Observational Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 16, 2021; 9(35): 10948-10955
Published online Dec 16, 2021. doi: 10.12998/wjcc.v9.i35.10948
Serum gastrin-17 concentration for prediction of upper gastrointestinal tract bleeding risk among peptic ulcer patients
Jun-Xian Wang, Yu-Ping Cao, Peng Su, Wei He, Xiao-Ping Li, Ya-Meng Zhu
Jun-Xian Wang, Yu-Ping Cao, Peng Su, Wei He, Xiao-Ping Li, Ya-Meng Zhu, Department of Gastroenterology, The Second People’s Hospital of Anhui Province, Hefei 230011, Anhui Province, China
Author contributions: Wang JX and Su P contributed study concept, design, analysis and interpretation of data; Cao YP, Su P, He W, Li XP and Zhu YM contributed acquisition of data; Wang JX, Cao YP and Su P wrote the manuscript; all authors wrote, read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Second People's Hospital of Anhui Province, Institutional Review Board (Approval No. 2015-036).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors have no potential competing interests to declare.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun-Xian Wang, PhD, Chief Doctor, Department of Gastroenterology, The Second People’s Hospital of Anhui Province, No. 1868 Dangshan Road, Hefei 230011, Anhui Province, China. ahwjx168@sina.com
Received: April 25, 2021
Peer-review started: April 25, 2021
First decision: June 3, 2021
Revised: June 18, 2021
Accepted: August 30, 2021
Article in press: August 30, 2021
Published online: December 16, 2021
Processing time: 229 Days and 0.9 Hours
Core Tip

Core Tip: Upper gastrointestinal tract bleeding is a severe complication of peptic ulcer that markedly increases mortality. Bleeding risk is elevated by hypersecretion of gastric acid, and secretion rate is associated with serum concentrations of gastrin 17 (G-17), pepsinogen I, and pepsinogen II. Thus, these values may predict bleeding risk among peptic ulcer patients. Indeed, bleeding risk was elevated in patients with G-17 above the normal range (> 15 pmol/L), and serum G-17 > 9.86 pmol/L distinguished bleeding from non-bleeding patients with 90.2% sensitivity and 68.2% specificity. Elevated G-17 may be an effective early predictor of bleeding from peptic ulcer.