Zhang CY, Wang B, Hua XT, Fan K, Li YF. Serum vascular endothelial growth factor and cortisol expression to predict prognosis of patients with hypertensive cerebral hemorrhage. World J Clin Cases 2023; 11(23): 5455-5461 [PMID: 37637696 DOI: 10.12998/wjcc.v11.i23.5455]
Corresponding Author of This Article
Bin Wang, Doctor, Chief Doctor, Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Shushan District, Hefei 230000, Anhui Province, China. hulier888@163.com
Research Domain of This Article
Neurosciences
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 16, 2023; 11(23): 5455-5461 Published online Aug 16, 2023. doi: 10.12998/wjcc.v11.i23.5455
Serum vascular endothelial growth factor and cortisol expression to predict prognosis of patients with hypertensive cerebral hemorrhage
Chao-Yong Zhang, Bin Wang, Xiang-Ting Hua, Kui Fan, Yu-Feng Li
Chao-Yong Zhang, Xiang-Ting Hua, Kui Fan, Yu-Feng Li, Department of Neurosurgery, Taihe Hospital Affiliated to Wannan Medical College, Taihe County People’s Hospital, Fuyang 236600, Anhui Province, China
Bin Wang, Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230000, Anhui Province, China
Author contributions: Zhang CY and Wang B contributed equally to this work; Zhang CY, Wang B, Hua XT, Fan K, and Li YF, designed the research study; Zhang CY, Wang B, Hua XT, and Fan K performed the research; Zhang CY, Wang B, and Li YF analyzed the data and wrote the manuscript; All authors have read and approve the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Taihe Hospital Affiliated to Wannan Medical College Institutional Review Board.
Informed consent statement: This study has signed an informed consent form with the patient.
Conflict-of-interest statement: All authors have no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Wang, Doctor, Chief Doctor, Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Shushan District, Hefei 230000, Anhui Province, China. hulier888@163.com
Received: June 6, 2023 Peer-review started: June 6, 2023 First decision: June 21, 2023 Revised: June 26, 2023 Accepted: July 14, 2023 Article in press: July 14, 2023 Published online: August 16, 2023 Processing time: 70 Days and 20.1 Hours
ARTICLE HIGHLIGHTS
Research background
Cerebral hemorrhage is a common and serious complication of hypertension affecting middle-aged and elderly men. General anesthesia can easily induce complications such as cognitive dysfunction in such patients, which is not conducive to postoperative recovery.
Research motivation
To investigate the correlation between vascular endothelial growth factor (VEGF) and cortisol (Cor) and the prognosis of patients with hypertensive cerebral hemorrhage.
Research objectives
To provide a reference for the prognosis and anesthesia of clinically related operations.
Research methods
Randomized controlled method and double-blinded method.
Research results
Cor and VGEF levels were statistically and significantly higher in patients with poor prognosis than in those with good prognosis (P < 0.05). Multifactor logistic regression analysis revealed that serum Cor and VGEF levels were independent factors influencing hypertensive cerebral hemorrhage.
Research conclusions
Cor and VGEF are associated with the occurrence and development of hypertensive cerebral hemorrhage and are significantly associated with neurological impairment and prognosis of patients.
Research perspectives
Future studies could focus on exploring the potential mechanisms underlying the correlation between serum Cor and VEGF levels and hypertensive intracerebral hemorrhage. Additionally, more clinical studies are needed to validate the potential of serum Cor and VEGF as biomarkers for predicting patient prognosis and guiding clinical treatment decisions. Finally, further research could aim to investigate potential therapeutic strategies targeting Cor and VEGF to improve patient outcomes.
