Chen ZY, Zhang Y, Tu Y, Zhao W, Li M. Effective chemotherapy for submandibular gland carcinoma ex pleomorphic adenoma with lung metastasis after radiotherapy: A case report. World J Clin Cases 2019; 7(6): 792-797 [PMID: 30968046 DOI: 10.12998/wjcc.v7.i6.792]
Corresponding Author of This Article
Mei Li, MD, Associate Chief Physician, Department of Head & Neck Cancer, Cancer Center, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Chengdu 610041, China. limeiscu78@163.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Mar 26, 2019; 7(6): 792-797 Published online Mar 26, 2019. doi: 10.12998/wjcc.v7.i6.792
Effective chemotherapy for submandibular gland carcinoma ex pleomorphic adenoma with lung metastasis after radiotherapy: A case report
Zhi-Yuan Chen, Yu Zhang, Yan Tu, Wei Zhao, Mei Li
Zhi-Yuan Chen, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Yu Zhang, Oncology Department, the Second People’s Hospital of Yunnan Province, Kunming 650000, Yunan Province, China
Yan Tu, Radiology Department, Yunnan Tumor Hospital, Kunming 650000, Yunan Province, China
Wei Zhao, Pathology Department, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Mei Li, Department of Head & Neck Cancer, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Li M designed the study; Tu Y and Zhao W contributed to the acquisition of data; Zhang Y and Chen ZY wrote the paper; Chen ZY and Zhang Y contributed equally to this work; all authors approved the final version of the manuscript.
Informed consent statement: Consent was obtained from the patient’s son for publication of this report and accompanying images.
Conflict-of-interest statement: All the authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Mei Li, MD, Associate Chief Physician, Department of Head & Neck Cancer, Cancer Center, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Chengdu 610041, China. limeiscu78@163.com
Telephone: +86-28-85423278 Fax: +86-28-85423278
Received: December 13, 2018 Peer-review started: December 13, 2018 First decision: January 12, 2019 Revised: February 16, 2019 Accepted: February 26, 2019 Article in press: February 26, 2019 Published online: March 26, 2019 Processing time: 103 Days and 6.8 Hours
Abstract
BACKGROUND
Only a few cases of carcinoma ex pleomorphic adenoma arising in the submandibular gland have ever been reported, all with a poor prognosis. The standard treatment for salivary gland carcinoma ex pleomorphic adenoma is surgical resection combined with postoperative radiotherapy, but the necessity of chemotherapy as well as the most appropriate treatment regimen for patients with distant metastasis after radiotherapy remains controversial.
CASE SUMMARY
This report presents the case of a 73-year-old woman who suffered submandibular gland carcinoma ex pleomorphic adenoma. She accepted surgery to remove the mass; she was found to have lung metastasis after radiotherapy. Her condition was controlled by chemotherapy with liposomal doxorubicin plus cisplatin.
CONCLUSION
The positive clinical outcome in the patient reveals that this chemotherapy regimen may be an alternative treatment for such a condition.
Core tip: The standard treatment for salivary gland carcinoma ex pleomorphic adenoma is surgical resection combined with postoperative radiotherapy, but the necessity of chemotherapy as well as the most appropriate treatment regimen for patients with distant metastasis after radiotherapy remains controversial. The positive clinical outcome in this case reveals that this chemotherapy regimen may be an alternative treatment for such a condition.
