Mucin 1 and interleukin-11 protein expression and inflammatory reactions in the intestinal mucosa of necrotizing enterocolitis children after surgery

Table 1 Comparison of mucin 1 protein and interleukin-11 protein between Necrotizing enterocolitis group and control group (mean ± SD, relative expression intensity)

Groups	n	MUC-1 protein	IL-11 protein
NEC group	48	0.461 ± 0.108	0.391 ± 0.085
Control group	22	0.958 ± 0.177	0.920 ± 0.204
t		-14.494	-15.381
P value		0.000	0.000

NEC: Necrotizing enterocolitis; MUC-1: Mucin 1; IL-11: Interleukin-11.

Table 2 Comparison of positive expression rate of mucin 1 protein, n (%)

Group	n	MUC-1protein
		Positive	Negative
NEC group	48	16 (33.33)	32 (66.67)
Control group	22	17 (77.27)	5 (22.73)
χ2		11.688
P value		0.001

NEC: Necrotizing enterocolitis; MUC-1: Mucin 1.

Table 3 Comparison of positive expression rate of interleukin-11 protein, n (%)

Groups	n	IL-11protein
		Positive	Negative
NEC group	48	13 (27.08)	35 (72.92)
Control group	22	18 (81.82)	4 (18.18)
χ2		18.317
P value		0.000

NEC: Necrotizing enterocolitis; IL-11: Interleukin-11.

Table 4 Comparison of serum tumor necrosis factor-α and interleukin-1β levels between necrotizing enterocolitis group and control group (mean ± SD)

Group	n	TNF-α (ng/L)	IL-1β (ng/mL)
NEC group	48	386.6 ± 76.4	18.63 ± 3.02
Control group	22	260.7 ± 48.8	14.19 ± 2.50
t		7.080	6.010
P value		0.000	0.000

NEC: Necrotizing enterocolitis; TNF-α: Tumor necrosis factor-α; IL-1β: Interleukin-1β.

Table 5 Linear correlation results

Index	Correlation	TNF-α	IL-1β
MUC-1 protein	r	-0.619	-0.486
	P value	0.000	0.000
IL-11 protein	r	-0.577	-0.528
	P value	0.000	0.000

MUC-1: Mucin 1; IL-11: Interleukin-11; TNF-α: Tumor necrosis factor-α; IL-1β: Interleukin-1β.