Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2021; 9(22): 6278-6286
Published online Aug 6, 2021. doi: 10.12998/wjcc.v9.i22.6278
Risk factors for preoperative carcinogenesis of bile duct cysts in adults
Xin Wu, Bing-Lu Li, Chao-Ji Zheng, Xiao-Dong He
Xin Wu, Bing-Lu Li, Chao-Ji Zheng, Xiao-Dong He, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Author contributions: All authors helped to perform the research; Wu X designed and performed the research and wrote the paper; Li BL designed the research and supervised the report; Zheng CJ and He XD contributed to the analysis and provided clinical advice.
Supported by the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences, No. 2019XK320012.
Institutional review board statement: This study was reviewed and approved by the Peking Union Medical College Hospital Institutional Review Board (S-K1483).
Informed consent statement: The requirement of informed consent for publication of data was waived owing to the retrospective nature of the study.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bing-Lu Li, MD, Professor, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. pumchlibinglu@163.com
Received: April 11, 2021
Peer-review started: April 11, 2021
First decision: April 23, 2021
Revised: May 6, 2021
Accepted: May 19, 2021
Article in press: May 19, 2021
Published online: August 6, 2021
Core Tip

Core Tip: Bile duct cyst (BDC) is a rare congenital bile duct malformation that is more common in Asian countries. The incidence of bile duct malignancy in BDC patients is 20- to 30-fold higher than that in the general population. However, few studies have been conducted on the risk factors for preoperative carcinogenesis of BDC. The present study retrospectively analyzed 109 BDC patients and found that gallbladder wall thickness > 0.3 cm and Todani type IV were independently associated with preoperative carcinogenesis. The clinical data and long-term follow-up information of ten BDC patients with dysplasia or carcinoma were also presented.