Lu YX, Wu Y, Liang PF, Wu RC, Tian LY, Mo HY. Efficacy of combination of localized closure, ethacridine lactate dressing, and phototherapy in treatment of severe extravasation injuries: A case series. World J Clin Cases 2021; 9(18): 4599-4606 [PMID: PMC8223846 DOI: 10.12998/wjcc.v9.i18.4599]
Corresponding Author of This Article
Ying Wu, MS, Associate Chief Nurse, Teaching and Research Section of Clinical Nursing, Department of Burn and Reconstructive Surgery, Xiangya Hospital of Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan Province, China. wuying2341@126.com
Research Domain of This Article
Dermatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 26, 2021; 9(18): 4599-4606 Published online Jun 26, 2021. doi: 10.12998/wjcc.v9.i18.4599
Efficacy of combination of localized closure, ethacridine lactate dressing, and phototherapy in treatment of severe extravasation injuries: A case series
Yan-Xu Lu, Xiangya Stomatological Hospital & School of Stomatology , Central South University, Changsha 410000, Hunan Province, China
Ying Wu, Teaching and Research Section of Clinical Nursing, Department of Burn and Reconstructive Surgery, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China
Peng-Fei Liang, Hui-Ying Mo, Department of Burn and Reconstructive Surgery, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China
Rong-Chan Wu, Phase 1 Clinical Trial Center, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China
Ling-Yun Tian, School of Nursing, Anhui University of Chinese Medicine, Hefei 230012, Anhui Province, China
Author contributions: Lu YX and Wu Y carried out the studies, participated in collecting the data, and drafted the manuscript; Tian LY and Mo HY performed the statistical analysis and participated in study design; Liang PF and Wu RC participated in acquisition and analysis of the data; all authors read and approved the final manuscript.
Supported byNatural Science Foundation of Hunan Provincial Science and Technology Department, No. 2019JJ40527.
Institutional review board statement: The study was approved by the Ethics Committee of the Xiangya Hospital of Central South University (approval No. 202001107).
Informed consent statement: The patients included in this study have given written informed consent for publishing the case details.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying Wu, MS, Associate Chief Nurse, Teaching and Research Section of Clinical Nursing, Department of Burn and Reconstructive Surgery, Xiangya Hospital of Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan Province, China. wuying2341@126.com
Received: December 9, 2020 Peer-review started: December 9, 2020 First decision: January 17, 2021 Revised: February 24, 2021 Accepted: April 6, 2021 Article in press: April 6, 2021 Published online: June 26, 2021 Processing time: 177 Days and 21.3 Hours
Abstract
BACKGROUND
The management of severe extravasation injuries is still controversial. Extravasation injuries can be treated in many ways.
AIM
To present a series of patients with severe extravasation injuries due to infusion who were managed with ethacridine lactate dressing combined with localized closure and phototherapy.
METHODS
In this study, we evaluated the data of eight patients, including six from the Department of Burn, one (with colorectal carcinoma) from the Veteran Cadre Department, and one (with leukemia) from the Hematology Department. Of these, three patients were male and five were female. Age of the patients ranged from 10 mo to 72 years, including two children (10 and 19 mo of age). In this study, the infusion was stopped immediately when the extravasation was identified. The extravasation event was managed routinely using a blocking solution. A ring-shaped localized closure was performed using the blocking agents. Moreover, ethacridine lactate dressing and phototherapy were applied for 3-5 d.
RESULTS
In this study, the drugs contained in the infusates were iodixanol, norepinephrine, alprostadil, amino acids, fat emulsion, cefoselis, cefoxitin, and potassium chloride + concentrated sodium chloride. All of the patients achieved complete healing after treatment and no obvious adverse reactions were observed.
CONCLUSION
The treatment of severe extravasation injuries using a combination of localized closure, ethacridine lactate dressing, and phototherapy resulted in satisfactory outcomes in patients.
Core Tip: The management of severe extravasation injuries is still controversial. The treatment of severe extravasation injuries can be performed using various methods. Ethacridine lactate dressing can be used to manage skin lesions, such as ulcers. In this study, the drugs contained in the infusates were iodixanol, norepinephrine, alprostadil, amino acids, fat emulsion, cefoselis, cefoxitin, and potassium chloride + concentrated sodium chloride. All eight patients achieved healing after treatment. No obvious adverse reactions were observed. Satisfactory effects were achieved in the treatment of severe extravasation injuries with a combination of localized closure, ethacridine lactate dressing, and phototherapy.
