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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 16, 2022; 10(29): 10451-10466
Published online Oct 16, 2022. doi: 10.12998/wjcc.v10.i29.10451
Published online Oct 16, 2022. doi: 10.12998/wjcc.v10.i29.10451
Clinicopathological characteristics and prognosis of gastric signet ring cell carcinoma
Hua-Kai Tian, Department of General Surgery, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Zuo Zhang, Department of Obstetrics and Gynecology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Zhi-Kun Ning, Department of Day Ward, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Jiang Liu, Zi-Tao Liu, Hao-Yu Huang, Zhen Zong, Department of Gastrointestinal Surgery, Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Hui Li, Department of Rheumatology and Immunology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Author contributions: Tian HK, Zhang Z, and Ning ZK contributed equally to this work; Tian HK and Li H conceived and designed this study; Zhang Z and Ning ZK collected and assembled the data; Zhang Z and Liu J analysed and interpreted the data; Tian HK and Liu J drafted the manuscript; Zong Z, Liu ZT, and Huang HY prepared the figures and tables; all authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China , No. 81860433 ; Natural Science Youth Foundation of Jiangxi Province , No. 20192BAB215036 ; Jiangxi Province Natural Science Key R&D Project-General Project , No. 20202BBG73024 ; Training Plan for Academic and Technical Young Leaders of Major Disciplines in Jiangxi Province , No. 20204BCJ23021 ; and Jiangxi Provincial Education Department , Science and Technology Research Project-Youth Project, No. GJJ210252.
Institutional review board statement: The Ethics Committee of the Second Affiliated Hospital of Nanchang University approved the study [No. Review[2018]No.(100)].
Informed consent statement: Since this is a retrospective clinical study, no informed consent form was signed.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hui Li, MD, Doctor, Department of Rheumatology and Immunology, First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, China. lihui0791nc@126.com
Received: May 22, 2022
Peer-review started: May 22, 2022
First decision: July 14, 2022
Revised: July 21, 2022
Accepted: September 1, 2022
Article in press: September 1, 2022
Published online: October 16, 2022
Peer-review started: May 22, 2022
First decision: July 14, 2022
Revised: July 21, 2022
Accepted: September 1, 2022
Article in press: September 1, 2022
Published online: October 16, 2022
Core Tip
Core Tip: This observational study analysed the clinicopathological features and prognosis of gastric signet ring cell carcinoma (GSRC). We compared GSRC with differentiated gastric adenocarcinoma and found that GSRC had unique clinicopathological features, was more common in younger female patients, and was more aggressive, showing higher lymph node metastasis and tumour size. However, the prognosis of early GSRC was relatively good, even better than that of differentiated adenocarcinoma. GSRC should be diagnosed early, and radical surgical resection with adjuvant radiotherapy and chemotherapy can significantly improve the survival rate of patients, though it still needs more clinical data to verify.