Huang SS, Lv WW, Liu YF, Yang SZ. Analgesic effect of parecoxib combined with ropivacaine in patients undergoing laparoscopic hepatectomy. World J Clin Cases 2019; 7(18): 2704-2711 [PMID: 31616686 DOI: 10.12998/wjcc.v7.i18.2704]
Corresponding Author of This Article
Shao-Zhong Yang, MD, MSc, Attending Doctor, Department of Anesthesiology, Qilu Hospital of Shandong University, Cultural West Road, Lixia District, Jinan 250012, Shandong Province, China. yszyang@163.com
Research Domain of This Article
Anesthesiology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 26, 2019; 7(18): 2704-2711 Published online Sep 26, 2019. doi: 10.12998/wjcc.v7.i18.2704
Analgesic effect of parecoxib combined with ropivacaine in patients undergoing laparoscopic hepatectomy
Shan-Shan Huang, Wei-Wei Lv, Yan-Feng Liu, Shao-Zhong Yang
Shan-Shan Huang, Shao-Zhong Yang, Department of Anesthesiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Wei-Wei Lv, Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Yan-Feng Liu, Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Author contributions: Huang SS and Lv WW contributed equally to this work and should be considered as co-first authors; Yang SZ and Liu YF designed and performed the research; Yang SZ and Lv WW analyzed the data and wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Qilu Hospital of Shandong University.
Informed consent statement: All the patients provided informed consent.
Conflict-of-interest statement: No conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shao-Zhong Yang, MD, MSc, Attending Doctor, Department of Anesthesiology, Qilu Hospital of Shandong University, Cultural West Road, Lixia District, Jinan 250012, Shandong Province, China. yszyang@163.com
Telephone: +86-531-82166458 Fax: +86-531-82166471
Received: June 15, 2019 Peer-review started: June 18, 2019 First decision: July 30, 2019 Revised: August 19, 2019 Accepted: August 26, 2019 Article in press: August 26, 2019 Published online: September 26, 2019
ARTICLE HIGHLIGHTS
Research background
The analgesic effect of the preoperative intravenous injection of parecoxib combined with long-acting local anesthetic ropivacaine for incision infiltration in patients undergoing laparoscopic hepatectomy is still unknown.
Research motivation
Analgesic effect of parecoxib combined with ropivacaine in patients undergoing laparoscopic hepatectomy may be promising.
Research objectives
To study the analgesic effect of the preoperative intravenous injection of parecoxib combined with long-acting local anesthetic ropivacaine for incision infiltration in laparoscopic hepatectomy patients.
Research methods
Laparoscopic hepatectomy patients were randomly divided into a combined group (parecoxib combined with ropivacaine) and a control group. The visual analogue scale (VAS) at rest and during movement was used to compare the analgesic effect of the two groups. The cumulative sufentanil, the recovery time for enterokinesia, the length of postoperative hospital stay, and the adverse reactions were recorded and compared between the two groups.
Research results
The VAS scores of the combined group were significantly lower than those of the control group. The recovery time for enterokinesia in the combined group was significantly shorter than that in the control group. The cumulative sufentanil in the combined group decreased significantly at 24, 36, and 48 h after operation.
Research conclusions
Preoperative intravenous injection of parecoxib combined with the long-acting local anesthetic ropivacaine for incision infiltration is a simple and effective method for postoperative analgesia in laparoscopic hepatectomy patients. And it could relieve postoperative pain and promote postoperative recovery.
Research perspectives
Injection of parecoxib combined with the long-acting local anesthetic ropivacaine for incision infiltration is useful for hepatectomy recovery.
