Observational Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 6, 2023; 11(10): 2246-2253
Published online Apr 6, 2023. doi: 10.12998/wjcc.v11.i10.2246
Interaction between the left ventricular ejection fraction and left ventricular strain and its relationship with coronary stenosis
Hai-Yan Gui, Shu-Wen Liu, Dong-Fang Zhu
Hai-Yan Gui, MRI Room, Harbin No. 4 Hospital, Harbin 150026, Heilongjiang Province, China
Shu-Wen Liu, Dong-Fang Zhu, Department of Cardiology, Harbin No. 4 Hospital, Harbin 150026, Heilongjiang Province, China
Author contributions: Gui HY designed and performed the research and wrote the manuscript; Liu SW contributed to the analysis and revised the manuscript; Zhu DF supervised the research.
Institutional review board statement: This study was approved by the ethics committee of Harbin No. 4 Hospital.
Informed consent statement: Written informed consent was obtained from all study participants or their legal guardian prior to study enrollment.
Conflict-of-interest statement: The authors have no conflicts of interest to reported.
Data sharing statement: All datasets are available from the corresponding author.
STROBE statement: The authors have read the STROBE Statement - checklist of items, and the manuscript was prepared and revised according to the STROBE Statement - checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Wen Liu, MM, Associate Chief Physician, Department of Cardiology, Harbin No. 4 Hospital, No. 119 Jingyu Street, Daowai District, Harbin 150026, Heilongjiang Province, China. shuwenl007@yeah.net
Received: January 20, 2023
Peer-review started: January 20, 2023
First decision: February 10, 2023
Revised: February 28, 2023
Accepted: March 3, 2023
Article in press: March 3, 2023
Published online: April 6, 2023
Processing time: 69 Days and 7 Hours
Abstract
BACKGROUND

Coronary artery stenosis (CAS) is the most common type of heart disease and the leading cause of death in both men and women globally. CAS occurs when the arteries that supply blood to the heart muscle harden and become narrower due to plaque buildup - cholesterol and other material - on their inner walls. As a result, the heart muscle cannot receive the blood or oxygen it needs. Most heart attacks happen when a blood clot suddenly cuts off the hearts' blood supply, causing permanent heart damage.

AIM

To analyze the relationship between the left ventricular ejection fraction (LVEF), left ventricular strain (LVS), and coronary stenosis.

METHODS

A total of 190 participants were enrolled in this trail. The control group comprised 93 healthy individuals, and observation group comprised 97 patients with coronary heart disease who were hospitalized between July 2020 and September 2021. Coronary lesions were assessed using the Gensini score, and the LVEF and LVS were measured using magnetic resonance imaging (MRI). The interaction between the LVEF and LVS was examined using a linear regression model. The relationship between LVEF and coronary stenosis was examined using Spearman’s correlation.

RESULTS

The LVEF of the observation group was lower than that of the control group. The left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV) of the observation group were significantly higher than those of the control group (P < 0.05). The longitudinal and circumferential strains (LS, CS) of the observation group were significantly higher than those of the control group; however, the radial strain (RS) of the observation group was significantly lower than that of the control group (P < 0.05). LVS, LS, and CS were significantly negatively correlated with the LVEF, and RS was positively correlated with the LVEF. There were significant differences in the LVEF, LVESV, and LVEDV of patients with different Gensini scores; the LVEF significantly decreased and the LVESV and LVEDV increased with increasing Gensini scores (P < 0.05). In the observation group, the LVEF was negatively correlated and the LVESV and LVEDV were positively correlated with coronary stenosis (P < 0.05).

CONCLUSION

The LVEF measured using MRI is significantly linearly correlated with LVS and negatively correlated with coronary stenosis.

Keywords: Magnetic resonance imaging; Left ventricular ejection fraction; Left ventricular strain; Coronary stenosis; Left ventricular end-diastolic volume; Left ventricular end-systolic volume

Core Tip: This study aimed to analyze the relationship between the left ventricular ejection fraction (LVEF), left ventricular strain (LVS), and coronary artery stenosis (CAS), 93 healthy individuals were selected as the control group, while 97 patients with coronary heart disease were selected as the observation group. Through the analysis of the Gensini score, magnetic resonance imaging, a linear regression model, and Spearman’s correlation, we found that LVEF is significantly linearly correlated with LVS and negatively correlated with CAS.