Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 26, 2021; 9(21): 5754-5768
Published online Jul 26, 2021. doi: 10.12998/wjcc.v9.i21.5754
Treatment strategies for hepatocellular carcinoma with extrahepatic metastasis
Hai-Yi Long, Tong-Yi Huang, Xiao-Yan Xie, Jian-Ting Long, Bao-Xian Liu
Hai-Yi Long, Tong-Yi Huang, Xiao-Yan Xie, Bao-Xian Liu, Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Jian-Ting Long, Department of Medical Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
Author contributions: Long HY and Huang TY were involved in review design and drafting of the manuscript; Xie XY and Long JT were involved in the critical revision of the manuscript; Liu BX was involved in review design and critical revision of the manuscript.
Supported by Natural Science Foundation of Guangdong Province of China, No. 2018A0303130165; and Science and Technology Program of Guangzhou, No. 201904010046.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bao-Xian Liu, MD, PhD, Assistant Professor, Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, the First Affiliated Hospital of Sun Yat-Sen University, No. 58 Zhongshan Road 2, Guangzhou 510080, Guangdong Province, China. liubxian@mail.sysu.edu.cn
Received: February 21, 2021
Peer-review started: February 21, 2021
First decision: April 19, 2021
Revised: April 20, 2021
Accepted: May 25, 2021
Article in press: May 25, 2021
Published online: July 26, 2021
Processing time: 149 Days and 18.5 Hours
Core Tip

Core Tip: The presence of extrahepatic metastasis (EHM) indicates an advanced stage of hepatocellular carcinoma (HCC), for which systemic therapy serves as the standard treatment modality. Efforts have been made to demonstrate the efficacy of locoregional management of EHM in symptom relief and potential benefit for overall survival. This review provides a summary of recent updates of the systemic agents for advanced HCC, with an emphasis on aggressive locoregional management of EHM by various treatment modalities.