Chen S, Zhou YC, Si S, Liu HY, Zhang QR, Yin TF, Xie CX, Yao SK, Du SY. Atypical Whipple’s disease with special endoscopic manifestations: A case report. World J Clin Cases 2022; 10(35): 13044-13051 [PMID: 36568994 DOI: 10.12998/wjcc.v10.i35.13044]
Corresponding Author of This Article
Shi-Yu Du, MD, PhD, Chief Physician, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shiyudu1975@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Shuo Chen, Qing-Rui Zhang, Shu-Kun Yao, Shi-Yu Du, Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China
Yuan-Chen Zhou, Teng-Fei Yin, Peking University China-Japan Friendship School of Clinical Medicine, Peking University, Beijing 100029, China
Shuang Si, Department of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China
Hong-Yan Liu, Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, China
Chu-Xi Xie, Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China
Author contributions: Chen S, Zhou YC, Zhang QR, and Yin TF wrote the main manuscript text under the guidance of Du SY and Yao SK; Si S, Liu HY, and Xie CX prepared the figures; all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shi-Yu Du, MD, PhD, Chief Physician, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shiyudu1975@163.com
Received: August 31, 2022 Peer-review started: August 31, 2022 First decision: October 12, 2022 Revised: October 30, 2022 Accepted: November 18, 2022 Article in press: November 28, 2022 Published online: December 16, 2022 Processing time: 99 Days and 19.4 Hours
Core Tip
Core Tip: Whipple’s disease is a rare disease diagnosed by invasive manipulation. We reported on the case of a 58-year-old male patient who complained of fatigue and decreased exercise capacity. Results of gastroscopy and capsule endoscopy showed multiple polypoid bulges distributed in the duodenal and proximal jejunum. A diagnosis of small intestinal adenomatosis was initially considered; hence, the Whipple procedure, a pylorus-preserving pancreaticoduodenectomy, was performed. Many polyglandular autoimmune syndromes-positive macrophages aggregated in the intestinal mucosa of the duodenum, upper jejunum, and surrounding lymph nodes. Based on comprehensive analysis of symptoms, laboratory findings, and pathological manifestations, the patient was finally diagnosed with Whipple’s disease.
