Case Control Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 16, 2022; 10(14): 4380-4394
Published online May 16, 2022. doi: 10.12998/wjcc.v10.i14.4380
Significance of preoperative peripheral blood neutrophil-lymphocyte ratio in predicting postoperative survival in patients with multiple myeloma bone disease
Zi-Yu Xu, Xing-Chen Yao, Xiang-Jun Shi, Xin-Ru Du
Zi-Yu Xu, Xing-Chen Yao, Xin-Ru Du, Department of Orthopedics, Beijing Chao-Yang Hospital, Beijing 100020, China
Xiang-Jun Shi, Department of Hematology, Beijing Chao-Yang Hospital, Beijing 100020, China
Author contributions: Xu ZY drafted and revised the manuscript, and contributed to the data collection and drafting of the manuscript; Yao XC and Shi XJ contributed to the data analysis and interpretation; Du XR and Xu ZY contributed to the conception of the article and manuscript revision; all authors read and approved the final manuscript.
Supported by the Municipal Natural Science Foundation of Beijing of China, No. 7192071.
Institutional review board statement: The study was reviewed and approved by Beijing Chao-Yang Hospital Human Research Ethics Committee.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin-Ru Du, PhD, Professor, Department of Orthopedics, Beijing Chao-Yang Hospital, No. 8 Gongren Tiyuguannan Road, Chaoyang District, Beijing 100020, China. duxinru@163.com
Received: August 29, 2021
Peer-review started: August 29, 2021
First decision: December 17, 2021
Revised: December 30, 2021
Accepted: March 25, 2022
Article in press: March 25, 2022
Published online: May 16, 2022
Processing time: 256 Days and 21.2 Hours
Core Tip

Core Tip: The clinical data of 82 multiple myeloma bone disease (MMBD) patients who underwent operations in our hospital were collected. By observing the change characteristics of neutrophil-lymphocyte ratio (NLR) at different stages after the operation, to make a preliminary analysis of the effect of the operation on the immune status of multiple myeloma patients and study the prognostic value of peripheral blood NLR in predicting the treatment of MMBD. Data showed that NLR was significant for the prediction of the postoperative survival (POS) of MMBD patients treated with the operation, and MMBD patients with high preoperative NLR (NLR ≥ 3) had a poorer prognosis and shorter POS.