Wang XJ, Xia P, Yang T, Cheng K, Chen AL, Li XP. Rehabilitation and pharmacotherapy of neuromyelitis optica spectrum disorder: A case report. World J Clin Cases 2021; 9(16): 3951-3959 [PMID: 34141752 DOI: 10.12998/wjcc.v9.i16.3951]
Corresponding Author of This Article
Xue-Ping Li, PhD, Chief Doctor, Department of Rehabilitation Medicine, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, Jiangsu Province, China. lixueping2020@njmu.edu.cn
Research Domain of This Article
Rehabilitation
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 6, 2021; 9(16): 3951-3959 Published online Jun 6, 2021. doi: 10.12998/wjcc.v9.i16.3951
Rehabilitation and pharmacotherapy of neuromyelitis optica spectrum disorder: A case report
Xiao-Ju Wang, Peng Xia, Ting Yang, Kai Cheng, An-Liang Chen, Xue-Ping Li
Xiao-Ju Wang, Peng Xia, Ting Yang, Kai Cheng, An-Liang Chen, Xue-Ping Li, Department of Rehabilitation Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu Province, China
Author contributions: Wang XJ and Xia P contributed equally to this article; Wang XJ wrote the manuscript; Xia P contributed to the data acquisition; Yang T and Cheng K followed the patient during treatment; Li XP and Chen AL revised the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Ping Li, PhD, Chief Doctor, Department of Rehabilitation Medicine, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, Jiangsu Province, China. lixueping2020@njmu.edu.cn
Received: November 22, 2020 Peer-review started: November 22, 2020 First decision: December 24, 2020 Revised: January 2, 2021 Accepted: March 5, 2021 Article in press: March 5, 2021 Published online: June 6, 2021
Abstract
BACKGROUND
Neuromyelitis optica spectrum disorder (NMOSD) is a demyelinating autoimmune disease that affects the central nervous system. It typically manifests as optic neuritis or extensive longitudinal myelitis, with or without the presence of anti-aquaporin protein 4 autoantibodies (immunoglobulin G).
CASE SUMMARY
We report the case of a 45-year-old woman with a history of Sjogren's syndrome who was diagnosed with NMOSD accompanied by spinal cord injury and left calf intermuscular vein thrombosis. The patient received hormone shock and gamma globulin therapy in the acute phase and standard rehabilitation treatment during convalescence. Upon discharge, the patient was able to control urination and defecation, stand independently, and walk short distances with the aid of a walker.
CONCLUSION
This case suggests that pharmacotherapy and standard rehabilitation treatment can improve the prognosis of NMSOD patients.
Core Tip: Neuromyelitis optica spectrum disorder (NMOSD) is a demyelinating autoimmune disorder of the central nervous system. It typically manifests as optic neuritis or extensive longitudinal myelitis, with or without the presence of anti-aquaporin protein 4 autoantibodies (immunoglobulin G). We report the case of a 45-year-old woman with a history of Sjogren's syndrome who was diagnosed with NMOSD accompanied by spinal cord injury and left calf intermuscular vein thrombosis. The patient received hormone shock and gamma globulin therapy in the acute phase and standard rehabilitation treatment during convalescence.
