure of the letter is well-organized, making it easy to follow the authors' line of reasoning. The abstract succinctly captures the essence of the study, and the core tip effectively highlights the main takeaways for the reader.The exploration of fecal microbiota transplantation (FMT) as a therapeutic strategy is both timely and relevant. The authors have successfully linked the current understanding of microbial imbalances to potential clinical applications, which could influence future treatment protocols for CD. In conclusion, Hasnaoui et al. have provided a thought-provoking analysis of the role of gut microbiota and MAT/CF in CD. Their work not only advances our understanding of the disease but also offers promising avenues for therapeutic intervention. "
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Hasnaoui A, Trigui R, Giuffrida M. Gut microbiota and mesenteric adipose tissue interactions in shaping phenotypes and treatment strategies for Crohn’s disease. World J Gastroenterol 2024; 30(46): 4969-4976
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