Published online Mar 26, 2022. doi: 10.12998/wjcc.v10.i9.2733
Peer-review started: July 12, 2021
First decision: December 17, 2021
Revised: December 27, 2021
Accepted: February 19, 2022
Article in press: February 19, 2022
Published online: March 26, 2022
Processing time: 253 Days and 2.3 Hours
Despite advances in medical therapy for Crohn’s disease (CD), most patients with CD require repeated resection surgeries.
To analyze the perforating and nonperforating indications of repeated CD operations and identify the anastomosis characteristics for postoperative CD.
We retrospectively reviewed 386 patients who underwent at least one resection for CD between 2003 and 2013.Clinical characteristics of each surgery were collected. Univariate and multivariate analyses were performed to determine risk factors for recurrence.
The indication for reoperation in CD tends to be the same as that for primary operation, i.e., perforating disease tends to represent as perforating disease and nonperforating as nonperforating. Concordance was found between the first surgery and second surgery in terms of the indication for the operation (P = 0.006), and the indication for the third surgery was also correlated with that for the second surgery (P = 0.033). Even if the correlation of surgical indications between repeated operations, the rate of perforating indication for the second and third surgeries was significantly higher than that of the first surgery. In addition, the presence of perforating CD was a predictor of recurrence for both the first and second surgeries. Moreover, anastomotic lesions were the most common sites of recurrence after the operation. Based on the importance of anastomosis, anastomosis might be a new type of disease location for the classification of postoperative CD.
CD not only has stable characteristics but also progresses chronically. Perforation is a progressive surgical indication for Crohn’s disease. For CD after surgery, anastomosis may be a new classification of disease location.
Core Tip: It was well-known that Crohn’s disease (CD) is a chronic disease characterized by progressive bowel destruction. Our findings suggest that CD becomes more severe and more extensive with the increase in number of surgeries. CD not only has stable characteristics, but also progresses chronically. Perforation is a progressive surgical indication for CD. For CD after operation, anastomosis may be a new classification of disease location.