Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 16, 2023; 11(14): 3187-3194
Published online May 16, 2023. doi: 10.12998/wjcc.v11.i14.3187
Value of optical coherence tomography measurement of macular thickness and optic disc parameters for glaucoma screening in patients with high myopia
Hua Mu, Rui-Shu Li, Zhen Yin, Zhuo-Lei Feng
Hua Mu, Rui-Shu Li, Zhen Yin, Zhuo-Lei Feng, Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Author contributions: Mu H designed the research study; Li RS performed the research; Mu H and Yin Z analyzed the data and wrote the manuscript; all authors have read and approve the final manuscript.
Institutional review board statement: The study was reviewed and approved by the [The First Affiliated Hospital of Harbin Medical University] Institutional Review Board.
Informed consent statement: The informed consent was obtained from every patient.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at Mh13836017782@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hua Mu, Doctor, Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang Province, China. mh13836017782@163.com
Received: February 24, 2023
Peer-review started: February 24, 2023
First decision: March 10, 2023
Revised: March 12, 2023
Accepted: April 12, 2023
Article in press: April 12, 2023
Published online: May 16, 2023
Processing time: 81 Days and 7.3 Hours
Abstract
BACKGROUND

The basic method of glaucoma diagnosis is visual field examination, however, in patients with high myopia, the diagnosis of glaucoma is difficult.

AIM

To explore the value of optical coherence tomography (OCT) for measuring optic disc parameters and macular thickness as a screening tool for glaucoma in patients with high myopia.

METHODS

Visual values (contrast sensitivity, color vision, and best-corrected visual acuity) in three groups, patients with high myopia in Group A, patients with high myopia and glaucoma in Group B, and patients with high myopia suspicious for glaucoma in Group C, were compared. Optic disc parameters, retinal nerve fiber layer (RNFL) thickness, and ganglion cell layer (GCC) thickness were measured using OCT technology and used to compare the peri-optic disc vascular density of the patients and generate receiver operator characteristic (ROC) test performance curves of the RNFL and GCC for high myopia and glaucoma.

RESULTS

Of a total of 98 patients admitted to our hospital from May 2018 to March 2022, totaling 196 eyes in the study, 30 patients with 60 eyes were included in Group A, 33 patients with 66 eyes were included in Group B, and 35 patients with 70 eyes were included in Group C. Data were processed for Groups A and B to analyze the efficacy of RNFL and GCC measures in distinguishing high myopia from high myopia with glaucoma. The area under the ROC curve was greater than 0.7, indicating an acceptable diagnostic value.

CONCLUSION

The value of OCT measurement of RNFL and GCC thickness in diagnosing glaucoma in patients with high myopia and suspected glaucoma is worthy of development for clinical use.

Keywords: High myopia suspected glaucoma, Optical coherence tomography, Retinal nerve fiber layer thickness, Ganglion cell layer thickness, Diagnostic efficacy

Core Tip: Glaucoma is an irreversible, blinding eye disease with a high clinical incidence that is characterized by loss of visual acuity, optic disc atrophy, and visual field defects. The basic method of glaucoma diagnosis is visual field examination, however, in patients with high myopia, the diagnosis of glaucoma is difficult. optical coherence tomography (OCT) is a high-resolution technique that uses low-coherence light interference to reflect light from biological tissues, allowing visualization of internal structures of the living body via tomographic imaging. The value of OCT measurement of retinal nerve fiber layer and ganglion cell layer thickness in diagnosing glaucoma in patients with high myopia and suspected glaucoma is worthy of development for clinical use.