Retrospective Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 26, 2019; 7(18): 2704-2711
Published online Sep 26, 2019. doi: 10.12998/wjcc.v7.i18.2704
Analgesic effect of parecoxib combined with ropivacaine in patients undergoing laparoscopic hepatectomy
Shan-Shan Huang, Wei-Wei Lv, Yan-Feng Liu, Shao-Zhong Yang
Shan-Shan Huang, Shao-Zhong Yang, Department of Anesthesiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Wei-Wei Lv, Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Yan-Feng Liu, Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Author contributions: Huang SS and Lv WW contributed equally to this work and should be considered as co-first authors; Yang SZ and Liu YF designed and performed the research; Yang SZ and Lv WW analyzed the data and wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Qilu Hospital of Shandong University.
Informed consent statement: All the patients provided informed consent.
Conflict-of-interest statement: No conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shao-Zhong Yang, MD, MSc, Attending Doctor, Department of Anesthesiology, Qilu Hospital of Shandong University, Cultural West Road, Lixia District, Jinan 250012, Shandong Province, China. yszyang@163.com
Telephone: +86-531-82166458 Fax: +86-531-82166471
Received: June 15, 2019
Peer-review started: June 18, 2019
First decision: July 30, 2019
Revised: August 19, 2019
Accepted: August 26, 2019
Article in press: August 26, 2019
Published online: September 26, 2019
Processing time: 102 Days and 19.2 Hours
Abstract
BACKGROUND

Currently, there is no uniform standard for analgesia during laparoscopic hepatectomy. Most of the analgesia schemes adopt epidural analgesia after laparotomy. Although the analgesia is effective, it has a great impact on the recovery of patients after laparoscopic hepatectomy and is not completely suitable for analgesia after laparoscopic hepatectomy. Although multimodal perioperative analgesia can significantly relieve postoperative pain, there is no relevant study of parecoxib combined with ropivacaine for post-laparoscopic hepatectomy analgesia.

AIM

To study the analgesic effect of the preoperative intravenous injection of parecoxib combined with long-acting local anesthetic ropivacaine for incision infiltration in patients undergoing laparoscopic hepatectomy.

METHODS

Forty-eight patients undergoing laparoscopic hepatectomy were randomly divided into a combined group (parecoxib combined with ropivacaine) and a control group. The visual analogue scale (VAS) at rest and during movement was used to compare the analgesic effect of the two groups. Meanwhile, the cumulative sufentanil, the recovery time for enterokinesia, the length of postoperative hospital stay, and the adverse reactions (nausea and vomiting) were recorded and compared between the two groups.

RESULTS

The change tendency in VAS scores for both groups was similar after operation. At rest, the VAS scores of the combined group were significantly lower than those of the control group at 0, 6, 12, 24 and 36 h, and during movement, the VAS scores of the combined group were significantly lower than those of the control group at 0, 6, 12, and 24 h. The recovery time for enterokinesia in the combined group was 2.9 d, which was significantly shorter than that in the control group. The cumulative sufentanil in the combined group decreased significantly at 24, 36, and 48 h after operation.

CONCLUSION

Preoperative intravenous injection of parecoxib combined with ropivacaine for incision infiltration is a simple and effective method for postoperative analgesia in laparoscopic hepatectomy, which could relieve pain and promote recovery.

Keywords: Analgesic effect; Parecoxib; Ropivacaine; Laparoscopic hepatectomy

Core tip: Forty-eight patients undergoing laparoscopic hepatectomy were randomly divided into a combined group (parecoxib combined with ropivacaine) and a control group. A visual analogue scale at rest and during movement was used to compare the analgesic effect of the two groups. Preoperative intravenous injection of parecoxib combined with the long-acting local anesthetic ropivacaine for incision infiltration is a simple and effective method for postoperative analgesia in patients undergoing laparoscopic hepatectomy, which could relieve postoperative pain and promote postoperative recovery.