Xu ZY, Yao XC, Shi XJ, Du XR. Significance of preoperative peripheral blood neutrophil-lymphocyte ratio in predicting postoperative survival in patients with multiple myeloma bone disease. World J Clin Cases 2022; 10(14): 4380-4394 [PMID: 35663088 DOI: 10.12998/wjcc.v10.i14.4380]
Corresponding Author of This Article
Xin-Ru Du, PhD, Professor, Department of Orthopedics, Beijing Chao-Yang Hospital, No. 8 Gongren Tiyuguannan Road, Chaoyang District, Beijing 100020, China. duxinru@163.com
Research Domain of This Article
Orthopedics
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. May 16, 2022; 10(14): 4380-4394 Published online May 16, 2022. doi: 10.12998/wjcc.v10.i14.4380
Significance of preoperative peripheral blood neutrophil-lymphocyte ratio in predicting postoperative survival in patients with multiple myeloma bone disease
Zi-Yu Xu, Xing-Chen Yao, Xiang-Jun Shi, Xin-Ru Du
Zi-Yu Xu, Xing-Chen Yao, Xin-Ru Du, Department of Orthopedics, Beijing Chao-Yang Hospital, Beijing 100020, China
Xiang-Jun Shi, Department of Hematology, Beijing Chao-Yang Hospital, Beijing 100020, China
Author contributions: Xu ZY drafted and revised the manuscript, and contributed to the data collection and drafting of the manuscript; Yao XC and Shi XJ contributed to the data analysis and interpretation; Du XR and Xu ZY contributed to the conception of the article and manuscript revision; all authors read and approved the final manuscript.
Supported bythe Municipal Natural Science Foundation of Beijing of China, No. 7192071.
Institutional review board statement: The study was reviewed and approved by Beijing Chao-Yang Hospital Human Research Ethics Committee.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin-Ru Du, PhD, Professor, Department of Orthopedics, Beijing Chao-Yang Hospital, No. 8 Gongren Tiyuguannan Road, Chaoyang District, Beijing 100020, China. duxinru@163.com
Received: August 29, 2021 Peer-review started: August 29, 2021 First decision: December 17, 2021 Revised: December 30, 2021 Accepted: March 25, 2022 Article in press: March 25, 2022 Published online: May 16, 2022 Processing time: 256 Days and 21.2 Hours
ARTICLE HIGHLIGHTS
Research background
This study investigated the preoperative peripheral blood neutrophil-lymphocyte ratio (NLR) in predicting postoperative survival (POS) in patients with multiple myeloma bone disease (MMBD).
Research motivation
As a marker of systematic inflammation, NLR has been used to diagnose infectious diseases. Although some retrospective studies have initially explored the influence of NLR on the prognosis of multiple myeloma (MM) in recent years, these studies didn't report on whether there is any change in the immune status of MM patients before and after the operation.
Research objectives
To analyze the effect of preoperative peripheral blood NLR on the prognosis of MMBD patients and evaluate the immune status of MMBD patients in different time periods.
Research methods
The clinical data of 82 MMBD patients who underwent surgical treatments in Beijing Chaoyang hospital were collected.
Research results
Data showed that the NLR cut-off values of the NLR ≥ 3 group and NLR ≥ 4 group were significantly correlated with POS. The POS of NLR ≥ 3 patients (14.86 ± 14.28) was significantly shorter than that of NLR < 3 patients (32.68 ± 21.76). The lymphocyte percentage 1 wk after operation (19.329 ± 9.083) was significantly lower than that before operation (25.723 ± 11.016). Survival analysis showed that postoperative chemotherapy and preoperative peripheral blood NLR were independent risk factors for POS.
Research conclusions
MMBD patients with high preoperative NLR had a poorer prognosis and shorter POS. NLR can predict the prognosis of MM patients undergoing surgical treatments.
Research perspectives
Preoperative peripheral blood NLR can predict POS in MMBD patients. The immune status of MMBD patients was at a normal low level and then it significantly declined after surgical treatments.
