Publisher Login
Manuscript Statistics
1
2
3
4
5
2025-07-15 | Browse: 2 | Download: 0
6
2025-07-15 | Browse: 0 | Download: 0
7
2025-07-15 | Browse: 3 | Download: 0
8
9
10
2025-07-15 | Browse: 2 | Download: 0
11
12
2025-07-15 | Browse: 2 | Download: 0
13
14
15
16
17
18
2025-07-15 | Browse: 1 | Download: 0
19
20
667 items Read more >>
1
"Dear journal editors, Thank you for your help throughout the entire process. In the final editing stage of the article, Figure 2-5 ..."
[Read more]
"Dear journal editors, Thank you for your help throughout the entire process. In the final editing stage of the article, Figure 2-5 were not arranged according to the previous plan. Some images in Figures were enlarged to achieve high resolution, which affected the aesthetics and readability of the Figures. Of course, this is just my personal opinion. Sincerely Ke Xu "
[Collapse]
Xiao M, Luo ZY, Yu AR, Xu K, Zhou W. BTNL9 exerts anti-cancer effects by inhibiting CDC20 to induce G2/M arrest in pancreatic cancer. World J Gastrointest Oncol 2025; 17(7): 108274
2
"I would like to commend the editorial team for the exceptionally efficient and seamless submission process. The platform was intuitive, ..."
[Read more]
"I would like to commend the editorial team for the exceptionally efficient and seamless submission process. The platform was intuitive, guidelines were clear, and communication was timely at every stage. This professionalism significantly reduced the usual stress associated with manuscript submission and allowed me to focus on the content itself. Such a positive experience reflects the journal’s commitment to supporting authors. Thank you for making this process remarkably smooth and pleasant—it’s greatly appreciated! "
[Collapse]
Liu QJ, Zhang JC, Wang YF, Zou MH, Zhou WX, Lu Y, Feng XC, Liu H. Correlation of radiotherapy, targeted therapy, and immunotherapy with hepatocellular carcinoma recurrence. World J Gastrointest Oncol 2025; 17(7): 107815
3
"This journal is amazing. The process is so smooth and so quick. The help desk, the editors and all the staff working here are so ..."
[Read more]
"This journal is amazing. The process is so smooth and so quick. The help desk, the editors and all the staff working here are so helpful. Their responses are always quick and so full of information. You will not feel any hurdles or any confusion here. I highly recommend this journal. Fully satisfied with it. Thankyou very much to all the staff working here in this journal. I had an amazing experience with this journal. Will be looking forward to publish more papers with this journal in future. "
[Collapse]
Hussain MM, Wang JM, Zhai AQ, Li FY, Hu HJ. Comparison of prognostic factors and their differences in intrahepatic, hilar, and distal cholangiocarcinoma: A systematic review and meta-analysis. World J Gastrointest Oncol 2025; 17(7): 107995
4
"Thank you for the opportunity. The publishing process for this manuscript was thorough and allowed the authors of this project to ..."
[Read more]
"Thank you for the opportunity. The publishing process for this manuscript was thorough and allowed the authors of this project to better improve the quality of their writing through peer review that was rigorous. We hope to continue receiving such wonderful feedback on future projects and look forward to other opportunities. "
[Collapse]
Huilgol DK, Lucke-Wold B. Beyond numbers: Public health insurance and oesophageal cancer mortality risk. World J Gastrointest Oncol 2025; 17(7): 107460
5
"Publishing with World Journal of Gastrointestinal Oncology has been a thoroughly positive experience. The editorial office is ..."
[Read more]
"Publishing with World Journal of Gastrointestinal Oncology has been a thoroughly positive experience. The editorial office is remarkably efficient. Reviewers were clearly experts in the field; their comments were detailed, balanced, and helped us strengthen both methodology and interpretation without requesting unnecessary experiments. The copy-editing team demonstrated exceptional professionalism—every linguistic nuance was refined, tables were reformatted for clarity, and proofs were returned promptly for final approval. Open-access fees were transparent and competitive. We therefore commend the journal for its commitment to scientific rigor, author service, and global dissemination, and we look forward to submitting future work to this venue. "
[Collapse]
Zhong MY, Jian GL, Ye JY, Chen KX, Huang WJ. Ultrasound diagnosis of small bowel adenocarcinoma in Crohn’s disease: A case report and review of literature. World J Gastrointest Oncol 2025; 17(7): 108258
6
"I am very satisfied with the entire process of publishing the paper. The editing speed was very fast, the comments from the reviewers ..."
[Read more]
"I am very satisfied with the entire process of publishing the paper. The editing speed was very fast, the comments from the reviewers were very fair, and the article was processed very promptly. The editor's attitude is very good, in short, I am very satisfied. We are also very satisfied with the production and layout of our article. We greatly appreciate the joint efforts of the editor and the magazine, and hope that the magazine will continue to improve. "
[Collapse]
Chen B, Chen J, Chen ZT, Feng ZP, Lv HB, Jiang GP. Genetic evidence for the causal influence of inflammatory factors on intrahepatic cholangiocarcinoma risk. World J Gastrointest Oncol 2025; 17(7): 108455
7
"Thank you again for recognizing the results of our reserch，the magazine is professional and has a short response time. Website editing ..."
[Read more]
"Thank you again for recognizing the results of our reserch，the magazine is professional and has a short response time. Website editing interface is quick and efficient.Short cycle time for receiving articles.Editors and experts are friendly and professional.Hopefully, in the near future, we will have new results to continue to submit to the journal.We hope World Journal Clinical Cases get better and better. "
[Collapse]
Xu LX, Kong YC. Ocular siderosis secondary to occult intraocular foreign body causing secondary glaucoma: A case report. World J Clin Cases 2025; 13(25): 104134
8
"We truly appreciate the insightful comments and constructive feedback from the editor and reviewers, which have greatly enhanced the ..."
[Read more]
"We truly appreciate the insightful comments and constructive feedback from the editor and reviewers, which have greatly enhanced the overall quality of our manuscript. I hope to minimize the time from manuscript submission to final publication. In this case, the time from acceptance to final publication has exceeded two months, which is longer than that of most journals. "
[Collapse]
Jiang L, Ma RX, He ES, Zheng XY, Peng X, Ma WH, Li Y, li HW, Zhang XY, Ji JY, Li YJ, Qu SL, Li LJ, Gong ZT. DNA methylation regulates the extinction of fear memory. World J Psychiatry 2025; 15(7): 107524
9
"The authors are satisfied with the whole process of editing and publishing our study.We thank the editors and reviewers of this ..."
[Read more]
"The authors are satisfied with the whole process of editing and publishing our study.We thank the editors and reviewers of this prestigious journal for their time and excellent work. We are confident that our next studies submitted to this journal will maintain the high quality of editing and publication. Thank you very much for your time and expertise "
[Collapse]
Aliaga Ramos J, Carvalho D, Nunes Arantes V. Innovative schemes of colonoscopy bowel preparation with oral lactulose: Optimizing traditional standards to improve colonoscopy quality. World J Gastrointest Endosc 2025; 17(7): 107168
10
"The authors are satisfied with the whole process of editing and publishing our study.We thank the editors and reviewers of this ..."
[Read more]
"The authors are satisfied with the whole process of editing and publishing our study.We thank the editors and reviewers of this prestigious journal for their time and excellent work. We are confident that our next studies submitted to this journal will maintain the high quality of editing and publication. Thank you very much for your time and expertise "
[Collapse]
Aliaga Ramos J, Arantes VN. Impact of gastric neoplasms location on clinical outcome of patients treated by endoscopic submucosal dissection. World J Gastrointest Endosc 2025; 17(7): 107911
11
"We sincerely appreciate the journal’s dedication to scientific quality and peer review. However, we would like to suggest shortening ..."
[Read more]
"We sincerely appreciate the journal’s dedication to scientific quality and peer review. However, we would like to suggest shortening the overall review time to improve publication efficiency. Long waiting periods may delay the dissemination of important findings. In addition, we recommend reducing or waiving article processing charges, as high fees may pose financial barriers for early-career researchers or authors from low-income regions. "
[Collapse]
Lin HY, Tan QH. Metagenomic next-generation sequencing may assist diagnosis of osteomyelitis caused by Mycobacterium houstonense: A case report. World J Orthop 2024; 15(11): 1095-1100
12
"I am very satisfied with the entire publication process of the World Journal of Gastrointestinal Oncology. The online submission system ..."
[Read more]
"I am very satisfied with the entire publication process of the World Journal of Gastrointestinal Oncology. The online submission system was efficient and user-friendly, allowing smooth manuscript tracking and communication. The peer review process was rigorous yet constructive, providing insightful feedback that significantly improved the clarity and scientific quality of our manuscript. The editorial team demonstrated professionalism and responsiveness throughout. The editing quality, PDF formatting, and online full-text presentation were all excellent. Figures and tables were precisely prepared and visually clear. I particularly appreciated the journal's strict adherence to academic norms, ethical standards, and the transparency of its academic misconduct checks. Furthermore, the time from submission to publication was reasonable and well managed. Overall, I had a highly positive experience with the journal and would gladly consider submitting future work to WJGO. I thank the editorial office and reviewers for their valuable contribution to improving the manuscript and supporting its publication. "
[Collapse]
Bae SU. Elevating surgical standards: The role of intraperitoneal isoperistaltic side-to-side anastomosis in colon cancer surgery. World J Gastrointest Oncol 2025; 17(6): 106645
13
"I am very satisfied with the entire editorial and publication process. The submission system was user-friendly, and the peer review ..."
[Read more]
"I am very satisfied with the entire editorial and publication process. The submission system was user-friendly, and the peer review reports were constructive, professional, and helped improve the manuscript quality. The editorial team provided timely and clear communication throughout, and the editing quality of both the article text and visual elements (figures and tables) was excellent. The final PDF and online full-text formats were well-prepared and professionally presented. I also appreciated the transparency of academic norms and ethical standards during the process, including the academic misconduct screening. The time from submission to publication was appropriate and efficient. Overall, it was a smooth and positive publishing experience, and I would be pleased to submit to this journal again in the future. "
[Collapse]
Bae SU. Central vascular ligation and complete mesocolon excision vs D3 lymphadenectomy: Standardization of surgical technique. World J Gastrointest Surg 2025; 17(4): 103704
14
"Your platform's full-process service is commendable! The manuscript submission system is convenient and smooth with clear guidelines. ..."
[Read more]
"Your platform's full-process service is commendable! The manuscript submission system is convenient and smooth with clear guidelines. Peer review comments are professional and pertinent, pointing out clear directions for revisions. During the revision phase, editors communicate efficiently and answer questions patiently. Language editing ensures both standardization and rigor, significantly improving manuscript quality. Publication fee standards are open and transparent with no hidden costs, and explanations are detailed. The electronic and online publishing processes are efficient, with short release cycles and trackable progress. The entire process reflects professional competence and an author-centric service philosophy, making it trustworthy! "
[Collapse]
Chen CN, Fan XY, Yang CM, Zhang XH, Liu J. Refractory chronic diarrhea complicated with optic neuritis in a young woman: A case report. World J Gastrointest Endosc 2025; 17(7): 106208
15
"The journal has published my editorial following a thorough peer-review process. The publication adhered to rigorous academic and ..."
[Read more]
"The journal has published my editorial following a thorough peer-review process. The publication adhered to rigorous academic and scholarly standards, and I am grateful to the editorial team for their valuable support throughout. I hope readers will find the editorial thought-provoking, both in stimulating critical thinking and enhancing clinical practice. I also hope it will inspire further research on the topic. Professor Samy Azer "
[Collapse]
Azer SA. Hemostasis: Role of PuraStat® in the prevention and management of gastrointestinal bleeding. World J Gastrointest Endosc 2025; 17(7): 106725
16
"The article was very well done processed and timely published. The articles appeared perfect and the format was nice. We appreciate ..."
[Read more]
"The article was very well done processed and timely published. The articles appeared perfect and the format was nice. We appreciate the dedication of editor , reviewer , editing and publishing section that made our work become available online very soon. Thank you every one very much for your time. Kind regards, T "
[Collapse]
Chaemsupaphan T, Shir Ali M, Fung C, Paramsothy S, Leong RW. Endocytoscopy in real-time assessment of histological and endoscopic activity in ulcerative colitis. World J Gastrointest Endosc 2025; 17(7): 108082
17
"In the submission of this study, the editor demonstrated a strong sense of responsibility and actively communicated with the authors ..."
[Read more]
"In the submission of this study, the editor demonstrated a strong sense of responsibility and actively communicated with the authors of the research. The peer reviewers also demonstrated a high level of professionalism. We sincerely thank the editor and all reviewers for their contributions to the publication of this mini-review. We hope to continue working with World Journal of Psychiatry and contribute more scholarly work in the future. "
[Collapse]
Sun YF, Zhang Q, Wang J, Zhou ZH. Neuroimaging and neuroelectrophysiological features of music's effects on anhedonia in major depressive disorder: A minireview. World J Psychiatry 2025; 15(7): 107721
18
"I find that overly rigid initial formatting requirements discourage submissions toy your journals, which are otherwise high-quality. ..."
[Read more]
"I find that overly rigid initial formatting requirements discourage submissions toy your journals, which are otherwise high-quality. Allowing flexibility in manuscript layout prior to peer review and permitting final adjustments post-acceptance would reduce barriers to submission and encourage broader participation. Relaxing early formatting guidelines may therefore improve submission rates, enhance global accessibility, and facilitate author engagement. "
[Collapse]
Negoi I. Correction to "Personalized surveillance in colorectal cancer: Integrating circulating tumor DNA and artificial intelligence into post-treatment follow-up". World J Gastroenterol 2025; 31(25): 109912
19
"We are deeply satisfied with the submission process to the World Journal of Psychiatry and Baishideng Publishing Group Inc. From the ..."
[Read more]
"We are deeply satisfied with the submission process to the World Journal of Psychiatry and Baishideng Publishing Group Inc. From the user-friendly online submission system to the editorial team's prompt and professional communication (all inquiries were addressed within 48 hours), and the rigorous yet transparent peer review—particularly the constructive feedback from reviewers which significantly enhanced our manuscript's quality. The final published PDF exhibited impeccable typesetting aligned with international academic standards. This seamless blend of efficiency and scholarly rigor makes us enthusiastically recommend this publishing experience to fellow researchers. "
[Collapse]
Li X, Xiong LP, Zhang Y, Zhao TT, Zhang CY. From operating room to recovery: Evidence and gaps in cardiac surgical nursing integrative psychological support. World J Psychiatry 2025; 15(7): 107103
20
"A Trustworthy Platform for Cutting-Edge Psychiatric Research As an author(Jiang-Bo Li) who recently published in World Journal of ..."
[Read more]
"A Trustworthy Platform for Cutting-Edge Psychiatric Research As an author(Jiang-Bo Li) who recently published in World Journal of Psychiatry, I am impressed by the journal's rigorous peer-review process. The reviewers provided exceptionally constructive feedback that significantly strengthened my work, demonstrating their expertise in the field. The editorial team maintained clear communication throughout, with prompt responses to queries and transparent manuscript tracking. What stands out most is the journal's commitment to scientific integrity. From meticulous reference checks to conflict-of-interest verification, every step reflects adherence to the highest publication standards. The immediate indexing of articles in major databases further enhances the credibility and visibility of published research. I particularly appreciate how World Journal of Psychiatry with clinical relevance, making it an ideal venue for research that bridges academia and practice. My positive experience confirms its status as a premier journal in psychiatric sciences, and I would confidently recommend it to colleagues. "
[Collapse]
Li JB, Rong W. Severe anxiety, depression, and sleep disorders worsen prognosis in patients with septic shock. World J Psychiatry 2025; 15(7): 107038
19016 items Read more >>
1
"Survival rates following radical surgery for gastric neuroendocrine neoplasms (g-NENs) are low, with high recurrence rates. Liu, et ..."
[Read more]
"Survival rates following radical surgery for gastric neuroendocrine neoplasms (g-NENs) are low, with high recurrence rates. Liu, et al’s study addressed a critical issue in determining the postoperative prognosis of gastric neuroendocrine tumors by identifying the significance of lymph node ratio. Moreover, the random survival forest model, a machine-learning approach, surpasses traditional Cox proportional hazards models by enhancing predictive accuracy, clinical utility, and overall performance. This model’s ability to stratify patient risks and personalize survival predictions can aid in formulating targeted postoperative strategies, thus realizing an important aspect of personalized “precision medicine”. This paper is indicative for journal readers in this field."
[Collapse]
Wang HN, An JH, Zong L. Estimating prognosis of gastric neuroendocrine neoplasms using machine learning: A step towards precision medicine. World J Gastrointest Oncol 2024; 16(12): 4548-4552
2
"Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths due to late diagnosis and high recurrence rates. ..."
[Read more]
"Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths due to late diagnosis and high recurrence rates. Key biomarkers such as enhancer of zeste homolog 2 and fatty acid binding protein 5, along with other genetic biomarkers provide insights into HCC progression and potential therapeutic targets. This paper is indicative for journal readers in this field.
"
[Collapse]
Shodry S, Hasan YTN, Ahdi IR, Ulhaq ZS. Gene targets with therapeutic potential in hepatocellular carcinoma. World J Gastrointest Oncol 2024; 16(12): 4543-4547
3
"In this Editorial we comment on the interesting article by Liu, et al. The controlling nutritional status (CONUT) score was ..."
[Read more]
"In this Editorial we comment on the interesting article by Liu, et al. The controlling nutritional status (CONUT) score was significantly associated with the prognosis of colorectal cancer patients, as supported by a large body of literature. Compared with other nutritional scores, the CONUT score might be introduced in clinical practice as an optimal prognostic nutritional index to predict patient outcome."
[Collapse]
Berardi R, Chiariotti R, Mentrasti G. Is nutritional status a new indicator to use in clinical practice for colorectal cancer patients? World J Gastrointest Oncol 2024; 16(12): 4537-4542
4
"In this Editorial, they highlighted potential pitfalls in the current classification of mixed neuroendocrine non-neuroendocrine ..."
[Read more]
"In this Editorial, they highlighted potential pitfalls in the current classification of mixed neuroendocrine non-neuroendocrine neoplasms and commented on challenges in the management of this heterogeneous group of malignancies in light of the paucity of evidence in the field. Improved biological and clinical knowledge were needed to generate robust classification schemes that will in turn provide clarity on the epidemiology of the disease, prognosis of affected patients and guidance for treatment tailoring. This paper is indicative for journal readers in this field."
[Collapse]
Cives M, Porta C, Palmirotta R. Mixed neuroendocrine non-neuroendocrine tumors: The quest for evidence. World J Gastrointest Oncol 2024; 16(12): 4532-4536
5
"Gastric cancer remains a formidable global health concern with significant morbidity and mortality rates, despite the fact that ..."
[Read more]
"Gastric cancer remains a formidable global health concern with significant morbidity and mortality rates, despite the fact that numerous advances have been made to improve conventional therapies. This Editorial article integrated network pharmacology insights with rigorous experimental validation to highlight the potential of Xiaojianzhong decoction as a multifaceted therapeutic approach for gastric cancer. This paper is indicative for journal readers in this field."
[Collapse]
Cheng CH, Hao WR, Cheng TH. Exploring Xiaojianzhong decoction's potential in gastric cancer treatment: Integrative insights and experimental validation. World J Gastrointest Oncol 2024; 16(12): 4553-4558
6
"Mixed neuroendocrine non-neuroendocrine neoplasms constitute rare tumors that are located mainly in the gastrointestinal tract and ..."
[Read more]
"Mixed neuroendocrine non-neuroendocrine neoplasms constitute rare tumors that are located mainly in the gastrointestinal tract and have high degrees of malignancy, and the frequency of these tumors has been increasing. The rare but steadily increasing number of gastrointestinal mixed neuroendocrine non-neuroendocrine neoplasms and pure neuroendocrine carcinomas require more radical treatment than slow-growing neuroendocrine neoplasms do and they are related to poor prognosis. They constitute a complicated diagnostic and therapeutic challenge. The current management strategy begins with surgery and is followed by chemotherapy. New chemotherapeutics and novel biological agents for targeted therapy, along with immunotherapy broaden the range of therapeutic options, providing promising outcomes. Effective management should be individualized and multidisciplinary. This paper is indicative for journal readers in this field."
[Collapse]
Pavlidis ET, Galanis IN, Pavlidis TE. Critical considerations for the management of gastrointestinal mixed neuroendocrine non-neuroendocrine neoplasms and pure neuroendocrine carcinomas. World J Gastrointest Oncol 2024; 16(12): 4559-4564
7
"Within the intricate milieu of colorectal cancer (CRC) tissues, cancer-associated fibroblasts (CAFs) act as pivotal orchestrators, ..."
[Read more]
"Within the intricate milieu of colorectal cancer (CRC) tissues, cancer-associated fibroblasts (CAFs) act as pivotal orchestrators, wielding considerable influence over tumor progression. Their review endeavored to dissect the multifaceted functions of CAFs within the realm of CRC, thereby highlighting their indispensability in fostering CRC malignant microenvironment and indicating the development of CAFs-targeted therapeutic interventions. Through a comprehensive synthesis of current knowledge, their review delineated insights into CAFs-mediated modulation of cancer cell proliferation, invasiveness, immune evasion, and neovascularization, elucidating the intricate web of interactions that sustain the pro-tumor metabolism and secretion of multiple factors. Additionally, recognizing the high level of heterogeneity within CAFs is crucial, as they encompass a range of subtypes, including myofibroblastic CAFs, inflammatory CAFs, antigen-presenting CAFs, and vessel-associated CAFs. Innovatively, the symbiotic relationship between CAFs and the intestinal microbiota is explored, shedding light on a novel dimension of CRC pathogenesis. Despite remarkable progress, the orchestrated dynamic functions of CAFs remain incompletely deciphered, underscoring the need for continued research endeavors for therapeutic advancements in CRC management. This review article is well written, and is informative for journal readers in this field."
[Collapse]
Cui JY, Ma J, Gao XX, Sheng ZM, Pan ZX, Shi LH, Zhang BG. Unraveling the role of cancer-associated fibroblasts in colorectal cancer. World J Gastrointest Oncol 2024; 16(12): 4565-4578
8
"In their report, they assessed the prognostic value of gamma-glutamyl transpeptidase to platelet ratio (GPR) in early hepatitis B ..."
[Read more]
"In their report, they assessed the prognostic value of gamma-glutamyl transpeptidase to platelet ratio (GPR) in early hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients. They evaluated the clinical utility of preoperative GPR in predicting outcomes for solitary HBV-related HCC patients using propensity score matching, restricted cubic spline, survival analyses and stratified analyses. Preoperative GPR levels facilitated recurrence monitoring and inform treatment strategies, potentially enhancing the quality of life for HCC patients. Although case report accompanied with some limitations for any conclusions, their report is interesting for journal readers in this field."
[Collapse]
Yang CK, Wei ZL, Shen XQ, Jia YX, Wu QY, Wei YG, Su H, Qin W, Liao XW, Zhu GZ, Peng T. Prognostic utility of gamma-glutamyl transpeptidase to platelet ratio in patients with solitary hepatitis B virus-related hepatocellular carcinoma after hepatectomy. World J Gastrointest Oncol 2024; 16(12): 4579-4596
9
"Their developed and validated a promising machine learning architecture for predicting the 3-category survival times (cutoff values ..."
[Read more]
"Their developed and validated a promising machine learning architecture for predicting the 3-category survival times (cutoff values of 3 years and 5 years) for four survival times (overall, disease-free, recurrence-free, and distant metastasis-free survival) and screened corresponding important variables. Fivefold cross validation and bootstrap validation were conducted. The models were evaluated with the area under the curve (AUC); moreover, the effectiveness of our variable screening methods was evaluated by comparing the models’ pre- and post-screening AUCs. SHapley Additive exPlanations were used to explain the decision-making process. Nomograms were drawn for various applications. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field."
[Collapse]
Ji XL, Xu S, Li XY, Xu JH, Han RS, Guo YJ, Duan LP, Tian ZB. Prognostic prediction models for postoperative patients with stage I to III colorectal cancer based on machine learning. World J Gastrointest Oncol 2024; 16(12): 4597-4613
10
"Their retrospective study explores the safety, efficacy, and long-term prognosis of local excision (LE) in patients with middle-low ..."
[Read more]
"Their retrospective study explores the safety, efficacy, and long-term prognosis of local excision (LE) in patients with middle-low rectal cancer who responded well to neoadjuvant chemoradiotherapy. Their results demonstrated that LE can achieve high rates of organ preservation and favorable oncological outcomes, including a 5-year disease-free survival rate of 88.4% and overall survival rate of 92.9%. Complications were manageable and non-severe. Their study supported the potential of minimally invasive treatments in selected patients, highlighting the importance of patient participation in treatment decisions. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field."
[Collapse]
Chen N, Li CL, Wang L, Yao YF, Peng YF, Zhan TC, Zhao J, Wu AW. Local excision for middle-low rectal cancer after neoadjuvant chemoradiation: A retrospective study from a single tertiary center. World J Gastrointest Oncol 2024; 16(12): 4614-4624
11
"Their retrospective analyses spanned a decade (January 1, 2012 to September 30, 2022) and included 5417 patients from Beijing Youan ..."
[Read more]
"Their retrospective analyses spanned a decade (January 1, 2012 to September 30, 2022) and included 5417 patients from Beijing Youan Hospital, Capital Medical University. Using Cox regression and competing risk regression models, they identified several key factors that significantly contributed to the risk of hepatocellular carcinoma in patients with cirrhosis. Specifically, their study underscored the increased association of hepatitis B cirrhosis with hepatocellular carcinoma incidence and highlights other significant risk factors, including male sex, advanced age, viral hepatitis-related cirrhosis, elevated blood ammonia, and lower albumin and platelet levels. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field."
[Collapse]
Zhou DQ, Liu JY, Zhao F, Zhang J, Liu LL, Jia JR, Cao ZH. Risk factors for hepatocellular carcinoma in cirrhosis: A comprehensive analysis from a decade-long study. World J Gastrointest Oncol 2024; 16(12): 4625-4635
12
"The Esophageal cancer (EC) often occurs in the elderly, with approximately 33% of patients aged ≥ 75 years at the time of diagnosis. ..."
[Read more]
"The Esophageal cancer (EC) often occurs in the elderly, with approximately 33% of patients aged ≥ 75 years at the time of diagnosis. Since patients aged 75 years and above are often excluded from many clinical trials of EC, there is a lack of agreement regarding the prognosis and treatment of this population. They retrospectively analyzed the clinical characteristics, toxic reactions, and survival information of elderly patients with EC aged ≥ 75 years who received intensity-modulated radiotherapy. Their analyses aimed to evaluate the prognostic factors affecting overall survival. They found that the Charlson comorbidity index and nutritional risk screening 2002 were independent prognostic factors for overall survival. Their results suggested that when formulating treatment plans for elderly patients with EC, full attention should be given to age-related biological indicators such as comorbidities and nutrition. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field."
[Collapse]
Hu LL, Rong F, Liu L, Zhang L, Zhang LL, Yang Q, Xia ZL, Wang H. Prognosis of radiotherapy for esophageal cancer in elderly patients exceeding seventy-five years old. World J Gastrointest Oncol 2024; 16(12): 4636-4649
13
"The γ-glutamyl transferase to albumin ratio has been confirmed for the first time to be predictive in hepatocellular carcinoma ..."
[Read more]
"The γ-glutamyl transferase to albumin ratio has been confirmed for the first time to be predictive in hepatocellular carcinoma undergoing transarterial chemoembolization and transarterial chemoembolization combined with systemic therapy in this large-sample multicenter study. A nomogram model for predicting postoperative survival was also established based on γ-glutamyl transferase to albumin ratio, which was empirically demonstrated to have strong predictive ability. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field."
[Collapse]
Wu ZY, Li H, Chen JL, Su K, Weng ML, Han YW. Nomogram model based on γ-glutamyl transferase to albumin ratio predicts survival in hepatocellular carcinoma patients with transarterial chemoembolization treatment. World J Gastrointest Oncol 2024; 16(12): 4650-4662
14
"The deep learning model (DLM) was validated to accurately predict the risk classification of gastrointestinal stromal tumors. The ..."
[Read more]
"The deep learning model (DLM) was validated to accurately predict the risk classification of gastrointestinal stromal tumors. The combined DLM outperformed DLM in predicting risk stratification. The combined model has potential to guide and facilitate clinical decision-making. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field."
[Collapse]
Li Y, Liu YB, Li XB, Cui XN, Meng DH, Yuan CC, Ye ZX. Deep learning model combined with computed tomography features to preoperatively predicting the risk stratification of gastrointestinal stromal tumors. World J Gastrointest Oncol 2024; 16(12): 4663-4674
15
"In their study, patients diagnosed with advanced gastroenteropancreatic neuroendocrine tumors who were treated with the temozolomide ..."
[Read more]
"In their study, patients diagnosed with advanced gastroenteropancreatic neuroendocrine tumors who were treated with the temozolomide and capecitabine regimen exhibited a median overall survival of 49 months, with 42% surviving at 60 months. The regimen was well-tolerated, and most patients experienced stable disease. Their results suggested that this treatment could be viable in settings where standard therapies are unavailable or inaccessible, although further prospective studies were needed for confirmation. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field."
[Collapse]
Cruz-Diaz WE, Paitan V, Medina J, Flores R, Haro-Varas J, Mantilla R, Castro-Oliden V. Temozolomide and capecitabine regimen as first-line treatment in advanced gastroenteropancreatic neuroendocrine tumors at a Latin American reference center. World J Gastrointest Oncol 2024; 16(12): 4675-4684
16
"Supplementation with 1,25-dihydroxy-vitamin D [1,25(OH)2D3] improved hepatic steatosis and lipid metabolism in nonalcoholic fatty ..."
[Read more]
"Supplementation with 1,25-dihydroxy-vitamin D [1,25(OH)2D3] improved hepatic steatosis and lipid metabolism in nonalcoholic fatty liver disease, linked to its capacity to reverse the proinflammatory M1 polarization of hepatic macrophages, partially by regulating the vitamin D receptor-peroxisome proliferator activated receptor γ pathway. The involvement of 1,25(OH)2D3 in inhibiting fatty-acid-induced proinflammatory M1 polarization of macrophages played a direct role in relieving lipid accumulation and metabolism in hepatocytes. Their results are informative for journal readers in this field."
[Collapse]
Luo WJ, Dong XW, Ye H, Zhao QS, Zhang QB, Guo WY, Liu HW, Xu F. Vitamin D 1,25-Dihydroxyvitamin D3 reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization. World J Gastrointest Oncol 2024; 16(12): 4685-4699
17
"Despite advances in therapy for colorectal cancer (CRC), the 5-year survival rate for CRC patients in China remains only 56.9%. Their ..."
[Read more]
"Despite advances in therapy for colorectal cancer (CRC), the 5-year survival rate for CRC patients in China remains only 56.9%. Their study explored the effects of matrine on CRC by targeting a newly identified anti-apoptotic protein, Shank-associated RH domain interactor (SHARPIN). SHARPIN was discovered through proteomic analysis and its expression was validated in both the TCGA database and our patient cohort using immunohistochemistry. Inhibiting SHARPIN expression led to increased apoptosis and reduced proliferation, invasion, and migration of CRC cells in vitro. Matrine's ability to inhibit SHARPIN and induce apoptosis highlights its potential as a promising therapeutic agent for CRC. Their results are informative for journal readers in this field."
[Collapse]
Zhou YC, Wang QQ, Zhou GYJ, Yin TF, Zhao DY, Sun XZ, Tan C, Zhou L, Yao SK. Matrine promotes colorectal cancer apoptosis by downregulating shank-associated RH domain interactor expression. World J Gastrointest Oncol 2024; 16(12): 4700-4715
18
"Their study highlighted spermine synthase (SMS) as a pivotal molecule regulating DNA damage and autophagy in cancer cells. SMS promoted ..."
[Read more]
"Their study highlighted spermine synthase (SMS) as a pivotal molecule regulating DNA damage and autophagy in cancer cells. SMS promoted DNA repair and activated the mammalian target of rapamycin signaling pathway, resulting in the inhibition of cellular autophagy. Collectively, SMS emerges as a promising therapeutic target to enhance colorectal cancer radiosensitivity, providing novel insights into the development of colorectal cancer treatment strategies. Their results are informative for journal readers in this field."
[Collapse]
Guo YB, Wu YM, Lin ZZ. Enhancing the radiosensitivity of colorectal cancer cells by reducing spermine synthase through promoting autophagy and DNA damage. World J Gastrointest Oncol 2024; 16(12): 4716-4727
19
"Their study systematically evaluated the efficacy and safety of transhepatic arterial chemoembolization with drug-loaded microspheres ..."
[Read more]
"Their study systematically evaluated the efficacy and safety of transhepatic arterial chemoembolization with drug-loaded microspheres in the treatment of unresectable primary liver cancer. Through a meta-analysis of relevant literature, the effect of this treatment in prolonging survival, relieving symptoms and improving quality of life of patients was discussed, and the incidence of adverse reactions and complications was evaluated, so as to provide more scientific treatment recommendations for clinicians. Their results are interesting."
[Collapse]
Deng J, Mi YH, Xie L, Sun XX, Liu DH, Long HJ, He LY, Wu DH, Shang HC. Efficacy and safety of transhepatic arterial chemoembolization with drug-loaded microspheres in unresectable primary liver cancer. World J Gastrointest Oncol 2024; 16(12): 4728-4737
20
"Pancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare malignancies affecting the pancreas, recognized by ..."
[Read more]
"Pancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare malignancies affecting the pancreas, recognized by the World Health Organization as neoplasms composed of morphologically recognizable neuroendocrine and non-neuroendocrine components, each constituting ≥ 30% of the tumor volume. However, whether the tumor should be classified as a MiNEN or collision tumor when there is clear divergence in histology and molecular profiles for each component is still debatable. Their case reports a rare case with high grade adenocarcinoma admixed with low grade neuroendocrine tumor in pancreas, which were demonstrated to have distinct molecular profiles. They discussed the potential impacts of tumor classification on staging and clinical management, hoping to encourage more discussions and studies on this rare entity. Although case report accompanied with some limitations for any conclusions, their report is interesting for journal readers in this field."
[Collapse]
Zhao X, Bocker Edmonston T, Miick R, Joneja U. Mixed pancreatic ductal adenocarcinoma and well-differentiated neuroendocrine tumor: A case report. World J Gastrointest Oncol 2024; 16(12): 4738-4745
15686 items Read more >>
Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2265
- Peer-reviewers
- 32301
- Manuscripts received today
- 23
- Manuscript reviews today
- 45
- Unhandled manuscripts today
- 169
- Active peer-reviewers today
- 1519
- Reviewer acceptance today
- 85
- Reviewer refusals today
- 45
- Total accepted manuscripts
- 36838
- Total rejected manuscripts
- 42326
- Total peer-reviewers
- 4285725
- Total submissions
- 34994
1
2
3
4
5
6
7
8
9
10
2025-09-20 | Browse: 7714 | Download: 907
11
2025-09-20 | Browse: 3408 | Download: 701
12
2025-09-20 | Browse: 4279 | Download: 698
13
14
2025-09-20 | Browse: 3410 | Download: 620
15
2025-09-20 | Browse: 4548 | Download: 681
16
2025-09-20 | Browse: 5796 | Download: 860
17
2025-09-20 | Browse: 4275 | Download: 654
18
2025-09-20 | Browse: 3760 | Download: 653
19
20
2025-09-20 | Browse: 4058 | Download: 702
59226 items Read more >>
1
2
3
2025-07-14 | Browse: 8 | Download: 10
4
2025-07-14 | Browse: 7 | Download: 7
5
6
2025-07-14 | Browse: 7 | Download: 8
7
2025-07-11 | Browse: 42 | Download: 58
8
9
10
2025-07-11 | Browse: 42 | Download: 41
11
12
13
14
15
16
17
18
2025-07-09 | Browse: 42 | Download: 97
19
20
9678 items Read more >>
70186 items Read more >>
1
"To the Editor, We read with great interest the article by Ren et al. [1], published in World Journal of Gastroenterology, which ..."
[Read more]
"To the Editor, We read with great interest the article by Ren et al. [1], published in World Journal of Gastroenterology, which investigates serum exosomal hsa-let-7f-5p as a potential non-invasive biomarker for detecting metastatic pancreatic cancer. The research presents a compelling advancement in the molecular diagnostics of one of the most aggressive malignancies. This study is both timely and relevant, considering the dismal survival rates in pancreatic cancer due to delayed diagnosis and poor response to conventional therapies [1, 2]. In this letter, we aim to provide a critical appraisal of the study design and methodology, place the findings in the context of the current scientific literature, evaluate the novelty and translational potential of hsa-let-7f-5p, and recommend avenues for future research. Ren et al. successfully shown that hsa-let-7f-5p is considerably higher in the serum exosomes of patients with metastatic pancreatic cancer than in those with localized illness. They discovered 42 differently expressed miRNAs using high-throughput sequencing and verified hsa-let-7f-5p using qRT-PCR, providing strong support for their result. These findings are consistent with a growing body of data that exosomal miRNAs, due to their stability in circulation and tumor selectivity, have intriguing diagnostic capacities in malignancies [3-5]. The reason for using serum exosomal miRNAs as biomarkers is widely understood. Exosomes are small vesicles released by nearly all cells, including tumor cells, that carry molecular cargo specific to their cell of origin. Previous research has demonstrated the usage of exosomal miRNAs such as miR-21, miR-1246, and miR-10b in pancreatic cancer [6-8]. However, few studies have focused on distinguishing metastatic from non-metastatic pancreatic cancer, which is an important clinical differential. One of the major strengths of Ren et al.'s work is the comprehensive pipeline employed for exosome isolation, characterization, and miRNA profiling. The authors validated exosomes using well-established techniques such as transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and western blotting. This multiparametric validation boosts the credibility of their results. The let-7 family of miRNAs is known for its tumor-suppressive and context-dependent oncogenic roles. While most members inhibit proliferation and metastasis, emerging evidence shows that specific let-7 members, such as let-7f-5p, can be upregulated in certain cancers and are associated with worse outcomes [9]. Ma et al. reported that hsa-let-7f-5p was highly expressed in pulmonary carcinoid tumors and regulated HMGA2, a protein involved in chromatin remodeling and EMT [10]. In prostate cancer, Valera et al. found higher hsa-let-7f-5p expression in older patients, suggesting its possible role in tumor progression with age [11]. Ren et al.’s results extend these findings to pancreatic cancer, highlighting the utility of hsa-let-7f-5p as a stage-specific biomarker rather than merely a diagnostic one. The strength of hsa-let-7f-5p as a diagnostic marker for metastasis is promising, but a comparative evaluation with other known biomarkers would enrich the discussion. For instance: miR-21 has been extensively validated as an oncogenic miRNA in pancreatic cancer and is known to promote invasion and resistance to gemcitabine [12]. miR-155 and miR-196a have been associated with poor prognosis and have been considered for early diagnostic panels [13]. In this investigation, I discovered many weaknesses. The first is a small sample size (n=36), and the lack of longitudinal follow-up data limits the findings' generalizability and prognostic application. Multicenter trials with larger and more diverse cohorts are required to verify hsa-let-7f-5p as a clinical biomarker. Furthermore, only four miRNAs were validated, leaving the other 38 (including 34 unique ones) untested. Some of these may have even greater discriminatory strength or synergistic benefit when integrated into multi-miRNA signatures, a method that has demonstrated increased accuracy in other malignancies. Moreover, the biological activities of hsa-let-7f-5p in encouraging metastasis warrant additional investigation. Functional research using in vitro invasion tests and in vivo metastasis models could help determine whether this miRNA is simply a marker or a mechanistic component to metastatic spread. Another topic to look at is if exosomal hsa-let-7f-5p levels alter in response to treatment. If so, this could lead to real-time, non-invasive therapy monitoring, which is critical in pancreatic oncology. The authors recommend using hsa-let-7f-5p in routine surveillance to detect metastases in pancreatic cancer patients, possibly in conjunction with imaging. We support this objective and urge that commercial assay kits be developed and clinically validated in accordance with CLIA/CAP requirements. Given that the majority of pancreatic cancer patients come with late-stage disease, a non-invasive technology for early detection of metastases can have a considerable impact on treatment decisions, such as avoiding non-curative surgery or starting systemic therapy earlier. Furthermore, including such biomarkers into AI-driven diagnostic pipelines has the potential to improve risk classification algorithms and customize treatment regimens, in line with precision medicine concepts. Ren et al. provide a valuable contribution to the field by identifying serum exosomal hsa-let-7f-5p as a potential diagnostic biomarker for metastatic pancreatic cancer. The study is technically sound, analytically robust, and biologically plausible. Nevertheless, broader validation, mechanistic studies, and clinical comparisons with existing biomarkers are necessary to cement its place in clinical practice. We commend the authors for their innovative and methodologically rigorous work and look forward to seeing the next phase of this research. Their findings not only enhance our understanding of pancreatic cancer metastasis but also pave the way for more personalized, non-invasive diagnostic tools in oncology. Reference: 1. Verma, H.K., et al., A Retrospective Look at Anti-EGFR Agents in Pancreatic Cancer Therapy. Curr Drug Metab, 2019. 20(12): p. 958-966. 2. Golivi, Y., et al., Small molecular inhibitors: Therapeutic strategies for pancreatic cancer. Drug Discovery Today, 2024. 29(7): p. 104053. 3. Wu, J. and Z. Shen, Exosomal miRNAs as biomarkers for diagnostic and prognostic in lung cancer. Cancer Med, 2020. 9(19): p. 6909-6922. 4. Lohajová Behulová, R., et al., Circulating exosomal miRNAs as a promising diagnostic biomarker in cancer. Physiol Res, 2023. 72(S3): p. S193-s207. 5. Li, C., et al., The role of Exosomal miRNAs in cancer. Journal of Translational Medicine, 2022. 20(1): p. 6. 6. Uddin, M.H., et al., Exosomal microRNA in Pancreatic Cancer Diagnosis, Prognosis, and Treatment: From Bench to Bedside. Cancers (Basel), 2021. 13(11). 7. Jafari, A., et al., The Emerging Role of Exosomal miRNAs as Biomarkers for Early Cancer Detection: A Comprehensive Literature Review. Technol Cancer Res Treat, 2023. 22: p. 15330338231205999. 8. Xu, Y., et al., The role of exosomal microRNAs in pancreatic cancer. Stem Cell Investigation, 2020. 7. 9. Gilles, M.E. and F.J. Slack, Let-7 microRNA as a potential therapeutic target with implications for immunotherapy. Expert Opin Ther Targets, 2018. 22(11): p. 929-939. 10. Ma, Q., et al., HMGA2 promotes cancer metastasis by regulating epithelial-mesenchymal transition. Front Oncol, 2024. 14: p. 1320887. 11. Valera, V.A., et al., microRNA Expression Profiling in Young Prostate Cancer Patients. J Cancer, 2020. 11(14): p. 4106-4114. 12. Chen, C., L. Demirkhanyan, and C.S. Gondi, The Multifaceted Role of miR-21 in Pancreatic Cancers. Cells, 2024. 13(11). 13. Yuan, W., et al., New combined microRNA and protein plasmatic biomarker panel for pancreatic cancer. Oncotarget, 2016. 7(48). "
[Collapse]
Ren S, Song LN, Zhao R, Tian Y, Wang ZQ. Serum exosomal hsa-let-7f-5p: A potential diagnostic biomarker for metastatic pancreatic cancer detection. World J Gastroenterol 2025; 31(26): 109500
2
"This paper provides an interesting exploration of Chinese medicine monomers in regulating autophagy for the prevention and treatment ..."
[Read more]
"This paper provides an interesting exploration of Chinese medicine monomers in regulating autophagy for the prevention and treatment of HCC. The review highlights the potential of various compounds in modulating key signaling pathways involved in autophagy, offering new insights into the development of therapeutic strategies for HCC. The integration of traditional Chinese medicine with modern pharmacology is an exciting approach that could open up novel treatment avenues for cancer. However, the study mainly focuses on preclinical findings, and the lack of clinical trial data limits its immediate application. Despite this, the research is highly relevant for both basic and clinical oncology, offering promising directions for future studies and therapeutic development. "
[Collapse]
Zheng SH, Xue TY, Wang QY, Ye YA, Zhang P. Chinese medicine monomers for hepatocellular carcinoma: New ideas related to autophagy. World J Gastroenterol 2025; 31(26): 106113
3
"This paper provides valuable insights into the potential of endocytoscopy as a real-time diagnostic tool for UC. The study highlights ..."
[Read more]
"This paper provides valuable insights into the potential of endocytoscopy as a real-time diagnostic tool for UC. The study highlights the effectiveness of the ECSS and ELECT score in assessing both endoscopic and histological activity. The findings suggest that endocytoscopy can offer a faster, non-invasive alternative to traditional histopathological methods, potentially improving clinical decision-making in UC management. However, the study is limited by its small sample size and single-center design, which may affect the generalizability of the results. Despite these limitations, the paper shows the promising role of endocytoscopy in assessing UC activity, with potential implications for more efficient and timely disease management in clinical practice. "
[Collapse]
Chaemsupaphan T, Shir Ali M, Fung C, Paramsothy S, Leong RW. Endocytoscopy in real-time assessment of histological and endoscopic activity in ulcerative colitis. World J Gastrointest Endosc 2025; 17(7): 108082
4
"This paper provides valuable insights into the complementary roles of VCE and SBE in diagnosing small bowel disorders. By comparing ..."
[Read more]
"This paper provides valuable insights into the complementary roles of VCE and SBE in diagnosing small bowel disorders. By comparing both techniques, the study highlights VCE’s superiority for non-invasive initial evaluations and SBE’s utility in therapeutic interventions and obtaining histopathological confirmation. The findings are clinically significant, especially in managing obscure gastrointestinal bleeding and small bowel tumors, offering a more structured approach for clinicians. However, the study could benefit from a discussion on emerging technologies and larger, prospective studies to further validate its findings. Overall, this paper is a useful reference for clinicians involved in small bowel diagnostics. "
[Collapse]
Gadour E, Miutescu B, Okasha HH, Ghiuchici AM, AlQahtani MS. Diagnostic yield of video capsule endoscopy vs simple balloon enteroscopy in small intestinal disorders: A systematic review. World J Gastrointest Endosc 2025; 17(7): 108264
5
"### Review of the Article “Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in ..."
[Read more]
"### Review of the Article “Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in metabolic dysfunction-associated steatotic liver disease” published in the World Journal of Gastroenterology This article represents a significant advancement in the non-invasive diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD) and offers valuable insights for clinical practice. #### Clinical Application Value The study introduces a non-invasive assessment method based on multiparametric ultrasound, which holds great significance for clinical practice. Given the large number of MASLD patients, traditional liver biopsy is not only costly but also associated with sampling errors and risks of complications. The introduction of multiparametric ultrasound provides clinicians with a safer and more convenient diagnostic tool, effectively reducing the need for liver biopsies and minimizing patient discomfort and medical costs. #### Innovation For the first time, this study compares viscosity measurements (Vi.PLUS) with the histopathological features of MASLD and finds that viscosity is closely related to the degree of inflammation and ballooning in MASH. This finding offers a new perspective for the non-invasive diagnosis of MASLD and paves the way for future research and clinical applications. #### Methodological Rigor The study employs a single-center, prospective, cross-sectional design with 120 patients, all of whom underwent liver biopsy as the reference standard. This rigorous study design and methodology ensure the reliability and scientific validity of the results. #### Practicality of the Results The study demonstrates that the VAS-MASH-US score, based on multiparametric ultrasound, has good sensitivity and specificity for diagnosing MASH. This scoring system provides clinicians with a practical tool to better identify high-risk patients who need liver biopsy, while reducing unnecessary invasive examinations for low-risk patients. #### Limitations of the Study Despite the significant findings, the study has some limitations. For example, it is a single-center study with a relatively small sample size, and the results have not yet been validated in an independent cohort. Additionally, differences in ultrasound equipment and techniques across centers may affect the generalizability of the results. #### Implications for Future Research This study provides new ideas and methods for the non-invasive diagnosis of MASLD, but further research is needed to validate these findings. For instance, multicenter studies in larger populations could verify the universality and accuracy of the VAS-MASH-US score. Moreover, exploring the combination of other non-invasive techniques with multiparametric ultrasound could further improve the diagnostic accuracy of MASLD. In summary, this article represents an important step forward in the non-invasive diagnosis of MASLD. Its innovation and practicality are commendable. It is hoped that more research will be conducted in the future to further refine this field and provide better medical services for MASLD patients. "
[Collapse]
Liguori A, Ainora ME, Di Gialleonardo L, Viceconti N, Petrucci L, Esposto G, Giustiniani MC, Mignini I, Borriello R, Galasso L, Paratore M, Garcovich M, Riccardi L, Pompili M, Grieco A, Gasbarrini A, Miele L, Zocco MA. Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(25): 105518
6
"Good case report of involvement of thyroid cartilage, however, it is a very rare incidence. Language quality is good. Content is ok ..."
[Read more]
"Good case report of involvement of thyroid cartilage, however, it is a very rare incidence. Language quality is good. Content is ok IHC report images should also be included to solidify the diagnosis and not just mentioning the report of IHC findings. Study stated to look for the distant metastasis including the thyroid/cartilage. However, hematogenous spread to more common distant organ should be more focused on rather than the rare ones. Especially-- liver, bone etc. Metastasis to thyroid cartilage- a poor prognostic factor--mentioned in the study. However, could not get any information/data for that "
[Collapse]
Ai MM, Lin T, Guo RY, Zhang YY, Yu F. Unexpected metastasis of thyroid cartilage involvement from lung adenocarcinoma: A case report. World J Clin Cases 2025; 13(25): 107471
7
"Good case report of involvement of thyroid cartilage, however, it is a very rare incidence. Language quality is good. Content is ok ..."
[Read more]
"Good case report of involvement of thyroid cartilage, however, it is a very rare incidence. Language quality is good. Content is ok IHC report images should also be included to solidify the diagnosis and not just mentioning the report of IHC findings. Study stated to look for the distant metastasis including the thyroid/cartilage. However, hematogenous spread to more common distant organ should be more focused on rather than the rare ones. Especially-- liver, bone etc. Metastasis to thyroid cartilage- a poor prognostic factor--mentioned in the study. However, could not get any information/data for that. "
[Collapse]
Ma TT, Lyu HR. Post-endoscopic retrograde appendicitis therapy stent impaction leading to exacerbation of appendicitis: A case report. World J Clin Cases 2025; 13(25): 106587
8
"tertiary care hospital over the last 7 years from the Himalayan and Sub-Himalayan regions of India. Studys aim--To analyze the ..."
[Read more]
"tertiary care hospital over the last 7 years from the Himalayan and Sub-Himalayan regions of India. Studys aim--To analyze the demography, clinical presentation, complications, and mortality risk factors in presumptive leptospirosis patients admitted--- was fulfilled, however, limited to one single center study and observation only. 2018-2024 data were collected based on Modified Faine’s criteria with ELISA diagnosis. \ Sample size is small. 62 number Study found- equal number of distribution of cases irrespective of sex. Complications include thrombocytopenia and liver involvement and AKI. MDS was serious complication observed in 66% of cases. Studies have also highlighted that early administration of antibiotics and aggressive supportive care can improve survival outcomes in critically ill patients with leptospirosis Limitation—only single center study with possible some selection bias. Overall Language quality and content-- Excellent. "
[Collapse]
Das D, Ponnampurathu S, Panda PK, Mathuria YP. Different clinical profile of leptospirosis in a tertiary care Indian hospital: A Himalayan experience. World J Clin Cases 2025; 13(25): 106335
9
"Study conducted from 1985 to 2022--total 47 patients included with PDTC. some of them lost on follow up. Good analysis of risk factors ..."
[Read more]
"Study conducted from 1985 to 2022--total 47 patients included with PDTC. some of them lost on follow up. Good analysis of risk factors and outcome. Good standard of article The scientific quality of very good The language quality is also professional and clear. The data analysis and charts are upto the mark. "
[Collapse]
Hsu CW, Hsueh C, Lu YL, Hsu CJ, Wong RJ, Lin SF. Risk factors and outcomes of metastatic poorly differentiated thyroid carcinoma. World J Clin Cases 2025; 13(25): 105204
10
"This paper reports on a clinical trial assessing the efficacy and safety of sirolimus in the treatment of gastrointestinal ..."
[Read more]
"This paper reports on a clinical trial assessing the efficacy and safety of sirolimus in the treatment of gastrointestinal angiodysplasia (GIAD). The results indicate that sirolimus is effective in reducing bleeding, improving hemoglobin levels, decreasing transfusion dependence, and improving lesion outcomes. Additionally, the adverse effects were mild and manageable. However, it should be noted that while patients with various underlying conditions were included, those with chronic kidney disease were not represented. This is a concern, as patients with chronic kidney disease often experience recurrent gastrointestinal bleeding due to angiodysplasia. Further studies involving a larger number of patients, including those with chronic kidney disease, are warranted. "
[Collapse]
Sun Q, Wu JC, Chen X, Li DH, Li BR, Xiao NJ, Wang XY, Tu XZ, Ning SB, Sun T. Efficacy and safety of sirolimus in the treatment of gastrointestinal angiodysplasias. World J Gastroenterol 2025; 31(25): 105677
11
"This paper provides an interesting exploration of the gut microbiota and its potential role in autoimmune overlap syndrome (OS), ..."
[Read more]
"This paper provides an interesting exploration of the gut microbiota and its potential role in autoimmune overlap syndrome (OS), combining features of autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC). The study integrates multi-omics data, focusing on microbial profiles and serum metabolites, to provide new insights into the pathophysiology of OS. The findings are clinically relevant, particularly in the context of identifying biomarkers for earlier and non-invasive diagnosis of OS, which could improve clinical management. However, the study is limited by its small sample size and lack of a healthy control group, which restricts the generalizability of the results. Despite these limitations, the paper opens up promising avenues for future research in microbiota-based diagnostics and therapeutic strategies for autoimmune liver diseases. "
[Collapse]
Wang Q, Sun LN, Shi H, Ma XY, Gao W, Xu B, Lin X, Liu YM, Huang CY, Jin RH. Multi-omics analysis reveals gut microbiota-metabolite interactions and their association with liver function in autoimmune overlap syndrome. World J Gastroenterol 2025; 31(25): 106371
12
"This study presents a comprehensive investigation into the use of multiparametric ultrasound (US) for the non-invasive assessment ..."
[Read more]
"This study presents a comprehensive investigation into the use of multiparametric ultrasound (US) for the non-invasive assessment of liver steatosis, fibrosis, and inflammation in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). The authors employed various advanced ultrasound techniques, including 2D shear-wave elastography (SWE), sound speed and attenuation imaging, and viscosity plane-wave ultrasound (Vi.PLUS), alongside traditional methods like FibroScan. The study's findings are promising, demonstrating that multiparametric ultrasound can effectively assess liver conditions such as fibrosis and steatosis, and even disease activity related to inflammation and ballooning. The diagnostic performance of the viscosity index (Vi.PLUS) and the VAS-MASH-US score was found to be good, especially for identifying patients with metabolic dysfunction-associated steatohepatitis (MASH). This approach could help reduce unnecessary liver biopsies, thereby minimizing costs and procedural risks, which is a significant clinical advantage. "
[Collapse]
Liguori A, Ainora ME, Di Gialleonardo L, Viceconti N, Petrucci L, Esposto G, Giustiniani MC, Mignini I, Borriello R, Galasso L, Paratore M, Garcovich M, Riccardi L, Pompili M, Grieco A, Gasbarrini A, Miele L, Zocco MA. Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(25): 105518
13
"Hepatocellular carcinoma (HCC) remains a major global health burden, ranking as the sixth most common cancer and the third leading ..."
[Read more]
"Hepatocellular carcinoma (HCC) remains a major global health burden, ranking as the sixth most common cancer and the third leading cause of cancer-related mortality worldwide. Despite advances in surveillance, early diagnosis, and the emergence of molecular-targeted and immunotherapeutic agents, the prognosis for many patients with HCC remains poor. This is particularly true in advanced-stage disease, where therapeutic resistance and immune escape mechanisms hinder durable responses. As our understanding of HCC pathogenesis deepens, the tumor microenvironment (TME) has emerged as a critical determinant of disease progression and therapeutic outcome. Among the key regulators in this microenvironment are galectins (Gals)—a family of glycan-binding proteins with various immunomodulatory and tumor-regulatory functions. Gal-1, Gal-3, Gal-4, and Gal-9 have attracted significant attention for their diverse roles in HCC. These proteins guide important cellular processes vital for tumor development, including inflammation, immune evasion, angiogenesis, epithelial–mesenchymal transition (EMT), proliferation, and metastasis. What sets galectins apart is their functional duality—their effects depend on their cellular location, expression levels, and the tumor microenvironment (TME). This complexity highlights their potential as both biomarkers and therapeutic targets in HCC. They coordinate processes like inflammation, angiogenesis, EMT, tumor growth, and spread. Importantly, galectins display dynamic, context-dependent behavior, capable of exerting both tumor-promoting and tumor-inhibiting effects depending on their expression, cellular localization, and the surrounding microenvironment. Recent studies, including the comprehensive review by Gajovic and colleagues (WJG 2025; 31:107260), highlight the diverse functions of Galectins in liver cancer. For instance, Gal-1 and Gal-3 are consistently associated with aggressive tumor features such as vascular invasion, immunosuppression, and poor prognosis. Conversely, Gal-4 and Gal-9 appear as favorable prognostic indicators in specific HCC subtypes, possibly due to their roles in immune activation and metastasis suppression. This duality not only reflects the complexity of Galectin biology but also encourages the development of improved biomarkers and personalized therapeutic strategies. The current therapeutic landscape of HCC—although expanded by immune checkpoint inhibitors and molecularly targeted agents—remains inadequate for many patients, especially those with advanced disease. In this context, Galectin-targeted therapies show considerable promise. Gal-3 inhibitors and Gal-3C fusion proteins, for example, are actively being studied for their ability to reverse immune suppression, disrupt tumor–stromal interactions, and improve the effectiveness of existing treatments. Meanwhile, profiling Galectin expression may help predict treatment responses and guide personalized therapy strategies. Elevated levels of Gal-1 and Gal-3 in serum or tumor tissue have consistently been associated with aggressive clinical features, such as vascular invasion, immune evasion, and poor overall survival. Conversely, Gal-4 and Gal-9 expression have been linked to favorable prognostic indicators in some patient groups, highlighting the biological diversity of HCC and the complex roles that galectins play in disease progression. The therapeutic implications are equally compelling. Galectin-targeted agents—such as Gal-3 inhibitors and Gal-3C fusion proteins—are being studied for their ability to modify the TME, boost anti-tumor immunity, and overcome resistance to current therapies. At the same time, integrating galectin profiling into clinical practice could improve risk assessment, enhance prognostic models, and support more personalized treatment approaches. However, these promising advancements must be accompanied by rigorous clinical validation. The dual and sometimes conflicting roles of galectins in cancer emphasize the importance of context—what may be beneficial in one cellular environment could be detrimental in another. Large-scale, well-controlled clinical trials and mechanistic research are critical for fully understanding the therapeutic potential of galectin modulation in HCC. Galectins are an area of study within the field of HCC biology and therapeutics that has not been extensively researched. In addressing treatment resistance and disease heterogeneity, galectins have potential for the development of biomarkers and targeted therapies. Including galectins in future HCC management strategies may contribute to more effective and personalized treatment methods. "
[Collapse]
Gajovic NM, Jovanovic IP, Jocic MV, Stojanovic B, Corovic IF, Todorovic N, Simovic Markovic BJ, Amedei A. Exploring the impact of galectins on liver cancer: From immunopathogenesis to potential targets. World J Gastroenterol 2025; 31(25): 107260
14
"This study demonstrates that reduced NRF2 activity contributes to ER stress and senescence in adipose-derived mesenchymal stem cells ..."
[Read more]
"This study demonstrates that reduced NRF2 activity contributes to ER stress and senescence in adipose-derived mesenchymal stem cells (ASCs) from hypertrophic obese mice, primarily through downregulation of MFN2. The use of multiple approaches, including NRF2/MFN2 knockdown and rescue, ChIP-qPCR, Co-IP, immunofluorescence, and IP-MS, adds robustness to the findings. Importantly, the functional relevance is strengthened by transplantation experiments, showing that disruption of NRF2 or MFN2 impairs the therapeutic potential of ASCs in insulin resistance, highlighting translational significance. However, while the authors suggest an interaction between MFN2 and BIP, the evidence remains indirect. Biochemical confirmation such as GST pull-down or FRET would be needed to verify a direct interaction. Additionally, NRF2 may affect ER stress and senescence through other targets beyond MFN2, which were not explored in this study. Future work should aim to clarify the structural basis of MFN2–BIP interaction and its functional consequences. Given the known role of MFN2 in mitochondrial dynamics and ER-mitochondrial tethering, investigating how this axis influences mitochondrial morphology, mitochondria-associated membranes integrity, and calcium signaling could provide further mechanistic insights. "
[Collapse]
Fang J. Reduced NRF2/Mfn2 activity promotes endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells in hypertrophic obese mice. World J Stem Cells 2025; 17(6): 104367
15
"Dear Editor, I read with great interest the editorial by Papadakos et al. on the evolving immunotherapeutic landscape in ..."
[Read more]
"Dear Editor, I read with great interest the editorial by Papadakos et al. on the evolving immunotherapeutic landscape in gastrointestinal stromal tumors (GISTs). The authors provide a comprehensive overview of the tumor microenvironment (TME), challenges in immunotherapy response, and emerging strategies. I would like to offer several complementary insights and suggest future directions for translational and clinical research. 1. Stratifying GISTs Through Immune Profiling: The authors rightly emphasize the immunosuppressive TME in GISTs. Building on this, emerging evidence from proteomic and transcriptomic studies supports the existence of distinct immune clusters ranging from inflamed “hot” tumors (TLS⁺/B-cell-rich) to immune-desert “cold” phenotypes. These immune subtypes have shown clear prognostic and predictive value for checkpoint inhibitor response, with objective response rates reaching 50% in TLS-rich subgroups. Integration of spatial profiling and CXCL13 expression as biomarkers may refine patient selection for PD-1/PD-L1 blockade. 2. 2. Rationale for Combination Strategies: While the editorial correctly notes the modest activity of ICIs in unselected patients, combinatorial approaches offer promise. For example, pegylated interferon-alpha-2b (PegIFNα2b) in conjunction with imatinib significantly enhances immune infiltration and suppresses PI3K/mTOR signaling, achieving remarkable response rates in early trials. Similarly, imatinib’s ability to reverse immunosuppression via IDO downregulation and Treg reduction provides a mechanistic rationale for synergy with ICIs, particularly in PDGFRA D842V-mutant GISTs. 3. Targeting Tumor Antigens and TME Components: Antibody-based therapies like SR1 (anti-KIT) have demonstrated macrophage-dependent cytotoxicity even in imatinib-resistant models. This offers a novel route to bypass TKI resistance. Additionally, novel modalities such as bispecific antibodies targeting KIT or PDGFRA in conjunction with CD3⁺ T cell engagement may overcome immune exclusion in “cold” tumors. 4. Addressing IDO Inhibitor Failures: The editorial notes the challenges with IDO1-targeted therapies. We propose that resistance may stem from spatial heterogeneity and compensatory activation of AhR and TDO2 pathways. Poly-pathway blockade, rather than IDO inhibition alone, may be essential to overcome this resistance. 5. Moving Forward: Future success in GIST immunotherapy will depend on Immune subtyping based on TLS, B cell density, and proteomic clusters (Im-I to Im-IV), Rational combination trials of TKIs + ICIs ± TME-modifying agents, Validation of biomarkers such as CXCL13, CD276, and KIT-derived neoantigens in prospective cohorts. In conclusion, the editorial provides an excellent foundation for discourse. We advocate for multi-center, biomarker-driven clinical trials to translate these emerging insights into tailored immunotherapy regimens for GIST patients. Sincerely, Fen Wang Oncology Department, Peking University Shenzhen Hospital. "
[Collapse]
Papadakos SP, Argyrou A, Karniadakis I, Vogli S, Theocharis S. Immunotherapy in gastrointestinal stromal tumors: Current landscape and future horizons. World J Clin Oncol 2025; 16(6): 104314
16
"Pulmonary fibrosis (PF), a chronic and fatal lung disease affecting millions of people worldwide, urgently needs more effective means. ..."
[Read more]
"Pulmonary fibrosis (PF), a chronic and fatal lung disease affecting millions of people worldwide, urgently needs more effective means. In this paper, the effect of cells vesicles in improving PF was verified through cell lines and rat models, and the possible pathways through which this effect was exerted were investigated. Anyway, there are still some aspects of the article that deserve further discussion. Most importantly, whether the therapeutic effect is exerted through the said signaling pathway needs to be further confirmed. In addition, the text has problems such as writing errors, suspected incompleteness of ethics, and relatively weak research significance. "
[Collapse]
Wang LL, Ouyang MY, Yang ZE, Xing SN, Zhao S, Yu HY. Mesenchymal stem cells-derived exosomes alleviate radiation induced pulmonary fibrosis by inhibiting the protein kinase B/nuclear factor kappa B pathway. World J Stem Cells 2025; 17(6): 106488
17
"We read with great interest the work of Abdelsamie and colleagues, who describe the characteristics of acute myocardial infarction ..."
[Read more]
"We read with great interest the work of Abdelsamie and colleagues, who describe the characteristics of acute myocardial infarction (AMI) in young patients, including presentation, risk factors, coronary angiography findings, and management strategies.1 While AMI is predominantly observed in individuals over 45, its occurrence in younger adults has garnered increasing attention due to its distinct risk factors and long-term consequences. When it occurs, early-onset AMI is often associated with substantial morbidity, psychosocial impact, and economic burden for patients and their families.2 We commend the authors for addressing this important topic, we would like to offer several suggestions that may help to further strengthen the clarity and clinical applicability of the study. First, the Methods section of the manuscript appears concise and would benefit from additional details to enhance reproducibility. Specifically, the Subjects subsection could provide a more comprehensive account of the exclusion criteria. While inclusion criteria are described, it remains unclear whether important conditions, such as severe cardiomyopathy, rheumatic heart disease, or malignancy, were excluded. Clarifying these aspects would strengthen the credibility and interpretability of the study findings. Additionally, more structured descriptions of Clinical data collection are warranted. It would be helpful to specify how many categories of clinical data were collected (e.g., demographic, biochemical, echocardiographic, electrocardiographic), which variables were included in each, and at what time points they were assessed (e.g., at admission, post-intervention, at discharge). Second, while the authors correctly note that single-vessel disease predominates among young AMI patients and present the distribution of culprit vessels, the severity and characteristics of the lesions remain insufficiently detailed. Specifically, the lack of ACC/AHA lesion classification and TIMI flow grading limits the angiographic assessment. These indices are clinically relevant for guiding intervention strategy and risk stratification and would add valuable context to the findings. Third, although the study aims to explore the presentation, risk factors, angiographic findings, and management of young AMI patients, it is noteworthy that clinical symptoms at presentation are not detailed. Given the clinical importance of symptom characterization for early recognition and diagnosis, including this information would help clinicians recognize such cases more effectively. Regarding the management domain, further elaboration on pharmacological therapy, particularly the use of beta-blockers, statins, and antiplatelet agents, would enhance the clinical relevance of the study. It also raises the question of whether young AMI patients tend to present with higher heart rates, and if so, whether adequate heart rate control was achieved during hospitalization or at discharge. As heart rate plays a crucial role in the progression and prognosis of coronary artery disease, such information would provide valuable insight into the effectiveness of secondary prevention strategies in this specific population. Finally, we appreciate the authors’ observation that obesity, hyperlipidemia, and smoking are prominent in young AMI patients. However, to strengthen this conclusion, we encourage the authors to consider a prospective cohort study design with multivariable adjustment, which could formally assess whether these are independent risk factors for early-onset AMI. Such analysis would increase the translational value of their findings and potentially guide targeted prevention strategies in this unique population. In conclusion, this study brings attention to a clinically important and under-explored population. We hope that the authors will consider these suggestions to further refine their methodological and clinical insights in future work. References 1. Ahmed Hegazi Abdelsamie HOA, Ahmed Taha Abdelwahed. Acute myocardial infarction in the young: A 3-year retrospective study. World Journal of Cardiology 2025;17(6) doi: 10.4330/wjc.v17.i6.106445 2. Aggarwal A, Srivastava S, Velmurugan M. Newer perspectives of coronary artery disease in young. World J Cardiol 2016;8(12):728-34. doi: 10.4330/wjc.v8.i12.728 "
[Collapse]
Hegazi Abdelsamie A, Abdelhadi HO, Abdelwahed AT. Acute myocardial infarction in the young: A 3-year retrospective study. World J Cardiol 2025; 17(6): 106445
18
"The manuscript by Camille Kass and co-authors focuses on the issue of eating disorders following bariatric surgery that may be ..."
[Read more]
"The manuscript by Camille Kass and co-authors focuses on the issue of eating disorders following bariatric surgery that may be associated with physical and physiological changes, as well as various psychological phenomena related to the effects of the surgery and dietary modifications. Diagnosis and treatment of these disorders require appropriate categorization within disease classification systems, particularly the DSM-5. However, creating such a classification with the inclusion of new categories in the existing list or expanding the diagnostic criteria requires a requires the accumulation of a sufficiently large database. The presented article describes a case of eating disorder after bariatric surgery with a detailed description of symptoms and their dynamics in the course of complex therapy. Based on the data obtained and the results of literature analysis, the authors conclude that the observed disorder is the closest to avoidant/restrictive food intake disorder according to DSM-5. At the same time, the results of the patient's follow-up confirm the opinions expressed by other authors about the need to include body dysmorphia, and the loss of personal identity associated with severe weight loss, in the diagnostic criteria for ARFID. The presented article has some relevance for the development of a diagnostic system for eating disorders. However, it should be noted that the authors did not practically consider the possible influence of the patient's premorbid background (generalized anxiety disorder) and its interaction with the effects of bariatric surgery on the observed eating disorders. In general, it seems reasonable and interesting to conduct such an analysis using author’s own results and data from the literature. "
[Collapse]
Cass K, Leggett A, Gibson DG. Diagnostic dilemma of avoidant/restrictive food intake disorder after bariatric surgery: A case report and review of literature. World J Clin Cases 2025; 13(24): 106941
19
"This article is a study on the development and validation of a visceral adipose tissue (VAT)-based delta radiomics model to predict ..."
[Read more]
"This article is a study on the development and validation of a visceral adipose tissue (VAT)-based delta radiomics model to predict secondary loss of response to infliximab therapy in patients with Crohn’s disease. Both VAT and mesenteric adipose tissue are types of fat tissue that influence the pathogenesis and treatment outcomes in Crohn’s disease, but each has distinct characteristics. VAT refers to a broad range of adipose tissue and affects systemic inflammation and treatment outcomes. In contrast, mesenteric adipose tissue is specifically located around the intestines and is deeply involved in local inflammation and the progression of intestinal pathology. Although mesenteric adipose tissue is considered a part of VAT, its specific role in Crohn’s disease has attracted particular attention. Abnormal proliferation of mesenteric adipose tissue has been suggested to contribute to complex conditions, including intestinal fibrosis, strictures, and perforation. In the future, further investigation into the relationship between VAT and mesenteric adipose tissue is warranted. "
[Collapse]
Li X, Song FL, He HF, Zeng SM, Feng ZC, Rong PF. Longitudinal computed tomography-based delta-radiomics of visceral adipose tissue predicts infliximab secondary loss of response in Crohn’s disease patients. World J Gastroenterol 2025; 31(21): 105895
20
"Commentary on articles published in World Journal of Gastroenterology Reader Perspective Prof. Zeinab Nabil Ahmed Said Reader’s code: ..."
[Read more]
"Commentary on articles published in World Journal of Gastroenterology Reader Perspective Prof. Zeinab Nabil Ahmed Said Reader’s code: 02441096) Prevalence and risk factors of Helicobacter pylori infection in Xinjiang Uygur Autonomous Region: A cross-sectional study of all age groups Jiang Q, Liu WD, Hui WJ, Kong WJ, Feng Y, Kuerbanjiang A, Huang XL, Gao F. Prevalence and risk factors of Helicobacter pylori infection in Xinjiang Uygur Autonomous Region: A cross-sectional study of all age groups. World J Gastroenterol 2025; 31(21): 106033 [PMID: 40538506 DOI: 10.3748/wjg.v31.i21.106033] The study is a cross sectional prevalence study to evaluate the H. pylori infection and risk factors in one of the large province in China that located in the northwest of the country with multiethnic aggregation. Such studies pave the way for policy makers for effective implementation of prevention and control strategies. The study involves 15 regions with 18951708 population. A total of 4665 people were surveyed, with questionnaire surveys and H. pylori antibody blood tests were conducted. 4361 were tested for H. pylori antibody. Social, economic factors, public health conditions, as well as dietary and living habits among different areas were evaluated to identify risk factors associated with H. pylori prevalence in different regions. Methodology: The reason for having blood samples in the morning on an empty stomach is not clarified. Also, the type of tested Ig must be mentioned. IgG is denoting previous exposure not current infection. Active infection is detected by urea breath tests and stool antigen tests. Results: It is better to say overall H pylori prevalence rather than infection. Tables: Significant p value is better to be marked, by *for example. Discussion: This section is well organized and theoretical analysis of data is well presented, however, to avoid the limitation of some missing data, sensitivity analysis is better to be done. "
[Collapse]
Zhang Y, Tang YW, Zhou J, Wei YR, Peng YT, Yan Z, Yue ZH. Electroacupuncture at ST36 ameliorates gastric dysmotility in rats with diabetic gastroparesis via the nucleus tractus solitarius-vagal axis. World J Gastroenterol 2025; 31(21): 107395
1004 items Read more >>
- ALL AUTHOR RESOURCES
- Appeals and Complaints
- Article Processing Charge
- Common Usage of Quantities and Units
- Copyright License Agreement
- Create an Account
- Criteria for Authorship
- Ethics Committee of BPG
- Ethics Statements
- Guidelines for Authors
- Journals
- Language Editing Process for Manuscripts Submitted by Non-Native Speakers of English
- Methods of Post-Publication Debate
- Open-Access
- Policies on Handle Allegations from Whistleblowers
- Publication Misconduct
- Quality of Publications
- Steps for Submitting Manuscripts
- Submit a Manuscript
- ALL PEER-REVIEWER RESOURCES
- Manuscript Decision
- Peer-Review Process
- Peer-Reviewer Tracking for Manuscripts
- Reviewer Acknowledgment
- REFERENCE CITATION ANALYSIS
- Find a Category
- Find a Journal
- Find a Scholar
- Find an Academic Assistant
- Find an Article
- Find an Article PDF
- Subscribe
- Today's Articles
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
California Corporate Number: 3537345