Synchronized early gastric cancer occurred in a patient with serrated polyposis syndrome: A case report

Table 1 Details of five gastric cancer-associated variants

Gene	Chr	Mutation	SIFT/Polyphen_2/MT	Pathways
MTHFR	1	exon5:c.C788T:p.A263V	D/D/P	Folate metabolism
		exon5:c.C665T:p.A222V
MTX1	1	exon1:c.T187A:p.S63T	-	Metabolism of proteins
CCDC6	10	exon9:c.C1408A:p.P470T	D/D/P	DNA damage response, Cell cycle, Apoptosis
GRID1	10	exon11:c.G1585A:p.V529I	D/D/D	Peptide ligand-binding receptors
ALDH2	12	exon11:c.G1369A:p.E457K	D/D/P	Ethanol degradation, Cytochrome P450
		exon12:c.G1510A:p.E504K

Chr: Chromosome; D: Deleterious; P: Possibly deleterious.