Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 16, 2023; 11(14): 3187-3194
Published online May 16, 2023. doi: 10.12998/wjcc.v11.i14.3187
Value of optical coherence tomography measurement of macular thickness and optic disc parameters for glaucoma screening in patients with high myopia
Hua Mu, Rui-Shu Li, Zhen Yin, Zhuo-Lei Feng
Hua Mu, Rui-Shu Li, Zhen Yin, Zhuo-Lei Feng, Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Author contributions: Mu H designed the research study; Li RS performed the research; Mu H and Yin Z analyzed the data and wrote the manuscript; all authors have read and approve the final manuscript.
Institutional review board statement: The study was reviewed and approved by the [The First Affiliated Hospital of Harbin Medical University] Institutional Review Board.
Informed consent statement: The informed consent was obtained from every patient.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at Mh13836017782@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hua Mu, Doctor, Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang Province, China. mh13836017782@163.com
Received: February 24, 2023
Peer-review started: February 24, 2023
First decision: March 10, 2023
Revised: March 12, 2023
Accepted: April 12, 2023
Article in press: April 12, 2023
Published online: May 16, 2023
Processing time: 81 Days and 7.3 Hours
ARTICLE HIGHLIGHTS
Research background

Glaucoma is an irreversible, blinding eye disease with a high clinical incidence that is characterized by loss of visual acuity, optic disc atrophy, and visual field defects. The basic method of glaucoma diagnosis is visual field examination, however, in patients with high myopia, the diagnosis of glaucoma is difficult.

Research motivation

Optical coherence tomography (OCT) is a high-resolution technique that uses low-coherence light interference to reflect light from biological tissues, allowing visualization of internal structures of the living body via tomographic imaging. It is commonly used to measure parameters of the ocular retinal nerve fiber layer and ganglion cell layer.

Research objectives

This study was to explore the value of OCT for measuring optic disc parameters and macular thickness as a screening tool for glaucoma in patients with high myopia. The results could promote the improvement of the diagnosis of glaucoma in patients with high myopia and suspected glaucoma.

Research methods

Visual values in patients with high myopia in, patients with high myopia and glaucoma, and patients with high myopia suspicious for glaucoma were compared. Optic disc parameters, retinal nerve fiber layer thickness (RNFL), and ganglion cell layer (GCC) thickness were measured using OCT technology and used to compare the peri-optic disc vascular density of the patients and generate receiver operator characteristic test performance curves of the RNFL and GCC for high myopia and glaucoma.

Research results

The visual value levels of the three groups were significantly different. There were statistically significant differences in cup area, optic disc area, and cup/disc diameter ratio among all groups. RNFL thicknesses in all quadrants were statistically different among the three groups. The area under the ROC curve was greater than 0.7, indicating an acceptable diagnostic value.

Research conclusions

The value of OCT measurement of RNFL and GCC thickness in diagnosing glaucoma in patients with high myopia and suspected glaucoma is worthy of development for clinical use.

Research perspectives

Further studies with large sample and other relevant factors are required to improve the screening of high myopia with glaucoma.