Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 26, 2021; 9(18): 4585-4598
Published online Jun 26, 2021. doi: 10.12998/wjcc.v9.i18.4585
Evaluation of a five-gene signature associated with stromal infiltration for diffuse large B-cell lymphoma
Ying-Yu Nan, Wen-Jun Zhang, De-Hong Huang, Qi-Ying Li, Yang Shi, Tao Yang, Xi-Ping Liang, Chun-Yan Xiao, Bing-Ling Guo, Ying Xiang
Ying-Yu Nan, Wen-Jun Zhang, De-Hong Huang, Qi-Ying Li, Yang Shi, Tao Yang, Xi-Ping Liang, Chun-Yan Xiao, Bing-Ling Guo, Ying Xiang, Department of Hematology, Chongqing University Cancer Hospital, Chongqing 400030, China
Author contributions: Xiang Y conceived and designed the study; Nan YY, Zhang WJ and Huang DH conducted the experiments, data analysis and manuscript drafting, and the three authors contributed equally to the study; Yang T performed the statistical analyses; Li QY, Shi Y, Liang XP, Xiao CY and Guo BL participated intellectual discussions and revised the manuscript; All authors reviewed and approved the final manuscript.
Supported by the Natural Science Foundation of Chongqing, No. cstc2019jcyj-msxmX0793.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Chongqing University Cancer Hospital.
Informed consent statement: The patients were not required to give informed consent to participate in this study because the analysis used anonymous data obtained from an archival database.
Conflict-of-interest statement: All authors declare having no conflict of interests.
Data sharing statement: The supporting information is provided along with the BPG online publication, and no additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying Xiang, MD, MSc, Chief Doctor, Department of Hematology, Chongqing University Cancer Hospital, No. 181 Hanyu Road, Shapingba District, Chongqing 400030, China. xiangying0331@163.com
Received: November 16, 2020
Peer-review started: November 16, 2020
First decision: January 17, 2021
Revised: January 26, 2021
Accepted: February 24, 2021
Article in press: February 24, 2021
Published online: June 26, 2021
Core Tip

Core Tip: In this project, we identified five genes that were overexpressed in diffuse large B-cell lymphoma (DLBCL), and the five gene signatures were closely associated with the development of DLBCL. More importantly, the five genes were positively correlated with stromal cell infiltration, especially in cancer-associated fibroblasts. Taken together, these genes might be novel therapeutic targets for DLBCL.