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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 16, 2022; 10(11): 3401-3413
Published online Apr 16, 2022. doi: 10.12998/wjcc.v10.i11.3401
Published online Apr 16, 2022. doi: 10.12998/wjcc.v10.i11.3401
Washed microbiota transplantation reduces serum uric acid levels in patients with hyperuricaemia
Jin-Rong Cai, Xin-Wen Chen, Yu-Jian He, Bin Wu, School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510030, Guangdong Province, China
Min Zhang, Department of Epidemiology and Health Statistics, Guangdong Pharmaceutical University, Guangzhou 510220, Guangdong Province, China
Li-Hao Wu, Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510030, Guangdong Province, China
Li-Hao Wu, Research Center, Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province, Guangzhou 510030, Guangdong Province, China
Author contributions: Cai JR, Chen XW, He YJ and Wu B jointly analysed the data, wrote the manuscript, and contributed equally to this article; Zhang M provided statistical advice; Wu LH designed the study and revised the manuscript; all authors read and approved the manuscript.
Supported by the Innovation and Entrepreneurship Training Program for College Students of Guangdong Province , No. S201910573028 .
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Guangdong Pharmaceutical University, No. 68.
Informed consent statement: All participants signed written informed consent.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Hao Wu, MD, Associate Professor, Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, No. 19 Nonglinxia Road, Yuexiu District, Guangzhou 510030, Guangdong Province, China.
Received: October 27, 2021
Peer-review started: October 27, 2021
First decision: December 27, 2021
Revised: January 8, 2022
Accepted: February 17, 2022
Article in press: February 27, 2022
Published online: April 16, 2022
Processing time: 163 Days and 1 Hours
Peer-review started: October 27, 2021
First decision: December 27, 2021
Revised: January 8, 2022
Accepted: February 17, 2022
Article in press: February 27, 2022
Published online: April 16, 2022
Processing time: 163 Days and 1 Hours
Core Tip
Core Tip: In this study, we demonstrate that washed microbiota transplantation (WMT) can lower serum uric acid (SUA) levels in patients with hyperuricaemia in the short term with only mild side effects but that WMT has no obvious effect on the SUA levels of people with normal uric acid levels.