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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2020; 12(4): 394-404
Published online Apr 15, 2020. doi: 10.4251/wjgo.v12.i4.394
Published online Apr 15, 2020. doi: 10.4251/wjgo.v12.i4.394
LINC00511 promotes gastric cancer cell growth by acting as a ceRNA
Chong-Bing Sun, Yong-Ning Liu, Meng-Chun Wang, Department of General Surgery, Weifang People's Hospital, Weifang 261041, Shandong Province, China
Hong-Yi Wang, Hong-Xia Zhang, You-Feng Gu, Xiao-Gang Leng, Department of Anorectal Surgery, Weifang People's Hospital, Weifang 261041, Shandong Province, China
Xiao-Qing Han, Department of Spine Surgery, Weifang People's Hospital, Weifang 261041, Shandong Province, China
Author contributions: Sun CB, Wang HY, Han XQ, Liu YQ, and Wang MC analyzed and interpreted data and wrote the article; Zhang HX, Gu YF and Leng XG drafted the work and collected the data.
Institutional review board statement: Approved by the hospital ethics committee of Weifang People's Hospital.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiao-Gang Leng, MD, Attending Doctor, Department of Anorectal Surgery, Weifang People's Hospital, No. 151 Guangwen Street, Kuiwen District, Weifang 261041, Shandong Province, China. docxiaogang@163.com
Received: December 21, 2019
Peer-review started: December 21, 2019
First decision: January 19, 2020
Revised: February 4, 2020
Accepted: March 22, 2020
Article in press: March 22, 2020
Published online: April 15, 2020
Peer-review started: December 21, 2019
First decision: January 19, 2020
Revised: February 4, 2020
Accepted: March 22, 2020
Article in press: March 22, 2020
Published online: April 15, 2020
Core Tip
Core tip: In this study, we aimed to determine whether the long noncoding RNAs LINC00511 exerted its carcinogenic function in gastric cancer (GC) via the miR-124-3p/PDK4 axis. First, we investigated the expression level of LINC00511 in GC cell lines, and we then examined the biological function of LINC00511 with functional assays. Next, we predicted and confirmed the interaction between LINC00511 and miR-124-3p. Furthermore, we further found that PDK4 was a downstream target of miR-124-3p. Finally, we concluded that LINC00511 plays an oncogenic role in GC by sponging miR-124-3p and targeting PDK4, indicating that LINC00511 may be a new molecular biomarker for GC.