Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 16, 2022; 10(8): 2644-2649
Published online Mar 16, 2022. doi: 10.12998/wjcc.v10.i8.2644
Synchronized early gastric cancer occurred in a patient with serrated polyposis syndrome: A case report
Ying-Ze Ning, Guan-Yi Liu, Xiao-Long Rao, Yong-Chen Ma, Long Rong
Ying-Ze Ning, Guan-Yi Liu, Xiao-Long Rao, Yong-Chen Ma, Long Rong, Department of Endoscopy Center, Peking University First Hospital, Beijing 100032, China
Author contributions: Ning YZ wrote the manuscript; Liu GY and Rao XL collected the data; Ma YC analyzed the data; Rong L designed the research study; all authors have read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Long Rong, MD, Chief Doctor, Professor, Department of Endoscopy Center, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100032, China. ronglong8@sina.com
Received: October 25, 2021
Peer-review started: October 25, 2021
First decision: December 17, 2021
Revised: December 28, 2021
Accepted: February 10, 2022
Article in press: February 10, 2022
Published online: March 16, 2022
Processing time: 136 Days and 8.4 Hours
Abstract
BACKGROUND

Serrated polyposis syndrome (SPS) is a relatively rare disease that is characterized by multiple serrated lesions/polyps. Very little is known regarding the extracolonic cancers associated with SPS. The genetic basis of the process remains unknown.

CASE SUMMARY

A 67-year-old male patient initially presented with belching and abdominal distension for a year as well as diarrhea for over 2 mo. The patient underwent colonoscopy and was diagnosed with serrated polyposis syndrome. Half a year later, a gastroscopy was performed during the postoperative re-examination to screen for other lesions of the upper gastrointestinal tract. An elevated lesion was detected in the anterior wall of the gastric antrum. Curative en bloc resection of the lesion was achieved via endoscopic submucosal dissection. The pathological result was high-grade dysplasia with focal intramucosal carcinoma. Exome sequencing was performed for the patient and five gastric cancer-associated variants (methylenetetrahydrofolate reductase, metaxin 1, coiled-coil domain containing 6, glutamate ionotropic receptor delta type subunit 1, and aldehyde dehydrogenase 1) were identified.

CONCLUSION

This paper reports a case that presented with both SPS and early gastric cancer. Genetic mutations that were potentially responsible for this condition were sought by exome sequencing.

Keywords: Serrated polyposis syndrome; Early gastric cancer; Gene mutation; Endoscopy; Exome sequencing; Case report

Core Tip: Serrated polyposis syndrome (SPS) is a relatively rare disease. Very little is known regarding the extracolonic cancers associated with SPS. The genetic basis of the process remains unknown. Here, we report a case that presented with SPS and synchronized early gastric cancer. Genetic mutations that were potentially responsible for this condition were sought by exome sequencing.