Xia Y, Yu XF, Ma ZJ, Sun ZW. Hemorrhagic transformation of ischemic cerebral proliferative angiopathy: A case report. World J Clin Cases 2021; 9(20): 5730-5736 [PMID: 34307632 DOI: 10.12998/wjcc.v9.i20.5730]
Corresponding Author of This Article
Zhong-Wu Sun, MD, Doctor, Department of Neurology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. sunzhwu@126.com
Research Domain of This Article
Clinical Neurology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 16, 2021; 9(20): 5730-5736 Published online Jul 16, 2021. doi: 10.12998/wjcc.v9.i20.5730
Hemorrhagic transformation of ischemic cerebral proliferative angiopathy: A case report
Yu Xia, Xian-Feng Yu, Zhen-Juan Ma, Zhong-Wu Sun
Yu Xia, Xian-Feng Yu, Zhen-Juan Ma, Zhong-Wu Sun, Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Author contributions: Xia Y was the patient’s neurosurgeon, reviewed the literature and contributed to manuscript drafting; Yu XF reviewed the literature and contributed to manuscript drafting; Ma ZJ analyzed and interpreted the imaging findings; Sun ZW were responsible for the revision of the manuscript for important intellectual content; All authors issued final approval for the version to be submitted.
Supported byNational Natural Science Foundation of China, No. 81771154.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhong-Wu Sun, MD, Doctor, Department of Neurology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. sunzhwu@126.com
Received: March 11, 2021 Peer-review started: March 11, 2021 First decision: March 25, 2021 Revised: April 6, 2021 Accepted: May 6, 2021 Article in press: May 6, 2021 Published online: July 16, 2021 Processing time: 118 Days and 0.8 Hours
Abstract
BACKGROUND
Cerebral proliferative angiopathy (CPA) is a rare vascular disease characterized by the presence of diffuse vascular proliferation, progressive vascular hyperflow and vasodilation of multiple vessels in the normal brain parenchyma. Unlike cerebral arteriovenous malformations, CPA has a mixed appearance between that of lesions with cell proliferation and endothelial proliferation. To date, the pathogenesis of CPA is unclear, in which changes induced by cortical ischemia in the elastic layer of the blood supply artery and smooth muscle cells may be involved.
CASE SUMMARY
In this article, we retrospectively analyzed a case of hemorrhagic transformation of ischemic CPA diagnosed by digital subtraction angiography and reviewed the related literature for further exploration of its pathogenesis, diagnosis and treatment.
CONCLUSION
The information in the present case report may facilitate further clinical research on this cerebrovascular disease.
Core Tip: This article reports a very rare case of ischemic cerebrovascular disease, namely ischemic cerebral proliferative angiopathy. After consulting major databases, we found that cases of ischemic and hemorrhagic cerebral proliferative angiopathy have been reported, but the biggest feature of this case is the phenomenon of hemorrhagic transformation after ischemia. So far, there are few reports of such diseases globally, and their pathogenesis is currently unclear. The diagnosis and treatment methods are limited. Therefore, this article reviews relevant literature to better understand this rare disease and provides clues for further clinical research.
