Tian L, He LY, Zhang HZ. Nedaplatin-induced syndrome of inappropriate secretion of antidiuretic hormone: A case report and review of the literature. World J Clin Cases 2021; 9(23): 6810-6815 [PMID: 34447829 DOI: 10.12998/wjcc.v9.i23.6810]
Corresponding Author of This Article
Hong-Zhen Zhang, PhD, Doctor, Department of Oncology, Hebei General Hospital, No. 348 Heping West Road, Shijiazhuang 050051, China. 1256596529@qq.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 16, 2021; 9(23): 6810-6815 Published online Aug 16, 2021. doi: 10.12998/wjcc.v9.i23.6810
Nedaplatin-induced syndrome of inappropriate secretion of antidiuretic hormone: A case report and review of the literature
Lei Tian, Li-Ya He, Hong-Zhen Zhang
Lei Tian, Li-Ya He, Hong-Zhen Zhang, Department of Oncology, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China
Author contributions: Tian L reviewed the literature and wrote the manuscript; He LY was the patient’s doctor in charge; Zhang HZ contributed to the literature review; and all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Zhen Zhang, PhD, Doctor, Department of Oncology, Hebei General Hospital, No. 348 Heping West Road, Shijiazhuang 050051, China. 1256596529@qq.com
Received: February 1, 2021 Peer-review started: February 1, 2021 First decision: April 25, 2021 Revised: May 6, 2021 Accepted: May 19, 2021 Article in press: May 19, 2021 Published online: August 16, 2021 Processing time: 185 Days and 4.9 Hours
Abstract
BACKGROUND
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is relatively common in several cancers, such as small cell lung cancer. However, nedaplatin-induced SIADH is rare. We describe a case of SIADH mediated by nedaplatin.
CASE SUMMARY
A 54-year-old female with nasopharyngeal carcinoma was treated with nedaplatin and developed severe hyponatremia due to SIADH. The side effects were successfully treated by fluid restriction and sodium supplementation.
CONCLUSION
This case report highlights the importance of cautiously treating life-threatening hyponatremia in patients treated with nedaplatin.
Core Tip: Nedaplatin has been shown to be an effective drug in a variety of cancers. Due to its wide application, it is important to pay attention to its side effects, especially rare side effects. Here, we report a case of a severe, rare syndrome of inappropriate secretion of antidiuretic hormone after initiating nedaplatin chemotherapy. Timely diagnosis, fluid restriction and sodium supplementation may be the most appropriate treatments.
