Published online Aug 16, 2023. doi: 10.12998/wjcc.v11.i23.5455
Peer-review started: June 6, 2023
First decision: June 21, 2023
Revised: June 26, 2023
Accepted: July 14, 2023
Article in press: July 14, 2023
Published online: August 16, 2023
Cerebral hemorrhage is a common and severe complication of hypertension in middle-aged and elderly men.
To investigate the correlation between vascular endothelial growth factor (VEGF) and cortisol (Cor) and the prognosis of patients with hypertensive cerebral hemorrhage.
A hundred patients with hypertensive intracerebral hemorrhage were enrolled from January 2020 to December 2022 and assigned to the hypertensive intra
A statistically significant difference in serum Cor and VGEF levels was observed among patients with varying degrees of neurological impairment (P < 0.05). Serum Cor and VGEF levels were significantly higher in the severe group than in the mild-to-moderate group. Cor and VEGF levels were significantly higher in patients with poor prognoses than in those with good prognoses. Multiple logistic regression analysis revealed that serum Cor and VGEF levels were independent factors affecting hypertensive intracerebral hemorrhage (P < 0.05).
Cor and VGEF are associated with the occurrence and development of hypertensive cerebral hemorrhage and are significantly associated with neurological impairment and prognosis of patients.
Core Tip: Investigation of the correlation between vascular endothelial growth factor (VEGF) and cortisol (Cor) levels and the prognosis of patients with hypertensive intracerebral hemorrhage indicated that Cor and VEGF are associated with the occurrence and development of cerebral hemorrhage, as well as neurological impairment and patient prognosis. Thus, Cor and VEGF may act as potential biomarkers for predicting the prognosis of patients with hypertensive intracerebral hemorrhage.