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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2022; 10(17): 5551-5565
Published online Jun 16, 2022. doi: 10.12998/wjcc.v10.i17.5551
Published online Jun 16, 2022. doi: 10.12998/wjcc.v10.i17.5551
Gut peptide changes in patients with obstructive jaundice undergoing biliary drainage: A prospective case control study
Tajana Pavić, Stipe Pelajić, Nina Blažević, Dominik Kralj, Ivan Lerotic, Davor Hrabar, Department of Gastroenterology and Hepatology, University Hospital Center Sestre Milosrdnice, Zagreb 10000, Croatia
Milan Milošević, Andrija Stampar School of Public Health WHO Collaborative Centre for Occupational Health, University of Zagreb, School of Medicine, Zagreb 10000, Croatia
Ivana Mikolasevic, Department of Gastroenterology, University Hospital Center Rijeka, Rijeka 51000, Croatia
Author contributions: Pavić T contributed to study design and conception and collected the data; Pelajić S, Blažević N, Kralj D, and Mikolasevic I wrote the draft of the manuscript and contributed to data interpretation; Milošević M performed statistical analysis; Lerotic I collected the data; Hrabar D served as scientific advisor and guided the study.
Institutional review board statement: The study was reviewed and approved by the University Hospital Center Sestre Milosrdnice Ethics Committee, No. EP-15584/10.
Conflict-of-interest statement: The authors declare that there is no conflict of interest to disclose.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at tajana.pavic@gmail.com .
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tajana Pavić, MD, PhD, Assistant Professor, Department of Gastroenterology and Hepatology, University Hospital Center Sestre Milosrdnice, Vinogradska cesta 29, Zagreb 10000, Croatia. tajana.pavic@gmail.com
Received: December 10, 2021
Peer-review started: December 10, 2021
First decision: January 8, 2022
Revised: January 20, 2022
Accepted: April 9, 2022
Article in press: April 9, 2022
Published online: June 16, 2022
Processing time: 180 Days and 9.8 Hours
Peer-review started: December 10, 2021
First decision: January 8, 2022
Revised: January 20, 2022
Accepted: April 9, 2022
Article in press: April 9, 2022
Published online: June 16, 2022
Processing time: 180 Days and 9.8 Hours
Core Tip
Core Tip: Biliary obstruction is a common condition with subsequent malnutrition that contributes to patient’s high morbidity and mortality. Therefore, it is important to better understand the interaction of hormonal and inflammatory parameters on nutritional status. We conducted a case control study to determine the influence of obstructive jaundice on the hormones controlling appetite and nutritional status and showed that patients with obstructive jaundice had worse nutritional status compared to controls, regardless of disease etiology. Plasma ghrelin and cholecystokinin levels were significantly higher in patients with obstructive jaundice, which may be associated with the development of malnutrition during the inflammatory response.