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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 16, 2021; 9(8): 1793-1802
Published online Mar 16, 2021. doi: 10.12998/wjcc.v9.i8.1793
Published online Mar 16, 2021. doi: 10.12998/wjcc.v9.i8.1793
Risk factors for post-hepatectomy liver failure in 80 patients
Ying Xing, Zheng-Rong Liu, Wei Yu, Hong-Yi Zhang, Mao-Min Song, Department of General Surgery, Tiantan Hospital, Beijing 100170, China
Author contributions: Xing Y was involved in patient treatment, statistical analysis, writing of the original draft, and critical revision of the manuscript; Yu W took part in the statistical analysis; Liu ZR was involved in inpatient treatment; Zhang HY took part in the study conception, design, and critical revision of the manuscript; Song MM was involved in the study conception, design, writing of the original draft, and critical revision of the manuscript; all authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee Approval Document of Tiantan Hospital, Institutional Review Board Approval No. KYSQ 2020-177-01.
Informed consent statement: All study participants provided written informed consent prior to study enrollment.
Conflict-of-interest statement: We do not have any patents, whether planned, pending or issued, broadly relevant to the work.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mao-Min Song, MD, Chief Doctor, Professor, Surgical Oncologist, Department of General Surgery, Tiantan Hospital, No. 119 Fanyang Street, Beijing 100170, China. chongshuyong@126.com
Received: September 19, 2020
Peer-review started: September 19, 2020
First decision: December 13, 2020
Revised: December 21, 2020
Accepted: December 27, 2020
Article in press: December 27, 2020
Published online: March 16, 2021
Peer-review started: September 19, 2020
First decision: December 13, 2020
Revised: December 21, 2020
Accepted: December 27, 2020
Article in press: December 27, 2020
Published online: March 16, 2021
Core Tip
Core Tip: The etiology of post-hepatectomy liver failure (PHLF) is unclear. The volume of liver resection and the liver functional reserve are mainly used to evaluate the risk of PHLF. In this study we explored the risk factors for PHLF in patients with liver tumors. We found that preoperative total bilirubin, platelets, aspartate amino-transferase-to-platelet ratio index, and spleen volume/liver volume ratio are independent risk factors for PHLF. Both biochemical results and spleen volume on imaging should be considered before establishing a surgical plan to minimize the risk of PHLF. These findings may provide guidance to safely perform liver surgery in such patients.