Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 16, 2021; 9(8): 1989-1995
Published online Mar 16, 2021. doi: 10.12998/wjcc.v9.i8.1989
Laryngopharyngeal reflux disease management for recurrent laryngeal contact granuloma: A case report
Kai Li, Wen-Yong Chen, Yun-Ying Li, Tu-Lu Wang, Meng-Jia Tan, Zong Chen, Hai Chen
Kai Li, Wen-Yong Chen, Yun-Ying Li, Tu-Lu Wang, Meng-Jia Tan, Zong Chen, Hai Chen, Department of Otorhinolaryngology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China
Author contributions: Li K, Chen WY and Wang TL were the patient’s otolaryngologists, reviewed the literature and contributed to manuscript drafting; Li YY reviewed the literature and contributed to manuscript drafting; Tan MJ and Chen Z performed laryngoscopy for this patient; Chen H was responsible for revision of the manuscript for important intellectual content; All authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors have no funding, financial relationships, or conflicts of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai Chen, MM, Assistant Professor, Doctor, Department of Otorhinolaryngology, The Second Clinical College of Guangzhou University of Chinese Medicine, Dade Road, Yuexiu District, Guangzhou 510000, Guangdong Province, China. cnchenhai@gzucm.edu.cn
Received: November 16, 2020
Peer-review started: November 16, 2020
First decision: December 24, 2020
Revised: January 5, 2021
Accepted: January 8, 2021
Article in press: January 8, 2021
Published online: March 16, 2021
Processing time: 104 Days and 21 Hours
Abstract
BACKGROUND

Laryngeal contact granuloma (LCG) is difficult to treat and frequently associated with high persistence and recurrence, despite the availability of both surgical and pharmacological treatment options. An appropriate strategy is therefore needed to help patients with multiple recurrences of LCG to potentially avoid unnecess-ary surgery.

CASE SUMMARY

We describe the case of a 34-year-old male patient with recurrent LCG in which a good response was achieved through successful management of laryngophar-yngeal reflux disease using a combination pharmacotherapeutic regimen consisting of anti-reflux therapy, pepsin secretion inhibition, bile acid neutralization, and lifestyle modifications. This patient underwent surgery to excise the granuloma, then relapsed, underwent a second surgery, which was followed by a second recurrence. The granuloma then disappeared after 9 mo of combined treatment with ilaprazole enteric-coated capsules (10 mg qd), mosapride tablets (5 mg tid) and compound digestive enzyme capsules (2 tablets). The drug regimen was discontinued after one year, and no recurrence of the lesion has been reported during the one-year follow-up period.

CONCLUSION

We report a combination of pharmacotherapeutics and lifestyle modifications for the management of laryngopharyngeal reflux disease to address recurring LCG.

Keywords: Recurrent laryngeal contact granuloma; Laryngopharyngeal reflux disease management; Anti-reflux therapy; Pepsin secretion inhibition; Bile acid neutralization; Case report

Core Tip: Laryngeal contact granuloma (LCG) is difficult to treat and frequently associated with high persistence and recurrence. We describe a patient with recurrent LCG in which a good response was achieved through successful management of laryngopharyngeal reflux disease using a combination pharmacotherapeutic regimen consisting of anti-reflux therapy, pepsin secretion inhibition, bile acid neutralization, and lifestyle modifications. The drug regimen was discontinued after one year, and no recurrence was observed during the one-year follow-up period. This case report highlights the efficacy of combined pharmacotherapeutics and lifestyle modifications in managing laryngopharyngeal reflux disease to address recurring LCG.