Published online Oct 16, 2022. doi: 10.12998/wjcc.v10.i29.10451
Peer-review started: May 22, 2022
First decision: July 14, 2022
Revised: July 21, 2022
Accepted: September 1, 2022
Article in press: September 1, 2022
Published online: October 16, 2022
The clinicopathological features and prognosis of gastric signet ring cell carcinoma (GSRC) remain controversial, particularly with regard to sensitivity to postoperative adjuvant therapy.
To our knowledge, this study is the first to analyse and compare the clinicopathological features and prognosis of GSRC with gastric adenocarcinoma of different degrees of differentiation and includes both Eastern and Western populations.
The aim of this study was to compare the pathological features of GSRC with those of gastric adenocarcinoma of different degrees of differentiation and the differences in survival prognosis between the different disease processes.
This study was first conducted by analysing the differences in clinicopathological features between GSRC and gastric adenocarcinoma in Western populations and comparing the survival prognosis of the different processes. Finally, validation was performed using an Eastern population.
GSRC was more commonly seen in younger female patients and was more aggressive in the progressive stage, showing more common lymph node metastasis and larger tumour size. However, the prognosis of early GSRC was relatively good, even better than that of differentiated adenocarcinoma. The prognosis of advanced GSRC was not significantly different from that of undifferentiated gastric adenocarcinoma and was worse than that of differentiated gastric adenocarcinoma. Postoperative adjuvant radiotherapy can improve the survival rate of GPC.
The prognosis of GSRC is better than that of undifferentiated type, especially in EGC, and its prognosis is even better than that of differentiated type. GSRC patients can benefit from early detection, surgical resection, and aggressive adjuvant therapy.
GSRC has unique clinicopathological features and prognosis, and early diagnosis and treatment can significantly improve survival rates. Patients may benefit from postoperative adjuvant radiotherapy, but further validation is needed.