Serum gastrin-17 concentration for prediction of upper gastrointestinal tract bleeding risk among peptic ulcer patients

Table 1 Demographic distributions of peptic ulcer patients with and without bleeding

Group	Sex		Age1 (yr)
	Male	Female
Peptic ulcer without bleeding	75	32	52.6 ± 14.7
Peptic ulcer complicated by bleeding	63	29	47.9 ± 17.4a
Total	138	61	50.43 ± 16.16

¹mean ± SD.

^aP < 0.05 compared to the non-bleeding group.

Table 2 Serum pepsinogen I, pepsinogen II, pepsinogen ratio, and gastrin-17 values for patient subgroups stratified by bleeding complication and ulcer type

Group		Number of cases (n)	PGI (μg/L)	PGII (μg/L)	PGR (PGI/II)	G-17 (pmol/L)
Peptic ulcer group	GU	45	197.90 ± 89.97	20.40 ± 13.70	11.46 ± 4.70	7.24 ± 8.43
	DU	49	224.43 ± 80.60	23.19 ± 17.05	12.58 ± 5.33	9.17 ± 6.33
	CU	13	220.48 ± 107.82	24.09 ± 10.16	10.70 ± 5.86	13.11 ± 10.91
	Total	107	225.86 ± 91.10	21.68 ± 14.47	12.74 ± 5.51	13.03 ± 13.20
Peptic ulcer complicated with upper gastrointestinal bleeding group	GU	20	240.52 ± 83.47	22.10 ± 15.30	15.15 ± 13.20	26.13 ± 13.68a
	DU	64	250.64 ± 85.70	19.22 ± 10.71	14.91 ± 5.32	25.84 ± 15.00a
	CU	8	238.55 ± 95.15	18.30 ± 7.51	14.70 ± 6.31	19.32 ± 8.87
	Total	92	234.98 ± 90.67	19.65 ± 12.25	14.44 ± 7.39	25.34 ± 14.29a

^aP < 0.01 compared to the corresponding non-bleeding group.

PGI: Pepsinogen I; PGII: Pepsinogen II; PGR: PGI/PGII ratio; G-17: Gastrin-17; GU: Gastric ulcer; DU: Duodenal ulcer; CU: Complex ulcer.

Table 3 Association between serum gastrin-17 and upper gastrointestinal bleeding

Serum G-17 level	Peptic ulcer, n (%)	Peptic ulcer complicated by bleeding, n (%)	Total, n	P value
Normal (≤ 15 pmol/L)	85 (72.6)	32 (27.4)	117
Elevated (> 15 pmol/L)	22 (26.8)	60 (73.2)	82
Total	107	92	199	0.000

G-17: Gastrin-17.