Observational Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 6, 2023; 11(10): 2246-2253
Published online Apr 6, 2023. doi: 10.12998/wjcc.v11.i10.2246
Interaction between the left ventricular ejection fraction and left ventricular strain and its relationship with coronary stenosis
Hai-Yan Gui, Shu-Wen Liu, Dong-Fang Zhu
Hai-Yan Gui, MRI Room, Harbin No. 4 Hospital, Harbin 150026, Heilongjiang Province, China
Shu-Wen Liu, Dong-Fang Zhu, Department of Cardiology, Harbin No. 4 Hospital, Harbin 150026, Heilongjiang Province, China
Author contributions: Gui HY designed and performed the research and wrote the manuscript; Liu SW contributed to the analysis and revised the manuscript; Zhu DF supervised the research.
Institutional review board statement: This study was approved by the ethics committee of Harbin No. 4 Hospital.
Informed consent statement: Written informed consent was obtained from all study participants or their legal guardian prior to study enrollment.
Conflict-of-interest statement: The authors have no conflicts of interest to reported.
Data sharing statement: All datasets are available from the corresponding author.
STROBE statement: The authors have read the STROBE Statement - checklist of items, and the manuscript was prepared and revised according to the STROBE Statement - checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Wen Liu, MM, Associate Chief Physician, Department of Cardiology, Harbin No. 4 Hospital, No. 119 Jingyu Street, Daowai District, Harbin 150026, Heilongjiang Province, China. shuwenl007@yeah.net
Received: January 20, 2023
Peer-review started: January 20, 2023
First decision: February 10, 2023
Revised: February 28, 2023
Accepted: March 3, 2023
Article in press: March 3, 2023
Published online: April 6, 2023
Processing time: 69 Days and 7 Hours
ARTICLE HIGHLIGHTS
Research background

Coronary artery stenosis (CAS) is a common term for the buildup of plaque in the heart’s arteries that could lead to a heart attack. However, the relationship between various cardiac function indicators and CAS is rarely studied.

Research motivation

CAS is one of the major cardiovascular diseases affecting humans worldwide. This disease has been shown to be the leading cause of death in both developed and developing countries. Exploring the correlation between cardiac function indicators and CAS will benefit the patients.

Research objectives

The purpose of our study was to analyze the correlation between the left ventricular ejection fraction (LVEF), left ventricular strain (LVS), and coronary stenosis.

Research methods

The control group comprised 93 healthy individuals, while the observation group comprised 97 patients with coronary artery disease who were hospitalized between July 2020 and September 2021. Coronary artery disease was assessed using the Gensini score, and LVEF and LVS were measured using magnetic resonance imaging. The interaction between LVEF and LVS was investigated using a linear regression model, while the relationship between LVEF and CAS was examined using Spearman’s correlation.

Research results

The LVEF of the observation group was lower than that of the control group. The left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV) of the observation group were significantly higher than those of the control group. The longitudinal strain (LS) and circumferential strain (CS) of the observation group were significantly higher than those of the control group; however, the radial strain (RS) of the observation group was lower than that of the control group. LVS, LS, and CS were significantly negatively correlated with the LVEF, while RS was positively correlated with the LVEF. There were significant differences in the LVEF, LVESV, and LVEDV of patients with different Gensini scores. The LVEF significantly decreased and the LVESV and LVEDV increased with increasing Gensini scores. In the observation group, the LVEF was negatively correlated and the LVESV and LVEDV were positively correlated with coronary stenosis.

Research conclusions

The LVEF showed a significant linear correlation with LVS and negative correlation with coronary stenosis.

Research perspectives

This study did not follow patients over time and did not include patients from other institutions. Therefore, further exploration and research are necessary.