Guan SH, Wang XY, Shang P, Du QC, Li MZ, Xing X, Yan B. Pyroptosis-related genes play a significant role in the prognosis of gastric cancer. World J Clin Cases 2022; 10(24): 8490-8505 [PMID: 36157810 DOI: 10.12998/wjcc.v10.i24.8490]
Corresponding Author of This Article
Bin Yan, PhD, Chief Doctor, Professor, Department of General Surgery, The Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, No. 1158 Gongyuan East Road, Shanghai 201700, China. yanbin202203@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Clinical and Translational Research
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 26, 2022; 10(24): 8490-8505 Published online Aug 26, 2022. doi: 10.12998/wjcc.v10.i24.8490
Pyroptosis-related genes play a significant role in the prognosis of gastric cancer
Shi-Hao Guan, Xin-Yu Wang, Ping Shang, Qian-Cheng Du, Ming-Zhi Li, Xiao Xing, Bin Yan
Shi-Hao Guan, Ping Shang, Ming-Zhi Li, Xiao Xing, Bin Yan, Department of General Surgery, The Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, China
Xin-Yu Wang, Department of General Surgery, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai 200434, China
Qian-Cheng Du, Department of General Surgery, Zhongshan-xuhui Hospital, Fudan University, Shanghai 200030, China
Author contributions: Guan SH is the author of the main idea, conceived and designed the study, collected and analyzed the data, and wrote and revised the manuscript; Yan B conceived and designed the study, collected and analyzed the data and wrote the manuscript; Shang P and Du QC participated in drafting and revising the manuscript, and collected the data; Li MZ and Xing X revised the manuscript, and participated in the acquisition, analysis and interpretation of data; Yan B and Wang XY revised the manuscript and coordinated the research team; and All authors approved the final version of the manuscript.
Institutional review board statement: The data in the manuscript are all from public databases and do not involve the ethics of human and animal specimens.
Informed consent statement: The data in the manuscript are all from public databases.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: The datasets used during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Yan, PhD, Chief Doctor, Professor, Department of General Surgery, The Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, No. 1158 Gongyuan East Road, Shanghai 201700, China. yanbin202203@163.com
Received: March 21, 2022 Peer-review started: March 21, 2022 First decision: May 1, 2022 Revised: May 14, 2022 Accepted: July 16, 2022 Article in press: July 16, 2022 Published online: August 26, 2022
ARTICLE HIGHLIGHTS
Research background
The expression of pyroptosis genes in gastric cancer (GC) has not been well analyzed for its correlation with the prognosis of GC and the immune infiltration of tumors.
Research motivation
This study provides some insights for a deeper understanding of GC pathogenesis.
Research objectives
To explore the correlation between pyroptosis genes and prognosis of GC.
Research methods
The authors constructed prognostic multigene markers of differentially expressed genes associated with pyroptosis by least absolute contraction and selection operator Cox regression. The risk model was analyzed by Kaplan-Meier curve, two-sided log-rank test and functional enrichment analysis.
Research results
Based on 63 pyroptosis differentially expressed genes, 5 gene signature were constructed and all GC patients were classified into two risk groups. Multivariate Cox regression analyses showed that the risk score was an independent risk factor for overall survival (OS). The immune function and immune cell scores of the high-risk group were generally higher than those of the low-risk group. Similar results were obtained in external validation.
Research conclusions
This novel model, which contains 5 pyroptosis-related genes, is an independent predicting factor for OS in GC patients. Pyroptosis-related genes play a significant role in tumor immune microenvironment.
Research perspectives
The underlying mechanism between pyroptosis-related genes in GC and tumor immunity is still poorly understood, and further research is needed.
