Yang Y, Zeng YC, Rumende P, Wang CG, Chen Y. Diagnosis and treatment discussion of congenital factor VII deficiency in pregnancy: A case report. World J Clin Cases 2021; 9(21): 6091-6101 [PMID: 34368331 DOI: 10.12998/wjcc.v9.i21.6091]
Corresponding Author of This Article
Yue Chen, MD, Chief Doctor, Department of Obstetrics, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuang Yong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. 1254500940@qq.com
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ying Yang, Ya-Chang Zeng, Pingkan Rumende, Chen-Guang Wang, Yue Chen, Department of Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Zeng YC, Chen Y, and Wang CG were the patient’s obstetricians; Yang Y reviewed the literature and contributed to manuscript drafting; Zeng YC, Yang Y, Chen Y, and Rumende P were responsible for the revision of the manuscript for important intellectual content; all authors issued final approval for the version to be submitted.
Supported byNatural Science Foundation of Guangxi, No. 2018JJB140171; Medical Excellence Award Funded by the Creative Research Development Grant from the First Affiliated Hospital of Guangxi Medical University (2020); Development and Application of Appropriate Medical and Health Technologies in Guangxi, No. S2018111; and Self-funded Scientific Research Project of Guangxi Health Commission, No. Z20190512.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yue Chen, MD, Chief Doctor, Department of Obstetrics, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuang Yong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. 1254500940@qq.com
Received: March 22, 2021 Peer-review started: March 22, 2021 First decision: April 29, 2021 Revised: May 9, 2021 Accepted: May 26, 2021 Article in press: May 26, 2021 Published online: July 26, 2021 Processing time: 121 Days and 2.8 Hours
Abstract
BACKGROUND
Congenital factor VII deficiency (FVIID) is a rare autosomal recessive genetic disorder. The clinical manifestations of this deficiency vary greatly. Predicting the risk of bleeding during and after childbirth of pregnant women with congenital FVIID is difficult. Recombinant factor VIIa is the most common replacement therapy for FVIID. However, no unified diagnosis and treatment plan for pregnant women with congenital FVIID has been established.
CASE SUMMARY
We report the clinical history of a pregnant woman who was considered to have congenital FVIID. Recombinant factor VIIa was prophylactically administered to the pregnant woman at the time of cervical fully opening. She successfully delivered a live infant without any complications, such as postpartum hemorrhage, neonatal abnormalities, and so on.
CONCLUSION
Prophylaxis of recombinant factor VIIa during delivery can effectively reduce the incidence of postpartum hemorrhage among pregnant women with congenital FVIID associated with a high risk of bleeding.
Core Tip: The clinical manifestations of congenital factor VII deficiency vary greatly and range from a mild asymptomatic case to fatal bleeding. During pregnancy, predicting the risk of bleeding during and after childbirth of pregnant women with congenital factor VII deficiency is difficult, causing serious challenges to obstetricians and gynecologists. We hereby report a case of a pregnant woman with congenital factor VII deficiency and discuss the perinatal period and delivery management of this disease.
