Risk factors for post-hepatectomy liver failure in 80 patients

Table 1 Comparisons of general data between the two groups

	PHLF group (n = 19)	Non-PHLF group (n = 61)
Gender
Male	16 (84.21%)	22 (36.07%)
Female	3 (15.79%)	39 (63.93%)
Age (yr)	60 (50,68)	57 (51,62)
History of hepatitis	9 (47.37%)	7 (11.48%)
History of diabetes	4 (21.05%)	5 (8.2%)
Liver cirrhosis	9 (47.37%)	4 (6.56%)
Operating time (h)	6.13-2.3	5.3-1.78
Bleeding (mL)	400 (200, 500)	300 (200, 500)
Hepatic hilum occlusion	9 (47.37%)	27 (44.26%)
ALT	28 (14.5, 40.1)	17.2 (10.4, 26.4)
AST	37.6 (25.2, 43.1)	20.1 (15.4, 25.7)
TBIL	21.4 (17.5, 36.2)	13.9 (10.6, 18.2)
DBIL	7 (5.8, 10.3)	5.1 (3.34, 7.7)
Creatinine	53 (41.4, 64.9)	50.3 (43.8, 61.1)
eGFR	120.66 (99.73, 129.65)	113.59 (105.84, 120.44)
ALB	35.67-6	39.45-3.66
WBC	4.8 (3.19, 6.73)	6.14 (4.98, 7.35)
LY	1.29 (0.86, 1.6)	1.39 (1.12, 1.85)
PLT	119.11-43.9	214.11-67.27
PT	11.5 (10.8, 13.3)	11.1 (10.6, 11.9)
INR	1.07 (1.03, 1.21)	1.02 (0.98, 1.1)
MELD	10 (8, 11)	7 (7, 8)
ALBI	-2.1-0.62	-2.59-0.33
APRI	0.78 (0.64, 1.04)	0.24 (0.17, 0.4)
Total liver volume	1385.26 (1239.85, 1487.93)	1294.16 (1174.19, 1385.63)
Remnant liver volume	854.12 (767.42, 1085.13)	984.13 (874.59, 1095.52)
Spleen volume	206.19 (176.83, 439.16)	162.79 (153.86, 175.23)
SV/LV	0.15 (0.13, 0.34)	0.12 (0.11, 0.14)
%RLV	0.65-0.14	0.76-0.08
BMI	23.11-2.4	23.6-2.48
Body surface area	1.73-0.14	1.68-0.12
SLV	1223.28-97.52	1188.79-86.27
SRLVR	0.7 (0.58, 0.85)	0.83 (0.75, 0.94)

PHLF: Post-hepatectomy liver failure; APRI: Aspartate aminotransferase-to-platelet ratio index; SV/LV: Spleen volume/Liver volume ratio; RLV: Remnant liver volume; BMI: Body Mass Index; SLV: Standard liver volume; AST: Aspartate aminotransferase.

Table 2 Univariate and multivariate analyses of the risk factors for post-hepatectomy liver failure

	Univariate analysis			Multivariate analysis
	OR	95%CI	P value	OR	95%CI	P value
Gender (reference = female)	9.455	(2.477-36.081)	0.001
Age	1.047	(0.987-1.111)	0.13
History of hepatitis	6.943	(2.099-22.963)	0.001
History of diabetes	2.987	(0.713-12.517)	0.135
Liver cirrhosis	12.825	(3.305-49.769)	< 0.001
Operating time	1.250	(0.953-1.639)	0.107
Bleeding	1.000	(0.999-1.001)	0.521
Hepatic hilum occlusion	1.133	(0.404-3.183)	0.812
ALT	1.007	(0.997-1.017)	0.188
AST	1.019	(0.995-1.043)	0.119
TBIL	1.031	(1.005-1.058)	0.018	1.177	(1.017, 1.362)	0.029
DBIL	1.026	(1.001-1.051)	0.038
Creatinine	1.006	(0.992-1.021)	0.398
eGFR	0.995	(0.971-1.019)	0.661
ALB	0.832	(0.733-0.944)	0.004
WBC	0.820	(0.624-1.078)	0.155
LY	0.927	(0.425-2.018)	0.848
PLT	0.968	(0.952-0.983)	< 0.001	0.949	(0.908, 0.992)	0.021
PT	1.512	(1.028-2.223)	0.036
INR	97.870	(1.336-7169.878)	0.036
MELD	1.375	(1.111-1.703)	0.003
ALBI	11.662	(2.96-45.95)	< 0.001
APRI	62.012	(8.376-459.096)	< 0.001	2.954	(1.021, 8.544)	0.046
Total liver volume	1.001	(1-1.002)	0.205
Remnant liver volume	0.998	(0.996-1.001)	0.222
Spleen volume	1.006	(1.002-1.009)	0.005
SV/LV	123.308	(2.076-7324.329)	0.021	< 0.001	(0,0.043)	0.036
%RLV	0.000	(0-0.008)	< 0.001
BMI	0.922	(0.749-1.136)	0.446
Body surface area	25.376	(0.325-1984.13)	0.146
SLV	1.005	(0.998-1.011)	0.146
SRLVR	0.068	(0.002-1.906)	0.114

PHLF: Post-hepatectomy liver failure; APRI: Aspartate aminotransferase-to-platelet ratio index; SV/LV: Spleen volume/Liver volume ratio; RLV: Remnant liver volume; BMI: Body Mass Index; SLV: Standard liver volume; SRLVR: Remnant liver volume/Standard liver volume (standard liver volume); AST: Aspartate aminotransferase.