Zhang CY, Sun J, Wang X, Wang CF, Zeng XD. Clinicopathological significance of human leukocyte antigen F-associated transcript 10 expression in colorectal cancer. World J Gastrointest Oncol 2019; 11(1): 9-16 [PMID: 30984346 DOI: 10.4251/wjgo.v11.i1.9]
Corresponding Author of This Article
Xian-Dong Zeng, MD, PhD, Chief Physician, Department of Surgical Oncology, Central Hospital Affiliated to Shenyang Medical College, No. 5 South Seven West Road, Tiexi District, Shenyang, Liaoning Province 110024, China. 1403973708@qq.com
Research Domain of This Article
Oncology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jan 15, 2019; 11(1): 9-16 Published online Jan 15, 2019. doi: 10.4251/wjgo.v11.i1.9
Clinicopathological significance of human leukocyte antigen F-associated transcript 10 expression in colorectal cancer
Chun-Yang Zhang, Jie Sun, Xing Wang, Cui-Fang Wang, Xian-Dong Zeng
Chun-Yang Zhang, Department of Emergency Medicine, Central Hospital Affiliated to Shenyang Medical College, Shenyang 110024, Liaoning Province, China
Jie Sun, Xing Wang, Cui-Fang Wang, Department of Pathology, Central Hospital Affiliated to Shenyang Medical College, Shenyang 110024, Liaoning Province, China
Xian-Dong Zeng, Department of Surgical Oncology, Central Hospital Affiliated to Shenyang Medical College, Shenyang 110024, Liaoning Province, China
Author contributions: Zhang CY and Sun J contributed equally to this work; Zhang CY, Sun J, Wang X, Wang CF and Zeng XD designed the research; Wang X performed pathology sectioning and immunohistochemical staining; Zhang CY and Sun J analyzed the data; Zhang CY, Sun J, Wang CF and Zeng XD wrote the paper.
Institutional review board statement: Institutional review board approval of Central Hospital Affiliated to Shenyang Medical College was obtained for this study.
Conflict-of-interest statement: The authors declared that they have no conflicts of interest to this work.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xian-Dong Zeng, MD, PhD, Chief Physician, Department of Surgical Oncology, Central Hospital Affiliated to Shenyang Medical College, No. 5 South Seven West Road, Tiexi District, Shenyang, Liaoning Province 110024, China. 1403973708@qq.com
Telephone: +86-24-85715888
Received: October 17, 2018 Peer-review started: October 18, 2018 First decision: November 14, 2018 Revised: December 5, 2018 Accepted: December 17, 2018 Article in press: December 17, 2018 Published online: January 15, 2019 Processing time: 90 Days and 5.2 Hours
Core Tip
Core tip: Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract. Genetic studies have demonstrated that the development of CRC is a complex process involving the activation of proto-oncogenes, inactivation of tumor suppressor genes, gene mutations, and dysregulation of apoptosis-related genes. Human leukocyte antigen F-associated transcript 10 (FAT10) is a regulatory protein of the ubiquitin-like modifier family that regulates various cell processes including mitosis, chromosome stability, apoptosis, immune control, and 26S-proteasome-mediated protein degradation. Our study investigated FAT10 expression in tumor and tumor-adjacent tissues of CRC patients and analyzed the relationship between FAT10 expression and the clinicopathological parameters of CRC.
