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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 16, 2022; 10(35): 12909-12919
Published online Dec 16, 2022. doi: 10.12998/wjcc.v10.i35.12909
Published online Dec 16, 2022. doi: 10.12998/wjcc.v10.i35.12909
Lipoprotein (a) variability is associated with mean follow-up C-reactive protein in patients with coronary artery disease following percutaneous coronary intervention
Si-Si Zhang, Wen-Yi Hu, Yi-Jing Li, Juan Yu, Shang Sang, Zakareya M Alsalman, Da-Qi Xie, Department of Cardiology, Ningbo Ninth Hospital, Ningbo 315300, Zhejiang Province, China
Author contributions: Zhang SS and Xie DQ designed the research; Zhang SS, Hu WY, Li YJ, and Yu J performed the research; Zhang SS and Sang S contributed new analytic tools; Zhang SS and Xie DQ analyzed the data; Zhang SS, Alsalman ZM, and Xie DQ wrote the paper.
Institutional review board statement: The study was reviewed and approved by the Sir Run Run Shaw Hospital Institutional Review Board (Approval No. 20220228-30).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors have no conflicts of interest to declare.
Data sharing statement: Data are not available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Da-Qi Xie, MD, PhD, Chief Physician, Department of Cardiology, Ningbo Ninth Hospital, No. 619 Xiejia Road, Ningbo 315300, Zhejiang Province, China.
Received: July 10, 2022
Peer-review started: July 10, 2022
First decision: August 4, 2022
Revised: September 12, 2022
Accepted: November 14, 2022
Article in press: November 14, 2022
Published online: December 16, 2022
Processing time: 156 Days and 17.3 Hours
Peer-review started: July 10, 2022
First decision: August 4, 2022
Revised: September 12, 2022
Accepted: November 14, 2022
Article in press: November 14, 2022
Published online: December 16, 2022
Processing time: 156 Days and 17.3 Hours
ARTICLE HIGHLIGHTS
Research background
Lipoprotein a [lp (a)] variability is gaining growing attention in cardiovascular disease.
Research motivation
The association between lp (a) variability and follow-up C-reactive protein (CRP) level in patients undergoing percutaneous coronary intervention (PCI) has not been investigated.
Research objectives
To explore the association between lp (a) variability and mean CRP levels within the 1st year post-PCI.
Research methods
This was a multicenter retrospective study.
Research results
Lp (a) variability was positively related to the mean follow-up CRP in patients undergoing PCI.
Research conclusions
High variability could be considered an independent risk factor for increased post-PCI CRP level.
Research perspectives
Prospective studies are further needed to verify the results of this paper.