Liang WT, Liu XF, Huang HB, Gao ZM, Li K. Prognostic significance of KIF23 expression in gastric cancer. World J Gastrointest Oncol 2020; 12(10): 1104-1118 [PMID: 33133380 DOI: 10.4251/wjgo.v12.i10.1104]
Corresponding Author of This Article
Kai Li, PhD, Chief Doctor, Full Professor, Department of Surgical Oncology, the First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang 110001, Liaoning Province, China. cmu_likai@126.com
Research Domain of This Article
Oncology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Oct 15, 2020; 12(10): 1104-1118 Published online Oct 15, 2020. doi: 10.4251/wjgo.v12.i10.1104
Prognostic significance of KIF23 expression in gastric cancer
Wei-Tian Liang, Xiao-Fang Liu, Hai-Bo Huang, Zi-Ming Gao, Kai Li
Wei-Tian Liang, Xiao-Fang Liu, Hai-Bo Huang, Zi-Ming Gao, Kai Li, Department of Surgical Oncology, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Liang WT and Li K designed and performed the experiments; Gao ZM analyzed the data; Liu XF and Huang HB helped perform the analysis with constructive discussions; Liang WT and Li K wrote the paper.
Institutional review board statement: This study was approved by the Research Ethics Committee of China Medical University according to the Helsinki Declaration.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest regarding the publication of this paper.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Kai Li, PhD, Chief Doctor, Full Professor, Department of Surgical Oncology, the First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang 110001, Liaoning Province, China. cmu_likai@126.com
Received: April 14, 2020 Peer-review started: April 14, 2020 First decision: May 15, 2020 Revised: May 29, 2020 Accepted: August 15, 2020 Article in press: August 15, 2020 Published online: October 15, 2020 Processing time: 183 Days and 3.2 Hours
ARTICLE HIGHLIGHTS
Research background
Kinesin super family 23 (KIF23) is a member of the KIF family, and it plays an important role in mitosis and cytokinesis. Loss of KIF23 expression can cause mitotic arrest. By querying the Oncomine database, differences in expression between tumor and normal tissues can be determined.
Research motivation
We detected the expression level of KIF23 protein in gastric cancer (GC) and adjacent normal tissues, and analyzed the association between KIF23 protein expression and clinicopathological factors.
Research objectives
This study aimed to study the expression and prognostic significance of KIF23 in GC.
Research methods
Immunohistochemistry was used to compare the expression of KIF23 in GC and normal gastric tissues. The data on the expression and prognosis of KIF23 in GC were mined using Oncomine and Kaplan–Meier plotter database.
Research results
Compared with normal gastric tissues, KIF23 expression was increased in GC tissues, and correlated with T, N, and tumor–node–metastasis stages. Survival analysis showed that patients with high expression of KIF23 had a poor overall survival. The prognostic survival indicators worsened in patients with T2 and T3 poorly differentiated adenocarcinoma with high expression of KIF23.
Research conclusions
KIF23 is highly expressed in GC, and it is associated with a poor prognosis of GC patients.
Research perspectives
We found that KIF23 overexpression in gastric cancer tissues is related to prognosis. Use of a database for large sample analysis can avoid errors caused by a small sample size and provide an important theoretical basis for clinical treatment. The specific mechanism of KIF23 in the development of gastric cancer needs further study.
