Clinical and Translational Research
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2022; 10(24): 8490-8505
Published online Aug 26, 2022. doi: 10.12998/wjcc.v10.i24.8490
Pyroptosis-related genes play a significant role in the prognosis of gastric cancer
Shi-Hao Guan, Xin-Yu Wang, Ping Shang, Qian-Cheng Du, Ming-Zhi Li, Xiao Xing, Bin Yan
Shi-Hao Guan, Ping Shang, Ming-Zhi Li, Xiao Xing, Bin Yan, Department of General Surgery, The Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, China
Xin-Yu Wang, Department of General Surgery, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai 200434, China
Qian-Cheng Du, Department of General Surgery, Zhongshan-xuhui Hospital, Fudan University, Shanghai 200030, China
Author contributions: Guan SH is the author of the main idea, conceived and designed the study, collected and analyzed the data, and wrote and revised the manuscript; Yan B conceived and designed the study, collected and analyzed the data and wrote the manuscript; Shang P and Du QC participated in drafting and revising the manuscript, and collected the data; Li MZ and Xing X revised the manuscript, and participated in the acquisition, analysis and interpretation of data; Yan B and Wang XY revised the manuscript and coordinated the research team; and All authors approved the final version of the manuscript.
Institutional review board statement: The data in the manuscript are all from public databases and do not involve the ethics of human and animal specimens.
Informed consent statement: The data in the manuscript are all from public databases.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: The datasets used during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Yan, PhD, Chief Doctor, Professor, Department of General Surgery, The Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, No. 1158 Gongyuan East Road, Shanghai 201700, China. yanbin202203@163.com
Received: March 21, 2022
Peer-review started: March 21, 2022
First decision: May 1, 2022
Revised: May 14, 2022
Accepted: July 16, 2022
Article in press: July 16, 2022
Published online: August 26, 2022
Processing time: 147 Days and 14.1 Hours
Core Tip

Core Tip: This study aims to evaluate the expression of pyroptosis-related genes in gastric cancer (GC) and its correlation with prognosis. Based on 63 pyroptosis differentially expressed genes, 5 gene signature were constructed and all GC patients were classified into two risk groups. Kaplan-Meier survival curve showed that the overall survival (OS) of patients in the high-risk group was significantly lower than that of the low-risk group. Multivariate Cox regression analyses showed that the risk score was an independent risk factor for OS. The immune function and immune cell scores of the high-risk group were generally higher than those of the low-risk group. Similar results were obtained in external validation.