Published online May 16, 2022. doi: 10.12998/wjcc.v10.i14.4380
Peer-review started: August 29, 2021
First decision: December 17, 2021
Revised: December 30, 2021
Accepted: March 25, 2022
Article in press: March 25, 2022
Published online: May 16, 2022
This study investigated the preoperative peripheral blood neutrophil-lymphocyte ratio (NLR) in predicting postoperative survival (POS) in patients with multiple myeloma bone disease (MMBD).
As a marker of systematic inflammation, NLR has been used to diagnose infectious diseases. Although some retrospective studies have initially explored the influence of NLR on the prognosis of multiple myeloma (MM) in recent years, these studies didn't report on whether there is any change in the immune status of MM patients before and after the operation.
To analyze the effect of preoperative peripheral blood NLR on the prognosis of MMBD patients and evaluate the immune status of MMBD patients in different time periods.
The clinical data of 82 MMBD patients who underwent surgical treatments in Beijing Chaoyang hospital were collected.
Data showed that the NLR cut-off values of the NLR ≥ 3 group and NLR ≥ 4 group were significantly correlated with POS. The POS of NLR ≥ 3 patients (14.86 ± 14.28) was significantly shorter than that of NLR < 3 patients (32.68 ± 21.76). The lymphocyte percentage 1 wk after operation (19.329 ± 9.083) was significantly lower than that before operation (25.723 ± 11.016). Survival analysis showed that postoperative chemotherapy and preoperative peripheral blood NLR were independent risk factors for POS.
MMBD patients with high preoperative NLR had a poorer prognosis and shorter POS. NLR can predict the prognosis of MM patients undergoing surgical treatments.
Preoperative peripheral blood NLR can predict POS in MMBD patients. The immune status of MMBD patients was at a normal low level and then it significantly declined after surgical treatments.