Cai JR, Chen XW, He YJ, Wu B, Zhang M, Wu LH. Washed microbiota transplantation reduces serum uric acid levels in patients with hyperuricaemia. World J Clin Cases 2022; 10(11): 3401-3413 [PMID: 35611199 DOI: 10.12998/wjcc.v10.i11.3401]
Corresponding Author of This Article
Li-Hao Wu, MD, Associate Professor, Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, No. 19 Nonglinxia Road, Yuexiu District, Guangzhou 510030, Guangdong Province, China. wulihao888@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Apr 16, 2022; 10(11): 3401-3413 Published online Apr 16, 2022. doi: 10.12998/wjcc.v10.i11.3401
Washed microbiota transplantation reduces serum uric acid levels in patients with hyperuricaemia
Jin-Rong Cai, Xin-Wen Chen, Yu-Jian He, Bin Wu, Min Zhang, Li-Hao Wu
Jin-Rong Cai, Xin-Wen Chen, Yu-Jian He, Bin Wu, School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510030, Guangdong Province, China
Min Zhang, Department of Epidemiology and Health Statistics, Guangdong Pharmaceutical University, Guangzhou 510220, Guangdong Province, China
Li-Hao Wu, Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510030, Guangdong Province, China
Li-Hao Wu, Research Center, Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province, Guangzhou 510030, Guangdong Province, China
Author contributions: Cai JR, Chen XW, He YJ and Wu B jointly analysed the data, wrote the manuscript, and contributed equally to this article; Zhang M provided statistical advice; Wu LH designed the study and revised the manuscript; all authors read and approved the manuscript.
Supported bythe Innovation and Entrepreneurship Training Program for College Students of Guangdong Province, No. S201910573028.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Guangdong Pharmaceutical University, No. 68.
Informed consent statement: All participants signed written informed consent.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Hao Wu, MD, Associate Professor, Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, No. 19 Nonglinxia Road, Yuexiu District, Guangzhou 510030, Guangdong Province, China. wulihao888@126.com
Received: October 27, 2021 Peer-review started: October 27, 2021 First decision: December 27, 2021 Revised: January 8, 2022 Accepted: February 17, 2022 Article in press: February 27, 2022 Published online: April 16, 2022 Processing time: 163 Days and 1 Hours
ARTICLE HIGHLIGHTS
Research background
Hyperuricaemia (HUA) pathogenesis is closely associated with intestinal bacteria.
Research motivation
Current treatments for HUA have failed to obtained satisfactory clinical results.
Research objectives
To investigate the effect and safety of washed microbiota transplantation (WMT) on serum uric acid (SUA) levels in different populations.
Research methods
A total of 144 patients who received WMT from July 2016 to April 2020 in the First Affiliated Hospital of Guangdong Pharmaceutical University and had SUA data before treatment were selected. The changes in SUA levels before and after treatment were retrospectively reviewed. According to the pretreatment SUA level, the patients were divided into a hyperuricaemia group (HUA group: SUA > 416 μM) and a normal uric acid group (NUA group: SUA ≥ 202 μM to ≤ 416 μM). Statistical product and service solutions 26.0 was used to analyse the data.
Research results
The average short-term SUA levels in the HUA group decreased after WMT (481.00 ± 99.85 vs 546.81 ± 109.64 μM, n = 32, P < 0.05). The levels decreased in 25/32 patients and returned to normal in 10/32 patients. The short-term level of SUA reduction after treatment moderately correlated with the SUA levels before treatment (r = 0.549, R² = 0.300, P < 0.05). The average SUA levels decreased after the first and second courses of WMT (469.74 ± 97.68 vs 540.00 ± 107.16 μM, n = 35, 465.57 ± 88.88 vs 513.19 ± 78.14 μM, n = 21, P < 0.05). Short-term and mid-term SUA levels in the NUA group after WMT and SUA levels after the first, second and third courses of WMT were similar to those before WMT (P > 0.05). Only 1/144 patients developed mild diarrhoea after WMT.
Research conclusions
WMT can lower the SUA level in patients with HUA in the short term with mild side effects, but WMT has no obvious effect on the SUA level of patients with NUA.
