Basic Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2020; 12(10): 1104-1118
Published online Oct 15, 2020. doi: 10.4251/wjgo.v12.i10.1104
Prognostic significance of KIF23 expression in gastric cancer
Wei-Tian Liang, Xiao-Fang Liu, Hai-Bo Huang, Zi-Ming Gao, Kai Li
Wei-Tian Liang, Xiao-Fang Liu, Hai-Bo Huang, Zi-Ming Gao, Kai Li, Department of Surgical Oncology, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Liang WT and Li K designed and performed the experiments; Gao ZM analyzed the data; Liu XF and Huang HB helped perform the analysis with constructive discussions; Liang WT and Li K wrote the paper.
Supported by the Shenyang High-level Innovation Talents Plan, No. RC190403.
Institutional review board statement: This study was approved by the Research Ethics Committee of China Medical University according to the Helsinki Declaration.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest regarding the publication of this paper.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Kai Li, PhD, Chief Doctor, Full Professor, Department of Surgical Oncology, the First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang 110001, Liaoning Province, China. cmu_likai@126.com
Received: April 14, 2020
Peer-review started: April 14, 2020
First decision: May 15, 2020
Revised: May 29, 2020
Accepted: August 15, 2020
Article in press: August 15, 2020
Published online: October 15, 2020
Processing time: 183 Days and 3.2 Hours
Core Tip

Core Tip: This study investigated the role of the kinesin super family 23 (KIF23) in the gastric cancer (GC), including its expression and prognosis significance in GC. We found that KIF23 is highly expressed in GC and is associated with a poor prognosis of patients. It may be of great significance in the diagnosis, treatment, and prognostic evaluation of GC. We believe that our study makes a significant contribution to the literature as it revealed a novel relationship between KIF23 and GC and may provide a new therapeutic target for treating GC.