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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2022; 14(11): 2183-2194
Published online Nov 15, 2022. doi: 10.4251/wjgo.v14.i11.2183
Published online Nov 15, 2022. doi: 10.4251/wjgo.v14.i11.2183
E3 ubiquitin ligase TRIM55 promotes metastasis of gastric cancer cells by mediating epithelial-mesenchymal transition
Wei-Wei Li, Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250021, Shandong Province, China
Wei-Wei Li, Department of Critical Care Medicine, The 960th Hospital of the People's Liberation Army Joint Logistics Support Force, Jinan 250031, Shandong Province, China
Hao Yuan, Shuai Kong, Shu-Bo Tian, Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China
Shuai Kong, Shu-Bo Tian, Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250021, Shandong Province, China
Author contributions: Li WW and Yuan H contributed equally to this work; Tian SB and Li WW designed the study; Li WW and Yuan H performed all experiments; Kong S and Tian SB analyzed the data and drafted the article; All authors read and approved the final manuscript.
Supported by Shandong Province Medicine and Health Science and Technology Development Plan Project , No. 2019WS477 .
Institutional review board statement: The study was reviewed and approved by the Shandong Provincial Hospital Affiliated to Shandong First Medical University Institutional Review Board.
Institutional animal care and use committee statement: No animal subjects were involved in our experiments.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at ttkl_bo@126com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Bo Tian, PhD, Chief Doctor, Surgeon, Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwuweiqi Road, Jinan 250021, Shandong Province, China.
Received: August 21, 2022
Peer-review started: August 21, 2022
First decision: September 13, 2022
Revised: September 28, 2022
Accepted: October 27, 2022
Article in press: October 27, 2022
Published online: November 15, 2022
Processing time: 85 Days and 19.2 Hours
Peer-review started: August 21, 2022
First decision: September 13, 2022
Revised: September 28, 2022
Accepted: October 27, 2022
Article in press: October 27, 2022
Published online: November 15, 2022
Processing time: 85 Days and 19.2 Hours
Core Tip
Core Tip: TRIM55 expression was elevated in gastric cancer (GC) cancer tissues. Depletion of TRIM55 in GC cells suppressed proliferation, migration and invasion of cells. Knockdown of TRIM55 affected the expression of cell epithelial-mesenchymal transition-related proteins. TRIM55 may serve as an oncogene in GC.