Washed microbiota transplantation reduces serum uric acid levels in patients with hyperuricaemia

Table 1 Main diagnosis of 144 patients receiving washed microbiota transplantation

Main diagnosis	n (%)
Irritable bowel syndrome	32 (22.22)
Functional constipation	22 (15.28)
Ulcerative colitis	14 (9.72)
Gastroesophageal reflux disease	14 (9.72)
Nonalcoholic fatty liver disease	11 (7.64)
Childhood autism	9 (6.25)
Functional enteropathy	5 (3.47)
Functional diarrhea	5 (3.47)
Gout	5 (3.47)
Cirrhosis after hepatitis	3 (2.08)
Functional abdominal pain syndrome	3 (2.08)
Radiation colitis	2 (1.39)
Chronic viral hepatitis B	2 (1.39)
Other	16 (11.11)

Table 2 Short-term (within 3 mo) and mid-term (within 3-6 mo) washed microbiota transplantation treatment courses in the hyperuricaemia group and normal uric acid group

Time	Group	n	1 course	2 courses	3 courses	4 courses
Short-term
	HUA group	32	1	21	10	-
	NUA group	74	1	51	22	-
Mid-term
	HUA group	9	-	1	6	2
	NUA group	20	-	-	15	5

HUA: Hyperuricaemia; NUA: Normal uric acid.

Table 3 Changes in short-term (within 3 mo) and mid-term (within 3-6 mo) serum uric acid levels before and after washed microbiota transplantation treatment

Group	SUA levels (μM)		P value	SUA levels (μM)		P value	SUA levels (μM)		P value
	Before treatment	Short-term effect after treatment		Before treatment	Mid-term effect after treatment		Short-term effect after treatment	Mid-term effect after treatment
HUA group (n = 44)	546.81 ± 109.64 (n = 32)	481.00 ± 99.85 (n = 32)	0.001	504.0 ± 100.3 (n = 9)	483.00 ± 101.21 (n = 9)	0.596	528.12 ± 111.89 (n = 8)	485.88 ± 107.80 (n = 8)	0.276
NUA group (n = 100)	322.8 ± 52.0 (n = 74)	326.62 ± 63.30 (n = 74)	0.500	308.30 ± 70.28 (n = 20)	325.50 ± 101.03 (n = 20)	0.350	309.10 ± 68.32 (n = 20)	325.50 ± 101.03 (n = 20)	0.301

SUA: Serum uric acid; HUA: Hyperuricaemia; NUA: Normal uric acid.

Table 4 Changes in serum uric acid before and after treatment in patients receiving different courses of washed microbiota transplantation

Group	SUA levels (μM)		P value	SUA levels (μM)		P value	SUA levels (μM)		P value
	Before treatment	After first course of WMT		Before treatment	After second course of WMT		Before treatment	After third course of WMT
HUA group (n = 44)	540.00 ± 107.16 (n = 35)	469.74 ± 97.68 (n = 35)	0.001	513.19 ± 78.14 (n = 21)	465.57 ± 88.88 (n = 21)	0.026	526.73 ± 111.30 (n = 11)	417.36 ± 92.84 (n = 11)	0.101
NUA group (n = 100)	320.55 ± 52.73 (n = 77)	328.86 ± 71.91 (n = 77)	0.184	317.29 ± 57.44 (n = 51)	323.18 ± 68.06 (n = 51)	0.442	333.00 ± 55.49 (n = 27)	328.59 ± 73.52 (n=27)	0.628

HUA: Hyperuricaemia; NUA: Normal uric acid; WMT: Washed microbiota transplantation.

Table 5 Changes in short-term (within 3 mo) and mid-term (within 3-6 mo) serum creatinine levels before and after washed microbiota transplantation treatment

Group	SCR levels (μM)		P value	SCR levels (μM)		P value
	Before treatment	Short-term effect after treatment		Before treatment	Mid-term effect after treatment
HUA group (n = 44)	73.00 ± 20.17 (n = 29)	72.07 ± 17.27 (n = 29)	0.575	68.44 ± 14.67 (n = 9)	67.78 ± 13.03 (n = 9)	0.798
NUA group (n = 100)	64.85 ± 13.74 (n = 73)	64.67 ± 13.22 (n = 73)	0.791	66.3 ± 14.6 (n = 20)	66.10 ± 14.02 (n = 20)	0.890

HUA: Hyperuricaemia; NUA: Normal uric acid.