Wu X, Li BL, Zheng CJ, He XD. Risk factors for preoperative carcinogenesis of bile duct cysts in adults. World J Clin Cases 2021; 9(22): 6278-6286 [PMID: 34434994 DOI: 10.12998/wjcc.v9.i22.6278]
Corresponding Author of This Article
Bing-Lu Li, MD, Professor, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. pumchlibinglu@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 6, 2021; 9(22): 6278-6286 Published online Aug 6, 2021. doi: 10.12998/wjcc.v9.i22.6278
Risk factors for preoperative carcinogenesis of bile duct cysts in adults
Xin Wu, Bing-Lu Li, Chao-Ji Zheng, Xiao-Dong He
Xin Wu, Bing-Lu Li, Chao-Ji Zheng, Xiao-Dong He, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Author contributions: All authors helped to perform the research; Wu X designed and performed the research and wrote the paper; Li BL designed the research and supervised the report; Zheng CJ and He XD contributed to the analysis and provided clinical advice.
Supported bythe Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences, No. 2019XK320012.
Institutional review board statement: This study was reviewed and approved by the Peking Union Medical College Hospital Institutional Review Board (S-K1483).
Informed consent statement: The requirement of informed consent for publication of data was waived owing to the retrospective nature of the study.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bing-Lu Li, MD, Professor, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. pumchlibinglu@163.com
Received: April 11, 2021 Peer-review started: April 11, 2021 First decision: April 23, 2021 Revised: May 6, 2021 Accepted: May 19, 2021 Article in press: May 19, 2021 Published online: August 6, 2021
ARTICLE HIGHLIGHTS
Research background
The currently recommended treatment modality for bile duct cyst (BDC) is operation due to the high incidence of bile duct malignancy. However, few studies have been conducted on the risk factors for preoperative carcinogenesis of BDC patients.
Research motivation
To find out the patient features that are indications for surgery in BDC and provide better treatment recommendation.
Research objectives
To analyze the risk factors associated with preoperative carcinogenesis in BDC patients.
Research methods
This retrospective study included patients with BDC treated at our hospital between January 2012 and December 2018. A database containing demographic characteristics, symptoms, laboratory tests, operation details, pathology information, and prognoses was constructed. The characteristics of BDC with dysplasia/carcinoma were compared with benign cysts. Univariate and multivariate analyses were used to analyze the risk factors for preoperative carcinogenesis.
Research results
A total of 109 patients with BDC were included. Ten patients had preoperative dysplasia or adenocarcinoma. Univariate analysis showed that gallbladder wall thickness > 0.3 cm, cyst transverse diameter > 3 cm, and Todani type IV were associated with preoperative carcinogenesis. Multivariate logistic regression analysis showed that gallbladder wall thickness > 0.3 cm and Todani type IV were independently associated with preoperative carcinogenesis. The follow-up information of ten patients with dysplasia/carcinoma was presented.
Research conclusions
BDC is a premalignant condition. Gallbladder wall thickness > 0.3 cm and Todani type IV are independent risk factors for preoperative carcinogenesis.
Research perspectives
The two risk factors are useful for deciding on the appropriate treatment strategy, especially in asymptomatic patients.
