Published online Nov 15, 2022. doi: 10.4251/wjgo.v14.i11.2183
Peer-review started: August 21, 2022
First decision: September 13, 2022
Revised: September 28, 2022
Accepted: October 27, 2022
Article in press: October 27, 2022
Published online: November 15, 2022
Processing time: 85 Days and 19.2 Hours
Gastric cancer (GC) is considered a major global health problem. The role of TRIM55, a member of the three-domain protein family, in GC is unknown.
To determine the expression of TRIM55 in GC tissues and its relationship with clinicopathological characteristics, and to investigate the effects of TRIM55 on the malignant biological behavior of GC cells.
Differential expression of TRIM55 in GC and para-cancer tissues was detected by immunohistochemistry, and the relationship between TRIM55 level and clini
TRIM55 expression was significantly increased in GC tissues compared with adjacent normal tissues. High expression of TRIM55 was associated with advanced pathological stage and poor prognosis. Overexpression of TRIM55 promoted invasion and metastasis of GC cells in vitro by regulating epithelial-mesenchymal transition (EMT), whereas knockdown of TRIM55 had the opposite effect. Our data showed that TRIM55 is highly expressed in GC tissues, and is associated with poor prognosis. TRIM55 plays the role of an oncogene in GC, and it promotes metastasis of GC through the regulation of EMT.
TRIM55 may be a possible target for the diagnosis and prognosis of GC patients.
Core Tip: TRIM55 expression was elevated in gastric cancer (GC) cancer tissues. Depletion of TRIM55 in GC cells suppressed proliferation, migration and invasion of cells. Knockdown of TRIM55 affected the expression of cell epithelial-mesenchymal transition-related proteins. TRIM55 may serve as an oncogene in GC.