Zhang CY, Sun J, Wang X, Wang CF, Zeng XD. Clinicopathological significance of human leukocyte antigen F-associated transcript 10 expression in colorectal cancer. World J Gastrointest Oncol 2019; 11(1): 9-16 [PMID: 30984346 DOI: 10.4251/wjgo.v11.i1.9]
Corresponding Author of This Article
Xian-Dong Zeng, MD, PhD, Chief Physician, Department of Surgical Oncology, Central Hospital Affiliated to Shenyang Medical College, No. 5 South Seven West Road, Tiexi District, Shenyang, Liaoning Province 110024, China. 1403973708@qq.com
Research Domain of This Article
Oncology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jan 15, 2019; 11(1): 9-16 Published online Jan 15, 2019. doi: 10.4251/wjgo.v11.i1.9
Clinicopathological significance of human leukocyte antigen F-associated transcript 10 expression in colorectal cancer
Chun-Yang Zhang, Jie Sun, Xing Wang, Cui-Fang Wang, Xian-Dong Zeng
Chun-Yang Zhang, Department of Emergency Medicine, Central Hospital Affiliated to Shenyang Medical College, Shenyang 110024, Liaoning Province, China
Jie Sun, Xing Wang, Cui-Fang Wang, Department of Pathology, Central Hospital Affiliated to Shenyang Medical College, Shenyang 110024, Liaoning Province, China
Xian-Dong Zeng, Department of Surgical Oncology, Central Hospital Affiliated to Shenyang Medical College, Shenyang 110024, Liaoning Province, China
Author contributions: Zhang CY and Sun J contributed equally to this work; Zhang CY, Sun J, Wang X, Wang CF and Zeng XD designed the research; Wang X performed pathology sectioning and immunohistochemical staining; Zhang CY and Sun J analyzed the data; Zhang CY, Sun J, Wang CF and Zeng XD wrote the paper.
Institutional review board statement: Institutional review board approval of Central Hospital Affiliated to Shenyang Medical College was obtained for this study.
Conflict-of-interest statement: The authors declared that they have no conflicts of interest to this work.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xian-Dong Zeng, MD, PhD, Chief Physician, Department of Surgical Oncology, Central Hospital Affiliated to Shenyang Medical College, No. 5 South Seven West Road, Tiexi District, Shenyang, Liaoning Province 110024, China. 1403973708@qq.com
Telephone: +86-24-85715888
Received: October 17, 2018 Peer-review started: October 18, 2018 First decision: November 14, 2018 Revised: December 5, 2018 Accepted: December 17, 2018 Article in press: December 17, 2018 Published online: January 15, 2019 Processing time: 90 Days and 5.2 Hours
ARTICLE HIGHLIGHTS
Research background
The worldwide mortality rate of colorectal cancer (CRC) is about one half of its morbidity. Ubiquitin is a key regulatory factor in the cell cycle and widely exists in eukaryotes. Human leukocyte antigen F-associated transcript 10 (FAT10), also known as diubiquitin, is an 18-kDa protein with 29% and 36% homology with the N and C termini of ubiquitin, respectively.
Research motivation
The function of FAT10 has not been fully elucidated, and some studies have shown that it plays an important role in various cell processes.
Research objectives
The objective of this study is to examine FAT10 expression and to analyze the relationship between FAT10 expression and the clinicopathological parameters of CRC.
Research methods
Immunohistochemistry and Western blotting were used to measure FAT10 expression in 61 cases of CRC and para-cancer colorectal tissues. In addition, the relationship between FAT10 expression and the clinicopathological parameters of CRC was statistically analyzed.
Research results
Immunohistochemical analysis showed that the positive rate of FAT10 expression in CRC was significantly higher than in tumor-adjacent tissue and normal colorectal mucosal tissue. Western blotting indicated that FAT10 expression was significantly higher in CRC than in tumor-adjacent tissue. FAT10 expression was closely associated with clinical stage and lymphatic spread of CRC.
Research conclusions
FAT10 expression is highly upregulated in CRC and is closely associated with clinical stage and lymphatic spread of CRC.
Research perspectives
Further exploration of the role of FAT10 in the development of CRC and the underlying mechanisms, especially its relationship with the cell cycle, will be important for understanding the value of FAT10 in CRC diagnosis, prognosis and therapy.
